Sangita Sinha

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Structures, mechanism, regulation and evolution of class III nucleotidyl cyclases
    S C Sinha
    University of Texas Southwestern Medical Center, Division of Infectious Diseases, Department of Internal Medicine, 5323 Harry Hines Blvd, Dallas 75390 9113, USA
    Rev Physiol Biochem Pharmacol 157:105-40. 2006
  2. pmc Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11
    Sangita Sinha
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Autophagy 4:989-97. 2008
  3. pmc JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
    Yongjie Wei
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell 30:678-88. 2008
  4. doi request reprint Beclin 2 functions in autophagy, degradation of g protein-coupled receptors, and metabolism
    Congcong He
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 154:1085-99. 2013
  5. pmc Bcl-2 family members: dual regulators of apoptosis and autophagy
    Beth Levine
    Howard Hughes Medical Institute, Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Autophagy 4:600-6. 2008

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Structures, mechanism, regulation and evolution of class III nucleotidyl cyclases
    S C Sinha
    University of Texas Southwestern Medical Center, Division of Infectious Diseases, Department of Internal Medicine, 5323 Harry Hines Blvd, Dallas 75390 9113, USA
    Rev Physiol Biochem Pharmacol 157:105-40. 2006
    ..Many of these regulators act by altering the interface of the catalytic domains and therefore the integrity of the catalytic site(s). This review focuses on both conserved and divergent mechanisms of class III NC function and regulation...
  2. pmc Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11
    Sangita Sinha
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Autophagy 4:989-97. 2008
    ..Thus, our results suggest that M11 inhibits autophagy through a mechanism that involves the binding of the Beclin 1 BH3 domain in the M11 hydrophobic surface groove...
  3. pmc JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
    Yongjie Wei
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell 30:678-88. 2008
    ..These findings define a mechanism that cells use to regulate autophagic activity in response to nutrient status...
  4. doi request reprint Beclin 2 functions in autophagy, degradation of g protein-coupled receptors, and metabolism
    Congcong He
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 154:1085-99. 2013
    ..Our findings identify Beclin 2 as a converging regulator of autophagy and GPCR turnover and highlight the functional and mechanistic diversity of Beclin family membersĀ in autophagy, endolysosomal trafficking, and metabolism. ..
  5. pmc Bcl-2 family members: dual regulators of apoptosis and autophagy
    Beth Levine
    Howard Hughes Medical Institute, Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Autophagy 4:600-6. 2008
    ..This hitherto neglected crosstalk between the core machineries regulating autophagy and apoptosis may redefine the role of Bcl-2 family proteins in oncogenesis and tumor progression...