K M Skubitz

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells
    Keith M Skubitz
    The Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, MN 55455, USA
    J Transl Med 6:78. 2008
  2. ncbi Identification of heterogeneity among soft tissue sarcomas by gene expression profiles from different tumors
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, MN 55455, USA
    J Transl Med 6:23. 2008
  3. ncbi Characterization of sarcomas by means of gene expression
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    J Lab Clin Med 144:78-91. 2004
  4. ncbi Differential gene expression in leiomyosarcoma
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School and the Masonic Cancer Center, MMC 286, University Hospital, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Cancer 98:1029-38. 2003
  5. ncbi Differential gene expression in uterine leiomyoma
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    J Lab Clin Med 141:297-308. 2003
  6. ncbi Inhalational interleukin-2 liposomes for pulmonary metastases: a phase I clinical trial
    K M Skubitz
    University of Minnesota Medical School and the Masonic Cancer Center, Minneapolis 55455, USA
    Anticancer Drugs 11:555-63. 2000
  7. ncbi Synthetic peptides of CD66a stimulate neutrophil adhesion to endothelial cells
    K M Skubitz
    Departments of Medicine and Laboratory Medicine and Pathology, and Biomedical Engineering Center, University of Minnesota Medical School and the Masonic Cancer Center, Minneapolis, MN 55455, USA
    J Immunol 164:4257-64. 2000
  8. ncbi CD63 associates with CD11/CD18 in large detergent-resistant complexes after translocation to the cell surface in human neutrophils
    K M Skubitz
    Department of Medicine, The University of Minnesota Medical School, Minneapolis, MN 55455, USA
    FEBS Lett 469:52-6. 2000
  9. ncbi CD43 is associated with tyrosine kinase activity in human neutrophils
    K M Skubitz
    Department of Medicine, The University of Minnesota Medical School, Minneapolis 55455, USA
    J Leukoc Biol 64:800-2. 1998
  10. ncbi Tyrosine kinase activity is associated with CD44 in human neutrophils
    K M Skubitz
    Department of Medicine, University of Minnesota Medical School, University Hospital, Minneapolis 55455, USA
    FEBS Lett 439:97-100. 1998

