K W Singletary

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. ncbi request reprint Inhibition of benzo[a]pyrene- and 1,6-dinitropyrene-DNA adduct formation in human mammary epithelial cells bydibenzoylmethane and sulforaphane
    K Singletary
    Department of Food Science and Human Nutrition, University of Illinois, 905 South Goodwin Avenue, Urbana 61801, USA
    Cancer Lett 155:47-54. 2000
  2. ncbi request reprint Genistein suppresses proliferation and MET oncogene expression and induces EGR-1 tumor suppressor expression in immortalized human breast epithelial cells
    Keith Singletary
    Department of Food Science and Human Nutrition, University of Illinois, Urbana Champaign, IL 61801, USA
    Anticancer Res 26:1039-48. 2006
  3. ncbi request reprint Ethanol inhibits benzo[a]pyrene-DNA adduct removal and increases 8-oxo-deoxyguanosine formation in human mammary epithelial cells
    Keith W Singletary
    Department of Food Science and Human Nutrition, University of Illinois, 467, Bevier Hall, 905 South Goodwin Avenue, Urbana Champaign, Urbana, IL, USA
    Cancer Lett 203:139-44. 2004
  4. ncbi request reprint Inhibition of rat mammary tumorigenesis by concord grape juice constituents
    Keith W Singletary
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, Illinois 61801
    J Agric Food Chem 51:7280-6. 2003
  5. ncbi request reprint Effect of grape seed proanthocyanidins on colon aberrant crypts and breast tumors in a rat dual-organ tumor model
    K W Singletary
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
    Nutr Cancer 39:252-8. 2001
  6. ncbi request reprint Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms
    K W Singletary
    Department of Food Science and Human Nutrition, University of Illinois, 905 S Goodwin Ave, 467 Bevier Hall, Urbana, IL 61801, USA
    JAMA 286:2143-51. 2001
  7. ncbi request reprint Effect of extrusion on isoflavone content and antiproliferative bioactivity of soy/corn mixtures
    K Singletary
    University of Illinois, Department of Food Science and Human Nutrition, Urbana, Illinois 61801, USA
    J Agric Food Chem 48:3566-71. 2000
  8. ncbi request reprint Anthocyanin-rich grape extract blocks breast cell DNA damage
    Keith W Singletary
    Department of Food Science and Human Nutrition, University of Illinois, Urbana Champaign, Illinois 61801, USA
    J Med Food 10:244-51. 2007
  9. ncbi request reprint Effect of ethanol on proliferation and estrogen receptor-alpha expression in human breast cancer cells
    K W Singletary
    Department of Food Science and Human Nutrition, University of Illinois, 467 Bevier Hall, 905 South Goodwin Avenue, Urbana Champaign, IL 61801, USA
    Cancer Lett 165:131-7. 2001
  10. ncbi request reprint Effects of genistein on cell proliferation and cell cycle arrest in nonneoplastic human mammary epithelial cells: involvement of Cdc2, p21(waf/cip1), p27(kip1), and Cdc25C expression
    R S Frey
    Department of Food Science and Human Nutrition, University of Illinois, 905 South Goodwin Avenue, 61801, Urbana, IL, USA
    Biochem Pharmacol 61:979-89. 2001

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Inhibition of benzo[a]pyrene- and 1,6-dinitropyrene-DNA adduct formation in human mammary epithelial cells bydibenzoylmethane and sulforaphane
    K Singletary
    Department of Food Science and Human Nutrition, University of Illinois, 905 South Goodwin Avenue, Urbana 61801, USA
    Cancer Lett 155:47-54. 2000
    ..Together these data suggest that dibenzoylmethane and sulforaphane warrant continued evaluation as breast cancer chemopreventive agents...
  2. ncbi request reprint Genistein suppresses proliferation and MET oncogene expression and induces EGR-1 tumor suppressor expression in immortalized human breast epithelial cells
    Keith Singletary
    Department of Food Science and Human Nutrition, University of Illinois, Urbana Champaign, IL 61801, USA
    Anticancer Res 26:1039-48. 2006
    ..Taken together, these genistein-induced changes in gene expressions provide insights into potential mechanisms by which this isoflavone may protect human breast cells against neoplastic transformation...
  3. ncbi request reprint Ethanol inhibits benzo[a]pyrene-DNA adduct removal and increases 8-oxo-deoxyguanosine formation in human mammary epithelial cells
    Keith W Singletary
    Department of Food Science and Human Nutrition, University of Illinois, 467, Bevier Hall, 905 South Goodwin Avenue, Urbana Champaign, Urbana, IL, USA
    Cancer Lett 203:139-44. 2004
    ..This inhibitory effect of ethanol on adduct removal in part may be related to ethanol-associated oxidative stress...
  4. ncbi request reprint Inhibition of rat mammary tumorigenesis by concord grape juice constituents
    Keith W Singletary
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, Illinois 61801
    J Agric Food Chem 51:7280-6. 2003
    ..These studies thus indicate that Concord grape juice constituents can inhibit the promotion stage of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis, in part by suppressing cell proliferation...
  5. ncbi request reprint Effect of grape seed proanthocyanidins on colon aberrant crypts and breast tumors in a rat dual-organ tumor model
    K W Singletary
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
    Nutr Cancer 39:252-8. 2001
    ..These results indicate that grape polyphenolics warrant further evaluation as potential colon cancer chemopreventive agents...
  6. ncbi request reprint Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms
    K W Singletary
    Department of Food Science and Human Nutrition, University of Illinois, 905 S Goodwin Ave, 467 Bevier Hall, Urbana, IL 61801, USA
    JAMA 286:2143-51. 2001
    ....
