DINENDER SINGLA

Summary

Affiliation: University of Central Florida
Country: USA

Publications

  1. ncbi request reprint Transplantation of embryonic stem cells into the infarcted mouse heart: formation of multiple cell types
    Dinender K Singla
    Department of Medicine, University of Wisconsin, H6 343 CSC, Box 3248, 600 Highland Avenue, Madison, WI 53792, USA
    J Mol Cell Cardiol 40:195-200. 2006
  2. pmc Regulation of PTEN/Akt pathway enhances cardiomyogenesis and attenuates adverse left ventricular remodeling following thymosin β4 Overexpressing embryonic stem cell transplantation in the infarcted heart
    Binbin Yan
    Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, United States of America
    PLoS ONE 8:e75580. 2013
  3. doi request reprint Induced pluripotent stem (iPS) cells repair and regenerate infarcted myocardium
    Dinender K Singla
    Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32816, United States
    Mol Pharm 8:1573-81. 2011
  4. pmc TGF-β2 treatment enhances cytoprotective factors released from embryonic stem cells and inhibits apoptosis in infarcted myocardium
    Dinender K Singla
    Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, 32816, USA
    Am J Physiol Heart Circ Physiol 300:H1442-50. 2011
  5. ncbi request reprint Stem cells in the infarcted heart
    Dinender K Singla
    Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 4000 Central Florida Blvd, Room 224, Orlando, FL 32816, USA
    J Cardiovasc Transl Res 3:73-8. 2010
  6. pmc Embryonic stem cells in cardiac repair and regeneration
    Dinender K Singla
    Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32816, USA
    Antioxid Redox Signal 11:1857-63. 2009
  7. pmc Factors released from embryonic stem cells inhibit apoptosis in H9c2 cells through PI3K/Akt but not ERK pathway
    Dinender K Singla
    Burnett s School of Biomedical Sciences, Univ of Central Florida, 4000 Central Florida Blvd, Orlando, FL, 32816, USA
    Am J Physiol Heart Circ Physiol 295:H907-13. 2008
  8. ncbi request reprint Transplanted embryonic stem cells following mouse myocardial infarction inhibit apoptosis and cardiac remodeling
    Dinender K Singla
    Department of Medicine, College of Medicine, University of Vermont, Colchester, Vermont, USA
    Am J Physiol Heart Circ Physiol 293:H1308-14. 2007
  9. pmc Factors released from embryonic stem cells inhibit apoptosis of H9c2 cells
    Dinender K Singla
    Department of Medicine, Division of Cardiology, Cardiovascular Research Institute, University of Vermont, College of Medicine, Colchester, Vermont, USA
    Am J Physiol Heart Circ Physiol 293:H1590-5. 2007
  10. ncbi request reprint wnt3a but not wnt11 supports self-renewal of embryonic stem cells
    Dinender K Singla
    Cardiovascular Research Institute, Department of Medicine, University of Vermont, Colchester, VT 05446, USA
    Biochem Biophys Res Commun 345:789-95. 2006

