Ram Raj Singh

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint IL-4 and many roads to lupuslike autoimmunity
    Ram Raj Singh
    Clin Immunol 108:73-9. 2003
  2. pmc Homeostatic regulation of marginal zone B cells by invariant natural killer T cells
    Xiangshu Wen
    Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e26536. 2011
  3. pmc SLE: translating lessons from model systems to human disease
    Ram Raj Singh
    Autoimmunity and Tolerance Lab, Div of Rheumatology, Dept of Medicine, Geffen School of Medicine, University of California Los Angeles, Rm 32 59 Rehabilitation Center, 1000 Veteran Avenue, Los Angeles, CA 90095 1670, USA
    Trends Immunol 26:572-9. 2005
  4. pmc TNFalpha blockade in human diseases: an overview of efficacy and safety
    Jan Lin
    UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Clin Immunol 126:13-30. 2008
  5. pmc Invariant NKT cells inhibit autoreactive B cells in a contact- and CD1d-dependent manner
    Jun Qi Yang
    Autoimmunity and Tolerance Laboratory, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 186:1512-20. 2011
  6. pmc CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice
    Jun Qi Yang
    Autoimmunity and Tolerance Laboratory, Department of Internal Medicine, University of Cincinnati, and Veterans Affairs Medical Center, Cincinnati, Ohio 45267, USA
    Eur J Immunol 34:1723-32. 2004
  7. pmc A role for sex chromosome complement in the female bias in autoimmune disease
    Deborah L Smith-Bouvier
    Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Exp Med 205:1099-108. 2008
  8. ncbi request reprint Repeated alpha-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice
    Jun Qi Yang
    Autoimmunity and Tolerance Laboratory, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 171:4439-46. 2003
  9. pmc Cutting edge: migration of langerhans dendritic cells is impaired in autoimmune dermatitis
    Anna U Eriksson
    Department of Medicine, Laboratory Medicine, Autoimmunity and Tolerance Laboratory, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 181:7468-72. 2008
  10. pmc Brief treatment with iNKT cell ligand α-galactosylceramide confers a long-term protection against lupus
    Jun Qi Yang
    Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, CA 90095, USA
    J Clin Immunol 32:106-13. 2012

Research Grants

  1. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2010
  2. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Singh; Fiscal Year: 2009
  3. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2010
  4. Pathogenesis of Lupus Dermatitis
    Ram Singh; Fiscal Year: 2009
  5. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Singh; Fiscal Year: 2009
  6. Academic Training in Rheumatology
    Ram Singh; Fiscal Year: 2007
  7. Kidney Damage in Murine Lupus
    Ram Singh; Fiscal Year: 2006
  8. Peptide Gene Vaccination in Lupus
    Ram Singh; Fiscal Year: 2004
  9. Kidney Damage in Murine Lupus
    Ram Singh; Fiscal Year: 2004
  10. Peptide Gene Vaccination in Lupus
    Ram Singh; Fiscal Year: 2002

