Keith M Skubitz

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Gene expression identifies heterogeneity of metastatic behavior among high-grade non-translocation associated soft tissue sarcomas
    Keith M Skubitz
    Department of Medicine, University Hospital, Minneapolis, MN, USA
    J Transl Med 12:176. 2014
  2. doi request reprint Gene expression identifies heterogeneity of metastatic propensity in high-grade soft tissue sarcomas
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Cancer 118:4235-43. 2012
  3. ncbi request reprint Gene expression in giant-cell tumors
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    J Lab Clin Med 144:193-200. 2004
  4. ncbi request reprint Paclitaxel and pegylated-liposomal doxorubicin are both active in angiosarcoma
    Keith M Skubitz
    Department of Medicine, The University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, Minnesota 55455, USA
    Cancer 104:361-6. 2005
  5. ncbi request reprint Differential gene expression identifies subgroups of renal cell carcinoma
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Lab Clin Med 147:250-67. 2006
  6. pmc Giant cell tumor of the uterus: case report and response to chemotherapy
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, and the Masonic Cancer Center, Minneapolis, MN 55455, USA
    BMC Cancer 7:46. 2007
  7. ncbi request reprint Sarcoma
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School and Masonic Cancer Center, Minneapolis, USA
    Mayo Clin Proc 82:1409-32. 2007
  8. doi request reprint Response of imatinib-resistant extra-abdominal aggressive fibromatosis to sunitinib: case report and review of the literature on response to tyrosine kinase inhibitors
    Keith M Skubitz
    Department of Medicine, The University of Minnesota Medical School, The Masonic Cancer Center, Minneapolis, MN 55455, USA
    Cancer Chemother Pharmacol 64:635-40. 2009
  9. doi request reprint Two new synthetic peptides from the N-domain of CEACAM1 (CD66a) stimulate neutrophil adhesion to endothelial cells
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Biopolymers 96:25-31. 2011
  10. ncbi request reprint Differential gene expression identifies subgroups of ovarian carcinoma
    Amy P N Skubitz
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minn 55455, USA
    Transl Res 148:223-48. 2006

