Research Topics
| Keith M SkubitzSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Gene expression identifies heterogeneity of metastatic propensity in high-grade soft tissue sarcomasKeith M Skubitz
Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Cancer 118:4235-43. 2012....
Gene expression in giant-cell tumorsKeith M Skubitz
Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
J Lab Clin Med 144:193-200. 2004..The genes identified in this study may play a role in the pathogenesis of GCTs, confirm the likely importance of OPGL in GCT pathogenesis, and may indicate other possible targets to which antitumor therapy could be directed...- Response of imatinib-resistant extra-abdominal aggressive fibromatosis to sunitinib: case report and review of the literature on response to tyrosine kinase inhibitorsKeith M Skubitz
Department of Medicine, The University of Minnesota Medical School, The Masonic Cancer Center, Minneapolis, MN 55455, USA
Cancer Chemother Pharmacol 64:635-40. 2009..The role of chemotherapy in AF is not well defined, but can be useful in some cases. We examined the response of a case to both imatinib and sunitinib... - Paclitaxel and pegylated-liposomal doxorubicin are both active in angiosarcomaKeith M Skubitz
Department of Medicine, The University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, Minnesota 55455, USA
Cancer 104:361-6. 2005.... - Two new synthetic peptides from the N-domain of CEACAM1 (CD66a) stimulate neutrophil adhesion to endothelial cellsKeith M Skubitz
Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Biopolymers 96:25-31. 2011..Some of these active peptides are identical to homologous regions of other CEACAMs... - Differential gene expression identifies subgroups of renal cell carcinomaKeith M Skubitz
Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
J Lab Clin Med 147:250-67. 2006..In addition, the genes identified as overexpressed in each set of clear cell renal cell carcinomas compared with normal tissues may represent useful targets for therapy... 
Giant cell tumor of the uterus: case report and response to chemotherapyKeith M Skubitz
Department of Medicine, University of Minnesota Medical School, and the Masonic Cancer Center, Minneapolis, MN 55455, USA
BMC Cancer 7:46. 2007..Rarely, GCT can originate at extraosseous sites. More rarely, GCT may exhibit a much more aggressive phenotype. The role of chemotherapy in metastatic GCT is not well defined...- SarcomaKeith M Skubitz
Department of Medicine, University of Minnesota Medical School and Masonic Cancer Center, Minneapolis, USA
Mayo Clin Proc 82:1409-32. 2007..Treatment and follow-up guidelines have been published by the National Comprehensive Cancer Network (www.nccn.org)... - Differential gene expression identifies subgroups of ovarian carcinomaAmy P N Skubitz
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minn 55455, USA
Transl Res 148:223-48. 2006..In addition, the genes identified as over-expressed in each set of serous ovarian carcinoma compared with normal tissues may represent potential biomarkers and/or targets for therapy... - Differential gene expression in ovarian carcinoma: identification of potential biomarkersKathleen Hibbs
Department of Laboratory Medicine and Pathology, University of Minnesota, MMC 609, 420 Delaware St S E, Minneapolis, MN 55455, USA
Am J Pathol 165:397-414. 2004..These results suggest that further exploration into other up-regulated genes may identify novel diagnostic, therapeutic, and/or prognostic biomarkers in ovarian carcinoma... - Identification of heterogeneity among soft tissue sarcomas by gene expression profiles from different tumorsKeith M Skubitz
Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, MN 55455, USA
J Transl Med 6:23. 2008..In addition, several genes that are targets of some anti-tumor drugs were found to be differentially expressed in particular subsets of STS... - Ovarian carcinoma ascites spheroids adhere to extracellular matrix components and mesothelial cell monolayersKathryn M Burleson
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
Gynecol Oncol 93:170-81. 2004.... - Establishment of an in vitro assay to measure the invasion of ovarian carcinoma cells through mesothelial cell monolayersRachael C Casey
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Clin Exp Metastasis 20:343-56. 2003.... - Differential gene expression in liposarcoma, lipoma, and adipose tissueKeith M Skubitz
Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, Minnesota 55455, USA
Cancer Invest 23:105-18. 2005..Such differences in gene expression may help differentiate among subtypes of sarcomas, and may also yield clues to the pathophysiology of this heterogeneous group of tumors... - Differential gene expression in leiomyosarcomaKeith M Skubitz
