Research Topics
| Meharvan SinghSummaryAffiliation: University of North Texas Country: USA Publications
Research Grants
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Detail Information
Publications
Novel mechanisms for estrogen-induced neuroprotectionMeharvan Singh
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Exp Biol Med (Maywood) 231:514-21. 2006..On the basis of this evidence, we discuss the clinical applicability of estrogens in treating various age-related disorders, including Alzheimer disease and stroke, and identify the caveats that must be considered...
Estrogens and progesterone as neuroprotectants: what animal models teach usMeharvan Singh
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Front Biosci 13:1083-9. 2008....- Progestins and neuroprotection: are all progestins created equal?M Singh
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA
Minerva Endocrinol 32:95-102. 2007.... - Mechanisms of progesterone-induced neuroprotectionMeharvan Singh
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
Ann N Y Acad Sci 1052:145-51. 2005.... - Progesterone-induced neuroprotectionMeharvan Singh
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Endocrine 29:271-4. 2006.... - Progesterone potentiates calcium release through IP3 receptors by an Akt-mediated mechanism in hippocampal neuronsJi Yeon Hwang
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
Cell Calcium 45:233-42. 2009..These results suggest a potential involvement of P4 in particular and of steroid hormone signaling pathways in general in the control of intracellular Ca(2+) signaling and its related functions... - Progesterone increases brain-derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explantsParamjit Kaur
Department of Pharmacology and Neuroscience and the Institute for Aging and Alzheimer s Disease Research, The Center FOR HER, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
J Neurosci Res 85:2441-9. 2007..Collectively, these data suggest that progesterone is protective via multiple and potentially related mechanisms. (c) 2007 Wiley-Liss, Inc... - The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expressionParmeet K Jodhka
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3400 Camp Bowie Boulevard, Fort Worth, Texas 76107 2699, USA
Endocrinology 150:3162-8. 2009.... - Progesterone increases the release of brain-derived neurotrophic factor from glia via progesterone receptor membrane component 1 (Pgrmc1)-dependent ERK5 signalingChang Su
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center at Fort Worth, 3400 Camp Bowie Boulevard, Fort Worth, Texas 76107, USA
Endocrinology 153:4389-400. 2012.... 
Progesterone potentiates IP(3)-mediated calcium signaling through Akt/PKBPeter Koulen
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107 2699, USA
Cell Physiol Biochem 21:161-72. 2008..With a direct control of the gain of the Ca(2+) second messenger system as a signaling gatekeeper for neuronal activity the present study identifies a novel pathway for interaction of the endocrine and central nervous system...- ERK1/2 and ERK5 have distinct roles in the regulation of brain-derived neurotrophic factor expressionChang Su
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA
J Neurosci Res 89:1542-50. 2011.... - More than a decade of estrogen neuroprotectionJames W Simpkins
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA
Alzheimers Dement 4:S131-6. 2008.... - Activation of a membrane-associated androgen receptor promotes cell death in primary cortical astrocytesJoshua W Gatson
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Texas 76107 2699, USA
Endocrinology 148:2458-64. 2007..Collectively, these data support the existence of two, potentially competing, pathways for androgens in a given cell or tissue that may provide insight into the controversy of whether androgen therapy is beneficial or detrimental... - Estrogens, progestins, menopause and neurodegeneration: basic and clinical studiesJ W Simpkins
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
Cell Mol Life Sci 62:271-80. 2005..Further clinical assessment of appropriate regimens of estrogens, progestins and their combination are supported by these data... - Neuroprotection and estrogen receptorsJames W Simpkins
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA james simpkins unthsc edu
Neuroendocrinology 96:119-30. 2012..Finally, further studies that are needed to parse out the relative contribution of receptor versus nonreceptor-mediated signaling are discussed... - The potential for estrogens in preventing Alzheimer's disease and vascular dementiaJames W Simpkins
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER Focused On Resources for her Health, Education and Research, University of North Texas Health Science Center, Fort Worth, TX, USA
Ther Adv Neurol Disord 2:31-49. 2009..Several approaches to enhance brain specificity of estrogen action are now underway in an attempt to reduce the side effects of chronic estrogen therapy in AD... - Genistein directly inhibits native and recombinant NMDA receptorsRenQi Huang
