Nina Singh

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Risk factors and outcomes in lung transplant recipients with nodular invasive pulmonary aspergillosis
    Nina Singh
    University of Pittsburgh, Pittsburgh, PA 15240, USA
    J Infect 67:72-8. 2013
  2. doi request reprint Donor-derived fungal infections in organ transplant recipients: guidelines of the American Society of Transplantation, infectious diseases community of practice
    N Singh
    University of Pittsburgh, PA, USA
    Am J Transplant 12:2414-28. 2012
  3. pmc Cytomegalovirus infection in critically ill patients: a systematic review
    Ryosuke Osawa
    Infectious Diseases Section, VA Medical Center, University Drive C, Pittsburgh, PA 15420 USA
    Crit Care 13:R68. 2009
  4. doi request reprint Evidence-based approach to challenging issues in the management of invasive aspergillosis
    N Singh
    University of Pittsburgh, Pittsburgh, PA, USA
    Med Mycol 47:S338-42. 2009
  5. doi request reprint Combination therapeutic approaches for the management of invasive aspergillosis in organ transplant recipients
    Nina Singh
    Infectious Diseases Section, Veterans Affairs Medical Center, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Mycoses 51:99-108. 2008
  6. ncbi request reprint Optimization of outcomes related to cytomegalovirus in organ transplant recipients
    Nina Singh
    Infectious Disease Section, VA Medical Center, Pittsburgh, PA 15420, USA
    Transplantation 82:15-6. 2006
  7. pmc Novel immune regulatory pathways and their role in immune reconstitution syndrome in organ transplant recipients with invasive mycoses
    N Singh
    Infectious Diseases Section, VA Medical Center, University Drive C, Pittsburgh, PA 15240, USA
    Eur J Clin Microbiol Infect Dis 27:403-8. 2008
  8. doi request reprint Antifungal management practices in liver transplant recipients
    N Singh
    VA Medical Center and University of Pittsburgh, Pittsburgh, PA, USA
    Am J Transplant 8:426-31. 2008
  9. pmc Pulmonary cryptococcosis in solid organ transplant recipients: clinical relevance of serum cryptococcal antigen
    Nina Singh
    University of Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 46:e12-8. 2008
  10. ncbi request reprint Systemic and cerebrospinal fluid T-helper cytokine responses in organ transplant recipients with Cryptococcus neoformans infection
    Nina Singh
    University of Pittsburgh, Pittsburgh, PA, USA
    Transpl Immunol 16:69-72. 2006

Research Grants

Detail Information

Publications113 found, 100 shown here

  1. doi request reprint Risk factors and outcomes in lung transplant recipients with nodular invasive pulmonary aspergillosis
    Nina Singh
    University of Pittsburgh, Pittsburgh, PA 15240, USA
    J Infect 67:72-8. 2013
    ..Whether nodular lesions have specific risk-factors or influence outcomes in lung transplant recipients with invasive aspergillosis, is not fully known...
  2. doi request reprint Donor-derived fungal infections in organ transplant recipients: guidelines of the American Society of Transplantation, infectious diseases community of practice
    N Singh
    University of Pittsburgh, PA, USA
    Am J Transplant 12:2414-28. 2012
    ..This document discusses the characteristics, evaluation and approach to the management of donor-derived fungal infections in organ transplant recipients...
  3. pmc Cytomegalovirus infection in critically ill patients: a systematic review
    Ryosuke Osawa
    Infectious Diseases Section, VA Medical Center, University Drive C, Pittsburgh, PA 15420 USA
    Crit Care 13:R68. 2009
    ..The precise role of cytomegalovirus (CMV) infection in contributing to outcomes in critically ill immunocompetent patients has not been fully defined...
  4. doi request reprint Evidence-based approach to challenging issues in the management of invasive aspergillosis
    N Singh
    University of Pittsburgh, Pittsburgh, PA, USA
    Med Mycol 47:S338-42. 2009
    ..Evidence-based studies are still needed to resolve critical issues pertaining to combination therapy...
  5. doi request reprint Combination therapeutic approaches for the management of invasive aspergillosis in organ transplant recipients
    Nina Singh
    Infectious Diseases Section, Veterans Affairs Medical Center, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Mycoses 51:99-108. 2008
    ..Finally, manipulating known predisposing immunological defects with immunotherapeutic agents is a potentially promising approach for the management of these challenging opportunistic mycoses...
  6. ncbi request reprint Optimization of outcomes related to cytomegalovirus in organ transplant recipients
    Nina Singh
    Infectious Disease Section, VA Medical Center, Pittsburgh, PA 15420, USA
    Transplantation 82:15-6. 2006
  7. pmc Novel immune regulatory pathways and their role in immune reconstitution syndrome in organ transplant recipients with invasive mycoses
    N Singh
    Infectious Diseases Section, VA Medical Center, University Drive C, Pittsburgh, PA 15240, USA
    Eur J Clin Microbiol Infect Dis 27:403-8. 2008
    ....
  8. doi request reprint Antifungal management practices in liver transplant recipients
    N Singh
    VA Medical Center and University of Pittsburgh, Pittsburgh, PA, USA
    Am J Transplant 8:426-31. 2008
    ..Our findings also merit investigations to better define the role of diagnostic assays and combination therapeutic strategies for invasive aspergillosis in liver transplant recipients...
