D Siscovick

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Using built environment characteristics to predict walking for exercise
    Gina S Lovasi
    Institute for Social and Economic Research and Policy, Columbia University, New York, NY, USA
    Int J Health Geogr 7:10. 2008
  2. ncbi request reprint Thrombosis in the young: effect of atherosclerotic risk factors on the risk of myocardial infarction associated with prothrombotic factors
    D S Siscovick
    Department of Medicine, University of Washington, Seattle 98101, USA
    Thromb Haemost 78:7-12. 1997
  3. ncbi request reprint Triggers of clinical coronary heart disease
    David S Siscovick
    Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA
    Epidemiology 17:495-7. 2006
  4. ncbi request reprint Influenza vaccination and the risk of primary cardiac arrest
    D S Siscovick
    Department of Medicine, University of Washington, Seattle, USA
    Am J Epidemiol 152:674-7. 2000
  5. ncbi request reprint Chlamydia pneumoniae and atherosclerotic risk in populations: the role of seroepidemiology
    D S Siscovick
    Cardiovascular Health Research Unit, University of Washington, Seattle, WA 9810l 1448, USA
    J Infect Dis 181:S417-20. 2000
  6. ncbi request reprint Dietary intake of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest
    D S Siscovick
    Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA 98101, USA
    Am J Clin Nutr 71:208S-12S. 2000
  7. pmc Type 2 diabetes mellitus and the risk of sudden cardiac arrest in the community
    David S Siscovick
    Medicine and Epidemiology, University of Washington, Cardiovascular Health Research Unit, 1730 Minor Avenue, Seattle, WA 98101, USA
    Rev Endocr Metab Disord 11:53-9. 2010
  8. pmc Fish consumption and stroke risk in elderly individuals: the cardiovascular health study
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, Boston, MA, USA
    Arch Intern Med 165:200-6. 2005
  9. pmc Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke
    Daniel A Enquobahrie
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    Am J Cardiol 101:1683-8. 2008
  10. pmc CRP gene variation and risk of community-acquired pneumonia
    Kenneth J Mukamal
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Respirology 15:160-4. 2010

Collaborators

Detail Information

Publications95

  1. pmc Using built environment characteristics to predict walking for exercise
    Gina S Lovasi
    Institute for Social and Economic Research and Policy, Columbia University, New York, NY, USA
    Int J Health Geogr 7:10. 2008
    ..In order to limit confounding by prior health conditions, the sample was restricted to participants in good self-reported health and without a documented history of cardiovascular disease...
  2. ncbi request reprint Thrombosis in the young: effect of atherosclerotic risk factors on the risk of myocardial infarction associated with prothrombotic factors
    D S Siscovick
    Department of Medicine, University of Washington, Seattle 98101, USA
    Thromb Haemost 78:7-12. 1997
    ....
  3. ncbi request reprint Triggers of clinical coronary heart disease
    David S Siscovick
    Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA
    Epidemiology 17:495-7. 2006
  4. ncbi request reprint Influenza vaccination and the risk of primary cardiac arrest
    D S Siscovick
    Department of Medicine, University of Washington, Seattle, USA
    Am J Epidemiol 152:674-7. 2000
    ....
  5. ncbi request reprint Chlamydia pneumoniae and atherosclerotic risk in populations: the role of seroepidemiology
    D S Siscovick
    Cardiovascular Health Research Unit, University of Washington, Seattle, WA 9810l 1448, USA
    J Infect Dis 181:S417-20. 2000
    ..pneumoniae and atherothrombotic risk...
  6. ncbi request reprint Dietary intake of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest
    D S Siscovick
    Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA 98101, USA
    Am J Clin Nutr 71:208S-12S. 2000
    ..These findings also may help to explain the apparent inconsistencies in earlier studies of long-chain n-3 PUFA intake and ischemic heart disease...
  7. pmc Type 2 diabetes mellitus and the risk of sudden cardiac arrest in the community
    David S Siscovick
    Medicine and Epidemiology, University of Washington, Cardiovascular Health Research Unit, 1730 Minor Avenue, Seattle, WA 98101, USA
    Rev Endocr Metab Disord 11:53-9. 2010
    ....
  8. pmc Fish consumption and stroke risk in elderly individuals: the cardiovascular health study
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, Boston, MA, USA
    Arch Intern Med 165:200-6. 2005
    ..Additionally, such relationships have not been specifically evaluated in the elderly, in whom disease burden may be high and diet less influential...
  9. pmc Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke
    Daniel A Enquobahrie
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    Am J Cardiol 101:1683-8. 2008
    ..77 to 0.99). No within-gene or gene-gene interaction was associated with MI or ischemic stroke risk. In conclusion, potential SNP-disease associations identified in the present study are novel and need further investigation...
