Dario Siniscalco

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Apoptotic genes expression in the lumbar dorsal horn in a model neuropathic pain in rat
    Sabatino Maione
    Department of Experimental Medicine, Second University of Naples, Napoli, Italy
    Neuroreport 13:101-6. 2002
  2. ncbi request reprint Molecular approaches for neuropathic pain treatment
    Dario Siniscalco
    Department of Experimental Medicine Section of Pharmacology L Donatelli, Second University of Naples, Via S Maria di Costantinopoli, 16 80138 Naples, Italy
    Curr Med Chem 14:1783-7. 2007
  3. doi request reprint Stem cell therapy: the great promise in lung disease
    Dario Siniscalco
    Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Via S Maria di Costantinopoli, 16 80138 Napoli, Italy
    Ther Adv Respir Dis 2:173-7. 2008
  4. pmc Long-lasting effects of human mesenchymal stem cell systemic administration on pain-like behaviors, cellular, and biomolecular modifications in neuropathic mice
    Dario Siniscalco
    Division of Pharmacology L Donatelli, Department of Experimental Medicine, Second University of Naples Naples, Italy
    Front Integr Neurosci 5:79. 2011
  5. pmc Role of neurotrophins in neuropathic pain
    Dario Siniscalco
    Department of Experimental Medicine, Division of Pharmacology L Donatelli, Second University of Naples, Via S Maria di Costantinopoli, 16 80138 Naples, Italy
    Curr Neuropharmacol 9:523-9. 2011
  6. pmc Therapeutic role of hematopoietic stem cells in autism spectrum disorder-related inflammation
    Dario Siniscalco
    Department of Experimental Medicine, Second University of Naples, Naples, Italy Centre for Autism La Forza del Silenzio, Caserta, Italy Cancellautismo, Florence, Italy
    Front Immunol 4:140. 2013
  7. ncbi request reprint The in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages
    Dario Siniscalco
    Department of Experimental Medicine, Second University of Naples, Via S, Maria di Costantinopoli, 16 80138 Naples, Italy
    J Neuroinflammation 11:78. 2014
  8. ncbi request reprint Involvement of dietary bioactive proteins and peptides in autism spectrum disorders
    Dario Siniscalco
    Department of Experimental Medicine Division of Pharmacology, Second University of Naples Via S Maria di Costantinopoli, 16 80138 Napoli, Italy
    Curr Protein Pept Sci 14:674-9. 2013
  9. doi request reprint Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders
    Dario Siniscalco
    Division of Pharmacology, Department of Experimental Medicine, Second University of Naples, Via S Maria di Costantinopoli, 16, 80138, Naples, Italy
    J Autism Dev Disord 43:2686-95. 2013
  10. pmc Epigenetic findings in autism: new perspectives for therapy
    Dario Siniscalco
    Department of Experimental Medicine, Second University of Naples Via S Maria di Costantinopoli, Napoli 16 80138, Italy
    Int J Environ Res Public Health 10:4261-73. 2013

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Apoptotic genes expression in the lumbar dorsal horn in a model neuropathic pain in rat
    Sabatino Maione
    Department of Experimental Medicine, Second University of Naples, Napoli, Italy
    Neuroreport 13:101-6. 2002
    ..These data suggest that in a chronic pain condition, where the acute phase has already resolved, specific apoptotic genes are still operative and possibly may serve as a critical change for cells surviving in the chronic pain state...
  2. ncbi request reprint Molecular approaches for neuropathic pain treatment
    Dario Siniscalco
    Department of Experimental Medicine Section of Pharmacology L Donatelli, Second University of Naples, Via S Maria di Costantinopoli, 16 80138 Naples, Italy
    Curr Med Chem 14:1783-7. 2007
    ..These methods could provide a new therapeutic approach to neuropathic pain relief...
  3. doi request reprint Stem cell therapy: the great promise in lung disease
    Dario Siniscalco
    Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Via S Maria di Costantinopoli, 16 80138 Napoli, Italy
    Ther Adv Respir Dis 2:173-7. 2008
    ..Therefore, lung stem cell biology may provide novel approaches to therapy and could represent a great promise for the future of molecular medicine. In fact, several diseases can be slowed or even blocked by stem cell transplantation...