  9. pmc Pulmonary cryptococcosis in solid organ transplant recipients: clinical relevance of serum cryptococcal antigen
    Nina Singh
    University of Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 46:e12-8. 2008
    ..The role of serum cryptococcal antigen in the diagnosis and determinants of antigen positivity in solid organ transplant (SOT) recipients with pulmonary cryptococcosis has not been fully defined...
  10. ncbi request reprint Systemic and cerebrospinal fluid T-helper cytokine responses in organ transplant recipients with Cryptococcus neoformans infection
    Nina Singh
    University of Pittsburgh, Pittsburgh, PA, USA
    Transpl Immunol 16:69-72. 2006
    ..The role of Th1 and Th2 mediated cytokine responses in the pathogenesis of Cryptococcus neoformans infection in organ transplant recipients has not been defined...
  11. ncbi request reprint Inching closer towards optimization of treatment for latent tuberculosis in liver transplant recipients
    Nina Singh
    Infectious Disease Section, VA Medical Center, University of Pittsburgh Medical Center, Pittsburgh, PA 15237, USA
    Transplantation 83:1536-7. 2007
  12. ncbi request reprint Immune reconstitution syndrome associated with opportunistic mycoses
    Nina Singh
    Infectious Disease Section, VA Medical Center, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Lancet Infect Dis 7:395-401. 2007
    ....
  13. pmc Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality
    Nina Singh
    University of Pittsburgh Medical Center, Pittsburgh, PA 15240, USA
    J Infect Dis 195:756-64. 2007
    ..Additionally, discerning the basis for transplant type-specific differences in disease severity has implications relevant for yielding further insights into the pathogenesis of C. neoformans infection in transplant recipients...
  14. doi request reprint Valganciclovir as preemptive therapy for cytomegalovirus in cytomegalovirus-seronegative liver transplant recipients of cytomegalovirus-seropositive donor allografts
    Nina Singh
    Division of Infectious Diseases, Department of Medicine, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Liver Transpl 14:240-4. 2008
    ..The indirect outcomes with the use of valganciclovir in R-/D+ patients were comparable to the outcomes of other subgroups of liver transplant recipients receiving preemptive therapy...
  15. doi request reprint Iron overload and unique susceptibility of liver transplant recipients to disseminated disease due to opportunistic pathogens
    Nina Singh
    School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Liver Transpl 14:1249-55. 2008
    ..Studies to assess iron homeostasis and the mechanisms by which iron overload contributes to the pathogenesis of opportunistic infections in liver transplant recipients are warranted...
  16. ncbi request reprint Antifungal management practices and evolution of infection in organ transplant recipients with cryptococcus neoformans infection
    Nina Singh
    University of Pittsburgh Medical Center, Pittsburgh, PA 15240, USA
    Transplantation 80:1033-9. 2005
    ..The risk of relapse and time to recurrence is not known. We assessed antifungal treatment practices for cryptococcosis in a cohort of prospectively followed organ transplant recipients...
  17. ncbi request reprint Late-onset invasive aspergillosis in organ transplant recipients in the current era
    Nina Singh
    University of Pittsburgh, Pittsburgh, PA, USA
    Med Mycol 44:445-9. 2006
    ..These data have implications relevant for prophylactic strategies and guiding clinical management of transplant recipients presenting with pulmonary infiltrates...
  18. doi request reprint Should intravesical Bacillus Calmette-Guérin be employed in transplant recipients with bladder carcinoma?
    H Y Sun
    VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
    Transpl Infect Dis 12:358-62. 2010
    ..We discuss the potential immunologic interactions between BCG and immunosuppression, and review relevant outcomes in renal transplant recipients with bladder cancer receiving intravesical BCG...
  19. ncbi request reprint Immune reconstitution syndrome and exacerbation of infections after pregnancy
    Nina Singh
    Veterans Affairs Medical Center, Infectious Diseases Section, Pittsburgh, PA 15240, USA
    Clin Infect Dis 45:1192-9. 2007
    ....
  20. ncbi request reprint Allograft loss in renal transplant recipients with cryptococcus neoformans associated immune reconstitution syndrome
    Nina Singh
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 80:1131-3. 2005
    ..0004). Temporal association of graft loss with IRS suggests a common pathophysiologic basis for these entities with implications relevant for the optimal management of renal transplant recipients with cryptococcosis...
  21. ncbi request reprint Combination of voriconazole and caspofungin as primary therapy for invasive aspergillosis in solid organ transplant recipients: a prospective, multicenter, observational study
    Nina Singh
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Transplantation 81:320-6. 2006
    ..The efficacy of the combination of voriconazole and caspofungin when used as primary therapy for invasive aspergillosis in organ transplant recipients has not been defined...
  22. doi request reprint Zygomycosis in solid organ transplant recipients: a prospective, matched case-control study to assess risks for disease and outcome
    Nina Singh
    Infectious Diseases Section, VA Medical Center, University Drive, Pittsburgh, PA 15240, USA
    J Infect Dis 200:1002-11. 2009
    ..Clinical characteristics, risks, and outcomes in solid organ transplant (SOT) recipients with zygomycosis in the era of modern immunosuppressive and newer antifungal agent use have not been defined...