  10. pmc CRP gene variation and risk of community-acquired pneumonia
    Kenneth J Mukamal
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Respirology 15:160-4. 2010
    ..Whether this variation influences risk of infection, and hence whether CRP has anti-infective activity in humans, is uncertain...
  11. ncbi request reprint Oral contraceptive use and association with glucose, insulin, and diabetes in young adult women: the CARDIA Study. Coronary Artery Risk Development in Young Adults
    Catherine Kim
    Robert Wood Johnson Clinical Scholars Program, University of Washington, Seattle, Washington, USA
    Diabetes Care 25:1027-32. 2002
    ..We studied the associations between 1) current use of oral contraceptives (OCs) and 2) glucose levels, insulin levels, and diabetes in young women...
  12. pmc Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 111:157-64. 2005
    ..Additionally, seafood-based, long-chain n-3 PUFAs may modify the effects of plant-based, intermediate-chain n-3 PUFAs. However, the interactions of these PUFAs in relation to CHD risk are not well established...
  13. ncbi request reprint Alcohol use and risk of ischemic stroke among older adults: the cardiovascular health study
    Kenneth J Mukamal
    Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Stroke 36:1830-4. 2005
    ..The association of light to moderate alcohol consumption with risk of ischemic stroke remains uncertain, as are the roles of potentially mediating factors and modification by apolipoprotein E (apoE) genotype...
  14. pmc Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School and Epidemiology, University of Washington, Seattle, WA, USA
    Am J Clin Nutr 92:1350-8. 2010
    ..Animal experiments suggest that circulating palmitoleic acid (cis-16:1n-7) from adipocyte de novo fatty acid synthesis may directly regulate insulin resistance and metabolic dysregulation...
  15. ncbi request reprint A case-crossover analysis of particulate matter air pollution and out-of-hospital primary cardiac arrest
    D Levy
    Department of Epidemiology, University of Washington, Seattle 98195-7232, USA
    Epidemiology 12:193-9. 2001
    ..The null results of this study may result from several factors, including the highly selected nature of this case series and the relatively low particulate matter levels in the Seattle metropolitan area...
  16. pmc Association of chronic kidney disease with the spectrum of ankle brachial index the CHS (Cardiovascular Health Study)
    Joachim H Ix
    Department of Medicine, University of California San Diego, USA
    J Am Coll Cardiol 54:1176-84. 2009
    ..This study sought to determine the association of chronic kidney disease (CKD) with high ankle brachial index (ABI) measurement and to compare its strength with that of CKD with a low ABI...
  17. pmc Common genetic determinants of vitamin D insufficiency: a genome-wide association study
    Thomas J Wang
    Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 376:180-8. 2010
    ..We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency...
  18. pmc IL1B genetic variation and plasma C-reactive protein level among young adults: the CARDIA study
    Daniel A Enquobahrie
    Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, USA
    Atherosclerosis 202:513-20. 2009
    ..However, whether IL1B genetic variation is associated with CRP level is unknown. Further, obesity, a state of low-grade inflammation that influences cellular IL-1 functions may modify this association...
  19. ncbi request reprint Long-term exposure to air pollution and incidence of cardiovascular events in women
    Kristin A Miller
    Department of Epidemiology, University of Washington, Seattle, USA
    N Engl J Med 356:447-58. 2007
    ..We examined the association of long-term exposure to particulate matter of less than 2.5 microm in aerodynamic diameter (PM2.5) with cardiovascular events...
  20. pmc Cystatin C concentration as a predictor of systolic and diastolic heart failure
    Andrew Moran
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Card Fail 14:19-26. 2008
    ..We hypothesized that kidney dysfunction would predict diastolic HF (DHF) better than systolic HF (SHF) in the Cardiovascular Health Study...
  21. pmc Serum phosphorus concentrations and arterial stiffness among individuals with normal kidney function to moderate kidney disease in MESA
    Joachim H Ix
    Department of Medicine, Division of Nephrology and Hypertension, University of California San Diego, San Diego, CA 92161, USA
    Clin J Am Soc Nephrol 4:609-15. 2009
    ..Higher phosphorus levels are associated with cardiovascular disease (CVD) events and mortality. Whether vascular stiffness may be responsible is unknown...
  22. ncbi request reprint Cardiac benefits of fish consumption may depend on the type of fish meal consumed: the Cardiovascular Health Study
    Dariush Mozaffarian
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Wash, USA
    Circulation 107:1372-7. 2003
    ..Few studies have examined associations of fish consumption with ischemic heart disease (IHD) risk among older adults or how different types of fish meals relate to IHD risk...
