Ram Raj Singh

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint IL-4 and many roads to lupuslike autoimmunity
    Ram Raj Singh
    Clin Immunol 108:73-9. 2003
  2. pmc SLE: translating lessons from model systems to human disease
    Ram Raj Singh
    Autoimmunity and Tolerance Lab, Div of Rheumatology, Dept of Medicine, Geffen School of Medicine, University of California Los Angeles, Rm 32 59 Rehabilitation Center, 1000 Veteran Avenue, Los Angeles, CA 90095 1670, USA
    Trends Immunol 26:572-9. 2005
  3. pmc Brief treatment with iNKT cell ligand α-galactosylceramide confers a long-term protection against lupus
    Jun Qi Yang
    Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, CA 90095, USA
    J Clin Immunol 32:106-13. 2012
  4. pmc A role for sex chromosome complement in the female bias in autoimmune disease
    Deborah L Smith-Bouvier
    Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Exp Med 205:1099-108. 2008
  5. pmc Invariant NKT cells inhibit autoreactive B cells in a contact- and CD1d-dependent manner
    Jun Qi Yang
    Autoimmunity and Tolerance Laboratory, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 186:1512-20. 2011
  6. pmc Treatment with imatinib results in reduced IL-4-producing T cells, but increased CD4(+) T cells in the broncho-alveolar lavage of patients with systemic sclerosis
    Anagha A Divekar
    Division of Rheumatology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA 90095, USA
    Clin Immunol 141:293-303. 2011
  7. pmc Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu
    Anagha A Divekar
    Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 186:924-30. 2011
  8. pmc Cutting edge: migration of langerhans dendritic cells is impaired in autoimmune dermatitis
    Anna U Eriksson
    Department of Medicine, Laboratory Medicine, Autoimmunity and Tolerance Laboratory, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 181:7468-72. 2008
  9. pmc A female preponderance for chemically induced lupus in SJL/J mice
    Deborah L Smith
    Department of Neurology, University of California Los Angeles, 635 Charles E Young Drive South, Room 475D, Los Angeles, CA 90095, USA
    Clin Immunol 122:101-7. 2007
  10. pmc Differences between CD8+ T cells in lupus-prone (NZB x NZW) F1 mice and healthy (BALB/c x NZW) F1 mice may influence autoimmunity in the lupus model
    George A Karpouzas
    Rheumatology, Harbor UCLA Medical Center, Torrance, USA
    Eur J Immunol 34:2489-99. 2004

Research Grants

  1. Academic Training in Rheumatology
    Ram Singh; Fiscal Year: 2007
  2. Pathogenesis of Lupus Dermatitis
    Ram Raj Singh; Fiscal Year: 2010
  3. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2010
  4. Kidney Damage in Murine Lupus
    Ram Singh; Fiscal Year: 2006
  5. Peptide Gene Vaccination in Lupus
    Ram Singh; Fiscal Year: 2005
  6. Augementing Peptide-specific Tolerance in ImmuneNephrit*
    Ram Singh; Fiscal Year: 2004
  7. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2010

Collaborators

  • Jennifer K King
  • Rhonda Voskuhl
  • Dinesh Khanna
  • Arthur P Arnold
  • Luc Van Kaer
  • A La Cava
  • Minoru Satoh
  • Hermine Brunner
  • B H Hahn
  • FRED DOUGLASS FINKELMAN
  • Jun Qi Yang
  • Anagha A Divekar
  • Vijay Saxena
  • Peter J Kim
  • Xiangshu Wen
  • Deborah L Smith-Bouvier
  • Anna U Eriksson
  • Min Zhou
  • Sienmi Du
  • Deborah L Smith
  • Xin Dong
  • Hongzhu Liu
  • Deijanira Alves De Albuquerque
  • George A Karpouzas
  • Seokmann Hong
  • Guo Chang Fan
  • Daniel E Furst
  • Rajeev Saggar
  • Shweta Dubey
  • Rajan Saggar
  • Fereidoun Abtin
  • Paul Maranian
  • Pallavi R Gangalum
  • Manda Sasidhar
  • Seema K Tiwari-Woodruff
  • Mohamad Azhar
  • Douglas W Lienesch
  • Thomas Doetschman
  • Ramireddy Bommireddy
  • Gbolahan Folayan
  • MyungShin Oh
  • Taehoon Chun
  • Gregory P Boivin
  • Chyung Ru Wang
  • Hai Bui
  • David E Adams
  • David P Witte
  • Fanny M Ebling
  • Westley H Reeves
  • Vincenzo Cerundolo
  • Jang June Park
  • Sebastian Joyce
  • Stephan D Gadola
  • Michael T Wilson
  • Srinivasa R Kakumanu
  • Aleksandar K Stanic
  • Avneesh K Singh
  • Akiei Mizutani