  23. ncbi request reprint Invasive aspergillosis in the recipients of liver retransplantation
    Nina Singh
    Veterans Administration Medical Center, Pittsburgh, PA, USA
    Liver Transpl 12:1205-9. 2006
    ..Given a greater risk for disseminated infection and poor outcome in late retransplant recipients with aspergillosis, potent and aggressive antifungal therapy should be considered upfront in these patients...
  24. pmc Cryptococcosis in solid organ transplant recipients: current state of the science
    Nina Singh
    University of Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 47:1321-7. 2008
    ..This review summarizes the current state of knowledge regarding cryptococcosis in transplant recipients and highlights areas where future investigations are needed to further optimize outcomes for these patients...
  25. pmc Central nervous system cryptococcosis in solid organ transplant recipients: clinical relevance of abnormal neuroimaging findings
    Nina Singh
    University of Pittsburgh, Pittsburgh, PA, USA
    Transplantation 86:647-51. 2008
    ..Prognostic implications of cryptococcal antigen and outcomes associated with central nervous system (CNS) cryptococcal lesions in solid organ transplant recipients have not been fully defined...
  26. ncbi request reprint Antiviral drugs for cytomegalovirus in transplant recipients: advantages of preemptive therapy
    Nina Singh
    University of Pittsburgh, Pittsburgh, PA, USA
    Rev Med Virol 16:281-7. 2006
    ..Preemptive therapy is a more logical and theoretically more appealing approach for the prevention of CMV disease in transplant recipients...
  27. doi request reprint Cutaneous cryptococcosis in solid organ transplant recipients
    Hsin Yun Sun
    VA Pittsburgh Healthcare System, University Drive C, Pittsburgh, PA 15240, USA
    Med Mycol 48:785-91. 2010
    ..Outcomes with appropriate management were comparable between SOT recipients with localized and disseminated cryptococcosis...
  28. pmc Identifying predictors of central nervous system disease in solid organ transplant recipients with cryptococcosis
    Ryosuke Osawa
    VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Transplantation 89:69-74. 2010
    ..We sought to determine whether a subset of solid organ transplant (SOT) recipients with high likelihood of central nervous system (CNS) disease could be identified in whom CSF analysis must be performed...
  29. ncbi request reprint Rhino-orbital-cerebral zygomycosis in solid organ transplant recipients
    Hsin Yun Sun
    Division of Infectious Diseases, Department of Medicine, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Transplantation 90:85-92. 2010
    ..Rhino-orbital-cerebral disease is a significant manifestation of zygomycosis in solid organ transplant (SOT) recipients. However, its characteristics and outcome are not well addressed...
  30. ncbi request reprint Opportunistic mycelial fungal infections in organ transplant recipients: emerging importance of non-Aspergillus mycelial fungi
    Shahid Husain
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Clin Infect Dis 37:221-9. 2003
    ..Thus, non-Aspergillus molds have emerged as significant pathogens in organ transplant recipients. These molds are more likely to be associated with disseminated infections and to be associated with poorer outcomes than is aspergillosis...
  31. ncbi request reprint An immune reconstitution syndrome-like illness associated with Cryptococcus neoformans infection in organ transplant recipients
    Nina Singh
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 40:1756-61. 2005
    ..We describe an immune reconstitution syndrome (IRS)-like entity in the course of evolution of Cryptococcus neoformans infection in organ transplant recipients...
  32. doi request reprint Unrecognized pretransplant and donor‐derived cryptococcal disease in organ transplant recipients
    Hsin Yun Sun
    VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240, USA
    Clin Infect Dis 51:1062-9. 2010
    ..Cryptococcosis occurring ≤30 days after transplantation is an unusual event, and its characteristics are not known...
  33. ncbi request reprint Indirect outcomes associated with cytomegalovirus (opportunistic infections, hepatitis C virus sequelae, and mortality) in liver-transplant recipients with the use of preemptive therapy for 13 years
    Nina Singh
    Veterans Affairs Medical Center, Infectious Disease Section, Pittsburgh, PA 15240, USA
    Transplantation 79:1428-34. 2005
    ..The effect of preemptive therapy on indirect sequelae associated with cytomegalovirus (CMV) in liver-transplant recipients has not been clearly delineated...
  34. ncbi request reprint Who among cytomegalovirus-seropositive liver transplant recipients is at risk for cytomegalovirus infection?
    Nina Singh
    Infectious Disease Section, Veterans Affairs Medical Center, Pittsburgh, PA 15240, USA
    Liver Transpl 11:700-4. 2005
    ..00001). In conclusion, CMV-seropositive liver transplant recipients at risk for CMV infection can be identified based on readily assessable variables. Preventive strategies may be selectively targeted toward these patients...
  35. ncbi request reprint Changes in the spectrum and risk factors for invasive candidiasis in liver transplant recipients: prospective, multicenter, case-controlled study
    Shahid Husain
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Transplantation 75:2023-9. 2003
    ..This study determines whether the spectrum, risk factors, and outcome of invasive candidiasis in liver transplant recipients have changed...
  36. pmc Lipid formulations of amphotericin B significantly improve outcome in solid organ transplant recipients with central nervous system cryptococcosis
    Hsin Yun Sun
    VA Pittsburgh Healthcare System, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 49:1721-8. 2009
    ....
  37. ncbi request reprint Infections due to Scedosporium apiospermum and Scedosporium prolificans in transplant recipients: clinical characteristics and impact of antifungal agent therapy on outcome
    Shahid Husain
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Clin Infect Dis 40:89-99. 2005
    ..Unique characteristics, impact of therapy with antifungal agents, and outcome of infections with Scedosporium species were assessed in transplant recipients...
