Christine F Skibola

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Post-GWAS functional characterization of susceptibility variants for chronic lymphocytic leukemia
    Fenna C M Sillé
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, United States of America
    PLoS ONE 7:e29632. 2012
  2. pmc A meta-analysis of genome-wide association studies of follicular lymphoma
    Christine F Skibola
    School of Public Health, Division of Environmental Health Sciences, University of California, Berkeley, 94720, USA
    BMC Genomics 13:516. 2012
  3. pmc Multi-locus HLA class I and II allele and haplotype associations with follicular lymphoma
    C F Skibola
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Tissue Antigens 79:279-86. 2012
  4. pmc Genetic susceptibility to lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Haematologica 92:960-9. 2007
  5. pmc Obesity, diet and risk of non-Hodgkin lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 16:392-5. 2007
  6. pmc Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA
    Nat Genet 41:873-5. 2009
  7. pmc Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium
    Christine F Skibola
    237A Hildebrand Hall, School of Public Health, University of California, Berkeley, Berkeley, CA 94720 7360, USA
    Am J Epidemiol 171:267-76. 2010
  8. pmc Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma
    Christine F Skibola
    School of Public Health, Division of Environmental Health Sciences, University of California Berkeley, Berkeley, California, USA
    PLoS ONE 3:e2816. 2008
  9. ncbi Polymorphisms in cytochrome P450 17A1 and risk of non-Hodgkin lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Br J Haematol 129:618-21. 2005
  10. ncbi Brown kelp modulates endocrine hormones in female sprague-dawley rats and in human luteinized granulosa cells
    Christine F Skibola
    School of Public Health, University of California Berkeley, Berkeley, CA, USA
    J Nutr 135:296-300. 2005

Research Grants

  1. A Genome-Wide Association Study of Non-Hodgkin Lymphoma
    Christine Skibola; Fiscal Year: 2006
  2. A Genome-Wide Association Study of Non-Hodgkin Lymphoma
    Christine Skibola; Fiscal Year: 2007
  3. Genetic Susceptibility to non-Hodgkin Lymphoma
    Christine Skibola; Fiscal Year: 2009
  4. A Genome-Wide Association Study of Non-Hodgkin Lymphoma
    Christine Skibola; Fiscal Year: 2009
  5. A Genome-Wide Association Study of Non-Hodgkin Lymphoma
    Christine F Skibola; Fiscal Year: 2010
  6. Genetic Susceptibility to non-Hodgkin Lymphoma
    Christine F Skibola; Fiscal Year: 2010