Department of Medicine, University of Minnesota Medical School and the Masonic Cancer Center, MMC 286, University Hospital, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Cancer 98:1029-38. 2003..Leiomyosarcomas (LMS) are a common subtype of soft tissue sarcoma. The molecular causes of the disease remain unclear... - Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cellsKeith M Skubitz
The Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, MN 55455, USA
J Transl Med 6:78. 2008..A model in which CEACAMs dimerize to form signaling complexes could accommodate the observations. Similar interactions may occur in other cells expressing CEACAMs... - Phase II trial of pegylated-liposomal doxorubicin (Doxil) in sarcomaKeith M Skubitz
University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, Minnesota, USA
Cancer Invest 21:167-76. 2003..Some responses were delayed. These data suggest that pegylated-liposomal doxorubicin has activity in this population of poor prognosis sarcoma and that this treatment is associated with modest toxicity... - Gene expression in aggressive fibromatosisKeith M Skubitz
Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
J Lab Clin Med 143:89-98. 2004..We conclude that gene-expression patterns may be useful in the further classification of subtypes of aggressive fibromatosis and that such classification could have clinical significance... - Differential gene expression in renal-cell cancerKeith M Skubitz
Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
J Lab Clin Med 140:52-64. 2002..The observed changes in gene expression in RCC should help further the understanding of the biology of RCC and may be useful in diagnosis, treatment, and imaging... - Phase II trial of pegylated-liposomal doxorubicin (Doxil) in mesotheliomaKeith M Skubitz
University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, MN 55455, USA
Cancer Invest 20:693-9. 2002..These data suggest that pegylated-liposomal doxorubicin has activity in mesothelioma, and that this treatment is associated with modest toxicity... - Cell membrane glycosylation mediates the adhesion, migration, and invasion of ovarian carcinoma cellsRachael C Casey
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Clin Exp Metastasis 20:143-52. 2003..Thus, the carbohydrate modifications of several proteoglycans may mediate the formation and spread of secondary tumor growth in ovarian carcinoma... - Characterization of sarcomas by means of gene expressionKeith M Skubitz
Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
J Lab Clin Med 144:78-91. 2004..In addition, distinct clusters were observed that contained only MFH and NOS samples. We conclude that gene-expression patterns may be useful in helping further classify subtypes of sarcomas... - Role of gene expression arrays in sarcomasKeith M Skubitz
Department of Medicine, University of Minnesota Medical School, MMC 286 University Hospital, Minneapolis, MN 55455, USA
Curr Oncol Rep 6:309-14. 2004..Gene expression may also be useful prognostically with respect to the natural history and response to therapy of these tumors... - Early detection of ovarian cancer using group biomarkersAlain B Tchagang
Department of Biomedical Engineering, University of Minnesota, 312 Church Street Southeast, Minneapolis, MN 55455, USA
Mol Cancer Ther 7:27-37. 2008..Our study also suggests that single or group biomarkers correlate with the stage of the disease... - Pegylated liposomal doxorubicin in the treatment of AIDS-related Kaposi's sarcomaAshish Udhrain
Department of Medicine, Mayo Clinic Arizona, AZ, USA
Int J Nanomedicine 2:345-52. 2007.... - Phase II trial of pegylated-liposomal doxorubicin (Doxil) in renal cell cancerKeith M Skubitz
University of Minnesota Medical School, and the Masonic Cancer Center, Minneapolis, USA
Invest New Drugs 20:101-4. 2002..No objective responses were observed in 11 evaluable patients. This study did not demonstrate activity of pegylated-liposomal doxorubicin in renal cell cancer, although it can be given with mild toxicity... - Differential gene expression in uterine leiomyomaKeith M Skubitz
Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
J Lab Clin Med 141:297-308. 2003..We conclude that differences in gene expression can be detected between leiomyomas and normal myometrium and that these changes in gene expression may yield clues to the pathophysiology of this common tumor... - Efficacy and safety of liposomal anthracyclines in phase I/II clinical trialsDavid S Alberts
The Arizona Cancer Center, Tucson, AZ, USA
Semin Oncol 31:53-90. 2004....