Collaborators

Detail Information

Publications24

  1. ncbi request reprint IL-4 and many roads to lupuslike autoimmunity
    Ram Raj Singh
    Clin Immunol 108:73-9. 2003
    ....
  2. pmc Homeostatic regulation of marginal zone B cells by invariant natural killer T cells
    Xiangshu Wen
    Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e26536. 2011
    ..Differential regulation of follicular B cells versus potentially autoreactive MZBs by iNKT cells has important implications for autoimmune diseases as well as for conditions that require a rapid innate B cell response...
  3. pmc SLE: translating lessons from model systems to human disease
    Ram Raj Singh
    Autoimmunity and Tolerance Lab, Div of Rheumatology, Dept of Medicine, Geffen School of Medicine, University of California Los Angeles, Rm 32 59 Rehabilitation Center, 1000 Veteran Avenue, Los Angeles, CA 90095 1670, USA
    Trends Immunol 26:572-9. 2005
    ..Understanding the mechanisms of each pathogenetic step would provide a rational basis for the development of disease stage-specific diagnostic markers and treatments...
  4. pmc TNFalpha blockade in human diseases: an overview of efficacy and safety
    Jan Lin
    UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Clin Immunol 126:13-30. 2008
    ..It is hoped that these two review articles will stimulate a fresh assessment of the priorities for research and clinical innovation to improve and extend therapeutic use and safety of TNFalpha antagonism...
  5. pmc Invariant NKT cells inhibit autoreactive B cells in a contact- and CD1d-dependent manner
    Jun Qi Yang
    Autoimmunity and Tolerance Laboratory, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 186:1512-20. 2011
    ..Such ability of iNKTs to suppress autoantibody production, without causing global suppression of B cells, has important implications for the development of iNKT-based therapy for autoimmune diseases...
  6. pmc CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice
    Jun Qi Yang
    Autoimmunity and Tolerance Laboratory, Department of Internal Medicine, University of Cincinnati, and Veterans Affairs Medical Center, Cincinnati, Ohio 45267, USA
    Eur J Immunol 34:1723-32. 2004
    ....
  7. pmc A role for sex chromosome complement in the female bias in autoimmune disease
    Deborah L Smith-Bouvier
    Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Exp Med 205:1099-108. 2008
    ..This is the first evidence that the XX sex chromosome complement, as compared with XY, confers greater susceptibility to autoimmune disease...
  8. ncbi request reprint Repeated alpha-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice
    Jun Qi Yang
    Autoimmunity and Tolerance Laboratory, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 171:4439-46. 2003
    ..Our results indicate that NKT cell deficiency can be corrected by repeated alpha-GalCer treatment and that NKT cells may play a protective role in inflammatory dermatitis of lupus-prone mice...
  9. pmc Cutting edge: migration of langerhans dendritic cells is impaired in autoimmune dermatitis
    Anna U Eriksson
    Department of Medicine, Laboratory Medicine, Autoimmunity and Tolerance Laboratory, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 181:7468-72. 2008
    ..The reduced, rather than increased, migration of LC from skin to skin-draining lymph nodes represents a novel functional abnormality of LC in autoimmune dermatitis...
  10. pmc Brief treatment with iNKT cell ligand α-galactosylceramide confers a long-term protection against lupus
    Jun Qi Yang
    Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, CA 90095, USA
    J Clin Immunol 32:106-13. 2012
    ..Identifying glycolipid regimens that can modulate iNKT responsiveness will have important implications for developing iNKT-based therapies for autoimmune diseases...
  11. pmc A female preponderance for chemically induced lupus in SJL/J mice
    Deborah L Smith
    Department of Neurology, University of California Los Angeles, 635 Charles E Young Drive South, Room 475D, Los Angeles, CA 90095, USA
    Clin Immunol 122:101-7. 2007
    ..This is the first evidence that a female sex bias exists in a chemically induced lupus model...
  12. ncbi request reprint Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis
    Jun Qi Yang
    Department of Internal Medicine, Autoimmunity and Tolerance Laboratory, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 171:2142-53. 2003
    ..These findings suggest that CD1d may play an immunoregulatory role in the development of lupus in the pristane-induced model...
  13. pmc Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage
    Vijay Saxena
    Autoimmunity and Tolerance Laboratory, Department of Medicine, University of California, Los Angeles 90095, USA
    J Immunol 180:1903-12. 2008
    ..Enhanced TGF-beta in target organs, in turn, can lead to dysregulated tissue repair, progressive fibrogenesis, and eventual end-organ damage...
  14. pmc Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu
    Anagha A Divekar
    Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 186:924-30. 2011
    ..Furthermore, simultaneous appearance of Dicer insufficiency and miR-155 overexpression in diseased mice suggests a Dicer-independent alternative mechanism of miRNA regulation under inflammatory conditions...
  15. ncbi request reprint Prevention and control of reciprocal T-B cell diversification: implications for lupus-like autoimmunity
    Ram Raj Singh
    Department of Internal Medicine, Autoimmunity and Tolerance Laboratory, University of Cincinnati College of Medicine, Medical Science Building, Room 7464, 231 Albert Sabin Way, Cincinnati, OH 45267 0563, USA
    Mol Immunol 40:1137-45. 2004
    ..Understanding the mechanisms of autoimmune diversification in lupus mice and of its down-regulation in normal animals may pave the way for developing novel treatments for autoantibody-mediated diseases such as lupus...
  16. pmc Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and protein kinase C signaling
    Jennifer A Fulcher
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Biol Chem 284:26860-70. 2009
    ....
  17. pmc TNFalpha blockade in human diseases: mechanisms and future directions
    Maida Wong
    UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Clin Immunol 126:121-36. 2008
    ..It is hoped that the overview will address the needs of clinicians to decide on optimal use, spur clinical innovation, and incite translational researchers to set priorities for in vivo human investigations...
  18. pmc Treatment with imatinib results in reduced IL-4-producing T cells, but increased CD4(+) T cells in the broncho-alveolar lavage of patients with systemic sclerosis
    Anagha A Divekar
    Division of Rheumatology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA 90095, USA
    Clin Immunol 141:293-303. 2011
    ..Thus, imatinib might confer its therapeutic effect in fibrosis via re-directing T cell responses from type 2 to other, non-type 2 cytokine producing CD4(+) T cells...
  19. pmc Differences between CD8+ T cells in lupus-prone (NZB x NZW) F1 mice and healthy (BALB/c x NZW) F1 mice may influence autoimmunity in the lupus model
    George A Karpouzas
    Rheumatology, Harbor UCLA Medical Center, Torrance, USA
    Eur J Immunol 34:2489-99. 2004
    ..Understanding these defects might identify targets for therapy in systemic lupus erythematosus...
  20. pmc Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model
    Jun Qi Yang
    University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Arthritis Rheum 56:1219-33. 2007
    ..The purpose of this study was to examine the role of these cells in the development of autoimmune disease in genetically lupus-prone (NZBxNZW)F1 (BWF1) mice...
  21. pmc An ACE inhibitor reduces Th2 cytokines and TGF-beta1 and TGF-beta2 isoforms in murine lupus nephritis
    Deijanira Alves De Albuquerque
    Department of Internal Medicine, University of Cincinnati College of Medicine, Veterans Administration Medical Center and Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45267 0563, USA
    Kidney Int 65:846-59. 2004
    ..Here, we examine the effects of treatment with captopril on lupus nephritis and discuss the potential mechanism(s) by which this agent exerts its renoprotective effects...
  22. pmc Vaccination with minigenes encoding V(H)-derived major histocompatibility complex class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus
    Guo Chang Fan
    Autoimmunity and Tolerance Laboratory, Division of Immunology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0563, USA
    J Exp Med 196:731-41. 2002
    ..Vaccine-mediated induction of anti-V(H) cytotoxic T lymphocytes that ablate autoreactive B cells represents a novel approach to treat autoantibody-mediated diseases...
  23. ncbi request reprint Induction of autoantibody production is limited in nonautoimmune mice
    Ram Raj Singh
    Department of Internal Medicine, University of Cincinnati College of Medicine and Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Immunol 169:587-94. 2002
    ..The induction of such inhibitory T cells may play a role in protecting nonautoimmune mice from developing chronic autoimmunity...

