Sharad S Singhal

Summary

Affiliation: University of North Texas
Country: USA

Publications

  1. ncbi RLIP76: A novel glutathione-conjugate and multi-drug transporter
    Sharad S Singhal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Biochem Pharmacol 77:761-9. 2009
  2. ncbi Diminished drug transport and augmented radiation sensitivity caused by loss of RLIP76
    Sharad S Singhal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, EAD RM No 542, Fort Worth, TX 76107 2699, United States
    FEBS Lett 582:3408-14. 2008
  3. ncbi Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer
    Sharad S Singhal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Int J Cancer 126:1327-38. 2010
  4. ncbi RLIP76: a target for kidney cancer therapy
    Sharad S Singhal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, USA
    Cancer Res 69:4244-51. 2009
  5. ncbi Regression of prostate cancer xenografts by RLIP76 depletion
    Sharad S Singhal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Biochem Pharmacol 77:1074-83. 2009
  6. ncbi Functional reconstitution of RLIP76 catalyzing ATP-dependent transport of glutathione-conjugates
    Sharad S Singhal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, USA
    Int J Oncol 34:191-9. 2009
  7. ncbi Increased expression of cdc2 inhibits transport function of RLIP76 and promotes apoptosis
    Sharad S Singhal
    Department of Molecular Biology and Immunology, 3500 Camp Bowie Blvd, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, United States
    Cancer Lett 283:152-8. 2009
  8. ncbi Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling
    Pankaj Chaudhary
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Biochemistry 49:6263-75. 2010
  9. ncbi A central role of RLIP76 in regulation of glycemic control
    Sanjay Awasthi
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, USA
    Diabetes 59:714-25. 2010
  10. ncbi Nutlin-3 enhances sorafenib efficacy in renal cell carcinoma
    Rit Vatsyayan
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, USA
    Mol Carcinog 52:39-48. 2013