  23. doi request reprint Soluble P-selectin, SELP polymorphisms, and atherosclerotic risk in European-American and African-African young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
    Alexander P Reiner
    Departments of Epidemiology, University of Washington, Seattle, WA 98195, USA
    Arterioscler Thromb Vasc Biol 28:1549-55. 2008
    ..To characterize the genetic and clinical correlates of soluble P-selectin, and the relationship of P-selectin to atherosclerotic risk, in young European-American (EA) and African-American (AA) adults...
  24. doi request reprint Familial aggregation of red blood cell membrane fatty acid composition: the Kibbutzim Family Study
    Rozenn N Lemaitre
    Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA 98101, USA
    Metabolism 57:662-8. 2008
    ..Future studies are needed to map the genes underlying the interindividual variation in these inherited phenotypes...
  25. pmc Differences in kidney function and incident hypertension: the multi-ethnic study of atherosclerosis
    Bryan Kestenbaum
    University of Washington, Division of Nephrology, Harborview Medical Center, Seattle, Washington 98104 2499, USA
    Ann Intern Med 148:501-8. 2008
    ..Kidney disease and hypertension commonly coexist, yet the direction of their association is still debated...
  26. pmc Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women's Health Initiative
    Ian H De Boer
    Division of Nephrology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Diabetes Care 31:701-7. 2008
    ..We examined the effect of calcium plus vitamin D supplementation on the incidence of drug-treated diabetes in postmenopausal women...
  27. ncbi request reprint Alcohol consumption and type 2 diabetes among older adults: the Cardiovascular Health Study
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont St, 3rd Floor, Boston, MA 02120, USA
    Obesity (Silver Spring) 15:1758-65. 2007
    ..The objective was to examine the role of total and beverage-specific alcohol consumption on the incidence of type 2 diabetes mellitus (DM) among elderly men and women...
  28. pmc Lipoprotein abnormalities associated with mild impairment of kidney function in the multi-ethnic study of atherosclerosis
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, Washington 98195, USA
    Clin J Am Soc Nephrol 3:125-32. 2008
    ..Abnormal lipoprotein metabolism has been implicated as a possible cause of these complications, but lipoproteins have not been described at the earliest stages of kidney disease...
  29. ncbi request reprint Newly detected atrial fibrillation and compliance with antithrombotic guidelines
    Nicole L Glazer
    Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, 1730 Minor Avenue, Seattle, WA 98101, USA
    Arch Intern Med 167:246-52. 2007
    ..Our objective was to assess compliance with antithrombotic guidelines and to identify patient characteristics associated with warfarin use...
  30. ncbi request reprint USF1 gene variants, cardiovascular risk, and mortality in European Americans: analysis of two US cohort studies
    Alexander P Reiner
    Department of Epidemiology, Box 357236, University of Washington, Seattle, WA 98195, USA
    Arterioscler Thromb Vasc Biol 27:2736-42. 2007
    ....
  31. ncbi request reprint Kidney function, electrocardiographic findings, and cardiovascular events among older adults
    Bryan Kestenbaum
    Division of Nephrology, Harborview Medical Center, University of Washington, Seattle, WA 98104 2499, USA
    Clin J Am Soc Nephrol 2:501-8. 2007
    ..Associations seemed stronger for participants with CKD; however, no significant interactions were detected. Resting electrocardiographic abnormalities are common in CKD and independently predict future clinical CV events in this setting...
  32. pmc Mild elevations of urine albumin excretion are associated with atherogenic lipoprotein abnormalities in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    Atherosclerosis 197:407-14. 2008
    ....
  33. pmc The association between A1C and subclinical cardiovascular disease: the multi-ethnic study of atherosclerosis
    Marguerite J McNeely
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes Care 32:1727-33. 2009
    ..To test the hypothesis that A1C is associated with subclinical cardiovascular disease (CVD) in a population without evident diabetes, after adjusting for traditional CVD risk factors and BMI...
  34. pmc Association between adiposity in midlife and older age and risk of diabetes in older adults
    Mary L Biggs
    Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    JAMA 303:2504-12. 2010
    ..Adiposity is a well-recognized risk factor for type 2 diabetes among young and middle-aged adults, but the relationship between body composition and type 2 diabetes is not well described among older adults...
  35. pmc Common genetic variants associate with serum phosphorus concentration
    Bryan Kestenbaum
    Division of Nephrology, Department of Medicine, University of Washington, Kidney Research Institute, Seattle, Washington 98104 2499, USA
    J Am Soc Nephrol 21:1223-32. 2010
    ..05 for each). In conclusion, common genetic variants associate with serum phosphorus in the general population. Further study of the loci identified in this study may help elucidate mechanisms of phosphorus regulation...
