A K Singh

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Lipopolysaccharide (LPS) induced activation of the immune system in control rats and rats chronically exposed to a low level of the organothiophosphate insecticide, acephate
    A K Singh
    Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St Paul Campus, St Paul, MN, USA
    Toxicol Ind Health 19:93-108. 2003
  2. ncbi request reprint How does peripheral lipopolysaccharide induce gene expression in the brain of rats?
    A K Singh
    Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Toxicology 201:197-207. 2004
  3. ncbi request reprint Development of quantitative structure-activity relationship (QSAR) models for predicting risk of exposure from carcinogens in animals
    A K Singh
    Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, 1333 Gortner Ave, University of Minnesota, St Paul Campus, St Paul, Minnesota 55418, USA
    Cancer Invest 19:611-20. 2001
  4. ncbi request reprint Red blood cell erythropoietin, not plasma erythropoietin, concentrations correlate with changes in hematological indices in horses receiving a single dose of recombinant human erythropoietin by subcutaneous injection
    A K Singh
    Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    J Vet Pharmacol Ther 30:175-8. 2007
  5. ncbi request reprint QSAR for acetylcholinesterase inhibition and toxicity of two classes of phosphoramidothioates
    D P Spassova
    Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, 1333 Gortner Ave, St. Paul, MN 55108, USA
    SAR QSAR Environ Res 11:453-71. 2001
  6. ncbi request reprint Acute effects of acephate and methamidophos and interleukin-1 on corticotropin-releasing factor (CRF) synthesis in and release from the hypothalamus in vitro
    A K Singh
    Department of Veterinary Diagnostic Medicine, Minnesota Veterinary Diagnostic Laboratory, University of Minnesota, 1333 Gorter Avenue, St Paul, MN 55108, USA
    Comp Biochem Physiol C Toxicol Pharmacol 132:9-24. 2002
  7. ncbi request reprint QSAR for the organophosphate-induced inhibition and 'aging' of the enzyme neuropathy target esterase (NTE)
    A K Singh
    Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St Paul Campus, 1333 Gortner Ave, St Paul, MN 55108, USA
    SAR QSAR Environ Res 12:275-95. 2001
  8. ncbi request reprint Development of QSAR models to predict estrogenic, carcinogenic, and cancer protective effects of phytoestrogens
    A K Singh
    Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, St. Paul, Minnesota, USA
    Cancer Invest 19:201-16. 2001
  9. ncbi request reprint Pasteurella (Mannheimia) haemolytica leukotoxin-induced cytolysis of bovine leukocytes: role of arachidonic acid and its regulation
    S Jeyaseelan
    Department of Veterinary Pathobiology, College of Veterinary Medicine, St. Paul, MN 55108, USA
    Microb Pathog 30:59-69. 2001
  10. ncbi request reprint Increased responsiveness of B. cells in the murine MRL/lpr model of lupus nephritis to interleukin-1 beta
    T V Lebedeva
    New England Medical Center, Department of Medicine, Boston, MA 02111
    J Am Soc Nephrol 5:1530-4. 1995

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Lipopolysaccharide (LPS) induced activation of the immune system in control rats and rats chronically exposed to a low level of the organothiophosphate insecticide, acephate
    A K Singh
    Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St Paul Campus, St Paul, MN, USA
    Toxicol Ind Health 19:93-108. 2003
    ..Thus, chronic low-level Ace exposure may impair the lineage commitment in lymphocytes, possibly by altering cytokine signaling in the brain...
  2. ncbi request reprint How does peripheral lipopolysaccharide induce gene expression in the brain of rats?
    A K Singh
    Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Toxicology 201:197-207. 2004
    ....
  3. ncbi request reprint Development of quantitative structure-activity relationship (QSAR) models for predicting risk of exposure from carcinogens in animals
    A K Singh
    Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, 1333 Gortner Ave, University of Minnesota, St Paul Campus, St Paul, Minnesota 55418, USA
    Cancer Invest 19:611-20. 2001
    ..However, the molecule's lipophilicity, length, and width may play important roles in the carcinogenic effects of chlorinated compounds...