Collaborators

Detail Information

Publications22

  1. ncbi Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells
    Keith M Skubitz
    The Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, MN 55455, USA
    J Transl Med 6:78. 2008
    ..A model in which CEACAMs dimerize to form signaling complexes could accommodate the observations. Similar interactions may occur in other cells expressing CEACAMs...
  2. ncbi Identification of heterogeneity among soft tissue sarcomas by gene expression profiles from different tumors
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, MN 55455, USA
    J Transl Med 6:23. 2008
    ..In addition, several genes that are targets of some anti-tumor drugs were found to be differentially expressed in particular subsets of STS...
  3. ncbi Characterization of sarcomas by means of gene expression
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    J Lab Clin Med 144:78-91. 2004
    ..In addition, distinct clusters were observed that contained only MFH and NOS samples. We conclude that gene-expression patterns may be useful in helping further classify subtypes of sarcomas...
  4. ncbi Differential gene expression in leiomyosarcoma
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School and the Masonic Cancer Center, MMC 286, University Hospital, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Cancer 98:1029-38. 2003
    ..Leiomyosarcomas (LMS) are a common subtype of soft tissue sarcoma. The molecular causes of the disease remain unclear...
  5. ncbi Differential gene expression in uterine leiomyoma
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    J Lab Clin Med 141:297-308. 2003
    ..We conclude that differences in gene expression can be detected between leiomyomas and normal myometrium and that these changes in gene expression may yield clues to the pathophysiology of this common tumor...
  6. ncbi Inhalational interleukin-2 liposomes for pulmonary metastases: a phase I clinical trial
    K M Skubitz
    University of Minnesota Medical School and the Masonic Cancer Center, Minneapolis 55455, USA
    Anticancer Drugs 11:555-63. 2000
    ..No significant toxicity was observed. We conclude that the delivery of IL-2 liposomes by inhalation is well tolerated. Further studies of inhalational IL-2 liposomes to determine efficacy as an anti-cancer therapy are warranted...
  7. ncbi Synthetic peptides of CD66a stimulate neutrophil adhesion to endothelial cells
    K M Skubitz
    Departments of Medicine and Laboratory Medicine and Pathology, and Biomedical Engineering Center, University of Minnesota Medical School and the Masonic Cancer Center, Minneapolis, MN 55455, USA
    J Immunol 164:4257-64. 2000
    ..The data suggest that peptide motifs from at least three regions of the N-terminal domain of CD66a are involved in the interaction of CD66a with other ligands and can initiate signal transduction in neutrophils...
  8. ncbi CD63 associates with CD11/CD18 in large detergent-resistant complexes after translocation to the cell surface in human neutrophils
    K M Skubitz
    Department of Medicine, The University of Minnesota Medical School, Minneapolis, MN 55455, USA
    FEBS Lett 469:52-6. 2000
    ..The data suggest that intracellular CD11, CD18 and CD63 are not in detergent-resistant complexes, but enter such complexes following translocation to the cell surface...
  9. ncbi CD43 is associated with tyrosine kinase activity in human neutrophils
    K M Skubitz
    Department of Medicine, The University of Minnesota Medical School, Minneapolis 55455, USA
    J Leukoc Biol 64:800-2. 1998
    ..The data suggest that associated tyrosine kinase activity may play a role in signal transduction via CD43 to regulate other cell functions...
  10. ncbi Tyrosine kinase activity is associated with CD44 in human neutrophils
    K M Skubitz
    Department of Medicine, University of Minnesota Medical School, University Hospital, Minneapolis 55455, USA
    FEBS Lett 439:97-100. 1998
    ..The data suggest that associated tyrosine kinase activity may play a role in signal transduction from CD44 in neutrophils to regulate other cell functions...
  11. ncbi Synthetic peptides from the N-domains of CEACAMs activate neutrophils
    K M Skubitz
    Department of Medicine, The University of Minnesota Medical School, Minneapolis, USA
    J Pept Res 58:515-26. 2001
    ..The data suggest that the regions SMPF of peptide CD66a-1, QLFG of peptide CD66a-2 and NRQIV of peptide CD66a-3 are critical for the activities of these peptides, and for the native CEACAMs...
  12. ncbi CD63 associates with tyrosine kinase activity and CD11/CD18, and transmits an activation signal in neutrophils
    K M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
    J Immunol 157:3617-26. 1996
    ..Associated protein kinase activity may play a role in signal transduction by CD63 to regulate other cell functions...
  13. ncbi CD66a, CD66b, CD66c, and CD66d each independently stimulate neutrophils
    K M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    J Leukoc Biol 60:106-17. 1996
    ..Sequential desensitization experiments indicated that CD66a, CD66b, CD66c, and CD66d can each independently transmit signals in neutrophils...
  14. ncbi CD50 (ICAM-3) is phosphorylated on tyrosine and is associated with tyrosine kinase activity in human neutrophils
    K M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis
    J Immunol 154:2888-95. 1995
    ..The data suggest that phosphorylation of CD50 on tyrosine by an associated tyrosine kinase plays a role in the function of CD50...
  15. ncbi Association of beta 1 integrin with protein kinase activity in large detergent resistant complexes
    A P Skubitz
    Department of Laboratory Medicine and Pathology and The Biomedical Engineering Center, University of Minnesota Medical School, Minneapolis 55455, USA
    FEBS Lett 426:386-91. 1998
    ..These results suggest that serine protein kinase activity associated with the beta 1 integrin may play a role in signaling via the beta 1 integrin...
  16. ncbi Beta 1-integrins regulate the formation and adhesion of ovarian carcinoma multicellular spheroids
    R C Casey
    Departments of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Pathol 159:2071-80. 2001
    ....
  17. ncbi Endogenous and exogenous adenosine inhibit granulocyte aggregation without altering the associated rise in intracellular calcium concentration
    K M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis
    Blood 72:29-33. 1988
    ..Furthermore, the augmentation of responses seen with ADA suggests that endogenous adenosine may be a physiologic autocrine regulator of granulocyte function...
  18. ncbi Preclinical studies targeting normal and leukemic hematopoietic cells with Yttrium-90-labeled anti-CD45 antibody in vitro and in vivo in nude mice
    D A Vallera
    University of Minnesota Cancer Center, Department of Therapeutic Radiology Radiation Oncology, Minneapolis 55455, USA
    Cancer Biother Radiopharm 18:133-45. 2003
    ....
  19. ncbi Preparation and characterization of monoclonal antibodies to human neutrophil cathepsin G, lactoferrin, eosinophil peroxidase, and eosinophil major basic protein
    K M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis
    J Leukoc Biol 46:109-18. 1989
    ..These antibodies should be useful for immunolocalization and quantification of their respective antigens as well as for other studies of the roles of these proteins in granulocyte function and differentiation...
  20. ncbi Redefined nomenclature for members of the carcinoembryonic antigen family
    N Beauchemin
    McGill Cancer Centre, McGill University, Montreal,
    Exp Cell Res 252:243-9. 1999
  21. ncbi Monoclonal antibodies that recognize lacto-N-fucopentaose III (CD15) react with the adhesion-promoting glycoprotein family (LFA-1/HMac-1/gp 150,95) and CR1 on human neutrophils
    K M Skubitz
    J Immunol 139:1631-9. 1987
    ..The data suggest that the antibodies studied can detect differences in post-translational modification among copies of certain surface proteins...
  22. ncbi The functional interactions between CD98, beta1-integrins, and CD147 in the induction of U937 homotypic aggregation
    J Y Cho
    Department of Immunology, Windeyer Institute of Medical Sciences, University College London, England
    Blood 98:374-82. 2001
    ..The results of this study support a central role for CD98 within a multimolecular unit that regulates cell aggregation...