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Transplantation of embryonic stem cells into the infarcted mouse heart: formation of multiple cell types
    Dinender K Singla
    Department of Medicine, University of Wisconsin, H6 343 CSC, Box 3248, 600 Highland Avenue, Madison, WI 53792, USA
    J Mol Cell Cardiol 40:195-200. 2006
    ..Therefore, ES cells hold promise for myocardial cellular therapy...
  2. pmc Regulation of PTEN/Akt pathway enhances cardiomyogenesis and attenuates adverse left ventricular remodeling following thymosin β4 Overexpressing embryonic stem cell transplantation in the infarcted heart
    Binbin Yan
    Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, United States of America
    PLoS ONE 8:e75580. 2013
    ..Moreover, we also demonstrate that there was a significant decrease in both cardiac apoptosis and fibrosis, thus improving cardiac function in the infarcted heart. ..
  3. doi request reprint Induced pluripotent stem (iPS) cells repair and regenerate infarcted myocardium
    Dinender K Singla
    Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32816, United States
    Mol Pharm 8:1573-81. 2011
    ....
  4. pmc TGF-β2 treatment enhances cytoprotective factors released from embryonic stem cells and inhibits apoptosis in infarcted myocardium
    Dinender K Singla
    Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, 32816, USA
    Am J Physiol Heart Circ Physiol 300:H1442-50. 2011
    ..We also suggest that T-ES-CM demonstrates additional beneficial effects that provide useful information for future therapeutic applications in regenerative medicine...
  5. ncbi request reprint Stem cells in the infarcted heart
    Dinender K Singla
    Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 4000 Central Florida Blvd, Room 224, Orlando, FL 32816, USA
    J Cardiovasc Transl Res 3:73-8. 2010
    ..In this review, we will discuss the effects of transplanted stem cells on engraftment and differentiation as well as factors released from stem cells on apoptosis and cardiac remodeling...
  6. pmc Embryonic stem cells in cardiac repair and regeneration
    Dinender K Singla
    Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32816, USA
    Antioxid Redox Signal 11:1857-63. 2009
    ..Our current knowledge of ES cell transplantation in the heart is very limited. This review discusses the use of various growth factors to enhance ES cells engraftment and differentiation, as well as the issue of teratoma formation...
  7. pmc Factors released from embryonic stem cells inhibit apoptosis in H9c2 cells through PI3K/Akt but not ERK pathway
    Dinender K Singla
    Burnett s School of Biomedical Sciences, Univ of Central Florida, 4000 Central Florida Blvd, Orlando, FL, 32816, USA
    Am J Physiol Heart Circ Physiol 295:H907-13. 2008
    ..In contrast, we observed no change in ES-CM-decreased apoptosis or pERK with PD-98050. In conclusion, we suggest that ES-CM inhibited apoptosis and is mediated by Akt but not the ERK pathway...
  8. ncbi request reprint Transplanted embryonic stem cells following mouse myocardial infarction inhibit apoptosis and cardiac remodeling
    Dinender K Singla
    Department of Medicine, College of Medicine, University of Vermont, Colchester, Vermont, USA
    Am J Physiol Heart Circ Physiol 293:H1308-14. 2007
    ..In conclusion, transplanted mouse ES cells in the infarcted heart inhibit apoptosis, fibrosis, and hypertrophy, thereby reducing adverse remodeling...
  9. pmc Factors released from embryonic stem cells inhibit apoptosis of H9c2 cells
    Dinender K Singla
    Department of Medicine, Division of Cardiology, Cardiovascular Research Institute, University of Vermont, College of Medicine, Colchester, Vermont, USA
    Am J Physiol Heart Circ Physiol 293:H1590-5. 2007
    ..Moreover, these findings suggest that released factors might be useful for therapeutic applications in ischemic heart disease as well as for many other diseases...
  10. ncbi request reprint wnt3a but not wnt11 supports self-renewal of embryonic stem cells
    Dinender K Singla
    Cardiovascular Research Institute, Department of Medicine, University of Vermont, Colchester, VT 05446, USA
    Biochem Biophys Res Commun 345:789-95. 2006
    ..Thus, our results show that conditioned medium from wnt3a but not wnt11 expressing cells can maintain ES cells in self-renewal and in a pluripotent state...
  11. ncbi request reprint Enhancement by growth factors of cardiac myocyte differentiation from embryonic stem cells: a promising foundation for cardiac regeneration
    Dinender K Singla
    Department of Medicine, Vascular Biology Unit, and Cardiovascular Research Institute, University of Vermont, Colchester, VT 05446, USA
    Biochem Biophys Res Commun 335:637-42. 2005
    ..This review addresses the current understanding of the role of growth factors in the differentiation of cardiac myocytes from ES-embryoid body cell systems in vitro as well as cardiac regeneration in vivo...
  12. ncbi request reprint p38 and ERK1/2 MAPKs mediate the interplay of TNF-alpha and IL-10 in regulating oxidative stress and cardiac myocyte apoptosis
    Sanjiv Dhingra
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Center, 351 Tache Avenue, Winnipeg, Manitoba, Canada
    Am J Physiol Heart Circ Physiol 293:H3524-31. 2007
    ..This study provides evidence in support of the essential role of p38 and ERK1/2 MAPKs in the interactive role of TNF-alpha and IL-10 in cardiac myocyte apoptosis...

Research Grants5

  1. Factors Released From Embryonic Stem cells and Cardiac Remodeling
    Dinender Kumar Singla; Fiscal Year: 2010
    ..Identification and delineation of favorable effects of factors released from ES cells might lead to a new therapeutic strategy that could be an alternative to or combined with cell transplantation. ..
  2. Cardiac Repair and Regeneration in Doxorubicin-induced Cardiomyopathy
    DINENDER SINGLA; Fiscal Year: 2009
    ....
  3. Factors Released From Embryonic Stem cells and Cardiac Remodeling
    DINENDER SINGLA; Fiscal Year: 2009
    ..Identification and delineation of favorable effects of factors released from ES cells might lead to a new therapeutic strategy that could be an alternative to or combined with cell transplantation. ..
  4. Cardiac Repair and Regeneration in Doxorubicin-induced Cardiomyopathy
    Dinender Kumar Singla; Fiscal Year: 2010
    ....