Meharvan Singh

Summary

Affiliation: University of North Texas
Country: USA

Publications

  1. ncbi request reprint Novel mechanisms for estrogen-induced neuroprotection
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Exp Biol Med (Maywood) 231:514-21. 2006
  2. ncbi request reprint Mechanisms of progesterone-induced neuroprotection
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Ann N Y Acad Sci 1052:145-51. 2005
  3. ncbi request reprint Progestins and neuroprotection: are all progestins created equal?
    M Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA
    Minerva Endocrinol 32:95-102. 2007
  4. ncbi request reprint Progesterone-induced neuroprotection
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Endocrine 29:271-4. 2006
  5. pmc Estrogens and progesterone as neuroprotectants: what animal models teach us
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Front Biosci 13:1083-9. 2008
  6. pmc Progesterone potentiates calcium release through IP3 receptors by an Akt-mediated mechanism in hippocampal neurons
    Ji Yeon Hwang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Cell Calcium 45:233-42. 2009
  7. pmc Oxidative stress defines the neuroprotective or neurotoxic properties of androgens in immortalized female rat dopaminergic neuronal cells
    Shaletha Holmes
    PhD, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3400 Camp Bowie Boulevard, Fort Worth, Texas 76107 2699
    Endocrinology 154:4281-92. 2013
  8. pmc Progesterone increases brain-derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explants
    Paramjit Kaur
    Department of Pharmacology and Neuroscience and the Institute for Aging and Alzheimer s Disease Research, The Center FOR HER, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    J Neurosci Res 85:2441-9. 2007
  9. pmc The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expression
    Parmeet K Jodhka
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3400 Camp Bowie Boulevard, Fort Worth, Texas 76107 2699, USA
    Endocrinology 150:3162-8. 2009
  10. pmc Progesterone increases the release of brain-derived neurotrophic factor from glia via progesterone receptor membrane component 1 (Pgrmc1)-dependent ERK5 signaling
    Chang Su
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center at Fort Worth, 3400 Camp Bowie Boulevard, Fort Worth, Texas 76107, USA
    Endocrinology 153:4389-400. 2012