Research Grants20

  1. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2010
    ..The results of the proposed study will not only aid our understanding of lupus, but will also potentially lead to identification of newer targets of treatment. ..
  2. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Singh; Fiscal Year: 2009
    ..The results of the proposed study will not only aid our understanding of lupus, but will also potentially lead to identification of newer targets of treatment. ..
  3. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2010
    ..The results of the proposed study will not only aid our understanding of lupus, but will also potentially lead to identification of newer targets of treatment. ..
  4. Pathogenesis of Lupus Dermatitis
    Ram Singh; Fiscal Year: 2009
    ..In particular, the application will focus on patho-physiological roles of skin dendritic cells, which will have important implications for vaccination and other inflammatory diseases that involve skin. ..
  5. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Singh; Fiscal Year: 2009
    ..The results of the proposed study will not only aid our understanding of lupus, but will also potentially lead to identification of newer targets of treatment. ..
  6. Academic Training in Rheumatology
    Ram Singh; Fiscal Year: 2007
    ..The application also seeks two-year training support for non-clinical postdoctoral trainees who desire to train in Rheumatology to develop an academic research career in the subspecialty. ..
  7. Kidney Damage in Murine Lupus
    Ram Singh; Fiscal Year: 2006
    ..abstract_text> ..
  8. Peptide Gene Vaccination in Lupus
    Ram Singh; Fiscal Year: 2004
    ..The studies will also elucidate the role of self-reactive CD8+ T cells in SLE. ..
  9. Kidney Damage in Murine Lupus
    Ram Singh; Fiscal Year: 2004
    ..abstract_text> ..
  10. Peptide Gene Vaccination in Lupus
    Ram Singh; Fiscal Year: 2002
    ..The studies will also elucidate the role of self-reactive CD8+ T cells in SLE. ..
  11. Peptide Gene Vaccination in Lupus
    Ram Singh; Fiscal Year: 2003
    ..The studies will also elucidate the role of self-reactive CD8+ T cells in SLE. ..
  12. Kidney Damage in Murine Lupus
    Ram Singh; Fiscal Year: 2003
    ..abstract_text> ..
  13. Peptide Gene Vaccination in Lupus
    Ram Singh; Fiscal Year: 2004
    ..The studies will also elucidate the role of self-reactive CD8+ T cells in SLE. ..
  14. Kidney Damage in Murine Lupus
    Ram Singh; Fiscal Year: 2005
    ..abstract_text> ..
  15. Peptide Gene Vaccination in Lupus
    Ram Singh; Fiscal Year: 2005
    ..The studies will also elucidate the role of self-reactive CD8+ T cells in SLE. ..
  16. Augementing Peptide-specific Tolerance in ImmuneNephrit*
    Ram Singh; Fiscal Year: 2004
    ..The methods developed for the induction of T cell tolerance may have implications for the vaccination and treatment of various immune-mediated disorders. ..
  17. Pathogenesis of Lupus Dermatitis
    Ram Raj Singh; Fiscal Year: 2010
    ..In particular, the application will focus on patho-physiological roles of skin dendritic cells, which will have important implications for vaccination and other inflammatory diseases that involve skin. ..
  18. Peptide Gene Vaccination in Lupus
    Ram Singh; Fiscal Year: 2001
    ..The studies will also elucidate the role of self-reactive CD8+ T cells in SLE. ..