  4. ncbi request reprint Red blood cell erythropoietin, not plasma erythropoietin, concentrations correlate with changes in hematological indices in horses receiving a single dose of recombinant human erythropoietin by subcutaneous injection
    A K Singh
    Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    J Vet Pharmacol Ther 30:175-8. 2007
  5. ncbi request reprint QSAR for acetylcholinesterase inhibition and toxicity of two classes of phosphoramidothioates
    D P Spassova
    Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, 1333 Gortner Ave, St. Paul, MN 55108, USA
    SAR QSAR Environ Res 11:453-71. 2001
    ..The insecticidal activity of Ace analogs may be due to direct interaction with the active center of the AChE. The mammalian toxicity of Ace analogs may be due to interaction with an 'allosteric' reaction center in the AChE...
  6. ncbi request reprint Acute effects of acephate and methamidophos and interleukin-1 on corticotropin-releasing factor (CRF) synthesis in and release from the hypothalamus in vitro
    A K Singh
    Department of Veterinary Diagnostic Medicine, Minnesota Veterinary Diagnostic Laboratory, University of Minnesota, 1333 Gorter Avenue, St Paul, MN 55108, USA
    Comp Biochem Physiol C Toxicol Pharmacol 132:9-24. 2002
    ..The insecticides, but not IL-1, disrupt feedback regulation of CRF synthesis in and release from the hypothalamus...
  7. ncbi request reprint QSAR for the organophosphate-induced inhibition and 'aging' of the enzyme neuropathy target esterase (NTE)
    A K Singh
    Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St Paul Campus, 1333 Gortner Ave, St Paul, MN 55108, USA
    SAR QSAR Environ Res 12:275-95. 2001
    ..The only exception is Eq. (3) that did not accurately predict the acephate-induced inhibition of AChE, possibly because acephate and other OPs inhibit the enzyme by distinct mechanisms...
  8. ncbi request reprint Development of QSAR models to predict estrogenic, carcinogenic, and cancer protective effects of phytoestrogens
    A K Singh
    Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, St. Paul, Minnesota, USA
    Cancer Invest 19:201-16. 2001
    ..Thus molecular shape and molecular connectivity of PEs play a key role in modulating estrogen-induced transactivation activity and DNA synthesis in BC cells...
  9. ncbi request reprint Pasteurella (Mannheimia) haemolytica leukotoxin-induced cytolysis of bovine leukocytes: role of arachidonic acid and its regulation
    S Jeyaseelan
    Department of Veterinary Pathobiology, College of Veterinary Medicine, St. Paul, MN 55108, USA
    Microb Pathog 30:59-69. 2001
    ..These results demonstrate that AA metabolites from cPLA(2)activation contribute to Lkt-induced cytolysis and G(i)type G-proteins, Ca(2+)and PKC, regulate the cPLA(2)activity...
  10. ncbi request reprint Increased responsiveness of B. cells in the murine MRL/lpr model of lupus nephritis to interleukin-1 beta
    T V Lebedeva
    New England Medical Center, Department of Medicine, Boston, MA 02111
    J Am Soc Nephrol 5:1530-4. 1995
    ..Collectively, these observations demonstrate increased B cell responsiveness to exogenous IL-1 beta and suggest that heightened IL-1 bioactivity in the murine MRL/lpr lupus model may influence high-level IgG and autoantibody production...
  11. ncbi request reprint Low cost bio-sorbent 'wheat bran' for the removal of cadmium from wastewater: kinetic and equilibrium studies
    K K Singh
    Water Pollution Research Laboratory, Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi 221 005, India
    Bioresour Technol 97:994-1001. 2006
    ..The applicability of Langmuir isotherm showed of monolayer coverage of the adsorbate on the surface of adsorbent. A generalized empirical model was proposed for the kinetics at different initial concentrations...
  12. ncbi request reprint Rho/ROCK pathway as a target of tumor therapy
    R Rattan
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci Res 83:243-55. 2006
    ....
  13. ncbi request reprint Dynamic, equilibrium and human studies of adsorption of 201Tl by Prussian blue
    Nidhi Bhardwaj
    Institute of Nuclear Medicine and Allied Sciences, Brig S K Mazumdar Marg, Delhi 110054, India
    Health Phys 90:250-7. 2006
    ..Our experience with the first two patients (serving as their own self-controls) suggests that Prussian blue therapy is a safe and effective method to significantly reduce radiation burden imparted by thallium myocardial scintigraphy...
