A K Singh
Affiliation: University of Minnesota
- Lipopolysaccharide (LPS) induced activation of the immune system in control rats and rats chronically exposed to a low level of the organothiophosphate insecticide, acephateA K Singh
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St Paul Campus, St Paul, MN, USA
Toxicol Ind Health 19:93-108. 2003..Thus, chronic low-level Ace exposure may impair the lineage commitment in lymphocytes, possibly by altering cytokine signaling in the brain...
- How does peripheral lipopolysaccharide induce gene expression in the brain of rats?A K Singh
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
Toxicology 201:197-207. 2004....
- Development of quantitative structure-activity relationship (QSAR) models for predicting risk of exposure from carcinogens in animalsA K Singh
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, 1333 Gortner Ave, University of Minnesota, St Paul Campus, St Paul, Minnesota 55418, USA
Cancer Invest 19:611-20. 2001..However, the molecule's lipophilicity, length, and width may play important roles in the carcinogenic effects of chlorinated compounds...
- Red blood cell erythropoietin, not plasma erythropoietin, concentrations correlate with changes in hematological indices in horses receiving a single dose of recombinant human erythropoietin by subcutaneous injectionA K Singh
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
J Vet Pharmacol Ther 30:175-8. 2007
- QSAR for acetylcholinesterase inhibition and toxicity of two classes of phosphoramidothioatesD P Spassova
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, 1333 Gortner Ave, St. Paul, MN 55108, USA
SAR QSAR Environ Res 11:453-71. 2001..The insecticidal activity of Ace analogs may be due to direct interaction with the active center of the AChE. The mammalian toxicity of Ace analogs may be due to interaction with an 'allosteric' reaction center in the AChE...
- Acute effects of acephate and methamidophos and interleukin-1 on corticotropin-releasing factor (CRF) synthesis in and release from the hypothalamus in vitroA K Singh
Department of Veterinary Diagnostic Medicine, Minnesota Veterinary Diagnostic Laboratory, University of Minnesota, 1333 Gorter Avenue, St Paul, MN 55108, USA
Comp Biochem Physiol C Toxicol Pharmacol 132:9-24. 2002..The insecticides, but not IL-1, disrupt feedback regulation of CRF synthesis in and release from the hypothalamus...
- QSAR for the organophosphate-induced inhibition and 'aging' of the enzyme neuropathy target esterase (NTE)A K Singh
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St Paul Campus, 1333 Gortner Ave, St Paul, MN 55108, USA
SAR QSAR Environ Res 12:275-95. 2001..The only exception is Eq. (3) that did not accurately predict the acephate-induced inhibition of AChE, possibly because acephate and other OPs inhibit the enzyme by distinct mechanisms...
- Development of QSAR models to predict estrogenic, carcinogenic, and cancer protective effects of phytoestrogensA K Singh
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, St. Paul, Minnesota, USA
Cancer Invest 19:201-16. 2001..Thus molecular shape and molecular connectivity of PEs play a key role in modulating estrogen-induced transactivation activity and DNA synthesis in BC cells...
- Pasteurella (Mannheimia) haemolytica leukotoxin-induced cytolysis of bovine leukocytes: role of arachidonic acid and its regulationS Jeyaseelan
Department of Veterinary Pathobiology, College of Veterinary Medicine, St. Paul, MN 55108, USA
Microb Pathog 30:59-69. 2001..These results demonstrate that AA metabolites from cPLA(2)activation contribute to Lkt-induced cytolysis and G(i)type G-proteins, Ca(2+)and PKC, regulate the cPLA(2)activity...
- Increased responsiveness of B. cells in the murine MRL/lpr model of lupus nephritis to interleukin-1 betaT V Lebedeva
New England Medical Center, Department of Medicine, Boston, MA 02111
J Am Soc Nephrol 5:1530-4. 1995..Collectively, these observations demonstrate increased B cell responsiveness to exogenous IL-1 beta and suggest that heightened IL-1 bioactivity in the murine MRL/lpr lupus model may influence high-level IgG and autoantibody production...
- Low cost bio-sorbent 'wheat bran' for the removal of cadmium from wastewater: kinetic and equilibrium studiesK K Singh
Water Pollution Research Laboratory, Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi 221 005, India
Bioresour Technol 97:994-1001. 2006..The applicability of Langmuir isotherm showed of monolayer coverage of the adsorbate on the surface of adsorbent. A generalized empirical model was proposed for the kinetics at different initial concentrations...