Detail Information

Publications35

  1. pmc Post-GWAS functional characterization of susceptibility variants for chronic lymphocytic leukemia
    Fenna C M Sillé
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, United States of America
    PLoS ONE 7:e29632. 2012
    ....
  2. pmc A meta-analysis of genome-wide association studies of follicular lymphoma
    Christine F Skibola
    School of Public Health, Division of Environmental Health Sciences, University of California, Berkeley, 94720, USA
    BMC Genomics 13:516. 2012
    ....
  3. pmc Multi-locus HLA class I and II allele and haplotype associations with follicular lymphoma
    C F Skibola
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Tissue Antigens 79:279-86. 2012
    ..These results provide further insight into the critical roles of HLA alleles and SNPs in FL pathogenesis that involve multi-locus effects across the HLA region...
  4. pmc Genetic susceptibility to lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Haematologica 92:960-9. 2007
    ..Numerous studies suggest that common genetic variants with low penetrance influence lymphoma risk, though replication studies will be needed to eliminate false positive associations...
  5. pmc Obesity, diet and risk of non-Hodgkin lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 16:392-5. 2007
    ..The accumulated scientific evidence concerning the associations between obesity, diet, and NHL suggests several identified modifiable risk factors that might be recommended to decrease lymphoma risk...
  6. pmc Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA
    Nat Genet 41:873-5. 2009
    ..7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1)...
  7. pmc Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium
    Christine F Skibola
    237A Hildebrand Hall, School of Public Health, University of California, Berkeley, Berkeley, CA 94720 7360, USA
    Am J Epidemiol 171:267-76. 2010
    ..04). These findings strengthen previous results for DLBCL and the LTA 252A>G/TNF -308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology...
  8. pmc Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma
    Christine F Skibola
    School of Public Health, Division of Environmental Health Sciences, University of California Berkeley, Berkeley, California, USA
    PLoS ONE 3:e2816. 2008
    ..Non-Hodgkin lymphoma (NHL) is the fifth most common cancer in the U.S. and few causes have been identified. Genetic association studies may help identify environmental risk factors and enhance our understanding of disease mechanisms...
  9. ncbi Polymorphisms in cytochrome P450 17A1 and risk of non-Hodgkin lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Br J Haematol 129:618-21. 2005
    ..44, 95% confidence interval (CI) 1.02-2.03], particularly diffuse large B-cell lymphoma (OR = 1.76, CI 1.14-2.71). Associations of CYP17A1 polymorphisms with increased risk of NHL suggest a role for oestrogen in lymphomagenesis...
  10. ncbi Brown kelp modulates endocrine hormones in female sprague-dawley rats and in human luteinized granulosa cells
    Christine F Skibola
    School of Public Health, University of California Berkeley, Berkeley, CA, USA
    J Nutr 135:296-300. 2005
    ..4, 31.8, and 40.7 micromol/L, respectively. These data show endocrine modulating effects of kelp at relevant doses and suggest that dietary kelp may contribute to the lower incidence of hormone-dependent cancers among the Japanese...
  11. pmc The effect of Fucus vesiculosus, an edible brown seaweed, upon menstrual cycle length and hormonal status in three pre-menopausal women: a case report
    Christine F Skibola
    School of Public Health, Molecular Epidemiology and Toxicology Laboratory, University of California, Berkeley, CA 94720, USA
    BMC Complement Altern Med 4:10. 2004
    ..To test this, bladderwrack was administered to three pre-menopausal women with abnormal menstrual cycling patterns and/or menstrual-related disease histories...
  12. ncbi Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Blood 104:2155-62. 2004
    ..The associations of DLCL and FL with TYMS 1494del6 and MTHFR 677TT genotypes, respectively, suggest that folate metabolism may play an important role in the pathogenesis of specific subtypes of NHL...
  13. ncbi Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 13:779-86. 2004
    ....
  14. pmc A functional TNFRSF5 gene variant is associated with risk of lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Blood 111:4348-54. 2008
    ..These results suggest that the TNFRSF5 -1C>T polymorphism may increase FL susceptibility through mechanisms that hinder cellular immune responses. Further studies are needed to explore these findings...
  15. pmc Chemokine polymorphisms and lymphoma: a pooled analysis
    Paige M Bracci
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94118 1944, USA
    Leuk Lymphoma 51:497-506. 2010
    ..The CCL5 -403A allele conferred reduced risks of FL and chronic lymphocytic leukemia/small lymphocytic lymphoma. Results should be interpreted conservatively. Continued investigation is warranted to confirm these findings...
  16. ncbi Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia
    Christine F Skibola
    NFCR Center for Genomics and Nutrition, School of Public Health, and the Department of Nutritional Sciences, University of California, Berkeley, CA 94720 7360, USA
    Blood 99:3786-91. 2002
    ....
  17. ncbi Polymorphisms and haplotypes in the cytochrome P450 17A1, prolactin, and catechol-O-methyltransferase genes and non-Hodgkin lymphoma risk
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 14:2391-401. 2005
    ..These results suggest that PRL, CYP17A1, and COMT may be relevant genetic loci for non-Hodgkin lymphoma and indicate a possible role for prolactin and estrogen in lymphoma pathogenesis...
  18. ncbi Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma
    Matthew S Forrest
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Br J Haematol 134:180-3. 2006
    ..67, 95% CI 0.45-0.99). These results suggest that variation in innate immune genes may alter NHL susceptibility...
  19. pmc Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina
    Craig Steinmaus
    Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA, USA
    Toxicol Appl Pharmacol 247:138-45. 2010
    ..These results add to the increasing body of evidence that variation in arsenic metabolism plays an important role in arsenic-disease susceptibility...
  20. pmc Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
    Lucia Conde
    School of Public Health, University of California, Berkeley, Berkeley, California, USA
    Nat Genet 42:661-4. 2010
    ..We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9))...
  21. pmc Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism
    Kristin E Porter
    School of Public Health, 237A Hildebrand Hall, University of California, Berkeley, CA 94720 7356, USA
    Environ Res 110:580-7. 2010
    ..No other genetic associations were found. These findings are the first to suggest that CBS polymorphisms may influence arsenic metabolism in humans and susceptibility to arsenic-related disease...
  22. ncbi Accuracy of multiplexed Illumina platform-based single-nucleotide polymorphism genotyping compared between genomic and whole genome amplified DNA collected from multiple sources
    Randi A Paynter
    Division of Environmental Health Sciences, School of Public Health, University of California, 140 Earl Warren Hall 7360, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 15:2533-6. 2006
    ..We conclude that highly multiplexed Illumina genotyping may be done on gDNA and wgaDNA obtained from whole blood, buccal samples, dried blood spots on Guthrie cards, and possibly even urine samples, with minimal misclassification...
  23. pmc Association of HLA-DQB1 alleles with risk of follicular lymphoma
    Nicholas K Akers
    School of Public Health, University of California, Berkeley, CA, USA
    Leuk Lymphoma 52:53-8. 2011
    ..51, 95% CI 0.38-0.69; adjusted p-value = 4.46 × 10(-5)). Although these findings require verification, the role of HLA class II proteins in B-cell survival and proliferation makes this a biologically plausible association...
  24. pmc An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis
    Xuefeng Ren
    Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 119:11-9. 2011
    ..Recent studies have suggested that epigenetic mechanisms may also mediate toxicity and carcinogenicity resulting from arsenic exposure...
  25. ncbi Screening the human serum proteome for genotype-phenotype associations: an analysis of the IL6 -174G>C polymorphism
    Christine M Hegedus
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Proteomics 7:548-57. 2007
    ..This study illustrates that proteome analysis can enhance our understanding of genotype-phenotype relationships. Additional studies are needed to clarify the interaction between the IL6 -174G>C polymorphism and ApoC-I...
  26. pmc A search for overlapping genetic susceptibility loci between non-Hodgkin lymphoma and autoimmune diseases
    Lucia Conde
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, USA
    Genomics 98:9-14. 2011
    ..These results support continued investigation to further elucidate the relationship between lymphoma and autoimmune diseases...
  27. pmc Arsenic immunotoxicity: a review
    Nygerma L Dangleben
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Environ Health 12:73. 2013
    ....
  28. pmc A generic coalescent-based framework for the selection of a reference panel for imputation
    Bogdan Pasaniuc
    International Computer Science Institute, Berkeley, California 94704, USA
    Genet Epidemiol 34:773-82. 2010
    ..Our method is generic and can potentially be incorporated in any of the available imputation methods as an add-on...
  29. pmc Benzene, the exposome and future investigations of leukemia etiology
    Martyn T Smith
    Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 192:155-9. 2011
    ..We propose that we should attempt to characterize the 'exposome' of human leukemia by using unbiased laboratory-based methods to find the unknown 'environmental' factors that contribute to leukemia etiology...
  30. pmc Decreased urinary beta-defensin-1 expression as a biomarker of response to arsenic
    Christine M Hegedus
    School of Public Health, University of California, Berkeley, California 94720 7356, USA
    Toxicol Sci 106:74-82. 2008
    ..Further studies are warranted to investigate the role of HBD-1 in As-related toxicity...
  31. ncbi Issues of processing and multiple testing of SELDI-TOF MS proteomic data
    Merrill D Birkner
    Division of Biostatistics, School of Public Health, University of California, Berkeley, USA
    Stat Appl Genet Mol Biol 5:Article11. 2006
    ..Given no sources of unmeasured bias (such as confounding of experimental conditions with disease status), proteins found to be statistically significant using this technique have a low probability of being false positives...
  32. pmc Systems biology of human benzene exposure
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 184:86-93. 2010
    ....
  33. pmc Integrating GWAS and expression data for functional characterization of disease-associated SNPs: an application to follicular lymphoma
    Lucia Conde
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA 94720 7360, USA
    Am J Hum Genet 92:126-30. 2013
    ..The application of integrative methods, such as those presented here, to other post-GWAS investigations will help identify causal disease variants and enhance our understanding of biological disease mechanisms...
  34. ncbi Molecular biomarkers for the study of childhood leukemia
    Martyn T Smith
    Division of Environmental Health Sciences, School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
    Toxicol Appl Pharmacol 206:237-45. 2005
    ..Several proteins have been identified that may serve as useful biomarkers for rapidly identifying different forms of childhood leukemia...
  35. ncbi Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children
    Martyn T Smith
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley 94720 7360, USA
    Blood 100:4590-3. 2002
    ..The inactivating NQO1 polymorphism is associated with an increased risk of de novo leukemia with MLL translocations in infants and children...