Collaborators

Detail Information

Publications21

  1. ncbi RLIP76: A novel glutathione-conjugate and multi-drug transporter
    Sharad S Singhal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Biochem Pharmacol 77:761-9. 2009
    ....
  2. ncbi Diminished drug transport and augmented radiation sensitivity caused by loss of RLIP76
    Sharad S Singhal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, EAD RM No 542, Fort Worth, TX 76107 2699, United States
    FEBS Lett 582:3408-14. 2008
    ..Loss of RLIP76 confers sensitivity to xenobiotics and radiation due to the loss of a common transport mechanism for glutathione-electrophile conjugates and xenobiotics...
  3. ncbi Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer
    Sharad S Singhal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Int J Cancer 126:1327-38. 2010
    ..These studies offer strong support for our overall hypothesis that RLIP76 is an overarching anti-apoptosis mechanism that, if inhibited, can be more broadly effective in the treatment of renal cell carcinoma...
  4. ncbi RLIP76: a target for kidney cancer therapy
    Sharad S Singhal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, USA
    Cancer Res 69:4244-51. 2009
    ....
  5. ncbi Regression of prostate cancer xenografts by RLIP76 depletion
    Sharad S Singhal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Biochem Pharmacol 77:1074-83. 2009
    ..These studies indicate that RLIP76 serves a key effector function for the survival of prostate cancer cells and that it is a valid target for cancer therapy...
  6. ncbi Functional reconstitution of RLIP76 catalyzing ATP-dependent transport of glutathione-conjugates
    Sharad S Singhal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, USA
    Int J Oncol 34:191-9. 2009
    ..K562 RLIP76 revealed higher specific activity of ATPase and transport for recombinant purified RLIP76, indicating that additional factors present in recombinant purified RLIP76 can modulate its transport activity...
  7. ncbi Increased expression of cdc2 inhibits transport function of RLIP76 and promotes apoptosis
    Sharad S Singhal
    Department of Molecular Biology and Immunology, 3500 Camp Bowie Blvd, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, United States
    Cancer Lett 283:152-8. 2009
    ..In the present communication, we propose that the accumulation-deficient drug-resistance mediated by RLIP76 can be modulated by inhibition of RLIP76 transport activity by cdc2...
  8. ncbi Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling
    Pankaj Chaudhary
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Biochemistry 49:6263-75. 2010
    ....
  9. ncbi A central role of RLIP76 in regulation of glycemic control
    Sanjay Awasthi
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, USA
    Diabetes 59:714-25. 2010
    ..Recent studies show that RLIP76 is the primary GS-E conjugate transporter in cells, and a regulator of oxidative-stress response. Because RLIP76(-/-) mice are hypoglycemic, we studied the role of RLIP76 in insulin resistance...
  10. ncbi Nutlin-3 enhances sorafenib efficacy in renal cell carcinoma
    Rit Vatsyayan
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, USA
    Mol Carcinog 52:39-48. 2013
    ..This is the first report showing the synergistic effect of sorafenib and nutlin-3 while providing a strong clinical-translational rationale for further testing of sorafenib and nutlin-3 combinatorial regimen in human RCC...
  11. ncbi hSET1: a novel approach for colon cancer therapy
    Sushma Yadav
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Biochem Pharmacol 77:1635-41. 2009
    ..These findings demonstrate that hSET1 over-expression promotes cell proliferation and cancer cell survival, and may be a novel target for cancer therapy...
  12. ncbi Role of RLIP76 in doxorubicin resistance in lung cancer
    Rit Vatsyayan
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Int J Oncol 34:1505-11. 2009
    ....
  13. ncbi RLIP76 in defense of radiation poisoning
    Jyotsana Singhal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Int J Radiat Oncol Biol Phys 72:553-61. 2008
    ..In other reports, Ralbp1 refers to the mouse enzyme (encoded by the Ralbp1 gene), which is structurally and functionally homologous to RLIP76, the human protein encoded by the human RALBP1 gene...
  14. ncbi Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1
    Sharad S Singhal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    J Biol Chem 283:19714-29. 2008
    ..These findings indicate a novel model for mutual regulation of Hsf-1 and Ralbp1 through Ralbp1-mediated sequestration of Hsf-1 in the cellular cytoskeleton and Hsf-1-mediated inhibition of the transport activity of membrane-bound Ralbp1...
  15. ncbi Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis
    Sharad S Singhal
    Corresponding Authors Sanjay Awasthi or Sharad S Singhal, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Mol Cancer Ther 10:16-28. 2011
    ..In RLIP76(-/-) mice, p53, p38, and JNK activation did not occur in response to either carcinogen. Our findings show a fundamental role of RLIP76 in chemical carcinogenesis...
  16. ncbi 2'-hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma
    Lokesh Dalasanur Nagaprashantha
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Carcinogenesis 32:568-75. 2011
    ....
  17. ncbi Targeting p53-null neuroblastomas through RLIP76
    Jyotsana Singhal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    Cancer Prev Res (Phila) 4:879-89. 2011
    ..Most importantly, our findings strongly indicate RLIP76 as a novel target for therapy of drug-resistant and p53-mutant neuroblastoma...
  18. ncbi RLIP76 and Cancer
    Sanjay Awasthi
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, USA
    Clin Cancer Res 14:4372-7. 2008
    ..Loss of RLIP76 by antibody or antisense therapy is associated with increased sensitivity to radiation and chemotherapy. Conversely, liposomally delivered RLIP may treat poisoning and wounds...
  19. ncbi RLIP76: a versatile transporter and an emerging target for cancer therapy
    Rit Vatsyayan
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, United States
    Biochem Pharmacol 79:1699-705. 2010
    ..In the present review, we will discuss the role of RLIP76 as a multi-drug transporter, its involvement in cancer, and the prospects of using RLIP76 inhibition as an emerging treatment for cancer...
  20. ncbi Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death
    Yogesh C Awasthi
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, USA
    Free Radic Biol Med 45:111-8. 2008
    ....
  21. ncbi The sensors and regulators of cell-matrix surveillance in anoikis resistance of tumors
    Lokesh Dalasanur Nagaprashantha
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Int J Cancer 128:743-52. 2011
    ....