Kai Singbartl

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Renal-pulmonary crosstalk
    Kai Singbartl
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Contrib Nephrol 174:65-70. 2011
  2. doi request reprint Intensivist-led management of brain-dead donors is associated with an increase in organ recovery for transplantation
    K Singbartl
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Transplant 11:1517-21. 2011
  3. pmc Differential effects of kidney-lung cross-talk during acute kidney injury and bacterial pneumonia
    Kai Singbartl
    Department of Critical Care Medicine, CRISMA Center, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Kidney Int 80:633-44. 2011
  4. pmc Urinary biomarkers and renal recovery in critically ill patients with renal support
    Nattachai Srisawat
    604 Scaife Hall, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Clin J Am Soc Nephrol 6:1815-23. 2011
  5. pmc Acute removal of common sepsis mediators does not explain the effects of extracorporeal blood purification in experimental sepsis
    Zhi Yong Peng
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 81:363-9. 2012
  6. pmc Bactericidal antibiotics temporarily increase inflammation and worsen acute kidney injury in experimental sepsis
    Zhi Yong Peng
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 40:538-43. 2012
  7. ncbi request reprint Effects of fluid resuscitation with 0.9% saline versus a balanced electrolyte solution on acute kidney injury in a rat model of sepsis*
    Feihu Zhou
    1The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 2Department of Critical Care Medicine, Chinese People s Liberation Army General Hospital, Beijing, China 3The Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 4Department of Cardiac Surgery, National University of Heart Center, Singapore 5Department of Anesthesiology, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, PA
    Crit Care Med 42:e270-8. 2014
  8. pmc One dose of cyclosporine A is protective at initiation of folic acid-induced acute kidney injury in mice
    Xiaoyan Wen
    The Clinical Research, Investigation and Systems Modeling of Acute illness Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Nephrol Dial Transplant 27:3100-9. 2012
  9. doi request reprint AKI in the ICU: definition, epidemiology, risk stratification, and outcomes
    Kai Singbartl
    Department of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 81:819-25. 2012
  10. pmc Association of statin use with risk and outcome of acute kidney injury in community-acquired pneumonia
    Raghavan Murugan
    CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin J Am Soc Nephrol 7:895-905. 2012

Collaborators

Detail Information

Publications14

  1. doi request reprint Renal-pulmonary crosstalk
    Kai Singbartl
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Contrib Nephrol 174:65-70. 2011
    ..The fact that multiorgan failure is not only the sum of organ functions lost, but also includes inflammatory dysregulation together with a lack of treatment options greatly emphasizes the need for future research in this area...
  2. doi request reprint Intensivist-led management of brain-dead donors is associated with an increase in organ recovery for transplantation
    K Singbartl
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Transplant 11:1517-21. 2011
    ..Institution of an intensivist-led organ donor support team may be a new and viable strategy to increase the number of organs available for transplantations...
  3. pmc Differential effects of kidney-lung cross-talk during acute kidney injury and bacterial pneumonia
    Kai Singbartl
    Department of Critical Care Medicine, CRISMA Center, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Kidney Int 80:633-44. 2011
    ..Thus, during acute kidney and pneumonia-induced lung injury, clinically relevant kidney-lung interactions are both neutrophil and platelet dependent...
  4. pmc Urinary biomarkers and renal recovery in critically ill patients with renal support
    Nattachai Srisawat
    604 Scaife Hall, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Clin J Am Soc Nephrol 6:1815-23. 2011
    ..Unfortunately, no reliable method to predict renal recovery exists. The discovery of biomarkers to aid in clinical risk prediction for recovery after AKI would represent a significant advance over current practice...
  5. pmc Acute removal of common sepsis mediators does not explain the effects of extracorporeal blood purification in experimental sepsis
    Zhi Yong Peng
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 81:363-9. 2012
    ..These results may have important implications for the design and conduct of future trials in sepsis including defining alternative targets for extracorporeal blood purification and other therapies...
  6. pmc Bactericidal antibiotics temporarily increase inflammation and worsen acute kidney injury in experimental sepsis
    Zhi Yong Peng
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 40:538-43. 2012
    ..To explore the relationships among bactericidal antimicrobial treatment of sepsis, inflammatory response, severity of acute kidney injury, and outcomes...
  7. ncbi request reprint Effects of fluid resuscitation with 0.9% saline versus a balanced electrolyte solution on acute kidney injury in a rat model of sepsis*
    Feihu Zhou
    1The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 2Department of Critical Care Medicine, Chinese People s Liberation Army General Hospital, Beijing, China 3The Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 4Department of Cardiac Surgery, National University of Heart Center, Singapore 5Department of Anesthesiology, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, PA
    Crit Care Med 42:e270-8. 2014
    ..To compare the acute effects of 0.9% saline versus a balanced electrolyte solution on acute kidney injury in a rat model of sepsis...
  8. pmc One dose of cyclosporine A is protective at initiation of folic acid-induced acute kidney injury in mice
    Xiaoyan Wen
    The Clinical Research, Investigation and Systems Modeling of Acute illness Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Nephrol Dial Transplant 27:3100-9. 2012
    ..It does, however, carry a significant risk of nephrotoxicity, especially with chronic use. By contrast, a single dose of CsA may be protective while limiting the risk of nephrotoxicity...
  9. doi request reprint AKI in the ICU: definition, epidemiology, risk stratification, and outcomes
    Kai Singbartl
    Department of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 81:819-25. 2012
    ..Experimental and small observational studies provide evidence that AKI impairs (innate) immunity and is associated with higher infection rates...
  10. pmc Association of statin use with risk and outcome of acute kidney injury in community-acquired pneumonia
    Raghavan Murugan
    CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin J Am Soc Nephrol 7:895-905. 2012
    ..This study examined whether statin use was associated with a lower risk for pneumonia-induced AKI and 1-year and cause-specific mortality in patients with AKI...
  11. doi request reprint Sex differences in deceased donor organ transplantation rates in the United States
    Raghavan Murugan
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Transplantation 92:1278-84. 2011
    ..Understanding sex differences in transplantation will help to design interventions to mitigate disparities in transplantation...
  12. pmc What blood temperature for an ex vivo extracorporeal circuit?
    Thomas Rimmelé
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Artif Organs 35:593-601. 2011
    ..Investigators in this field must be aware of the fact that blood temperature is a crucial confounding parameter and the type of "background noise" they will face depending on the strategy adopted...
  13. doi request reprint Blood purification in sepsis: a new paradigm
    Zhiyong Peng
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Contrib Nephrol 165:322-8. 2010
    ..Finally, the emerging paradigm of sepsis-induced immune suppression provides additional rationale for the development of extracorporeal blood purification therapy for sepsis...
  14. doi request reprint Recovery from acute kidney injury: determinants and predictors
    Nattachai Srisawat
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Contrib Nephrol 165:284-91. 2010
    ..This review will describe the current understanding of the renal recovery process, and the role of clinical severity scores and novel biomarkers such as NGAL, HGF, and cystatin C in predicting renal recovery...