Research Topics
Genomes and GenesSpecies | Dario SiniscalcoSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Publications
Apoptotic genes expression in the lumbar dorsal horn in a model neuropathic pain in ratSabatino Maione
Department of Experimental Medicine, Second University of Naples, Napoli, Italy
Neuroreport 13:101-6. 2002..These data suggest that in a chronic pain condition, where the acute phase has already resolved, specific apoptotic genes are still operative and possibly may serve as a critical change for cells surviving in the chronic pain state...- Molecular approaches for neuropathic pain treatmentDario Siniscalco
Department of Experimental Medicine Section of Pharmacology L Donatelli, Second University of Naples, Via S Maria di Costantinopoli, 16 80138 Naples, Italy
Curr Med Chem 14:1783-7. 2007..These methods could provide a new therapeutic approach to neuropathic pain relief... 
Stem cell therapy: the great promise in lung diseaseDario Siniscalco
Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Via S Maria di Costantinopoli, 16 80138 Napoli, Italy
Ther Adv Respir Dis 2:173-7. 2008..Therefore, lung stem cell biology may provide novel approaches to therapy and could represent a great promise for the future of molecular medicine. In fact, several diseases can be slowed or even blocked by stem cell transplantation...
Autism spectrum disorders: is mesenchymal stem cell personalized therapy the future?Dario Siniscalco
Division of Pharmacology L Donatelli, Department of Experimental Medicine, Second University of Naples, Napoli, Italy
J Biomed Biotechnol 2012:480289. 2012..Due to the particular immune and neural dysregulation observed in ASDs, mesenchymal stem cell transplantation could offer a unique tool to provide better resolution for this disease...- The expression of caspases is enhanced in peripheral blood mononuclear cells of autism spectrum disorder patientsDario Siniscalco
Department of Experimental Medicine, Division of Pharmacology, Second University of Naples, via S Maria di Costantinopoli 16, 80138 Naples, Italy
J Autism Dev Disord 42:1403-10. 2012..Our data are suggestive of a possible role of the caspase pathway in ASD clinical outcome and of the use of caspase as potential diagnostic and/or therapeutic tools in ASD management... - Intra-brain microinjection of human mesenchymal stem cells decreases allodynia in neuropathic miceDario Siniscalco
Division of Pharmacology L Donatelli, Department of Experimental Medicine, Second University of Naples, 80138 Naples, Italy
Cell Mol Life Sci 67:655-69. 2010..Transplanted hMSCs were able to reduce astrocytic and microglial cell activation... - Neuropathic pain: is the end of suffering starting in the gene therapy?D Siniscalco
Department of Experimental Medicine Section of Pharmacology L Donatelli, Second University of Naples Via S Maria di Costantinopoli, 16 80138 Naples, Italy
Curr Drug Targets 6:75-80. 2005.... - Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic ratsDario Siniscalco
Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, via S Maria di Costantinopoli 16, 80138 Napoli, Italy
Pharmacol Res 57:223-33. 2008.... - Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic painDario Siniscalco
Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Via S Maria di Costantinopoli, 16, 80138 Napoli, Italy
Pharmacol Res 55:158-66. 2007..These findings suggest that ROS regulate expression of some apoptotic genes which might play a role in the onset of neuropathic pain... - Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesiaPatrizia Oliva
Department of Experimental Medicine, Section of Pharmacology L. Donatelli, The Second University of Naples, Italy
Eur J Pharmacol 530:40-7. 2006..These data show that periaqueductal grey prostaglandin receptor stimulation increased formalin-induced nociceptive response in the late phase by increasing glutamate release and by producing a biphasic change in GABA release... - A single subcutaneous injection of ozone prevents allodynia and decreases the over-expression of pro-inflammatory caspases in the orbito-frontal cortex of neuropathic miceCarlo Fuccio
Department of Experimental Medicine, Faculty of Medicine and Surgery, Second University of Naples, Naples, Italy
Eur J Pharmacol 603:42-9. 2009.... - Blockade of glutamate mGlu5 receptors in a rat model of neuropathic pain prevents early over-expression of pro-apoptotic genes and morphological changes in dorsal horn lamina IIVito De Novellis
Department of Experimental Medicine, Section of Pharmacology L. Donatelli, Second University of Naples, Via S. Maria di Costantinopoli, 16 80138 Naples, Italy
Neuropharmacology 46:468-79. 2004.... - Modification of cysteinyl leukotriene receptors expression in capsular contracture: follow-up study and definitive resultsElisa Grella
Department of Plastic and Reconstructive Surgery, Second University of Naples, Naples, Italy
Ann Plast Surg 63:206-8. 2009..These findings could at least partially provide a biomolecular basis that justifies the use of specific antileukotriene drugs in the treatment of this disease... - The galactosylation of N(ω)-nitro-L-arginine enhances its anti-nocifensive or anti-allodynic effects by targeting glia in healthy and neuropathic miceCatia Giordano
Department of Experimental Medicine, Section of Pharmacology L Donatelli, Faculty of Medicine and Surgery, Second University of Naples, Via Costantinopoli, 16 80138 Naples, Italy
Eur J Pharmacol 656:52-62. 2011..NAGAL showed a greater efficacy in inhibiting visceral pain and allodynia than L-NAME possibly by a greater cell permeation through the hexose transporter which is highly over-expressed by activated glia... - Differential roles of mGlu8 receptors in the regulation of glutamate and gamma-aminobutyric acid release at periaqueductal grey levelIda Marabese