  7. ncbi request reprint Effect of extrusion on isoflavone content and antiproliferative bioactivity of soy/corn mixtures
    K Singletary
    University of Illinois, Department of Food Science and Human Nutrition, Urbana, Illinois 61801, USA
    J Agric Food Chem 48:3566-71. 2000
    ..Therefore, extrusion of soy protein/cornmeal-containing foods are likely to retain a considerable portion of their isoflavone content and some of the health benefits associated with soy...
  8. ncbi request reprint Anthocyanin-rich grape extract blocks breast cell DNA damage
    Keith W Singletary
    Department of Food Science and Human Nutrition, University of Illinois, Urbana Champaign, Illinois 61801, USA
    J Med Food 10:244-51. 2007
    ....
  9. ncbi request reprint Effect of ethanol on proliferation and estrogen receptor-alpha expression in human breast cancer cells
    K W Singletary
    Department of Food Science and Human Nutrition, University of Illinois, 467 Bevier Hall, 905 South Goodwin Avenue, Urbana Champaign, IL 61801, USA
    Cancer Lett 165:131-7. 2001
    ..Therefore, ethanol added at physiologically relevant concentrations to ER+ human breast cancer cell cultures can enhance cell proliferation and increase the content of ERalpha...
  10. ncbi request reprint Effects of genistein on cell proliferation and cell cycle arrest in nonneoplastic human mammary epithelial cells: involvement of Cdc2, p21(waf/cip1), p27(kip1), and Cdc25C expression
    R S Frey
    Department of Food Science and Human Nutrition, University of Illinois, 905 South Goodwin Avenue, 61801, Urbana, IL, USA
    Biochem Pharmacol 61:979-89. 2001
    ..Down-regulation of the cell cycle-associated phosphatase Cdc25C combined with up-regulation of p21(waf/cip1) expression appear to be important mechanisms by which genistein decreases Cdc2 kinase activity and causes G2 cell cycle arrest...
  11. ncbi request reprint Purple grape juice inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation
    Kwan Jae Jung
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Cancer Lett 233:279-88. 2006
    ..Thus, grape juice constituents appear to have benefit in decreasing susceptibility of the rat mammary gland to the tumor-initiating action of DMBA...
  12. ncbi request reprint Optical coherence tomography: feasibility for basic research and image-guided surgery of breast cancer
    Stephen A Boppart
    Department of Electrical and Computer Engineering, Bioengineering Program, Beckman Institute for Advanced Science and Technology, College of Medicine, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Breast Cancer Res Treat 84:85-97. 2004
    ..These results illustrate the potential of OCT for a wide range of basic research studies and for intra-operative image-guidance to identify foci of tumor cells within surgical margins during the surgical treatment of breast cancer...
  13. ncbi request reprint Soy extract inhibits mammary adenocarcinoma growth in a syngeneic mouse model
    Amy L Hewitt
    Department of Food Science and Human Nutrition, University of Illinois, Urbana Champaign, IL 61801, USA
    Cancer Lett 192:133-43. 2003
    ..This suggests that genistein along with other constituent(s) in the soy extract may also contribute to suppression of F3II tumor growth...
  14. ncbi request reprint Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization
    Steven J T Jackson
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
    J Nutr 134:2229-36. 2004
    ....
  15. ncbi request reprint Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization
    Steven J T Jackson
    Department of Food Science and Human Nutrition, University of Illinois, 467 Bevier Hall M C 182, 905 S Goodwin Ave, Urbana, IL 61801, USA
    Carcinogenesis 25:219-27. 2004
    ..Inhibition of mammary carcinogenesis appears in part to involve perturbation of mitotic microtubules and early M-phase block associated with cdc2 kinase activation, indicating that cells arrest prior to metaphase exit...
  16. ncbi request reprint Induction of macroautophagy in human colon cancer cells by soybean B-group triterpenoid saponins
    Allison A Ellington
    Department of Food Science and Human Nutrition, 905 South Goodwin Avenue, 467 Bevier Hall, Urbana, IL 61801, USA
    Carcinogenesis 26:159-67. 2005
    ..These findings suggest that B-group soyasaponins may be another colon-cancer suppressive component of soy that warrants further examination as a potential chemopreventive phytochemical...
  17. ncbi request reprint Inhibition of Akt signaling and enhanced ERK1/2 activity are involved in induction of macroautophagy by triterpenoid B-group soyasaponins in colon cancer cells
    Allison A Ellington
    Department of Food Science and Human Nutrition, University of Illinois, 905 South Goodwin Avenue, Bevier Hall, Urbana, IL 61801, USA
    Carcinogenesis 27:298-306. 2006
    ....
  18. ncbi request reprint Genistein activates p38 mitogen-activated protein kinase, inactivates ERK1/ERK2 and decreases Cdc25C expression in immortalized human mammary epithelial cells
    Randall S Frey
    University of Illinois, Department of Food Science and Human Nutrition, Urbana 61801, USA
    J Nutr 133:226-31. 2003
    ..These data suggest an important interplay between the p38 pathway and G2 cell cycle checkpoint control and provide insights into possible mechanisms whereby this isoflavone may inhibit early events in mammary carcinogenesis...
  19. ncbi request reprint Sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization
    Steven J T Jackson
    Medical College of Georgia, Vascular Biology Center, CB 3330, 1459 Laney Walker Boulevard Augusta, GA 30912, USA
    Vascul Pharmacol 46:77-84. 2007
    ..This mechanism of SUL-induced endothelial microtubule disruption and early mitotic arrest may further discern a potential role of SUL as a chemopreventive agent...