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
Neuropharmacology 58:1246-51. 2010..Thus, other PTK inhibitors may be more suitable for studying involvement of PTKs in NMDA receptor-mediated events... - Androgens exacerbate motor asymmetry in male rats with unilateral 6-hydroxydopamine lesionRebecca L Cunningham
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
Horm Behav 60:617-24. 2011..Collectively, the data support the hypothesis that androgens may underlie the gender bias observed in PD... - Progesterone and neuroprotectionMeharvan Singh
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
Horm Behav 63:284-90. 2013.... - Is serum brain-derived neurotrophic factor related to craving for or use of alcohol, cocaine, or methamphetamine?Craig Hilburn
University of North Texas Health Science Center at Fort Worth, TX, USA
Neuropsychiatr Dis Treat 7:357-64. 2011..Here, we examined craving and serum BDNF levels in persons with alcohol versus psychostimulant dependence. Our goals were to explore BDNF as an objective biomarker for 1) craving 2) abstinence, and 3) years of chronic substance use... - Neuroendocrine mechanism for tolerance to cerebral ischemia-reperfusion injury in male ratsShao-Hua Yang
Department of Pharmacology and Neuroscience, Health Science Center at Fort Worth, University of North Texas, Fort Worth, Texas 76107, USA
J Neurobiol 62:341-51. 2005..In summary, stress-induced testosterone reduction contributes to ischemia tolerance in cerebral ischemia-reperfusion injury in males, which could be related to the loss of inhibition by testosterone of Hsp70 and -90 expression... - A novel organotypic culture model of the postnatal mouse retina allows the study of glutamate-mediated excitotoxicityHua Xin
University of North Texas Health Science Center, Department of Pharmacology and Neuroscience, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
J Neurosci Methods 159:35-42. 2007..The described retina explant culture on glass coverslips allows for effective pharmacological manipulation including the study of neuronal cell death and RGC physiology... - Dihydrotestosterone differentially modulates the mitogen-activated protein kinase and the phosphoinositide 3-kinase/Akt pathways through the nuclear and novel membrane androgen receptor in C6 cellsJoshua W Gatson
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, 76107-2699, USA
Endocrinology 147:2028-34. 2006.... - ERK/MAPK pathway regulates GABAA receptorsCathy L Bell-Horner
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, USA
J Neurobiol 66:1467-74. 2006..Collectively, our results implicate the MAPK pathway as a negative modulator of GABAA receptor function, whose influence on GABA-gated currents may be mediated by phosphorylation of the alpha subunit... - ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injuryC Dominique Toran-Allerand
Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Neurosci 22:8391-401. 2002.... - Constitutive GABAA receptor endocytosis is dynamin-mediated and dependent on a dileucine AP2 adaptin-binding motif within the beta 2 subunit of the receptorDina Herring
Department of Pharmacology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
J Biol Chem 278:24046-52. 2003..This is the first report to our knowledge that an AP2 adaptin dileucine recognition motif is critical for the endocytosis of ligand-gated ion channels belonging to this superfamily... - Consortium for the Assessment of Research on Progestins and Estrogens (CARPE) Fort Worth, Texas August 1-3, 2003James W Simpkins
J Womens Health (Larchmt) 13:1165-8. 2004 - Protein kinase C activity is necessary for estrogen-induced Erk phosphorylation in neocortical explantsGyorgy Setalo
Department of Anatomy, Columbia University College of Physicians and Surgeons, 650 West 168th Street, Black Building 1615, New York, NY 10032, USA
Neurochem Res 30:779-90. 2005..Collectively, these data suggest a critical role for PKC in mediating estrogen induction of ERK activation in the developing brain via a MEK-dependent but B-Raf-independent pathway... - Estradiol-induced phosphorylation of ERK1/2 in explants of the mouse cerebral cortex: the roles of heat shock protein 90 (Hsp90) and MEK2Gyorgy Setalo
Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032
J Neurobiol 50:1-12. 2002....
Research Grants
- Progesterone, GABA Receptors and Cell SurvivalMeharvan Singh; Fiscal Year: 2005..abstract_text> ..
- Novel Mechanistic Targets of Steroid Hormones in the BrainMeharvan Singh; Fiscal Year: 2007..PRINCIPAL INVESTIGATOR: The Principal Investigator, Dr. Meharvan Singh, is a highly talented investigator. He completed his Ph.D...
- Membrane Androgen Receptors in NeuroprotectionMeharvan Singh; Fiscal Year: 2007....
- A DIAGNOSTIC TEST TO ASSESS RISK ASSOCIATED WITH ANDROGEN THERAPYMeharvan Singh; Fiscal Year: 2007....