  38. ncbi request reprint Hepatic iron content and the risk of Staphylococcus aureus bacteremia in liver transplant recipients
    Nina Singh
    Veterans Affairs Healthcare System, Pittsburgh, PA, USA
    Prog Transplant 17:332-6. 2007
    ..A readily quantifiable assessment of hepatic iron at the time of transplantation can potentially identify patients without carriage who may be at risk for early S aureus bacteremia...
  39. ncbi request reprint Lack of efficacy of mupirocin in the prevention of infections with Staphylococcus aureus in liver transplant recipients and candidates
    David L Paterson
    Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 75:194-8. 2003
    ..However, the role of decolonization with mupirocin applied intranasally for the prevention of S. aureus infections in these patients has not been determined...
  40. ncbi request reprint Prospective assessment of Platelia Aspergillus galactomannan antigen for the diagnosis of invasive aspergillosis in lung transplant recipients
    Shahid Husain
    University of Pittsburgh Medical Center, Thomas E Starzl Transplantation Institute, Pittsburgh, PA, USA
    Am J Transplant 4:796-802. 2004
    ..Patients with cystic fibrosis or chronic obstructive pulmonary disease may transiently have a positive test in the early post-transplant period...
  41. ncbi request reprint Efficacy of valganciclovir administered as preemptive therapy for cytomegalovirus disease in liver transplant recipients: impact on viral load and late-onset cytomegalovirus disease
    Nina Singh
    Veterans Affairs Medical Center, Infectious Disease Section, Pittsburgh, PA 15240, USA
    Transplantation 79:85-90. 2005
    ..The efficacy of valganciclovir used as preemptive therapy for cytomegalovirus (CMV) disease in liver transplant recipients is not known...
  42. ncbi request reprint Bacteremias in liver transplant recipients: shift toward gram-negative bacteria as predominant pathogens
    Nina Singh
    Veterans Affairs Medical Center, Pittsburgh, PA 15240, USA
    Liver Transpl 10:844-9. 2004
    ..g., fungi, primarily Candida species, and CMV. Gram-negative bacteria have emerged as predominant pathogens in bacteremic liver transplant recipients...
  43. ncbi request reprint Impact of an aggressive infection control strategy on endemic Staphylococcus aureus infection in liver transplant recipients
    Nina Singh
    Division of Infectious Diseases, Department of Medicine, VA Medical Center, Pittsburgh, PA 15240, USA
    Infect Control Hosp Epidemiol 27:122-6. 2006
    ..The role of active surveillance programs based on the detection of colonization in the prevention of S. aureus infection in liver transplant recipients has not been defined...
  44. ncbi request reprint Impact of evolving trends in recipient and donor characteristics on cytomegalovirus infection in liver transplant recipients
    Nina Singh
    Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Transplantation 77:106-10. 2004
    ..This study determines whether the recipient and donor characteristics that influence the cytomegalovirus (CMV) infection rate after liver transplantation have changed...
  45. doi request reprint Impact of the duration of posttransplant renal replacement therapy on bacterial infections in liver transplant recipients
    Hsin Yun Sun
    Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Liver Transpl 17:1212-7. 2011
    ..654). In conclusion, although both short-term RRT and long-term RRT confer a higher risk of bacterial infections, only long-term RRT is a statistically significant predictor of these infections...
  46. ncbi request reprint Aspergillus galactomannan antigen in the bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in lung transplant recipients
    Shahid Husain
    Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Transplantation 83:1330-6. 2007
    ..The clinical utility of Platelia Aspergillus enzyme immunoassay (EIA) for galactomannan (GM) antigen detection in bronchoalveolar lavage (BAL) for the diagnosis of invasive aspergillosis (IA) in lung transplant recipients is not known...
  47. ncbi request reprint Trends in risk profiles for and mortality associated with invasive aspergillosis among liver transplant recipients
    Nina Singh
    Infectious Disease Section, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Clin Infect Dis 36:46-52. 2003
    ....
  48. pmc Reactivity of platelia Aspergillus galactomannan antigen with piperacillin-tazobactam: clinical implications based on achievable concentrations in serum
    Nina Singh
    Veterans Affairs Medical Center, Infectious Disease Section, University Dr C, Pittsburgh, PA 15240, USA
    Antimicrob Agents Chemother 48:1989-92. 2004
    ....
  49. pmc Voriconazole inhibition of the metabolism of tacrolimus in a liver transplant recipient and in human liver microsomes
    Raman Venkataramanan
    School of Pharmacy, University of Pittsburgh, and Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Antimicrob Agents Chemother 46:3091-3. 2002
    ..Close monitoring of the blood concentration and adjustment in the dose of tacrolimus are warranted in transplant recipients treated with voriconazole...
  50. doi request reprint Cryptococcosis in solid-organ, hematopoietic stem cell, and tissue transplant recipients: evidence-based evolving trends
    Hsin Yun Sun
    VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 48:1566-76. 2009
    ..Despite rare infectious complication, certain peculiar attributes of cryptococcal disease in hematopoietic stem cell recipients and tissue transplant recipients warrant recognition...