  36. pmc Common genetic variation, residential proximity to traffic exposure, and left ventricular mass: the multi-ethnic study of atherosclerosis
    Victor C Van Hee
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, USA
    Environ Health Perspect 118:962-9. 2010
    ..Understanding genetic factors that influence susceptibility to these effects may provide insight into relevant mechanistic pathways...
  37. pmc Endogenous red blood cell membrane fatty acids and sudden cardiac arrest
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
    Metabolism 59:1029-34. 2010
    ..Further work is needed to investigate if conditions that favor de novo fatty acid synthesis, such as high-carbohydrate/low-fat diets, might also increase the risk of SCA...
  38. pmc Albuminuria, impaired kidney function and cardiovascular outcomes or mortality in the elderly
    Dena E Rifkin
    Tufts Medical Center and Tufts University School of Medicine, University of Washington, Seattle, USA
    Nephrol Dial Transplant 25:1560-7. 2010
    ..Kidney disease is a risk factor for mortality and cardiovascular disease in older adults, but the separate and combined effects of albuminuria and cystatin C, a novel marker of glomerular filtration, are not known...
  39. pmc Obesity and change in estimated GFR among older adults
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    Am J Kidney Dis 54:1043-51. 2009
    ..Obesity assessed in midlife has been associated with chronic kidney disease...
  40. pmc Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk
    Nona Sotoodehnia
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA
    Heart Rhythm 6:1306-14. 2009
    ..Angiotensin-converting enzyme (ACE)-related pathways influence arrhythmias and sudden cardiac arrest (SCA) risk...
  41. pmc Incidence and progression of coronary calcification in chronic kidney disease: the Multi-Ethnic Study of Atherosclerosis
    Bryan R Kestenbaum
    Division of Nephrology, Department of Medicine, Harborview Medical Center, Kidney Research Institute, University of Washington, Seattle, Washington 98104 2499, USA
    Kidney Int 76:991-8. 2009
    ..Our study shows that coronary artery calcification is common in people with stage 3 disease, progresses rapidly, and may contribute to cardiovascular risk...
  42. pmc Risk of preterm delivery and other adverse perinatal outcomes in relation to maternal use of psychotropic medications during pregnancy
    Ronit Calderon-Margalit
    Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, WA 98101, USA
    Am J Obstet Gynecol 201:579.e1-8. 2009
    ..The purpose of this study was to determine the association of maternal psychotropic medication use during pregnancy with preterm delivery and other adverse perinatal outcomes...
  43. pmc Cystatin C, albuminuria, and mortality among older adults with diabetes
    Ian H De Boer
    University of Washington, Seattle, Washington, USA
    Diabetes Care 32:1833-8. 2009
    ..Joint associations of albuminuria and impaired GFR with mortality have not been comprehensively evaluated in this population...
  44. pmc Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
    Nona Sotoodehnia
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA
    Nat Genet 42:1068-76. 2010
    ..These findings extend our current knowledge of ventricular depolarization and conduction...
  45. pmc 25-hydroxyvitamin D levels inversely associate with risk for developing coronary artery calcification
    Ian H De Boer
    Department of Medicine, Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    J Am Soc Nephrol 20:1805-12. 2009
    ..Accelerated development of atherosclerosis may underlie, in part, the increased cardiovascular risk associated with vitamin D deficiency...
  46. pmc Red blood cell membrane alpha-linolenic acid and the risk of sudden cardiac arrest
    Rozenn N Lemaitre
    Department of Medicine, University of Washington, Seattle, WA 98101, USA
    Metabolism 58:534-40. 2009
    ..The association was independent of red blood cell levels of long-chain n-3 fatty acids, trans-fatty acids, and linoleic acid. Higher membrane levels of alpha-linolenic acid are associated with higher risk of sudden cardiac arrest...
  47. doi request reprint Frequency and type of seafood consumed influence plasma (n-3) fatty acid concentrations
    Hyoju Chung
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
    J Nutr 138:2422-7. 2008
    ..fried fish), types of seafood (fish vs. shellfish), and the overall seafood consumption when assessing health effects of long-chain (n-3) fatty acids of seafood consumption...
  48. pmc Ascertainment of warfarin and aspirin use by medical record review compared with automated pharmacy data
    Renu K Garg
    Department of Epidemiology, University of Washington, Seattle, WA 98101 1448, USA
    Pharmacoepidemiol Drug Saf 20:313-6. 2011
    ..This study aimed to measure agreement on warfarin and aspirin use between medical records and automated pharmacy data among patients with newly detected atrial fibrillation (AF)...
  49. ncbi request reprint The association of alcohol consumption and incident heart failure: the Cardiovascular Health Study
    Chris L Bryson
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    J Am Coll Cardiol 48:305-11. 2006
    ..We investigated the association between alcohol consumption and incident congestive heart failure (CHF) both overall and after adjusting for incident myocardial infarction (MI)...