Detail Information

Publications18

  1. ncbi request reprint IL-4 and many roads to lupuslike autoimmunity
    Ram Raj Singh
    Clin Immunol 108:73-9. 2003
    ....
  2. pmc SLE: translating lessons from model systems to human disease
    Ram Raj Singh
    Autoimmunity and Tolerance Lab, Div of Rheumatology, Dept of Medicine, Geffen School of Medicine, University of California Los Angeles, Rm 32 59 Rehabilitation Center, 1000 Veteran Avenue, Los Angeles, CA 90095 1670, USA
    Trends Immunol 26:572-9. 2005
    ..Understanding the mechanisms of each pathogenetic step would provide a rational basis for the development of disease stage-specific diagnostic markers and treatments...
  3. pmc Brief treatment with iNKT cell ligand α-galactosylceramide confers a long-term protection against lupus
    Jun Qi Yang
    Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, CA 90095, USA
    J Clin Immunol 32:106-13. 2012
    ..Identifying glycolipid regimens that can modulate iNKT responsiveness will have important implications for developing iNKT-based therapies for autoimmune diseases...
  4. pmc A role for sex chromosome complement in the female bias in autoimmune disease
    Deborah L Smith-Bouvier
    Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Exp Med 205:1099-108. 2008
    ..This is the first evidence that the XX sex chromosome complement, as compared with XY, confers greater susceptibility to autoimmune disease...
  5. pmc Invariant NKT cells inhibit autoreactive B cells in a contact- and CD1d-dependent manner
    Jun Qi Yang
    Autoimmunity and Tolerance Laboratory, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 186:1512-20. 2011
    ..Such ability of iNKTs to suppress autoantibody production, without causing global suppression of B cells, has important implications for the development of iNKT-based therapy for autoimmune diseases...
  6. pmc Treatment with imatinib results in reduced IL-4-producing T cells, but increased CD4(+) T cells in the broncho-alveolar lavage of patients with systemic sclerosis
    Anagha A Divekar
    Division of Rheumatology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA 90095, USA
    Clin Immunol 141:293-303. 2011
    ..Thus, imatinib might confer its therapeutic effect in fibrosis via re-directing T cell responses from type 2 to other, non-type 2 cytokine producing CD4(+) T cells...
  7. pmc Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu
    Anagha A Divekar
    Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 186:924-30. 2011
    ..Furthermore, simultaneous appearance of Dicer insufficiency and miR-155 overexpression in diseased mice suggests a Dicer-independent alternative mechanism of miRNA regulation under inflammatory conditions...
  8. pmc Cutting edge: migration of langerhans dendritic cells is impaired in autoimmune dermatitis
    Anna U Eriksson
    Department of Medicine, Laboratory Medicine, Autoimmunity and Tolerance Laboratory, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 181:7468-72. 2008
    ..The reduced, rather than increased, migration of LC from skin to skin-draining lymph nodes represents a novel functional abnormality of LC in autoimmune dermatitis...
  9. pmc A female preponderance for chemically induced lupus in SJL/J mice
    Deborah L Smith
    Department of Neurology, University of California Los Angeles, 635 Charles E Young Drive South, Room 475D, Los Angeles, CA 90095, USA
    Clin Immunol 122:101-7. 2007
    ..This is the first evidence that a female sex bias exists in a chemically induced lupus model...
  10. pmc Differences between CD8+ T cells in lupus-prone (NZB x NZW) F1 mice and healthy (BALB/c x NZW) F1 mice may influence autoimmunity in the lupus model
    George A Karpouzas
    Rheumatology, Harbor UCLA Medical Center, Torrance, USA
    Eur J Immunol 34:2489-99. 2004
    ..Understanding these defects might identify targets for therapy in systemic lupus erythematosus...
  11. pmc Vaccination with minigenes encoding V(H)-derived major histocompatibility complex class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus
    Guo Chang Fan
    Autoimmunity and Tolerance Laboratory, Division of Immunology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0563, USA
    J Exp Med 196:731-41. 2002
    ..Vaccine-mediated induction of anti-V(H) cytotoxic T lymphocytes that ablate autoreactive B cells represents a novel approach to treat autoantibody-mediated diseases...
  12. ncbi request reprint Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis
    Jun Qi Yang
    Department of Internal Medicine, Autoimmunity and Tolerance Laboratory, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 171:2142-53. 2003
    ..These findings suggest that CD1d may play an immunoregulatory role in the development of lupus in the pristane-induced model...
  13. pmc An ACE inhibitor reduces Th2 cytokines and TGF-beta1 and TGF-beta2 isoforms in murine lupus nephritis
    Deijanira Alves De Albuquerque
    Department of Internal Medicine, University of Cincinnati College of Medicine, Veterans Administration Medical Center and Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45267 0563, USA
    Kidney Int 65:846-59. 2004
    ..Here, we examine the effects of treatment with captopril on lupus nephritis and discuss the potential mechanism(s) by which this agent exerts its renoprotective effects...
  14. ncbi request reprint Prevention and control of reciprocal T-B cell diversification: implications for lupus-like autoimmunity
    Ram Raj Singh
    Department of Internal Medicine, Autoimmunity and Tolerance Laboratory, University of Cincinnati College of Medicine, Medical Science Building, Room 7464, 231 Albert Sabin Way, Cincinnati, OH 45267 0563, USA
    Mol Immunol 40:1137-45. 2004
    ..Understanding the mechanisms of autoimmune diversification in lupus mice and of its down-regulation in normal animals may pave the way for developing novel treatments for autoantibody-mediated diseases such as lupus...
  15. pmc Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage
    Vijay Saxena
    Autoimmunity and Tolerance Laboratory, Department of Medicine, University of California, Los Angeles 90095, USA
    J Immunol 180:1903-12. 2008
    ..Enhanced TGF-beta in target organs, in turn, can lead to dysregulated tissue repair, progressive fibrogenesis, and eventual end-organ damage...
  16. pmc Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model
    Jun Qi Yang
    University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Arthritis Rheum 56:1219-33. 2007
    ..The purpose of this study was to examine the role of these cells in the development of autoimmune disease in genetically lupus-prone (NZBxNZW)F1 (BWF1) mice...
  17. pmc CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice
    Jun Qi Yang
    Autoimmunity and Tolerance Laboratory, Department of Internal Medicine, University of Cincinnati, and Veterans Affairs Medical Center, Cincinnati, Ohio 45267, USA
    Eur J Immunol 34:1723-32. 2004
    ....
  18. ncbi request reprint Induction of autoantibody production is limited in nonautoimmune mice
    Ram Raj Singh
    Department of Internal Medicine, University of Cincinnati College of Medicine and Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Immunol 169:587-94. 2002
    ..The induction of such inhibitory T cells may play a role in protecting nonautoimmune mice from developing chronic autoimmunity...