- Rho/ROCK pathway as a target of tumor therapyR Rattan
Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Neurosci Res 83:243-55. 2006....
- Dynamic, equilibrium and human studies of adsorption of 201Tl by Prussian blueNidhi Bhardwaj
Institute of Nuclear Medicine and Allied Sciences, Brig S K Mazumdar Marg, Delhi 110054, India
Health Phys 90:250-7. 2006..Our experience with the first two patients (serving as their own self-controls) suggests that Prussian blue therapy is a safe and effective method to significantly reduce radiation burden imparted by thallium myocardial scintigraphy...
- Process development for the removal and recovery of hazardous dye erythrosine from wastewater by waste materials-Bottom Ash and De-Oiled Soya as adsorbentsAlok Mittal
Department of Applied Chemistry, Maulana Azad National Institute of Technology, Bhopal 462007, India
J Hazard Mater 138:95-105. 2006..Attempts have also been made for the recovery of the adsorbed dye from exhausted columns by eluting dilute NaOH and more than 90% of the dye was recovered...
- Degradation and detoxification of endosulfan isomers by a defined co-culture of two Bacillus strainsN Awasthi
Industrial Toxicology Research Center, Mahatma Gandhi Marg, Post Box No 80, 226 001, Lucknow, India
Appl Microbiol Biotechnol 62:279-83. 2003..The microbial degradation of endosulfan isomers was also accompanied by a decrease in its toxicity to the test organism Tubifex tubifex Müller...
- Organochlorine pesticide residues in water and fish samples: first report from rivers and streams of Kumaon Himalayan region, IndiaU K Sarkar
National Bureau of Fish Genetic Resources, Canal Ring Road, Post Office Dilkusha Lucknow 226002, Uttar Pradesh, India
Bull Environ Contam Toxicol 70:485-93. 2003
- Urinary cytokines: clinically useful markers of chronic renal disease progression?W Wong
Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Opin Nephrol Hypertens 10:807-11. 2001..The use of urinary cytokine markers as predictors of progression of renal disease is reviewed in this paper...
- Lovastatin treatment decreases mononuclear cell infiltration into the CNS of Lewis rats with experimental allergic encephalomyelitisR Stanislaus
Department of Pediatrics and Pathology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
J Neurosci Res 66:155-62. 2001..These observations indicate that Lovastatin treatment may be of therapeutic value against inflammatory disease process associated with infiltration of activated mononuclear cells into the tissue...
- High glucose decreases matrix metalloproteinase-2 activity in rat mesangial cells via transforming growth factor-beta1R Singh
Department of Medicine, Veterans Affairs Hospital, Hines, Ill 60141, USA
Exp Nephrol 9:249-57. 2001..We conclude that the decrease in MMP-2 activity induced by glucose loading is mediated via TGF-beta1...
- Inhibitory effect of silibinin on ligand binding to erbB1 and associated mitogenic signaling, growth, and DNA synthesis in advanced human prostate carcinoma cellsY Sharma
Center for Cancer Causation and Prevention, AMC Cancer Research Center, Denver, Colorado 80262-0238, USA
Mol Carcinog 30:224-36. 2001....
- Cytokine gene expression in the MRL/lpr model of lupus nephritisS Lemay
New England Medical Center, Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
Kidney Int 50:85-93. 1996....
- In vitro role of IL-1 in heightened IgG, anti-DNA, and nephritogenic idiotype production by B cells derived from the murine MRL/lpr lupus modelA K Singh
Department of Medicine, New England Medical Center, Boston, Massachusetts 02111
Clin Immunol Immunopathol 72:410-5. 1994..Furthermore, heightened IL-1 activity appears to be influenced by both age and the presence of the lpr mutation...
- Interleukin-1 contributes to high level IgG production in the murine MRL/lpr lupus modelA K Singh
Department of Medicine Nephrology, New England Medical Center, Boston, MA 02111
Immunol Invest 23:281-92. 1994..Collectively, these results indicate a potentially important but complex role for IL-1 in influencing high-level IgG production in MRL/lpr mice with established disease...
- Enhanced production of SCL-LCL-PHA co-polymer by sludge-isolated Pseudomonas aeruginosa MTCC 7925A K Singh
Agricultural and Food Engineering Department, Indian Institute of Technology, Kharagpur, West Bengal, India
Lett Appl Microbiol 46:350-7. 2008..To boost short-chain-length-long-chain-length polyhydroxyalkanoate (SCL-LCL-PHA) co-polymer yield in Pseudomonas aeruginosa MTCC 7925 by manipulating culture conditions...