  4. pmc Long-lasting effects of human mesenchymal stem cell systemic administration on pain-like behaviors, cellular, and biomolecular modifications in neuropathic mice
    Dario Siniscalco
    Division of Pharmacology L Donatelli, Department of Experimental Medicine, Second University of Naples Naples, Italy
    Front Integr Neurosci 5:79. 2011
    ..This study could provide novel findings in MSC pre-clinical biology and their therapeutic potential in regenerative medicine...
  5. pmc Role of neurotrophins in neuropathic pain
    Dario Siniscalco
    Department of Experimental Medicine, Division of Pharmacology L Donatelli, Second University of Naples, Via S Maria di Costantinopoli, 16 80138 Naples, Italy
    Curr Neuropharmacol 9:523-9. 2011
    ..Nowadays, pain research is directing towards new molecular methods. By targeting neurotrophin molecules it may be possible to provide better pain control than currently available...
  6. pmc Therapeutic role of hematopoietic stem cells in autism spectrum disorder-related inflammation
    Dario Siniscalco
    Department of Experimental Medicine, Second University of Naples, Naples, Italy Centre for Autism La Forza del Silenzio, Caserta, Italy Cancellautismo, Florence, Italy
    Front Immunol 4:140. 2013
    ..This prospective review will focus on the current state-of-the-art knowledge and challenges intrinsic in the application of HSCs for ASD-related immunological disorders...
  7. ncbi request reprint The in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages
    Dario Siniscalco
    Department of Experimental Medicine, Second University of Naples, Via S, Maria di Costantinopoli, 16 80138 Naples, Italy
    J Neuroinflammation 11:78. 2014
    ....
  8. ncbi request reprint Involvement of dietary bioactive proteins and peptides in autism spectrum disorders
    Dario Siniscalco
    Department of Experimental Medicine Division of Pharmacology, Second University of Naples Via S Maria di Costantinopoli, 16 80138 Napoli, Italy
    Curr Protein Pept Sci 14:674-9. 2013
    ..This review will focus on the state-of-the-art regarding the involvement of dietary bioactive proteins and peptides in ASDs. Identification of novel therapeutic targets for ASD management will be also discussed. ..
  9. doi request reprint Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders
    Dario Siniscalco
    Division of Pharmacology, Department of Experimental Medicine, Second University of Naples, Via S Maria di Costantinopoli, 16, 80138, Naples, Italy
    J Autism Dev Disord 43:2686-95. 2013
    ..5 ± 1.32 vs. 6.70 ± 1.25 in autistic children and healthy subjects, respectively). Our data indicate CB2 receptor as potential therapeutic target for the pharmacological management of the autism care. ..
  10. pmc Epigenetic findings in autism: new perspectives for therapy
    Dario Siniscalco
    Department of Experimental Medicine, Second University of Naples Via S Maria di Costantinopoli, Napoli 16 80138, Italy
    Int J Environ Res Public Health 10:4261-73. 2013
    ....
  11. doi request reprint Possible use of Trichuris suis ova in autism spectrum disorders therapy
    Dario Siniscalco
    Department of Experimental Medicine, Second University of Naples, Italy
    Med Hypotheses 81:1-4. 2013
    ..Trichuris suis ova (TSO) show strong immunomodulatory properties. Authors hypothesize that TSO could be useful in addressing ASD immune dysregulations. TSO could be a novel therapeutic option for ASD management...
  12. pmc Autism spectrum disorders: is mesenchymal stem cell personalized therapy the future?
    Dario Siniscalco
    Division of Pharmacology L Donatelli, Department of Experimental Medicine, Second University of Naples, Napoli, Italy
    J Biomed Biotechnol 2012:480289. 2012
    ..Due to the particular immune and neural dysregulation observed in ASDs, mesenchymal stem cell transplantation could offer a unique tool to provide better resolution for this disease...
  13. doi request reprint The expression of caspases is enhanced in peripheral blood mononuclear cells of autism spectrum disorder patients
    Dario Siniscalco
    Department of Experimental Medicine, Division of Pharmacology, Second University of Naples, via S Maria di Costantinopoli 16, 80138 Naples, Italy
    J Autism Dev Disord 42:1403-10. 2012
    ..Our data are suggestive of a possible role of the caspase pathway in ASD clinical outcome and of the use of caspase as potential diagnostic and/or therapeutic tools in ASD management...