  14. ncbi request reprint Process development for the removal and recovery of hazardous dye erythrosine from wastewater by waste materials-Bottom Ash and De-Oiled Soya as adsorbents
    Alok Mittal
    Department of Applied Chemistry, Maulana Azad National Institute of Technology, Bhopal 462007, India
    J Hazard Mater 138:95-105. 2006
    ..Attempts have also been made for the recovery of the adsorbed dye from exhausted columns by eluting dilute NaOH and more than 90% of the dye was recovered...
  15. ncbi request reprint Degradation and detoxification of endosulfan isomers by a defined co-culture of two Bacillus strains
    N Awasthi
    Industrial Toxicology Research Center, Mahatma Gandhi Marg, Post Box No 80, 226 001, Lucknow, India
    Appl Microbiol Biotechnol 62:279-83. 2003
    ..The microbial degradation of endosulfan isomers was also accompanied by a decrease in its toxicity to the test organism Tubifex tubifex Müller...
  16. ncbi request reprint Organochlorine pesticide residues in water and fish samples: first report from rivers and streams of Kumaon Himalayan region, India
    U K Sarkar
    National Bureau of Fish Genetic Resources, Canal Ring Road, Post Office Dilkusha Lucknow 226002, Uttar Pradesh, India
    Bull Environ Contam Toxicol 70:485-93. 2003
  17. ncbi request reprint Urinary cytokines: clinically useful markers of chronic renal disease progression?
    W Wong
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Nephrol Hypertens 10:807-11. 2001
    ..The use of urinary cytokine markers as predictors of progression of renal disease is reviewed in this paper...
  18. ncbi request reprint Lovastatin treatment decreases mononuclear cell infiltration into the CNS of Lewis rats with experimental allergic encephalomyelitis
    R Stanislaus
    Department of Pediatrics and Pathology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
    J Neurosci Res 66:155-62. 2001
    ..These observations indicate that Lovastatin treatment may be of therapeutic value against inflammatory disease process associated with infiltration of activated mononuclear cells into the tissue...
  19. ncbi request reprint High glucose decreases matrix metalloproteinase-2 activity in rat mesangial cells via transforming growth factor-beta1
    R Singh
    Department of Medicine, Veterans Affairs Hospital, Hines, Ill 60141, USA
    Exp Nephrol 9:249-57. 2001
    ..We conclude that the decrease in MMP-2 activity induced by glucose loading is mediated via TGF-beta1...
  20. ncbi request reprint Inhibitory effect of silibinin on ligand binding to erbB1 and associated mitogenic signaling, growth, and DNA synthesis in advanced human prostate carcinoma cells
    Y Sharma
    Center for Cancer Causation and Prevention, AMC Cancer Research Center, Denver, Colorado 80262-0238, USA
    Mol Carcinog 30:224-36. 2001
    ....
  21. ncbi request reprint Cytokine gene expression in the MRL/lpr model of lupus nephritis
    S Lemay
    New England Medical Center, Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
    Kidney Int 50:85-93. 1996
    ....
  22. ncbi request reprint In vitro role of IL-1 in heightened IgG, anti-DNA, and nephritogenic idiotype production by B cells derived from the murine MRL/lpr lupus model
    A K Singh
    Department of Medicine, New England Medical Center, Boston, Massachusetts 02111
    Clin Immunol Immunopathol 72:410-5. 1994
    ..Furthermore, heightened IL-1 activity appears to be influenced by both age and the presence of the lpr mutation...
  23. ncbi request reprint Interleukin-1 contributes to high level IgG production in the murine MRL/lpr lupus model
    A K Singh
    Department of Medicine Nephrology, New England Medical Center, Boston, MA 02111
    Immunol Invest 23:281-92. 1994
    ..Collectively, these results indicate a potentially important but complex role for IL-1 in influencing high-level IgG production in MRL/lpr mice with established disease...
  24. doi request reprint Enhanced production of SCL-LCL-PHA co-polymer by sludge-isolated Pseudomonas aeruginosa MTCC 7925
    A K Singh
    Agricultural and Food Engineering Department, Indian Institute of Technology, Kharagpur, West Bengal, India
    Lett Appl Microbiol 46:350-7. 2008
    ..To boost short-chain-length-long-chain-length polyhydroxyalkanoate (SCL-LCL-PHA) co-polymer yield in Pseudomonas aeruginosa MTCC 7925 by manipulating culture conditions...