Amy Pn Skubitz

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Targeting CD133 in an in vivo ovarian cancer model reduces ovarian cancer progression
    Amy P N Skubitz
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Gynecol Oncol 130:579-87. 2013
  2. pmc Identification of heterogeneity among soft tissue sarcomas by gene expression profiles from different tumors
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, MN 55455, USA
    J Transl Med 6:23. 2008
  3. pmc Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells
    Keith M Skubitz
    The Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, MN 55455, USA
    J Transl Med 6:78. 2008
  4. pmc Quantitative proteomic analysis by iTRAQ(R) for the identification of candidate biomarkers in ovarian cancer serum
    Kristin Lm Boylan
    Department of Laboratory Medicine and Pathology, University of Minnesota, MMC 609, 420 Delaware St, SE, Minneapolis, MN, USA
    Proteome Sci 8:31. 2010
  5. ncbi request reprint Differential gene expression identifies subgroups of ovarian carcinoma
    Amy P N Skubitz
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minn 55455, USA
    Transl Res 148:223-48. 2006
  6. pmc Leucine-rich alpha-2-glycoprotein-1 is upregulated in sera and tumors of ovarian cancer patients
    John D Andersen
    Department of Laboratory Medicine and Pathology, University of Minnesota, MMC 609, 420 Delaware St, SE Minneapolis, MN, USA
    J Ovarian Res 3:21. 2010
  7. pmc Differential gene expression in ovarian carcinoma: identification of potential biomarkers
    Kathleen Hibbs
    Department of Laboratory Medicine and Pathology, University of Minnesota, MMC 609, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Am J Pathol 165:397-414. 2004
  8. pmc Nectin 4 overexpression in ovarian cancer tissues and serum: potential role as a serum biomarker
    Melissa S DeRycke
    Dept of Laboratory Medicine and Pathology, MMC 609, 420 Delaware St, SE, Minneapolis, MN 55455, USA
    Am J Clin Pathol 134:835-45. 2010
  9. doi request reprint Early detection of ovarian cancer using group biomarkers
    Alain B Tchagang
    Department of Biomedical Engineering, University of Minnesota, 312 Church Street Southeast, Minneapolis, MN 55455, USA
    Mol Cancer Ther 7:27-37. 2008
  10. doi request reprint Two new synthetic peptides from the N-domain of CEACAM1 (CD66a) stimulate neutrophil adhesion to endothelial cells
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Biopolymers 96:25-31. 2011