  51. ncbi request reprint Cryptococcus neoformans Infection in Patients With Cirrhosis, Including Liver Transplant Candidates
    Nina Singh
    Infectious Disease Section, Veterans Affairs Medical Center and University of Pittsburgh Medical Center, Thomas E Starzl Transplantation Institute, Pittsburgh, Pennsylvania 15240, USA
    Medicine (Baltimore) 83:188-92. 2004
    ..Evaluation of culture-negative neutrocytic ascites in febrile cirrhotic patients warrants consideration of cryptococcal peritonitis...
  52. doi request reprint Impact of rifaximin use for hepatic encephalopathy on the risk of early post-transplant infections in liver transplant recipients
    Hsin Yun Sun
    Veterans Affairs Pittsburgh Healthcare System, University Drive C, Pittsburgh, PA 15240, USA
    Clin Transplant 26:849-52. 2012
    ..Whether the use of rifaximin for hepatic encephalopathy during liver transplant candidacy has an impact on post-transplant infections is not known...
  53. doi request reprint Opportunistic infection-associated immune reconstitution syndrome in transplant recipients
    Hsin Yun Sun
    Infectious Diseases Section, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240, USA
    Clin Infect Dis 53:168-76. 2011
    ....
  54. ncbi request reprint Impact of human herpesvirus-6 on the frequency and severity of recurrent hepatitis C virus hepatitis in liver transplant recipients
    Nina Singh
    Veteran Affairs Medical Center, Pittsburgh, PA, USA
    Clin Transplant 16:92-6. 2002
    ..44 vs. 1.00, p = 0.12) in patients with recurrent HCV hepatitis. Thus, HHV-6 viremia in HCV-positive liver transplant recipients identified a subgroup of patients at increased risk for early fibrosis upon HCV recurrence...
  55. ncbi request reprint Alternative therapy use in liver transplant recipients
    Lisa Tickerhoof
    VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Prog Transplant 16:226-31. 2006
    ..The extent of use of alternative therapies and the psychosocial variables predictive of their use have not been well defined in liver transplant recipients...
  56. doi request reprint Identifying a targeted population at high risk for infections after liver transplantation in the MELD era
    Hsin Yun Sun
    Veteran s Affair Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Clin Transplant 25:420-5. 2011
    ..42, p < 0.05) remained associated with infections. The overall frequency of infections did not increase in the MELD era. Pre-defined risk factors accurately predicted the risk of infections in these patients...
  57. ncbi request reprint Trends in invasive fungal infections in liver transplant recipients: correlation with evolution in transplantation practices
    Nina Singh
    VA Medical Center, Infectious Disease Section, University Drive C, Pittsburgh, PA 15240, USA
    Transplantation 73:63-7. 2002
    ..We assessed the temporal trends in invasive fungal infections in the context of evolution in liver transplantation practices, technical developments, and other risk factors...
  58. ncbi request reprint Antifungal prophylaxis in solid-organ transplant recipients: considerations for clinical trial design
    Nina Singh
    Veterans Affairs Medical Center and University of Pittsburgh, Thomas E Starzl Transplantation Institute, Pittsburgh, PA 15240, USA
    Clin Infect Dis 39:S200-6. 2004
    ..There are several key issues regarding clinical trial design for antifungal prophylaxis in organ transplant recipients...
  59. ncbi request reprint The impact of novel immunosuppressive agents on infections in organ transplant recipients and the interactions of these agents with antimicrobials
    Shahid Husain
    Veterans Affairs Medical Center and University of Pittsburgh, Thomas E Starzl Transplantation Institute, Pittsburgh, PA, 15240, USA
    Clin Infect Dis 35:53-61. 2002
    ....
  60. ncbi request reprint Safety and efficacy of isoniazid chemoprophylaxis administered during liver transplant candidacy for the prevention of posttransplant tuberculosis
    Nina Singh
    Veterans Affairs Medical Center and University of Pittsburgh, Pittsburgh, PA 15240, USA
    Transplantation 74:892-5. 2002
    ..We sought to determine whether isoniazid prophylaxis administered during liver transplant candidacy was safe and effective for the prevention of posttransplantation tuberculosis...
  61. pmc Aspergillus infections in transplant recipients
    Nina Singh
    University of Pittsburgh Medical Center, VA Medical Center, Infectious Disease Section, University Dr C, Pittsburgh, PA 15240, USA
    Clin Microbiol Rev 18:44-69. 2005
    ....
  62. ncbi request reprint Infectious complications in organ transplant recipients with the use of calcineurin-inhibitor agent-based immunosuppressive regimens
    Nina Singh
    VA Medical Center, Infectious Disease Section, University Drive C, Pittsburgh, Pennsylvania, USA
    Curr Opin Infect Dis 18:342-5. 2005
    ....
  63. pmc Efficacy of galactomannan antigen in the Platelia Aspergillus enzyme immunoassay for diagnosis of invasive aspergillosis in liver transplant recipients
    Eun Jeong Kwak
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15240, USA
    J Clin Microbiol 42:435-8. 2004
    ..Galactomannan positivity correlated with mortality, even when controlled for the number of tests performed. Whether galactomannan positivity identifies a subgroup at risk for poor outcome warrants further evaluation...
  64. doi request reprint Immune reconstitution inflammatory syndrome in non-HIV immunocompromised patients
    Hsin Yun Sun
    VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240, USA
    Curr Opin Infect Dis 22:394-402. 2009
    ..The present review aims to propose the pathogenesis of immune reconstitution inflammatory syndrome, summarize its occurrence in immunocompromised patients without HIV infection, and suggest potential treatment options...