  50. ncbi request reprint Plasma phospholipid trans fatty acids, fatal ischemic heart disease, and sudden cardiac death in older adults: the cardiovascular health study
    Rozenn N Lemaitre
    University of Washington, Cardiovascular Health Research Unit, Department of Medicine, 1730 Minor Ave, Suite 1360, Seattle, Washington 98101, USA
    Circulation 114:209-15. 2006
    ..To extend these findings, we investigated the associations of plasma phospholipid trans fatty acids with fatal ischemic heart disease (IHD) and sudden cardiac death...
  51. ncbi request reprint Angiotensin II type 1 receptor polymorphisms in the cardiovascular health study: relation to blood pressure, ethnicity, and cardiovascular events
    Lucia A Hindorff
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Am J Hypertens 15:1050-6. 2002
    ..We examined the association between this polymorphism and new-onset hypertension, blood pressure (BP) control, and incident cardiovascular events in a large population-based cohort of older adults...
  52. ncbi request reprint Inhaled beta-2 adrenergic receptor agonists and primary cardiac arrest
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98101, USA
    Am J Med 113:711-6. 2002
    ..We sought to investigate if short-acting, inhaled beta2-adrenergic receptor agonists were associated with higher risk of primary cardiac arrest in patients with asthma or chronic obstructive pulmonary disease (COPD)...
  53. ncbi request reprint n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle 98101, USA
    Am J Clin Nutr 77:319-25. 2003
    ....
  54. pmc Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels
    Christopher S Carlson
    Department of Genome Sciences, University of Washington, Seattle, WA, USA
    Am J Hum Genet 77:64-77. 2005
    ..We also demonstrate the functional importance of these SNPs in vitro...
  55. ncbi request reprint Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly
    Susan R Heckbert
    Department of Epidemiology, University of Washington, Seattle, USA
    Circulation 107:2021-4. 2003
    ..We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study...
  56. ncbi request reprint beta(2)-Adrenergic receptor polymorphisms and determinants of cardiovascular risk: the Cardiovascular Health Study
    Lucia A Hindorff
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Am J Hypertens 18:392-7. 2005
    ....
  57. ncbi request reprint Family history as a risk factor for stroke in young women
    Helen Kim
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    Am J Prev Med 27:391-6. 2004
    ..A population-based, case-control study was conducted to examine the association of FHS and risk of stroke in young women, and to determine whether the association is independent of other stroke risk factors...
  58. ncbi request reprint Digoxin therapy and the risk of primary cardiac arrest in patients with congestive heart failure: effect of mild-moderate renal impairment
    Thomas D Rea
    Cardiovascular Health Research Unit, University of Washington, Department of Medicine, Metropolitan Park, 1730 Minor Avenue, East Tower, Seattle, WA 98101, USA
    J Clin Epidemiol 56:646-50. 2003
    ..The cardiac safety of digoxin therapy for congestive heart failure (CHF) is a source of concern, especially among those with renal impairment...
  59. ncbi request reprint Moderate renal impairment and risk of dementia among older adults: the Cardiovascular Health Cognition Study
    Stephen L Seliger
    Division of Nephrology, University of Washington, Seattle, Washington 98195, USA
    J Am Soc Nephrol 15:1904-11. 2004
    ..Strategies to prevent or delay the onset of dementia in patients with moderate renal impairment are needed...
  60. ncbi request reprint Incidence of out-of-hospital cardiac arrest
    Thomas D Rea
    Cardiovascular Health Research Unit, Department of Medicine, Seattle, Washington 98101, USA
    Am J Cardiol 93:1455-60. 2004
    ..The results provide insights regarding absolute and population-attributable risk in clinically defined subgroups, information that may aid strategies aimed at reducing mortality from CA...
  61. ncbi request reprint Hospitalization for pneumonia in the Cardiovascular Health Study: incidence, mortality, and influence on longer-term survival
    Ellen S O'Meara
    Department of Biostatistics, University of Washington, Seattle, Washington 98115, USA
    J Am Geriatr Soc 53:1108-16. 2005
    ..To estimate the rate of hospitalization for pneumonia in community-dwelling older adults and to assess its risk factors and contribution to mortality...
  62. ncbi request reprint Genetic variants of coagulation factor XIII, postmenopausal estrogen therapy, and risk of nonfatal myocardial infarction
    Alexander P Reiner
    Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, WA 98101 1448, USA
    Blood 102:25-30. 2003
    ..03). If confirmed, these findings may permit a better assessment of the cardiovascular risks and benefits associated with postmenopausal estrogen therapy...