Research Grants7

  1. A Genome-Wide Association Study of Non-Hodgkin Lymphoma
    Christine Skibola; Fiscal Year: 2006
    ..The data generated from this study will provide a framework for further investigation within the NHL consortium, InterLymph. Results will later be combined with that from other InterLymph case-control studies in pooled analyses. ..
  2. A Genome-Wide Association Study of Non-Hodgkin Lymphoma
    Christine Skibola; Fiscal Year: 2007
    ..The data generated from this study will provide a framework for further investigation within the NHL consortium, InterLymph. Results will later be combined with that from other InterLymph case-control studies in pooled analyses. ..
  3. Genetic Susceptibility to non-Hodgkin Lymphoma
    Christine Skibola; Fiscal Year: 2009
    ....
  4. A Genome-Wide Association Study of Non-Hodgkin Lymphoma
    Christine Skibola; Fiscal Year: 2009
    ..Results will later be combined with that from other InterLymph case-control studies in pooled analyses. ..
  5. A Genome-Wide Association Study of Non-Hodgkin Lymphoma
    Christine F Skibola; Fiscal Year: 2010
    ..Results will later be combined with that from other InterLymph case-control studies in pooled analyses. ..
  6. Genetic Susceptibility to non-Hodgkin Lymphoma
    Christine F Skibola; Fiscal Year: 2010
    ....