Detail Information

Publications30

  1. ncbi request reprint Gene expression identifies heterogeneity of metastatic behavior among high-grade non-translocation associated soft tissue sarcomas
    Keith M Skubitz
    Department of Medicine, University Hospital, Minneapolis, MN, USA
    J Transl Med 12:176. 2014
    ..This study was designed to confirm our earlier observations in a larger independent data set...
  2. doi request reprint Gene expression identifies heterogeneity of metastatic propensity in high-grade soft tissue sarcomas
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Cancer 118:4235-43. 2012
    ....
  3. ncbi request reprint Gene expression in giant-cell tumors
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    J Lab Clin Med 144:193-200. 2004
    ..The genes identified in this study may play a role in the pathogenesis of GCTs, confirm the likely importance of OPGL in GCT pathogenesis, and may indicate other possible targets to which antitumor therapy could be directed...
  4. ncbi request reprint Paclitaxel and pegylated-liposomal doxorubicin are both active in angiosarcoma
    Keith M Skubitz
    Department of Medicine, The University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, Minnesota 55455, USA
    Cancer 104:361-6. 2005
    ....
  5. ncbi request reprint Differential gene expression identifies subgroups of renal cell carcinoma
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Lab Clin Med 147:250-67. 2006
    ..In addition, the genes identified as overexpressed in each set of clear cell renal cell carcinomas compared with normal tissues may represent useful targets for therapy...
  6. pmc Giant cell tumor of the uterus: case report and response to chemotherapy
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, and the Masonic Cancer Center, Minneapolis, MN 55455, USA
    BMC Cancer 7:46. 2007
    ..Rarely, GCT can originate at extraosseous sites. More rarely, GCT may exhibit a much more aggressive phenotype. The role of chemotherapy in metastatic GCT is not well defined...
  7. ncbi request reprint Sarcoma
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School and Masonic Cancer Center, Minneapolis, USA
    Mayo Clin Proc 82:1409-32. 2007
    ..Treatment and follow-up guidelines have been published by the National Comprehensive Cancer Network (www.nccn.org)...
  8. doi request reprint Response of imatinib-resistant extra-abdominal aggressive fibromatosis to sunitinib: case report and review of the literature on response to tyrosine kinase inhibitors
    Keith M Skubitz
    Department of Medicine, The University of Minnesota Medical School, The Masonic Cancer Center, Minneapolis, MN 55455, USA
    Cancer Chemother Pharmacol 64:635-40. 2009
    ..The role of chemotherapy in AF is not well defined, but can be useful in some cases. We examined the response of a case to both imatinib and sunitinib...
  9. doi request reprint Two new synthetic peptides from the N-domain of CEACAM1 (CD66a) stimulate neutrophil adhesion to endothelial cells
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Biopolymers 96:25-31. 2011
    ..Some of these active peptides are identical to homologous regions of other CEACAMs...
  10. ncbi request reprint Differential gene expression identifies subgroups of ovarian carcinoma
    Amy P N Skubitz
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minn 55455, USA
    Transl Res 148:223-48. 2006
    ..In addition, the genes identified as over-expressed in each set of serous ovarian carcinoma compared with normal tissues may represent potential biomarkers and/or targets for therapy...
  11. pmc Differential gene expression in ovarian carcinoma: identification of potential biomarkers
    Kathleen Hibbs
    Department of Laboratory Medicine and Pathology, University of Minnesota, MMC 609, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Am J Pathol 165:397-414. 2004
    ..These results suggest that further exploration into other up-regulated genes may identify novel diagnostic, therapeutic, and/or prognostic biomarkers in ovarian carcinoma...
  12. ncbi request reprint Ovarian carcinoma ascites spheroids adhere to extracellular matrix components and mesothelial cell monolayers
    Kathryn M Burleson
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Gynecol Oncol 93:170-81. 2004
    ....
  13. pmc Identification of heterogeneity among soft tissue sarcomas by gene expression profiles from different tumors
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, MN 55455, USA
    J Transl Med 6:23. 2008
    ..In addition, several genes that are targets of some anti-tumor drugs were found to be differentially expressed in particular subsets of STS...
  14. ncbi request reprint Establishment of an in vitro assay to measure the invasion of ovarian carcinoma cells through mesothelial cell monolayers
    Rachael C Casey
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Clin Exp Metastasis 20:343-56. 2003
    ....
  15. ncbi request reprint Differential gene expression in liposarcoma, lipoma, and adipose tissue
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, Minnesota 55455, USA
    Cancer Invest 23:105-18. 2005
    ..Such differences in gene expression may help differentiate among subtypes of sarcomas, and may also yield clues to the pathophysiology of this heterogeneous group of tumors...
  16. pmc Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells
    Keith M Skubitz
    The Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, MN 55455, USA
    J Transl Med 6:78. 2008
    ..A model in which CEACAMs dimerize to form signaling complexes could accommodate the observations. Similar interactions may occur in other cells expressing CEACAMs...
  17. ncbi request reprint Phase II trial of pegylated-liposomal doxorubicin (Doxil) in sarcoma
    Keith M Skubitz
    University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, Minnesota, USA
    Cancer Invest 21:167-76. 2003
    ..Some responses were delayed. These data suggest that pegylated-liposomal doxorubicin has activity in this population of poor prognosis sarcoma and that this treatment is associated with modest toxicity...
  18. ncbi request reprint Differential gene expression in leiomyosarcoma
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School and the Masonic Cancer Center, MMC 286, University Hospital, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Cancer 98:1029-38. 2003
    ..Leiomyosarcomas (LMS) are a common subtype of soft tissue sarcoma. The molecular causes of the disease remain unclear...
  19. ncbi request reprint Cell membrane glycosylation mediates the adhesion, migration, and invasion of ovarian carcinoma cells
    Rachael C Casey
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Clin Exp Metastasis 20:143-52. 2003
    ..Thus, the carbohydrate modifications of several proteoglycans may mediate the formation and spread of secondary tumor growth in ovarian carcinoma...
  20. ncbi request reprint Phase II trial of pegylated-liposomal doxorubicin (Doxil) in mesothelioma
    Keith M Skubitz
    University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, MN 55455, USA
    Cancer Invest 20:693-9. 2002
    ..These data suggest that pegylated-liposomal doxorubicin has activity in mesothelioma, and that this treatment is associated with modest toxicity...
  21. ncbi request reprint Differential gene expression in renal-cell cancer
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    J Lab Clin Med 140:52-64. 2002
    ..The observed changes in gene expression in RCC should help further the understanding of the biology of RCC and may be useful in diagnosis, treatment, and imaging...
  22. ncbi request reprint Gene expression in aggressive fibromatosis
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
    J Lab Clin Med 143:89-98. 2004
    ..We conclude that gene-expression patterns may be useful in the further classification of subtypes of aggressive fibromatosis and that such classification could have clinical significance...
  23. ncbi request reprint Role of gene expression arrays in sarcomas
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, MMC 286 University Hospital, Minneapolis, MN 55455, USA
    Curr Oncol Rep 6:309-14. 2004
    ..Gene expression may also be useful prognostically with respect to the natural history and response to therapy of these tumors...
  24. ncbi request reprint Characterization of sarcomas by means of gene expression
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    J Lab Clin Med 144:78-91. 2004
    ..In addition, distinct clusters were observed that contained only MFH and NOS samples. We conclude that gene-expression patterns may be useful in helping further classify subtypes of sarcomas...
  25. ncbi request reprint Phase II trial of pegylated-liposomal doxorubicin (Doxil) in renal cell cancer
    Keith M Skubitz
    University of Minnesota Medical School, and the Masonic Cancer Center, Minneapolis, USA
    Invest New Drugs 20:101-4. 2002
    ..No objective responses were observed in 11 evaluable patients. This study did not demonstrate activity of pegylated-liposomal doxorubicin in renal cell cancer, although it can be given with mild toxicity...
  26. doi request reprint Early detection of ovarian cancer using group biomarkers
    Alain B Tchagang
    Department of Biomedical Engineering, University of Minnesota, 312 Church Street Southeast, Minneapolis, MN 55455, USA
    Mol Cancer Ther 7:27-37. 2008
    ..Our study also suggests that single or group biomarkers correlate with the stage of the disease...
  27. pmc Pegylated liposomal doxorubicin in the treatment of AIDS-related Kaposi's sarcoma
    Ashish Udhrain
    Department of Medicine, Mayo Clinic Arizona, AZ, USA
    Int J Nanomedicine 2:345-52. 2007
    ....
  28. ncbi request reprint Differential gene expression in uterine leiomyoma
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    J Lab Clin Med 141:297-308. 2003
    ..We conclude that differences in gene expression can be detected between leiomyomas and normal myometrium and that these changes in gene expression may yield clues to the pathophysiology of this common tumor...
  29. doi request reprint Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity
    Benjamin S Misemer
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, Minnesota
    Cancer Med 3:81-90. 2014
    ..IHC also correlated with the probability of recurrence following excision. These proteins may be involved in AF pathogenesis and the corresponding pathways could serve as potential targets of therapy...
  30. ncbi request reprint Efficacy and safety of liposomal anthracyclines in phase I/II clinical trials
    David S Alberts
    The Arizona Cancer Center, Tucson, AZ, USA
    Semin Oncol 31:53-90. 2004
    ....