Research Grants20

  1. Academic Training in Rheumatology
    Ram Singh; Fiscal Year: 2007
    ..The application also seeks two-year training support for non-clinical postdoctoral trainees who desire to train in Rheumatology to develop an academic research career in the subspecialty. ..
  2. Pathogenesis of Lupus Dermatitis
    Ram Raj Singh; Fiscal Year: 2010
    ..In particular, the application will focus on patho-physiological roles of skin dendritic cells, which will have important implications for vaccination and other inflammatory diseases that involve skin. ..
  3. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2010
    ..The results of the proposed study will not only aid our understanding of lupus, but will also potentially lead to identification of newer targets of treatment. ..
  4. Kidney Damage in Murine Lupus
    Ram Singh; Fiscal Year: 2006
    ..abstract_text> ..
  5. Peptide Gene Vaccination in Lupus
    Ram Singh; Fiscal Year: 2005
    ..The studies will also elucidate the role of self-reactive CD8+ T cells in SLE. ..
  6. Augementing Peptide-specific Tolerance in ImmuneNephrit*
    Ram Singh; Fiscal Year: 2004
    ..The methods developed for the induction of T cell tolerance may have implications for the vaccination and treatment of various immune-mediated disorders. ..
  7. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2010
    ..The results of the proposed study will not only aid our understanding of lupus, but will also potentially lead to identification of newer targets of treatment. ..