Research Grants

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Novel mechanisms for estrogen-induced neuroprotection
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Exp Biol Med (Maywood) 231:514-21. 2006
    ..On the basis of this evidence, we discuss the clinical applicability of estrogens in treating various age-related disorders, including Alzheimer disease and stroke, and identify the caveats that must be considered...
  2. ncbi request reprint Mechanisms of progesterone-induced neuroprotection
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Ann N Y Acad Sci 1052:145-51. 2005
    ....
  3. ncbi request reprint Progestins and neuroprotection: are all progestins created equal?
    M Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA
    Minerva Endocrinol 32:95-102. 2007
    ....
  4. ncbi request reprint Progesterone-induced neuroprotection
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Endocrine 29:271-4. 2006
    ....
  5. pmc Estrogens and progesterone as neuroprotectants: what animal models teach us
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Front Biosci 13:1083-9. 2008
    ....
  6. pmc Progesterone potentiates calcium release through IP3 receptors by an Akt-mediated mechanism in hippocampal neurons
    Ji Yeon Hwang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Cell Calcium 45:233-42. 2009
    ..These results suggest a potential involvement of P4 in particular and of steroid hormone signaling pathways in general in the control of intracellular Ca(2+) signaling and its related functions...
  7. pmc Oxidative stress defines the neuroprotective or neurotoxic properties of androgens in immortalized female rat dopaminergic neuronal cells
    Shaletha Holmes
    PhD, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3400 Camp Bowie Boulevard, Fort Worth, Texas 76107 2699
    Endocrinology 154:4281-92. 2013
    ..Overall, our results indicate that androgens are neuroprotective when oxidative stress levels are minimal, but when oxidative stress levels are elevated, androgens exacerbate oxidative stress damage. ..
  8. pmc Progesterone increases brain-derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explants
    Paramjit Kaur
    Department of Pharmacology and Neuroscience and the Institute for Aging and Alzheimer s Disease Research, The Center FOR HER, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    J Neurosci Res 85:2441-9. 2007
    ..Collectively, these data suggest that progesterone is protective via multiple and potentially related mechanisms. (c) 2007 Wiley-Liss, Inc...
  9. pmc The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expression
    Parmeet K Jodhka
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3400 Camp Bowie Boulevard, Fort Worth, Texas 76107 2699, USA
    Endocrinology 150:3162-8. 2009
    ....
  10. pmc Progesterone increases the release of brain-derived neurotrophic factor from glia via progesterone receptor membrane component 1 (Pgrmc1)-dependent ERK5 signaling
    Chang Su
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center at Fort Worth, 3400 Camp Bowie Boulevard, Fort Worth, Texas 76107, USA
    Endocrinology 153:4389-400. 2012
    ....
  11. ncbi request reprint The impact of APOE status on relationship of biomarkers of vascular risk and systemic inflammation to neuropsychiatric symptoms in Alzheimer's disease
    James R Hall
    Institute of Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA Department of Psychiatry and Behavioral Health, University of North Texas Health Science Center, Fort Worth, TX, USA
    J Alzheimers Dis 40:887-96. 2014
    ..These findings suggest that dysregulation of inflammatory activity is related to NPS, that cholesterol is a significant factor in the occurrence of NPS, and that gender and APOE status need to be considered. ..
  12. pmc Progesterone-induced neuroprotection: factors that may predict therapeutic efficacy
    Meharvan Singh
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Brain Res 1514:98-106. 2013
    ..This article is part of a Special Issue entitled Hormone Therapy...
  13. doi request reprint Progesterone potentiates IP(3)-mediated calcium signaling through Akt/PKB
    Peter Koulen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107 2699, USA
    Cell Physiol Biochem 21:161-72. 2008
    ..With a direct control of the gain of the Ca(2+) second messenger system as a signaling gatekeeper for neuronal activity the present study identifies a novel pathway for interaction of the endocrine and central nervous system...
  14. ncbi request reprint ERK1/2 and ERK5 have distinct roles in the regulation of brain-derived neurotrophic factor expression
    Chang Su
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA
    J Neurosci Res 89:1542-50. 2011
    ....
  15. ncbi request reprint Oxidative stress, testosterone, and cognition among Caucasian and Mexican-American men with and without Alzheimer's disease
    Rebecca L Cunningham
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA Center FOR HER, University of North Texas Health Science Center, Fort Worth, TX, USA
    J Alzheimers Dis 40:563-73. 2014
    ..The use of testosterone among aging men has been increasing, but results from studies addressing the effectiveness of testosterone replacement therapy have been equivocal...
  16. ncbi request reprint Activation of a membrane-associated androgen receptor promotes cell death in primary cortical astrocytes
    Joshua W Gatson
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Texas 76107 2699, USA
    Endocrinology 148:2458-64. 2007
    ..Collectively, these data support the existence of two, potentially competing, pathways for androgens in a given cell or tissue that may provide insight into the controversy of whether androgen therapy is beneficial or detrimental...
  17. doi request reprint More than a decade of estrogen neuroprotection
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA
    Alzheimers Dement 4:S131-6. 2008
    ....
  18. ncbi request reprint Estrogens, progestins, menopause and neurodegeneration: basic and clinical studies
    J W Simpkins
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Cell Mol Life Sci 62:271-80. 2005
    ..Further clinical assessment of appropriate regimens of estrogens, progestins and their combination are supported by these data...
  19. pmc Progesterone and neuroprotection
    Meharvan Singh
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Horm Behav 63:284-90. 2013
    ....
  20. doi request reprint Neuroprotection and estrogen receptors
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA james simpkins unthsc edu
    Neuroendocrinology 96:119-30. 2012
    ..Finally, further studies that are needed to parse out the relative contribution of receptor versus nonreceptor-mediated signaling are discussed...
