Ravindra N Singh

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron
    Nirmal K Singh
    Department of Medicine LRB 326, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Mol Cell Biol 26:1333-46. 2006
  2. ncbi In vivo selection reveals combinatorial controls that define a critical exon in the spinal muscular atrophy genes
    Natalia N Singh
    Department of Medicine LRB 326, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605 2324, USA
    RNA 10:1291-305. 2004
  3. ncbi Association of severity of spinal muscular atrophy with the loss of NAIP gene
    Ravindra N Singh
    Department of Medicine (LRB 326, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Neurol India 54:246. 2006
  4. ncbi Unfolding the mystery of alternative splicing through a unique method of in vivo selection
    Ravindra N Singh
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Front Biosci 12:3263-72. 2007
  5. ncbi The regulation and regulatory activities of alternative splicing of the SMN gene
    Natalia N Singh
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA
    Crit Rev Eukaryot Gene Expr 14:271-85. 2004
  6. ncbi Modulating role of RNA structure in alternative splicing of a critical exon in the spinal muscular atrophy genes
    Natalia N Singh
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Nucleic Acids Res 35:371-89. 2007
  7. ncbi An extended inhibitory context causes skipping of exon 7 of SMN2 in spinal muscular atrophy
    Natalia N Singh
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Biochem Biophys Res Commun 315:381-8. 2004
  8. ncbi Evolving concepts on human SMN pre-mRNA splicing
    Ravindra N Singh
    Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
    RNA Biol 4:7-10. 2007
  9. ncbi Binding of a group II intron-encoded reverse transcriptase/maturase to its high affinity intron RNA binding site involves sequence-specific recognition and autoregulates translation
    Ravindra N Singh
    Institute for Cellular and Molecular Biology, Department of Chemistry and Biochemistry, and Section of Molecular Genetics and Microbiology, School of Biological Sciences, University of Texas at Austin, 78712, USA
    J Mol Biol 318:287-303. 2002

Collaborators

  • Natalia N Singh
  • Elliot J Androphy
  • Nirmal K Singh

Detail Information

Publications9

  1. ncbi Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron
    Nirmal K Singh
    Department of Medicine LRB 326, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Mol Cell Biol 26:1333-46. 2006
    ....
  2. ncbi In vivo selection reveals combinatorial controls that define a critical exon in the spinal muscular atrophy genes
    Natalia N Singh
    Department of Medicine LRB 326, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605 2324, USA
    RNA 10:1291-305. 2004
    ..This method offers unparallel advantage for determining the relative strength of splice sites, as well as for identifying the novel exonic cis-elements...
  3. ncbi Association of severity of spinal muscular atrophy with the loss of NAIP gene
    Ravindra N Singh
    Department of Medicine (LRB 326, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Neurol India 54:246. 2006
  4. ncbi Unfolding the mystery of alternative splicing through a unique method of in vivo selection
    Ravindra N Singh
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Front Biosci 12:3263-72. 2007
    ..Considering this unbiased method uses in vivo conditions, it has potential to identify critical regulatory elements as therapeutic targets for a growing number of splicing-associated diseases...
  5. ncbi The regulation and regulatory activities of alternative splicing of the SMN gene
    Natalia N Singh
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA
    Crit Rev Eukaryot Gene Expr 14:271-85. 2004
    ..Recent advances in our understanding of SMN gene splicing reveals multiple challenges that are specific to in vivo regulation, which we now know is intimately connected with other biological pathways...
  6. ncbi Modulating role of RNA structure in alternative splicing of a critical exon in the spinal muscular atrophy genes
    Natalia N Singh
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Nucleic Acids Res 35:371-89. 2007
    ..Our findings reveal for the first time the critical role of RNA structure in regulation of alternative splicing of human SMN...
  7. ncbi An extended inhibitory context causes skipping of exon 7 of SMN2 in spinal muscular atrophy
    Natalia N Singh
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Biochem Biophys Res Commun 315:381-8. 2004
    ....
  8. ncbi Evolving concepts on human SMN pre-mRNA splicing
    Ravindra N Singh
    Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
    RNA Biol 4:7-10. 2007
    ..Considering an antisense-based strategy confers a unique advantage of sequence specificity, availability of many target worthy cis-elements holds strong potential for antisense-mediated therapy of SMA...
  9. ncbi Binding of a group II intron-encoded reverse transcriptase/maturase to its high affinity intron RNA binding site involves sequence-specific recognition and autoregulates translation
    Ravindra N Singh
    Institute for Cellular and Molecular Biology, Department of Chemistry and Biochemistry, and Section of Molecular Genetics and Microbiology, School of Biological Sciences, University of Texas at Austin, 78712, USA
    J Mol Biol 318:287-303. 2002
    ..The recognition of the DIVa loop-stem-loop structure accounts, in part, for the intron specificity of group II intron maturases and has parallels in template-recognition mechanisms used by other reverse transcriptases...