  65. ncbi request reprint Persistent lack of human herpesvirus-6 specific T-helper cell response in liver transplant recipients
    Nina Singh
    Infectious Disease Section, VA Medical Center, University Drive C, Pittsburgh, PA 15240, USA
    Transpl Infect Dis 4:59-63. 2002
    ..Specific immunologic defects predisposing to human herpesvirus-6 (HHV-6), e.g. the role of HHV-6 specific T-helper cell memory response in liver transplant recipients, have not been assessed...
  66. doi request reprint Characterisation of breakthrough invasive mycoses in echinocandin recipients: an evidence-based review
    Hsin Yun Sun
    VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
    Int J Antimicrob Agents 35:211-8. 2010
    ....
  67. doi request reprint Colitis as a manifestation of infliximab-associated disseminated cryptococcosis
    Ryosuke Osawa
    Infectious Diseases Section, VA Pittsburgh Healthcare System and University of Pittsburgh, PA 15240, USA
    Int J Infect Dis 14:e436-40. 2010
    ..In cases with opportunistic infections, discontinuation of TNF-alpha inhibitors is a common practice, however rapid rebound of inflammatory responses may incur the risk of immune reconstitution syndrome...
  68. ncbi request reprint Aspergillus infections after lung transplantation: clinical differences in type of transplant and implications for management
    Nina Singh
    Veterans Affairs Medical Center and University of Pittsburgh Medical Center, Thomas E Starzl Transplantation Institute, Pittsburgh, Pennsylvania 15240, USA
    J Heart Lung Transplant 22:258-66. 2003
    ..It has not been fully discerned whether there are differences in the characteristics, risk factors and outcome of Aspergillus infection in single as compared with bilateral lung transplant recipients...
  69. ncbi request reprint Antifungal attributes of immunosuppressive agents: new paradigms in management and elucidating the pathophysiologic basis of opportunistic mycoses in organ transplant recipients
    Nina Singh
    University of Pittsburgh Medical Center, Thomas E Starzl Transplantation Institute, Pittsburgh, PA, USA
    Transplantation 77:795-800. 2004
    ....
  70. ncbi request reprint Preemptive prophylaxis with a lipid preparation of amphotericin B for invasive fungal infections in liver transplant recipients requiring renal replacement therapy
    N Singh
    Veterans Affairs Medical Center and University of Pittsburgh, Thomas E. Starzl Transplantation Institute, PA 15240, USA
    Transplantation 71:910-3. 2001
    ..e., those requiring renal replacement therapy. However, no beneficial effect on survival could be documented...
  71. ncbi request reprint Late-onset cytomegalovirus disease as a significant complication in solid organ transplant recipients receiving antiviral prophylaxis: a call to heed the mounting evidence
    Nina Singh
    Veterans Affairs Medical Center and University of Pittsburgh, Pennsylvania 15240, USA
    Clin Infect Dis 40:704-8. 2005
  72. ncbi request reprint Cryptococcus neoformans infection
    David L Paterson
    VA Medical Center and the University of Pittsburgh, Thomas E Starzl Transplantation Institute, Pittsburgh, PA, USA
    Liver Transpl 8:846-7. 2002
  73. ncbi request reprint Imaging findings in invasive zygomycosis
    Nina Singh
    Infectious Disease Section, Veterans Affairs Medical Center and University of Pittsburgh, Thomas E Starzl Transplantation Institute, Pittsburgh, PA 15240, USA
    Liver Transpl 8:306-7. 2002
  74. ncbi request reprint Treatment of opportunistic mycoses: how long is long enough?
    Nina Singh
    University of Pittsburgh, Thomas E Starzl Transplantation Institution, Pittsburgh, PA, USA
    Lancet Infect Dis 3:703-8. 2003
    ....
  75. ncbi request reprint Severing the Gordian knot of prevention of cytomegalovirus in liver transplant recipients: the principle is the sword
    Nina Singh
    Veterans Affairs Medical Center Infectious Diseases Section, Pittsburgh, PA 15240, USA
    Liver Transpl 11:891-4. 2005
  76. ncbi request reprint Fungal infections in the recipients of solid organ transplantation
    Nina Singh
    Infectious Disease Section, Veterans Affairs Medical Center, University of Pittsburgh, Thomas E Starzl Transplantation Institute, Pittsburgh, PA, USA
    Infect Dis Clin North Am 17:113-34, viii. 2003
    ..This article reviews the epidemiology, clinical manifestations, pathogenetic basis, diagnosis, and management of invasive fungal infections after organ transplantation in context of emerging trends and new developments in these areas...
  77. ncbi request reprint Interactions between viruses in transplant recipients
    Nina Singh
    Veterans Affairs Medical Center and University of Pittsburgh, Pittsburgh, PA 15240, USA
    Clin Infect Dis 40:430-6. 2005
    ..The pathways and mediators that modulate biological activity represent potential targets for immunomodulatory interventions as adjunctive therapies for transplant recipients...
  78. ncbi request reprint Cytomegalovirus infection in solid organ transplant recipients: new challenges and their implications for preventive strategies
    Nina Singh
    VA Medical Center and University of Pittsburgh, Infectious Disease Section, University Drive C, Pittsburgh, PA 15240, USA
    J Clin Virol 35:474-7. 2006
    ..Late-onset CMV disease is being increasingly recognized as a significant post-transplantation complication...
