Genomes and Genes
Manvendra K Singh
Affiliation: University of Pennsylvania
- MicroRNA-processing enzyme Dicer is required in epicardium for coronary vasculature developmentManvendra K Singh
Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 286:41036-45. 2011..These results demonstrate a critical role for Dicer, and by implication miRNAs, in murine epicardial development...
- Semaphorin 3d signaling defects are associated with anomalous pulmonary venous connectionsKarl Degenhardt
Department of Pediatrics, Division of Cardiology, Children s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Nat Med 19:760-5. 2013..These results identify Sema3d as a crucial pulmonary venous patterning cue and provide experimental evidence for an alternate developmental model to explain abnormal pulmonary venous connections...
- Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defectsYing Zhang
Department of Cell and Developmental Biology, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Dev Biol 325:82-93. 2009..These results demonstrate an important role for PlexinD1 in embryonic and adult vasculature...
- Gata4 and Gata5 cooperatively regulate cardiac myocyte proliferation in miceManvendra K Singh
Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Biol Chem 285:1765-72. 2010..These results demonstrate functional redundancy between Gata4 and Gata5 during cardiac development and implicate Gata5 as a candidate modifier gene for congenital heart disease...
- New approaches under development: cardiovascular embryology applied to heart diseaseKarl Degenhardt
Division of Cardiology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
J Clin Invest 123:71-4. 2013..In particular, research in stem cell biology, the cardiomyocyte lineage, and the interactions of the myocardium and epicardium have opened the door to new approaches for healing the injured heart...
- Murine craniofacial development requires Hdac3-mediated repression of Msx gene expressionNikhil Singh
Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Dev Biol 377:333-44. 2013..These results suggest that Hdac3 serves as a critical regulator of craniofacial morphogenesis, in part by repressing core apoptotic pathways in cranial neural crest cells...