Rajan Singh

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi Follistatin promotes adipocyte differentiation, browning, and energy metabolism
    Melissa Braga
    Division of Endocrinology and Charles R Drew University of Medicine and Science, Los Angeles, CA 90059 and
    J Lipid Res 55:375-84. 2014
  2. pmc Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways
    Rajan Singh
    Division of Endocrinology and Research Centers in Minority Institutions Core Laboratory, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 150:1259-68. 2009
  3. ncbi Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew School of Medicine, Los Angeles, California 90059, USA
    Endocrinology 147:141-54. 2006
  4. doi Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis
    Shehla Pervin
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California, Los Angeles, USA
    Cancer Res 68:4862-74. 2008
  5. ncbi Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 144:5081-8. 2003
  6. ncbi The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Gerontol A Biol Sci Med Sci 58:M1103-10. 2003
  7. ncbi Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men
    Ravi Jasuja
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    J Clin Endocrinol Metab 90:855-63. 2005
  8. pmc Inhibition of in vitro and in vivo brown fat differentiation program by myostatin
    Melissa Braga
    Division of Endocrinology and Metabolism, Charles R Drew University of Medicine and Science, Los Angeles, USA
    Obesity (Silver Spring) 21:1180-8. 2013
  9. ncbi MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer
    Shehla Pervin
    Department of Obstetrics and Gynecology and Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1740, USA
    Cancer Res 63:8853-60. 2003
  10. pmc Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy
    Shehla Pervin
    Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA, USA
    PLoS ONE 8:e53287. 2013

Detail Information

Publications17

  1. doi Follistatin promotes adipocyte differentiation, browning, and energy metabolism
    Melissa Braga
    Division of Endocrinology and Charles R Drew University of Medicine and Science, Los Angeles, CA 90059 and
    J Lipid Res 55:375-84. 2014
    ..Furthermore, Fst treatment significantly increases cellular respiration in Fst-deficient cells. Our results implicate a novel role of Fst in the induction of brown adipocyte character and regulation of energy metabolism. ..
  2. pmc Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways
    Rajan Singh
    Division of Endocrinology and Research Centers in Minority Institutions Core Laboratory, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 150:1259-68. 2009
    ..In conclusion, our data suggest the involvement of AR, beta-catenin, and TCF-4 pathway during androgen action to activate a number of Wnt target genes, including Fst, and cross communication with the Smad signaling pathway...
  3. ncbi Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew School of Medicine, Los Angeles, California 90059, USA
    Endocrinology 147:141-54. 2006
    ..These data provide evidence for a regulatory role for androgens in inhibiting adipogenic differentiation and a mechanistic explanation consistent with the observed reduction in fat mass in men treated with androgens...
  4. doi Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis
    Shehla Pervin
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California, Los Angeles, USA
    Cancer Res 68:4862-74. 2008
    ....
  5. ncbi Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 144:5081-8. 2003
    ..The observation that differentiation of pluripotent cells is androgen dependent provides a unifying explanation for the reciprocal effects of androgens on muscle and fat mass in men...
  6. ncbi The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Gerontol A Biol Sci Med Sci 58:M1103-10. 2003
    ..The hypothesis that the primary site of androgen action is the pluripotent stem cell provides a unifying explanation for the observed reciprocal effects of testosterone on muscle and fat mass...
  7. ncbi Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men
    Ravi Jasuja
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    J Clin Endocrinol Metab 90:855-63. 2005
    ....
  8. pmc Inhibition of in vitro and in vivo brown fat differentiation program by myostatin
    Melissa Braga
    Division of Endocrinology and Metabolism, Charles R Drew University of Medicine and Science, Los Angeles, USA
    Obesity (Silver Spring) 21:1180-8. 2013
    ..Although the beneficial effects of Mst inhibition on muscle mass are well known, its role in the regulation of lipid metabolism, and energy expenditure is not very clear...
  9. ncbi MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer
    Shehla Pervin
    Department of Obstetrics and Gynecology and Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1740, USA
    Cancer Res 63:8853-60. 2003
    ..Our results indicate that expression of MKP-1 by NO leading to dephosphorylation of ERK1/2 is the initial essential event that commits the cells to the apoptotic pathway in breast cancer cells...
  10. pmc Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy
    Shehla Pervin
    Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA, USA
    PLoS ONE 8:e53287. 2013
    ..Our findings therefore, suggest that combination therapy using 1,25D with drugs specifically targeting key survival pathways in MCSCs warrant testing in prospective clinical trial for treatment of aggressive breast cancer...
  11. ncbi Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin/eIF4E pathway
    Shehla Pervin
    Departments of Obstetrics and Gynecology and Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA, USA
    Cancer Res 67:289-99. 2007
    ....
  12. doi Nitric oxide, N omega-hydroxy-L-arginine and breast cancer
    Shehla Pervin
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1740, USA
    Nitric Oxide 19:103-6. 2008
    ....
  13. ncbi NO to breast: when, why and why not?
    Shehla Pervin
    Division of Endocrinology and Metabolism at Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Curr Pharm Des 16:451-62. 2010
    ..In this review we re-examine the mechanisms by which nitric oxide promotes initiation and progression of breast cancer and address some of the controversies in the field...
  14. pmc Proteomic identification of mitochondrial targets of arginase in human breast cancer
    Rajan Singh
    Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, California, United States of America Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS ONE 8:e79242. 2013
    ..As mSHMT is a key player in folate metabolism, our data provides a novel link between arginine and folate metabolism in human breast cancer, both of which are critical for tumor cell proliferation. ..
  15. ncbi Nitric-oxide-induced Bax integration into the mitochondrial membrane commits MDA-MB-468 cells to apoptosis: essential role of Akt
    Shehla Pervin
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095 1740, USA
    Cancer Res 63:5470-9. 2003
    ..We also observed a decline in the levels of cytosolic phospho-Akt at 16-24 h of DETA-NONOate treatment. We also conclude that decrease in phospho-Akt is an essential event upstream from Bax integration in MDA-MB-468 cells...
  16. ncbi Caspase-8-mediated BID cleavage and release of mitochondrial cytochrome c during Nomega-hydroxy-L-arginine-induced apoptosis in MDA-MB-468 cells. Antagonistic effects of L-ornithine
    Rajan Singh
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1740, USA
    J Biol Chem 277:37630-6. 2002
    ..Exogenous l-ornithine did not inhibit NOHA-induced caspase-8 activation and cleavage of BH(3) interacting domain but acted at the mitochondrial level and inhibited the NOHA-induced cytochrome c release and apoptosis...
  17. doi Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts
    Jorge N Artaza
    Division of Endocrinology Metabolism and Molecular Medicine and RCMI Molecular Core, The Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California, 90059 USA
    J Endocrinol 196:235-49. 2008
    ....