  14. ncbi request reprint Neuropathic pain: is the end of suffering starting in the gene therapy?
    D Siniscalco
    Department of Experimental Medicine Section of Pharmacology L Donatelli, Second University of Naples Via S Maria di Costantinopoli, 16 80138 Naples, Italy
    Curr Drug Targets 6:75-80. 2005
    ....
  15. pmc Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats
    Dario Siniscalco
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, via S Maria di Costantinopoli 16, 80138 Napoli, Italy
    Pharmacol Res 57:223-33. 2008
    ....
  16. doi request reprint Intra-brain microinjection of human mesenchymal stem cells decreases allodynia in neuropathic mice
    Dario Siniscalco
    Division of Pharmacology L Donatelli, Department of Experimental Medicine, Second University of Naples, 80138 Naples, Italy
    Cell Mol Life Sci 67:655-69. 2010
    ..Transplanted hMSCs were able to reduce astrocytic and microglial cell activation...
  17. doi request reprint Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat
    Livio Luongo
    Department of Experimental Medicine, Division of Pharmacology L Donatelli, The Second University of Naples SUN, Via Costantinopoli 16, 80138 Naples, Italy
    Neuropharmacology 66:317-29. 2013
    ..This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'...
  18. ncbi request reprint Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic pain
    Dario Siniscalco
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Via S Maria di Costantinopoli, 16, 80138 Napoli, Italy
    Pharmacol Res 55:158-66. 2007
    ..These findings suggest that ROS regulate expression of some apoptotic genes which might play a role in the onset of neuropathic pain...
  19. pmc TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception
    Catia Giordano
    Endocannabinoid Research Group, Department of Experimental Medicine, Division of Pharmacology L Donatelli, Second University of Naples, Italy
    Cereb Cortex 22:2495-518. 2012
    ..We suggest that SNI triggers both TRPV1-dependent and independent glutamate- and caspase-mediated cross-talk among IL-PL cortex neurons and glia, which either participates or counteracts pain...
  20. ncbi request reprint Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia
    Patrizia Oliva
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, The Second University of Naples, Italy
    Eur J Pharmacol 530:40-7. 2006
    ..These data show that periaqueductal grey prostaglandin receptor stimulation increased formalin-induced nociceptive response in the late phase by increasing glutamate release and by producing a biphasic change in GABA release...
  21. doi request reprint A single subcutaneous injection of ozone prevents allodynia and decreases the over-expression of pro-inflammatory caspases in the orbito-frontal cortex of neuropathic mice
    Carlo Fuccio
    Department of Experimental Medicine, Faculty of Medicine and Surgery, Second University of Naples, Naples, Italy
    Eur J Pharmacol 603:42-9. 2009
    ....
  22. ncbi request reprint Blockade of glutamate mGlu5 receptors in a rat model of neuropathic pain prevents early over-expression of pro-apoptotic genes and morphological changes in dorsal horn lamina II
    Vito De Novellis
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Via S Maria di Costantinopoli, 16 80138 Naples, Italy
    Neuropharmacology 46:468-79. 2004
    ....
  23. doi request reprint Modification of cysteinyl leukotriene receptors expression in capsular contracture: follow-up study and definitive results
    Elisa Grella
    Department of Plastic and Reconstructive Surgery, Second University of Naples, Naples, Italy
    Ann Plast Surg 63:206-8. 2009
    ..These findings could at least partially provide a biomolecular basis that justifies the use of specific antileukotriene drugs in the treatment of this disease...
  24. doi request reprint The galactosylation of N(ω)-nitro-L-arginine enhances its anti-nocifensive or anti-allodynic effects by targeting glia in healthy and neuropathic mice
    Catia Giordano
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Faculty of Medicine and Surgery, Second University of Naples, Via Costantinopoli, 16 80138 Naples, Italy
    Eur J Pharmacol 656:52-62. 2011
    ..NAGAL showed a greater efficacy in inhibiting visceral pain and allodynia than L-NAME possibly by a greater cell permeation through the hexose transporter which is highly over-expressed by activated glia...