  21. pmc The potential for estrogens in preventing Alzheimer's disease and vascular dementia
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER Focused On Resources for her Health, Education and Research, University of North Texas Health Science Center, Fort Worth, TX, USA
    Ther Adv Neurol Disord 2:31-49. 2009
    ..Several approaches to enhance brain specificity of estrogen action are now underway in an attempt to reduce the side effects of chronic estrogen therapy in AD...
  22. pmc Genistein directly inhibits native and recombinant NMDA receptors
    RenQi Huang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Neuropharmacology 58:1246-51. 2010
    ..Thus, other PTK inhibitors may be more suitable for studying involvement of PTKs in NMDA receptor-mediated events...
  23. pmc Risk factors for mild cognitive impairment among Mexican Americans
    Sid E O'Bryant
    Department of Internal Medicine, University of North Texas Health Sciences Center, Fort Worth, TX, USA Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Sciences Center, Fort Worth, TX, USA Electronic address
    Alzheimers Dement 9:622-631.e1. 2013
    ..Although a great deal of literature has focused on risk factors for mild cognitive impairment (MCI), little published work examines risk for MCI among Mexican Americans...
  24. pmc Androgens exacerbate motor asymmetry in male rats with unilateral 6-hydroxydopamine lesion
    Rebecca L Cunningham
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Horm Behav 60:617-24. 2011
    ..Collectively, the data support the hypothesis that androgens may underlie the gender bias observed in PD...
  25. pmc Biomarkers of vascular risk, systemic inflammation, and microvascular pathology and neuropsychiatric symptoms in Alzheimer's disease
    James R Hall
    Institute of Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    J Alzheimers Dis 35:363-71. 2013
    ..Gender differences suggest distinct impact of specific risks with total cholesterol, a measure of cardiovascular risk, being the strongest marker for males and IL-15, a marker of inflammation, being the strongest for females...
  26. ncbi request reprint Neuroendocrine mechanism for tolerance to cerebral ischemia-reperfusion injury in male rats
    Shao Hua Yang
    Department of Pharmacology and Neuroscience, Health Science Center at Fort Worth, University of North Texas, Fort Worth, Texas 76107, USA
    J Neurobiol 62:341-51. 2005
    ..In summary, stress-induced testosterone reduction contributes to ischemia tolerance in cerebral ischemia-reperfusion injury in males, which could be related to the loss of inhibition by testosterone of Hsp70 and -90 expression...
  27. pmc Is serum brain-derived neurotrophic factor related to craving for or use of alcohol, cocaine, or methamphetamine?
    Craig Hilburn
    University of North Texas Health Science Center at Fort Worth, TX, USA
    Neuropsychiatr Dis Treat 7:357-64. 2011
    ..Here, we examined craving and serum BDNF levels in persons with alcohol versus psychostimulant dependence. Our goals were to explore BDNF as an objective biomarker for 1) craving 2) abstinence, and 3) years of chronic substance use...
  28. ncbi request reprint Dihydrotestosterone differentially modulates the mitogen-activated protein kinase and the phosphoinositide 3-kinase/Akt pathways through the nuclear and novel membrane androgen receptor in C6 cells
    Joshua W Gatson
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, 76107 2699, USA
    Endocrinology 147:2028-34. 2006
    ....
  29. ncbi request reprint A novel organotypic culture model of the postnatal mouse retina allows the study of glutamate-mediated excitotoxicity
    Hua Xin
    University of North Texas Health Science Center, Department of Pharmacology and Neuroscience, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    J Neurosci Methods 159:35-42. 2007
    ..The described retina explant culture on glass coverslips allows for effective pharmacological manipulation including the study of neuronal cell death and RGC physiology...
  30. ncbi request reprint ERK/MAPK pathway regulates GABAA receptors
    Cathy L Bell-Horner
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, USA
    J Neurobiol 66:1467-74. 2006
    ..Collectively, our results implicate the MAPK pathway as a negative modulator of GABAA receptor function, whose influence on GABA-gated currents may be mediated by phosphorylation of the alpha subunit...
  31. ncbi request reprint Consortium for the Assessment of Research on Progestins and Estrogens (CARPE) Fort Worth, Texas August 1-3, 2003
    James W Simpkins
    J Womens Health (Larchmt) 13:1165-8. 2004
  32. ncbi request reprint Protein kinase C activity is necessary for estrogen-induced Erk phosphorylation in neocortical explants
    Gyorgy Setalo
    Department of Anatomy, Columbia University College of Physicians and Surgeons, 650 West 168th Street, Black Building 1615, New York, NY 10032, USA
    Neurochem Res 30:779-90. 2005
    ..Collectively, these data suggest a critical role for PKC in mediating estrogen induction of ERK activation in the developing brain via a MEK-dependent but B-Raf-independent pathway...
  33. ncbi request reprint Constitutive GABAA receptor endocytosis is dynamin-mediated and dependent on a dileucine AP2 adaptin-binding motif within the beta 2 subunit of the receptor
    Dina Herring
    Department of Pharmacology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    J Biol Chem 278:24046-52. 2003
    ..This is the first report to our knowledge that an AP2 adaptin dileucine recognition motif is critical for the endocytosis of ligand-gated ion channels belonging to this superfamily...
  34. ncbi request reprint ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury
    C Dominique Toran-Allerand
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 22:8391-401. 2002
    ....
  35. ncbi request reprint Estradiol-induced phosphorylation of ERK1/2 in explants of the mouse cerebral cortex: the roles of heat shock protein 90 (Hsp90) and MEK2
    Gyorgy Setalo
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032
    J Neurobiol 50:1-12. 2002
    ....

Research Grants5

  1. Progesterone, GABA Receptors and Cell Survival
    Meharvan Singh; Fiscal Year: 2005
    ..abstract_text> ..
  2. Novel Mechanistic Targets of Steroid Hormones in the Brain
    Meharvan Singh; Fiscal Year: 2007
    ..PRINCIPAL INVESTIGATOR: The Principal Investigator, Dr. Meharvan Singh, is a highly talented investigator. He completed his Ph.D...
  3. Membrane Androgen Receptors in Neuroprotection
    Meharvan Singh; Fiscal Year: 2007
    ....
  4. A DIAGNOSTIC TEST TO ASSESS RISK ASSOCIATED WITH ANDROGEN THERAPY
    Meharvan Singh; Fiscal Year: 2007
    ....