  79. ncbi request reprint Impact of current transplantation practices on the changing epidemiology of infections in transplant recipients
    Nina Singh
    Veterans Affairs Medical Center and University of Pittsburgh, Thomas E Starzl Transplantation Institute, Pittsburgh 15240, USA
    Lancet Infect Dis 3:156-61. 2003
    ....
  80. ncbi request reprint Evolving trends in multiple-antibiotic-resistant bacteria in liver transplant recipients: a longitudinal study of antimicrobial susceptibility patterns
    N Singh
    Infectious Disease Section, Veterans Affairs Medical Center, Pittsburgh, PA 15240, USA
    Liver Transpl 7:22-6. 2001
    ..001). These longitudinal trends have implications not only for guiding therapeutic practices, but ultimately for devising strategies to curtail multiple-antibiotic resistance in liver transplant recipients...
  81. ncbi request reprint Changing epidemiology and predictors of mortality in patients with spontaneous bacterial peritonitis at a liver transplant unit
    N Singh
    Veterans Affairs Medical Center, Pittsburgh, PA 15240, USA
    Clin Microbiol Infect 9:531-7. 2003
    ..To determine whether antimicrobial resistance in pathogens and outcome in patients with spontaneous bacterial peritonitis (SBP) has evolved over time...
  82. ncbi request reprint Invasive aspergillosis in organ transplant recipients: new issues in epidemiologic characteristics, diagnosis, and management
    N Singh
    VA Medical Center, Infectious Disease Section, University Drive C, Pittsburgh, PA 15240, USA
    Med Mycol 43:S267-70. 2005
    ..A focus of a great interest and controversy is the use of combination therapy for invasive aspergillosis in transplant recipients...
  83. ncbi request reprint Fever in liver transplant recipients in the intensive care unit
    N Singh
    Veterans Affairs Medical Center and University of Pittsburgh, PA 15240, USA
    Clin Transplant 13:504-11. 1999
    ..001) was significantly higher in febrile patients in the ICU, as compared to the patients in the non-ICU setting. These data have implications for diagnostic evaluation and management of critically ill febrile liver transplant recipients...
  84. ncbi request reprint Bacteremia in lung transplant recipients in the current era
    S Husain
    Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Transplant 6:3000-7. 2006
    ..Recognition of variables portending a high risk for antibiotic resistance and for poor outcome has implications relevant for optimizing antibiotic prescription and for improving outcomes in lung transplant recipients...
  85. ncbi request reprint Posttransplantation dialysis-associated infections: morbidity and impact on outcome in liver transplant recipients
    N Singh
    Veterans Affairs Medical Center and University of Pittsburgh, University Dr C, Pittsburgh, PA 15240, USA
    Liver Transpl 7:100-5. 2001
    ..The need for dialysis portended a grave outcome in liver transplant recipients and identified a subgroup of patients at a significantly greater risk for major infections, particularly fungal infections, after liver transplantation...
  86. pmc Serologic evidence for reactivation of cryptococcosis in solid-organ transplant recipients
    D C Saha
    Infectious Diseases Section, VA Medical Center, University Drive C, Pittsburgh, PA 15240, USA
    Clin Vaccine Immunol 14:1550-4. 2007
    ..These findings also highlight the potential utility of serologic studies in identifying patients at risk for the development of cryptococcosis after transplantation...
  87. ncbi request reprint Methicillin-resistant Staphylococcus aureus: the other emerging resistant gram-positive coccus among liver transplant recipients
    N Singh
    Veterans Affairs Medical Center and University of Pittsburgh, Thomas E Starzl Transplantation Institute, PA 15240, USA
    Clin Infect Dis 30:322-7. 2000
    ..These infections have unique risk factors, time of onset, and a significant difference in site-specific mortality; deep-seated bacteremic infections, in particular, portend a grave outcome...
  88. ncbi request reprint Infections of the central nervous system in transplant recipients
    N Singh
    VA Medical Center and University of Pittsburgh, Thomas E Starzl Transplantation Institute, Pittsburgh, Pennsylvania 15240, USA
    Transpl Infect Dis 2:101-11. 2000
    ....
  89. ncbi request reprint Preemptive therapy versus universal prophylaxis with ganciclovir for cytomegalovirus in solid organ transplant recipients
    N Singh
    Veterans Affairs Medical Center and University of Pittsburgh, Thomas E Starzl Transplantation Institute, Pittsburgh, PA 15240, USA
    Clin Infect Dis 32:742-51. 2001
    ..Although neither approach is wholly adequate, a discussion of the relative merits and limitations of the 2 approaches may guide the selection of a rational approach toward prevention of CMV infection in organ transplant recipients...
  90. ncbi request reprint A survey of CMV prevention strategies after liver transplantation
    J Levitsky
    Department of Medicine, Division of Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Am J Transplant 8:158-61. 2008
    ..In conclusion, the majority of LT centers utilize CMV prophylaxis over other strategies. Valganciclovir is the most commonly used agent for both antiviral prophylaxis and treatment of CMV viremia in the preemptive approach...