  63. ncbi request reprint Cell membrane trans-fatty acids and the risk of primary cardiac arrest
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle 98101, USA
    Circulation 105:697-701. 2002
    ..The relation of trans-fatty acid intake to life-threatening arrhythmias and primary cardiac arrest is unknown...
  64. ncbi request reprint Coagulation factor XIII polymorphisms and the risk of myocardial infarction and ischaemic stroke in young women
    Alexander P Reiner
    Department of Medicine, University of Washington, Seattle, USA
    Br J Haematol 116:376-82. 2002
    ..The relationship of factor XIIIA polymorphisms to cerebrovascular disease requires further study...
  65. ncbi request reprint Diuretic therapy, the alpha-adducin gene variant, and the risk of myocardial infarction or stroke in persons with treated hypertension
    Bruce M Psaty
    Cardiovascular Health Research Unit, 1730 Minor Ave, Suite 1360, Seattle, WA 98101, USA
    JAMA 287:1680-9. 2002
    ..Whether this genetic variant modifies the effect of diuretic therapy on the incidence of myocardial infarction (MI) and stroke is unknown...
  66. ncbi request reprint Trans-fatty acids and sudden cardiac death
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, USA
    Atheroscler Suppl 7:13-5. 2006
    ..While further studies are needed to investigate possible effects of trans-18:2 on arrhythmia, it would be prudent to limit dietary intake of trans-18:2...
  67. ncbi request reprint Factor V Leiden, prothrombin G20210A, and risk of sudden coronary death in apparently healthy persons
    Alexander P Reiner
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Cardiol 90:66-8. 2002
  68. ncbi request reprint The association of PAI-1 promoter 4G/5G insertion/deletion polymorphism with myocardial infarction and stroke in young women
    Lucia A Hindorff
    Department of Epidemiology, University of Washington, Seattle, WA 98101 1448, USA
    J Cardiovasc Risk 9:131-7. 2002
    ..Whether these results apply to young women is not known...
  69. ncbi request reprint Exposure to ambient fine particulate matter and primary cardiac arrest among persons with and without clinically recognized heart disease
    J Sullivan
    Department of Environmental Health, School of Public Health, University of Washington, Seattle, WA 98105, USA
    Am J Epidemiol 157:501-9. 2003
    ..06, 1.55). This association was not present in the 0- or 1-day lag analyses or in persons with other diseases. There was no consistent association between increased levels of fine particulate matter and risk of primary cardiac arrest...
  70. ncbi request reprint Sudden death and myocardial infarction in first degree relatives as predictors of primary cardiac arrest
    Yechiel Friedlander
    Department of Social Medicine, The Hebrew University Hadassah School of Public Health, PO Box 12272, Jerusalem 91120, Israel
    Atherosclerosis 162:211-6. 2002
    ..Findings suggest a potential role of familial factors related to both MI and SD in PCA. Stronger findings for a familial patterning of PCA were noted for early onset disease in cases and their relatives...
  71. ncbi request reprint The prevalence and risk factors of retinal microvascular abnormalities in older persons: The Cardiovascular Health Study
    Tien Yin Wong
    Singapore Eye Research Institute, Singapore, Republic of Singapore
    Ophthalmology 110:658-66. 2003
    ..To describe the prevalence of retinal microvascular characteristics and their associations with atherosclerosis in elderly, nondiabetic persons...
  72. ncbi request reprint The fish story: a diet-heart hypothesis with clinical implications: n-3 polyunsaturated fatty acids, myocardial vulnerability, and sudden death
    David S Siscovick
    Circulation 107:2632-4. 2003
  73. ncbi request reprint Sequence variation in the soluble epoxide hydrolase gene and subclinical coronary atherosclerosis: interaction with cigarette smoking
    Qi Wei
    Institute of Molecular Medicine, University of Texas Health Science Center Houston, Houston, TX 77030, United States
    Atherosclerosis 190:26-34. 2007
    ..This detailed investigation of the association of EPHX2 genetic variation with CAC supports EPHX2's emerging role as a risk factor for atherosclerosis, whose effects are influenced by smoking...
  74. ncbi request reprint Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women's Health Initiative observational study
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    JAMA 288:980-7. 2002
    ..Several inflammatory biomarkers, including CRP, are associated with increased cardiovascular risk. However, whether the effect of HRT on CRP represents a clinical hazard is unknown...
  75. ncbi request reprint Walking compared with vigorous exercise for the prevention of cardiovascular events in women
    JoAnn E Manson
    Division of Preventive Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston 02215, USA
    N Engl J Med 347:716-25. 2002
    ..The role of walking, as compared with vigorous exercise, in the prevention of cardiovascular disease remains controversial. Data for women who are members of minority racial or ethnic groups are particularly sparse...