Collaborators

Detail Information

Publications29

  1. pmc Targeting CD133 in an in vivo ovarian cancer model reduces ovarian cancer progression
    Amy P N Skubitz
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Gynecol Oncol 130:579-87. 2013
    ..The hypothesis driving this study is that despite their low numbers in ovarian cancer tumors, CSC can be eradicated using CD133 targeted therapy and tumor growth can be inhibited...
  2. pmc Identification of heterogeneity among soft tissue sarcomas by gene expression profiles from different tumors
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, MN 55455, USA
    J Transl Med 6:23. 2008
    ..In addition, several genes that are targets of some anti-tumor drugs were found to be differentially expressed in particular subsets of STS...
  3. pmc Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells
    Keith M Skubitz
    The Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, MN 55455, USA
    J Transl Med 6:78. 2008
    ..A model in which CEACAMs dimerize to form signaling complexes could accommodate the observations. Similar interactions may occur in other cells expressing CEACAMs...
  4. pmc Quantitative proteomic analysis by iTRAQ(R) for the identification of candidate biomarkers in ovarian cancer serum
    Kristin Lm Boylan
    Department of Laboratory Medicine and Pathology, University of Minnesota, MMC 609, 420 Delaware St, SE, Minneapolis, MN, USA
    Proteome Sci 8:31. 2010
    ..In this study, we used pooled serum depleted of the most highly abundant proteins to reduce the dynamic range of proteins, and thereby enhance the identification of serum biomarkers using the quantitative proteomic method iTRAQ(R)...
  5. ncbi request reprint Differential gene expression identifies subgroups of ovarian carcinoma
    Amy P N Skubitz
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minn 55455, USA
    Transl Res 148:223-48. 2006
    ..In addition, the genes identified as over-expressed in each set of serous ovarian carcinoma compared with normal tissues may represent potential biomarkers and/or targets for therapy...
  6. pmc Leucine-rich alpha-2-glycoprotein-1 is upregulated in sera and tumors of ovarian cancer patients
    John D Andersen
    Department of Laboratory Medicine and Pathology, University of Minnesota, MMC 609, 420 Delaware St, SE Minneapolis, MN, USA
    J Ovarian Res 3:21. 2010
    ..We previously demonstrated the upregulation of leucine-rich alpha-2-glycoprotein-1 (LRG1) in the sera of ovarian cancer patients compared to healthy women using quantitative mass spectrometry...
  7. pmc Differential gene expression in ovarian carcinoma: identification of potential biomarkers
    Kathleen Hibbs
    Department of Laboratory Medicine and Pathology, University of Minnesota, MMC 609, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Am J Pathol 165:397-414. 2004
    ..These results suggest that further exploration into other up-regulated genes may identify novel diagnostic, therapeutic, and/or prognostic biomarkers in ovarian carcinoma...
  8. pmc Nectin 4 overexpression in ovarian cancer tissues and serum: potential role as a serum biomarker
    Melissa S DeRycke
    Dept of Laboratory Medicine and Pathology, MMC 609, 420 Delaware St, SE, Minneapolis, MN 55455, USA
    Am J Clin Pathol 134:835-45. 2010
    ....
  9. doi request reprint Early detection of ovarian cancer using group biomarkers
    Alain B Tchagang
    Department of Biomedical Engineering, University of Minnesota, 312 Church Street Southeast, Minneapolis, MN 55455, USA
    Mol Cancer Ther 7:27-37. 2008
    ..Our study also suggests that single or group biomarkers correlate with the stage of the disease...
  10. doi request reprint Two new synthetic peptides from the N-domain of CEACAM1 (CD66a) stimulate neutrophil adhesion to endothelial cells
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Biopolymers 96:25-31. 2011
    ..Some of these active peptides are identical to homologous regions of other CEACAMs...
  11. ncbi request reprint Gene expression in giant-cell tumors
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    J Lab Clin Med 144:193-200. 2004
    ..The genes identified in this study may play a role in the pathogenesis of GCTs, confirm the likely importance of OPGL in GCT pathogenesis, and may indicate other possible targets to which antitumor therapy could be directed...
  12. ncbi request reprint Characterization of sarcomas by means of gene expression
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    J Lab Clin Med 144:78-91. 2004
    ..In addition, distinct clusters were observed that contained only MFH and NOS samples. We conclude that gene-expression patterns may be useful in helping further classify subtypes of sarcomas...
  13. ncbi request reprint Cell membrane glycosylation mediates the adhesion, migration, and invasion of ovarian carcinoma cells
    Rachael C Casey
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Clin Exp Metastasis 20:143-52. 2003
    ..Thus, the carbohydrate modifications of several proteoglycans may mediate the formation and spread of secondary tumor growth in ovarian carcinoma...
  14. ncbi request reprint Differential gene expression in uterine leiomyoma
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    J Lab Clin Med 141:297-308. 2003
    ..We conclude that differences in gene expression can be detected between leiomyomas and normal myometrium and that these changes in gene expression may yield clues to the pathophysiology of this common tumor...
  15. ncbi request reprint Differential gene expression in leiomyosarcoma
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School and the Masonic Cancer Center, MMC 286, University Hospital, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Cancer 98:1029-38. 2003
    ..Leiomyosarcomas (LMS) are a common subtype of soft tissue sarcoma. The molecular causes of the disease remain unclear...
  16. pmc Claudin 4 Is differentially expressed between ovarian cancer subtypes and plays a role in spheroid formation
    Kristin L M Boylan
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA E Mails K L M B B M M S D J D A K M H S E P
    Int J Mol Sci 12:1334-58. 2011