  91. ncbi request reprint Human herpesviruses-6, -7 and -8 in organ transplant recipients
    N Singh
    Veterans Affairs Medical Center and University of Pittsburgh, Thomas E Starzl Transplantation Institute, Pittsburgh, Pennsylvania, USA
    Clin Microbiol Infect 6:453-9. 2000
    ..Human herpesvirus-8 has been causally associated with post-transplant Kaposi's sarcoma. The complete spectrum of pathogenicity and ultimately the effective prophylaxis and management of these viruses has yet to be fully elucidated...
  92. ncbi request reprint Trends in the epidemiology of opportunistic fungal infections: predisposing factors and the impact of antimicrobial use practices
    N Singh
    Veterans Affairs Medical Center and Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15240, USA
    Clin Infect Dis 33:1692-6. 2001
    ..This review discusses the implications of these trends for guiding judicious use of antimicrobial prophylactics and for unraveling the pathophysiological basis of fungal infections...
  93. ncbi request reprint T-helper cell responses in liver transplant recipients: correlation with cytomegalovirus and other major infections
    N Singh
    Veterans Affairs Medical Center and University of Pittsburgh Medical Center, Thomas E Starzl Transplantation Institute Pittsburgh, Pennsylvania, USA
    Transpl Infect Dis 6:93-6. 2004
    ..Impairment in proliferative response to ConA identified a subgroup of patients with major infections after liver transplantation...
  94. ncbi request reprint Seasonal pattern of early mortality and infectious complications in liver transplant recipients
    N Singh
    Veterans Affairs Medical Center and University of Pittsburgh, Pittsburgh, PA 15240, USA
    Liver Transpl 7:884-9. 2001
    ..Whether the seasonal clustering of deaths and infections is triggered by respiratory viruses, yet unrecognized viruses, or unknown exogenous factors remains to be determined...
  95. ncbi request reprint Cytomegalovirus antigenemia directed pre-emptive prophylaxis with oral versus I.V. ganciclovir for the prevention of cytomegalovirus disease in liver transplant recipients: a randomized, controlled trial
    N Singh
    Veterans Affairs Medical Center and University of Pittsburgh, Thomas E Starzl Transplantation Institute, Pennsylvania 15240, USA
    Transplantation 70:717-22. 2000
    ..v. ganciclovir for the prevention of CMV disease after liver transplantation, and to determine whether withholding prophylaxis in the absence of CMV antigenemia, reliably identified patients in whom no prophylaxis was necessary...
  96. ncbi request reprint Encephalitis caused by human herpesvirus-6 in transplant recipients: relevance of a novel neurotropic virus
    N Singh
    Veterans Affairs Medical Center and University of Pittsburgh, Thomas E Starzl Transplantation Center, Pennsylvania, USA
    Transplantation 69:2474-9. 2000
    ..Human herpesvirus-6 (HHV-6) is a neurotropic virus. Encephalitis is a significant clinical manifestation of HHV-6; however, sparse data on this entity exist in transplant recipients...
  97. ncbi request reprint Changing spectrum of invasive candidiasis and its therapeutic implications
    N Singh
    University of Pittsburgh Medical Center, PA, USA
    Clin Microbiol Infect 7:1-7. 2001
    ..Given the inherent decreased susceptibility of many of the non-albicans Candida species to currently available antifungal agents, these evolving trends have far-reaching clinical relevance...
  98. ncbi request reprint Staphylococcus aureus rectal carriage and its association with infections in patients in a surgical intensive care unit and a liver transplant unit
    Cheryl Squier
    Veterans Affairs Medical Center, Infectious Disease Section, Pittsburgh, PA 15240, USA
    Infect Control Hosp Epidemiol 23:495-501. 2002
    ..The role of rectal carriage of Staphylococcus aureus as a risk factor for nosocomial S. aureus infections in critically ill patients has not been fully discerned...
  99. doi request reprint Pulmonary zygomycosis in solid organ transplant recipients in the current era
    H Y Sun
    VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Am J Transplant 9:2166-71. 2009
    ..2%. In summary, pulmonary zygomycosis is the most common manifestation in solid organ transplant recipients with zygomycosis, and disseminated disease often involves the cutaneous/soft tissue sites but not the brain...
  100. ncbi request reprint Control of an outbreak of infection due to extended-spectrum beta-lactamase--producing Escherichia coli in a liver transplantation unit
    D L Paterson
    Infectious Disease Section, Veterans Affairs Medical Center, Pittsburgh, PA, USA
    Clin Infect Dis 33:126-8. 2001
    ..Control of the outbreak was achieved by a combination of contact isolation, feedback on hand hygiene, and gut decontamination with an orally administered fluoroquinolone. These interventions led to abrupt curtailment of the outbreak...
  101. pmc Performance characteristics of the platelia Aspergillus enzyme immunoassay for detection of Aspergillus galactomannan antigen in bronchoalveolar lavage fluid
    S Husain
    University of Pittsburgh, Pittsburgh, PA, USA
    Clin Vaccine Immunol 15:1760-3. 2008
    ..Galactomannan testing in BAL is useful for diagnosis of aspergillosis in transplant patients. The significance of positive results in patients without confirmed aspergillosis requires further evaluation...

Research Grants3

  1. C. Neoformans Infection in Organ Transplant Recipients
    Nina Singh; Fiscal Year: 2005
    ..Finally, the data regarding reactivation or primary infection has implications relevant for the prevention of C. neoformans infection in transplant recipients. ..