  76. ncbi request reprint From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I
    Morteza Naghavi
    The Center for Vulnerable Plaque Research, University of Texas Houston, The Texas Heart Institute, and President Bush Center for Cardiovascular Health, Memorial Hermann Hospital, Houston, USA
    Circulation 108:1664-72. 2003
    ..We encourage healthcare policy makers to promote translational research for screening and treatment of vulnerable patients...
  77. ncbi request reprint Traditional and novel risk factors in older adults: cardiovascular risk assessment late in life
    Kenneth J Mukamal
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Geriatr Cardiol 13:69-80. 2004
    ..Future Cardiovascular Health Study investigations will help to clarify which combination of traditional and newer risk factors provides the best estimate of cardiovascular risk for older adults...
  78. ncbi request reprint Alcohol consumption and inflammatory markers in older adults: the Cardiovascular Health Study
    Kenneth J Mukamal
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, RO 114, Boston, MA, USA
    Atherosclerosis 173:79-87. 2004
    ..We sought to determine the relation of alcohol intake and systemic inflammation in a population-based sample of older adults...
  79. ncbi request reprint Patterns of association between PPARgamma genetic variation and indices of adiposity and insulin action in African-Americans and whites: the CARDIA Study
    Qi Wei
    Institute of Molecular Medicine, The University of Texas Health Science Center Houston, 1825 Pressler St, Houston, TX 77030, USA
    J Mol Med (Berl) 84:955-65. 2006
    ..It underscores the role of genetic and environmental contexts in shaping the patterns of associations of PPARgamma sequence variants with metabolic traits in human populations...
  80. ncbi request reprint Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study
    Gabriella Tikellis
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    Arch Ophthalmol 125:68-73. 2007
    ..To examine the association between the apolipoprotein E (APOE) gene and age-related maculopathy (ARM) in an older population...
  81. ncbi request reprint Diabetic cardiomyopathy and subclinical cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Alain G Bertoni
    Wake Forest University Health Sciences, Department of Public Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes Care 29:588-94. 2006
    ..We examined whether diabetic cardiomyopathy is associated with subclinical atherosclerosis and if abnormalities are found with impaired fasting glucose (IFG)...
  82. ncbi request reprint Relationship of uric acid with progression of kidney disease
    Michel Chonchol
    Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Kidney Dis 50:239-47. 2007
    ..Uric acid levels are increased in patients with kidney dysfunction. We tested the hypothesis that uric acid may be associated with kidney disease progression...
  83. ncbi request reprint Alcohol consumption and risk of coronary heart disease in older adults: the Cardiovascular Health Study
    Kenneth J Mukamal
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Am Geriatr Soc 54:30-7. 2006
    ..To evaluate several aspects of the relationship between alcohol use and coronary heart disease in older adults, including beverage type, mediating factors, and type of outcome...
  84. pmc Alcohol consumption, interleukin-6 and apolipoprotein E genotypes, and concentrations of interleukin-6 and serum amyloid P in older adults
    Kenneth J Mukamal
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02446, USA
    Am J Clin Nutr 86:444-50. 2007
    ..Whether alcohol intake is associated with concentrations of interleukin-6 (IL-6) and serum amyloid P (SAP) is uncertain...
  85. ncbi request reprint Fibrinogen and CRP in Israeli families: genetic and environmental sources of concentrations and longitudinal changes
    Yechiel Friedlander
    Unit of Epidemiology, Hebrew University Hadassah School of Public Health, Jerusalem, Israel
    Atherosclerosis 189:169-77. 2006
    ..To estimate the genetic and environmental determinants of plasma fibrinogen and C-reactive protein (CRP)...
  86. ncbi request reprint Cystatin C and subclinical brain infarction
    Stephen L Seliger
    Division of Nephrology, University of Maryland, Baltimore, MD 21201, USA
    J Am Soc Nephrol 16:3721-7. 2005
    ..Compared with creatinine, CysC, a novel marker of renal function, has a stronger and more direct association with SBI in the elderly...
  87. ncbi request reprint Electrocardiographic QT interval prolongation and risk of primary cardiac arrest in diabetic patients
    Eric A Whitsel
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Diabetes Care 28:2045-7. 2005
  88. ncbi request reprint Cystatin C and the risk of death and cardiovascular events among elderly persons
    Michael G Shlipak
    General Internal Medicine Section, Veterans Affairs Medical Center, University of California, San Francisco, USA
    N Engl J Med 352:2049-60. 2005
    ..We compared creatinine and cystatin C levels as predictors of mortality from cardiovascular causes and from all causes in the Cardiovascular Health Study, a cohort study of elderly persons living in the community...
  89. doi request reprint Dietary fish and omega-3 fatty acid consumption and heart rate variability in US adults
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 117:1130-7. 2008
    ..We hypothesized that habitual consumption of fish and marine omega-3 fatty acids would be associated with more favorable HRV, elucidating electrophysiological influences and supporting effects on clinical risk...