Department of Experimental Medicine, Section of Pharmacology L Donatelli, Faculty of Medicine and Surgery, Second University of Naples, Via Costantinopoli, 16, 80138 Naples, Italy
Neuropharmacology 49:157-66. 2005..In particular, both the facilitation of glutamate and the inhibition of GABA releases require the participation of coupling to adenylate cyclase and the subsequent activation of the PKA pathway... - Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the ratLivio Luongo
Department of Experimental Medicine, Division of Pharmacology L Donatelli, The Second University of Naples SUN, Via Costantinopoli 16, 80138 Naples, Italy
Neuropharmacology 66:317-29. 2013..This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'... - Metabotropic glutamate receptor 5 and dorsal raphe serotonin release in inflammatory pain in ratEnza Palazzo
Department of Experimental Medicine, Section of Pharmacology L Donatelli, Faculty of Medicine and Surgery, II University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
Eur J Pharmacol 492:169-76. 2004..In these conditions, peripheral but not dorsal raphe mGlu(5) receptors blockade prevented over activation of dorsal raphe serotonergic neurons and reversed thermal hyperalgesia... - TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perceptionCatia Giordano
Endocannabinoid Research Group, Department of Experimental Medicine, Division of Pharmacology L Donatelli, Second University of Naples, Italy
Cereb Cortex 22:2495-518. 2012..We suggest that SNI triggers both TRPV1-dependent and independent glutamate- and caspase-mediated cross-talk among IL-PL cortex neurons and glia, which either participates or counteracts pain... - Modification of cysteinyl leukotriene receptor expression in capsular contracture: Preliminary resultsGiovanni F Nicoletti
Department of Plastic and Reconstructive Surgery, Pharmacology Section, Second University of Naples, Naples, Italy
Ann Plast Surg 58:212-4. 2007..These preliminary findings suggest a primary role for cysteinyl leukotrienes in the activation and up-regulation of capsular contraction mechanisms... - The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic ratsVito De Novellis
Department of Experimental Medicine, Division of Pharmacology, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
Mol Pain 7:7. 2011.... - The endovanilloid/endocannabinoid system: a new potential target for osteoporosis therapyFrancesca Rossi
Department of Pediatrics, Second University of Naples, Naples, Italy
Bone 48:997-1007. 2011..Our data pave the way to the use of TRPV1 agonist together with CB2 agonists or CB1 antagonists in osteoporosis... - Long-lasting effects of human mesenchymal stem cell systemic administration on pain-like behaviors, cellular, and biomolecular modifications in neuropathic miceDario Siniscalco
Division of Pharmacology L Donatelli, Department of Experimental Medicine, Second University of Naples Naples, Italy
Front Integr Neurosci 5:79. 2011..This study could provide novel findings in MSC pre-clinical biology and their therapeutic potential in regenerative medicine... - Transplantation of human mesenchymal stem cells in the study of neuropathic painDario Siniscalco
Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Naples, Italy
Methods Mol Biol 617:337-45. 2010..We conclude that stem cell transplantation could be a useful therapeutic tool in the future of regenerative medicine... - Role of neurotrophins in neuropathic painDario Siniscalco
Department of Experimental Medicine, Division of Pharmacology L Donatelli, Second University of Naples, Via S Maria di Costantinopoli, 16 80138 Naples, Italy
Curr Neuropharmacol 9:523-9. 2011..Nowadays, pain research is directing towards new molecular methods. By targeting neurotrophin molecules it may be possible to provide better pain control than currently available... - Mesenchymal stem cell therapy for the treatment of chronic obstructive pulmonary diseaseBruno D'Agostino
Department of Experimental Medicine, Second University of Naples, Section of Pharmacology L Donatelli, Via S Maria di Costantinopoli, 16 80138 Napoli, Italy
Expert Opin Biol Ther 10:681-7. 2010..This article reviews recent advances in regenerative medicine in COPD and highlights that their potential application although promising and very attractive, are still a far away opinion... - Novel insights in basic and applied stem cell therapyDario Siniscalco
Department of Experimental Medicine, Division of Pharmacology L Donatelli, Second University of Naples, Naples, Italy
J Cell Physiol 227:2283-6. 2012..All of these themes were discussed in this meeting, covering stem cell subtypes with their newest basic and applied research... - State-of-the-Art on Basic and Applied Stem Cell Therapy; Stem Cell Research Italy-International Society for Cellular Therapy Europe, Joint Meeting, Montesilvano (PE)-Italy, June 10-12, 2011Dario Siniscalco
1 Department of Experimental Medicine, A Cascino, Second University of Naples, Naples, Italy
Stem Cells Dev 21:668-9. 2012..Angelo (Pescara)-Italy, on June 10th-12th, 2011, focused on the state-of-the-art of stem cell therapy and associated novel findings on stem cell research ( www.stemcellitaly.org )... - AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic painBarbara Costa
Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
Br J Pharmacol 148:1022-32. 2006..Taken together, these findings suggest that inhibition of endocannabinoid uptake, by blocking the putative anandamide carrier, results in the relief of neuropathic pain and may represent a novel strategy for treating chronic pain...