  25. ncbi request reprint Differential roles of mGlu8 receptors in the regulation of glutamate and gamma-aminobutyric acid release at periaqueductal grey level
    Ida Marabese
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Faculty of Medicine and Surgery, Second University of Naples, Via Costantinopoli, 16, 80138 Naples, Italy
    Neuropharmacology 49:157-66. 2005
    ..In particular, both the facilitation of glutamate and the inhibition of GABA releases require the participation of coupling to adenylate cyclase and the subsequent activation of the PKA pathway...
  26. ncbi request reprint Metabotropic glutamate receptor 5 and dorsal raphe serotonin release in inflammatory pain in rat
    Enza Palazzo
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Faculty of Medicine and Surgery, II University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Eur J Pharmacol 492:169-76. 2004
    ..In these conditions, peripheral but not dorsal raphe mGlu(5) receptors blockade prevented over activation of dorsal raphe serotonergic neurons and reversed thermal hyperalgesia...
  27. ncbi request reprint Modification of cysteinyl leukotriene receptor expression in capsular contracture: Preliminary results
    Giovanni F Nicoletti
    Department of Plastic and Reconstructive Surgery, Pharmacology Section, Second University of Naples, Naples, Italy
    Ann Plast Surg 58:212-4. 2007
    ..These preliminary findings suggest a primary role for cysteinyl leukotrienes in the activation and up-regulation of capsular contraction mechanisms...
  28. pmc The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats
    Vito De Novellis
    Department of Experimental Medicine, Division of Pharmacology, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Mol Pain 7:7. 2011
    ....
  29. doi request reprint The endovanilloid/endocannabinoid system: a new potential target for osteoporosis therapy
    Francesca Rossi
    Department of Pediatrics, Second University of Naples, Naples, Italy
    Bone 48:997-1007. 2011
    ..Our data pave the way to the use of TRPV1 agonist together with CB2 agonists or CB1 antagonists in osteoporosis...
  30. doi request reprint Transplantation of human mesenchymal stem cells in the study of neuropathic pain
    Dario Siniscalco
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Naples, Italy
    Methods Mol Biol 617:337-45. 2010
    ..We conclude that stem cell transplantation could be a useful therapeutic tool in the future of regenerative medicine...
  31. doi request reprint Mesenchymal stem cell therapy for the treatment of chronic obstructive pulmonary disease
    Bruno D'Agostino
    Department of Experimental Medicine, Second University of Naples, Section of Pharmacology L Donatelli, Via S Maria di Costantinopoli, 16 80138 Napoli, Italy
    Expert Opin Biol Ther 10:681-7. 2010
    ..This article reviews recent advances in regenerative medicine in COPD and highlights that their potential application although promising and very attractive, are still a far away opinion...
  32. pmc Antibodies against food antigens in patients with autistic spectrum disorders
    Laura de Magistris
    CIRANAD, Second University of Naples, Via Pansini 5, Building 3, 80131 Naples, Italy
    Biomed Res Int 2013:729349. 2013
    ..The prevalence of antibodies to gliadin and milk proteins in autistic children with paired/impaired intestinal permeability and under dietary regimen either regular or restricted is reported...
  33. doi request reprint Novel insights in basic and applied stem cell therapy
    Dario Siniscalco
    Department of Experimental Medicine, Division of Pharmacology L Donatelli, Second University of Naples, Naples, Italy
    J Cell Physiol 227:2283-6. 2012
    ..All of these themes were discussed in this meeting, covering stem cell subtypes with their newest basic and applied research...
  34. ncbi request reprint State-of-the-Art on Basic and Applied Stem Cell Therapy; Stem Cell Research Italy-International Society for Cellular Therapy Europe, Joint Meeting, Montesilvano (PE)-Italy, June 10-12, 2011
    Dario Siniscalco
    1 Department of Experimental Medicine, A Cascino, Second University of Naples, Naples, Italy
    Stem Cells Dev 21:668-9. 2012
    ..Angelo (Pescara)-Italy, on June 10th-12th, 2011, focused on the state-of-the-art of stem cell therapy and associated novel findings on stem cell research ( www.stemcellitaly.org )...
  35. pmc AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Br J Pharmacol 148:1022-32. 2006
    ..Taken together, these findings suggest that inhibition of endocannabinoid uptake, by blocking the putative anandamide carrier, results in the relief of neuropathic pain and may represent a novel strategy for treating chronic pain...