  90. ncbi request reprint Cardiovascular risk factors for retinal vein occlusion and arteriolar emboli: the Atherosclerosis Risk in Communities & Cardiovascular Health studies
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Ophthalmology 112:540-7. 2005
    ..To examine the associations of retinal vein occlusion and arteriolar emboli with cardiovascular disease...
  91. pmc Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study
    Myriam Fornage
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Stroke 39:1952-9. 2008
    ....
  92. doi request reprint Metabolic syndrome and mortality in older adults: the Cardiovascular Health Study
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Arch Intern Med 168:969-78. 2008
    ..In addition, few studies have compared the predictive utility of MetS to that of its individual risk factors...
  93. ncbi request reprint Parental history of stroke and myocardial infarction predicts coronary artery calcification: The Coronary Artery Risk Development in Young Adults (CARDIA) study
    Myriam Fornage
    Institute of Molecular Medicine, University of Texas Health Science Center Houston, Houston, TX 77030, USA
    Eur J Cardiovasc Prev Rehabil 11:421-6. 2004
    ..This study investigates the association between coronary artery calcification (CAC) and parental history of stroke and MI in African-Americans and Caucasians from the CARDIA study...
  94. pmc Fish intake and risk of incident atrial fibrillation
    Dariush Mozaffarian
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, Boston, Mass, USA
    Circulation 110:368-73. 2004
    ..Although effects of fish intake, including potential antiarrhythmic effects, may favorably influence risk of AF, relationships between fish intake and AF incidence have not been evaluated...
  95. ncbi request reprint Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease
    Michael G Shlipak
    San Francisco Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121, USA
    Ann Intern Med 145:237-46. 2006
    ..73 m2)...

Research Grants32

  1. Polyunsaturated fats & risk of primary cardiac arrest
    David Siscovick; Fiscal Year: 2005
    ..The proposed research provides a unique opportunity to examine more fully the role of dietary intake of n-3 PUFAs, particularly ALA, in efforts to reduce PCA, a major component of coronary heart disease mortality in the community. ..
  2. Inflammation Genomics and Atherosclerosis
    David Siscovick; Fiscal Year: 2006
    ..abstract_text> ..
  3. CVD Epidemiology Training Program
    David Siscovick; Fiscal Year: 2007
    ..abstract_text> ..
  4. Maternal Obesity, Fetal Genomics, and Atherosclerotic Metabolic Risk
    David Siscovick; Fiscal Year: 2007
    ..The long-term goals of the proposed study are to identify potential mechanistic targets for interventions to prevent the consequences of MO on the intra-uterine environment and adult AMR. ..
  5. HUMAN GENETIC VARIATION IN FATTY ACID METABOLISM AND SUDDEN CARDIAC ARREST
    David Siscovick; Fiscal Year: 2009
    ..As a result, the proposed research has implications both for the development of new knowledge and the application of knowledge to reduce mortality from sudden cardiac arrest in the community. ..
  6. Genome-wide study of sudden cardiac arrest in the community
    David Siscovick; Fiscal Year: 2009
    ..The study results will provide insight into the molecular mechanisms of SCA and potentially help target the development of novel drug therapies to reduce mortality from SCA. ..
  7. Maternal Obesity, Fetal Genomics, and Atherosclerotic Metabolic Risk
    David Siscovick; Fiscal Year: 2009
    ..The long-term goals of the proposed study are to identify potential mechanistic targets for interventions to prevent the consequences of MO on the intra-uterine environment and adult AMR. ..
  8. HUMAN GENETIC VARIATION IN FATTY ACID METABOLISM AND SUDDEN CARDIAC ARREST
    David Siscovick; Fiscal Year: 2010
    ..As a result, the proposed research has implications both for the development of new knowledge and the application of knowledge to reduce mortality from sudden cardiac arrest in the community. ..
  9. POLYUNSATURATED FATS AND RISK OF PRIMARY CARDIAC ARREST
    David Siscovick; Fiscal Year: 1993
    ....
  10. POLYUNSATURATED FATS AND THE RISK OF PCA
    David Siscovick; Fiscal Year: 1999
    ....
  11. Androgens and subclinical atherosclerosis in young women
    David Siscovick; Fiscal Year: 2003
    ..In short, the proposed study addresses a potentially important and relatively unexplored area of investigation related to women's cardiovascular health. ..
  12. Genome-wide study of sudden cardiac arrest in the community
    David Siscovick; Fiscal Year: 2010
    ..The study results will provide insight into the molecular mechanisms of SCA and potentially help target the development of novel drug therapies to reduce mortality from SCA. ..