    ..The inability of the NIH:OVCAR5 cells treated with claudin 4 shRNA to form compact spheroids was verified by FITC-dextran exclusion. These results demonstrate a role for claudin 4 and tight junctions in spheroid formation and integrity...
  17. ncbi request reprint Role of gene expression arrays in sarcomas
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, MMC 286 University Hospital, Minneapolis, MN 55455, USA
    Curr Oncol Rep 6:309-14. 2004
    ..Gene expression may also be useful prognostically with respect to the natural history and response to therapy of these tumors...
  18. ncbi request reprint Differential gene expression identifies subgroups of renal cell carcinoma
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Lab Clin Med 147:250-67. 2006
    ..In addition, the genes identified as overexpressed in each set of clear cell renal cell carcinomas compared with normal tissues may represent useful targets for therapy...
  19. ncbi request reprint Differential gene expression in liposarcoma, lipoma, and adipose tissue
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, Minnesota 55455, USA
    Cancer Invest 23:105-18. 2005
    ..Such differences in gene expression may help differentiate among subtypes of sarcomas, and may also yield clues to the pathophysiology of this heterogeneous group of tumors...
  20. pmc S100A1 expression in ovarian and endometrial endometrioid carcinomas is a prognostic indicator of relapse-free survival
    Melissa S DeRycke
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, USA
    Am J Clin Pathol 132:846-56. 2009
    ..In the endometrioid subtype of ovarian and endometrial cancers, relapse-free survival was decreased for patients with S100A1+ tumors. These data suggest that S100A1 is a marker for poor prognosis of endometrioid subtypes of cancer...
  21. ncbi request reprint Differential gene expression in renal-cell cancer
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    J Lab Clin Med 140:52-64. 2002
    ..The observed changes in gene expression in RCC should help further the understanding of the biology of RCC and may be useful in diagnosis, treatment, and imaging...
  22. pmc Quantitative comparison of immunohistochemical staining measured by digital image analysis versus pathologist visual scoring
    Anthony E Rizzardi
    Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street SE, MMC76, Minneapolis, MN 55455, USA
    Diagn Pathol 7:42. 2012
    ..g., carcinomatous areas of tissue specimens) and quantify IHC staining intensity within those areas can produce highly similar data to visual evaluation by a pathologist...
  23. pmc Identification of candidate biomarkers in ovarian cancer serum by depletion of highly abundant proteins and differential in-gel electrophoresis
    John D Andersen
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Electrophoresis 31:599-610. 2010
    ..Western blotting validated the relative increases in serum protein levels for three of the proteins identified, demonstrating the utility of this approach for the identification of novel serum biomarkers for ovarian cancer...
  24. ncbi request reprint Adhesion molecules
    Amy P N Skubitz
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Cancer Treat Res 107:305-29. 2002
    ..Then, when ovarian carcinoma cells can no longer interact with mesothelial cells and their associated ECM, the dissemination of ovarian carcinoma cells in vivo may be prevented...
  25. ncbi request reprint Ovarian carcinoma spheroids disaggregate on type I collagen and invade live human mesothelial cell monolayers
    Kathryn M Burleson
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Clin Exp Metastasis 21:685-97. 2004
    ..Based on their ability to attach to, disaggregate on, and invade into live human mesothelial cell monolayers, spheroids should thus be regarded as potential contributors to the dissemination of ovarian cancer...
  26. ncbi request reprint Gene expression in aggressive fibromatosis
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
    J Lab Clin Med 143:89-98. 2004
    ..We conclude that gene-expression patterns may be useful in the further classification of subtypes of aggressive fibromatosis and that such classification could have clinical significance...
  27. ncbi request reprint Establishment of an in vitro assay to measure the invasion of ovarian carcinoma cells through mesothelial cell monolayers
    Rachael C Casey
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Clin Exp Metastasis 20:343-56. 2003
    ....
  28. pmc Gene expression identifies heterogeneity of metastatic behavior among high-grade non-translocation associated soft tissue sarcomas
    Keith M Skubitz
    Department of Medicine, University Hospital, Minneapolis, MN, USA
    J Transl Med 12:176. 2014
    ..This study was designed to confirm our earlier observations in a larger independent data set...
  29. ncbi request reprint Ovarian carcinoma ascites spheroids adhere to extracellular matrix components and mesothelial cell monolayers
    Kathryn M Burleson
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Gynecol Oncol 93:170-81. 2004
    ....

Research Grants5

  1. Biomarkers with Biological Function in Ovarian Carcinoma
    Amy Skubitz; Fiscal Year: 2005
    ..The association between levels of expression/secretion of the cell adhesion proteins with biological functional activities and patient information will be determined. ..
  2. Biomarkers with Biological Function in Ovarian Carcinoma
    Amy Skubitz; Fiscal Year: 2006
    ..The association between levels of expression/secretion of the cell adhesion proteins with biological functional activities and patient information will be determined. ..
  3. Biomarkers with Biological Function in Ovarian Carcinoma
    Amy Skubitz; Fiscal Year: 2007
    ..The association between levels of expression/secretion of the cell adhesion proteins with biological functional activities and patient information will be determined. ..
  4. Biomarkers with Biological Function in Ovarian Carcinoma
    Amy Skubitz; Fiscal Year: 2009
    ..The association between levels of expression/secretion of the cell adhesion proteins with biological functional activities and patient information will be determined. ..