CHARLES SING

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Long-range autocorrelations of CpG islands in the human genome
    Benjamin Koester
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e29889. 2012
  2. ncbi request reprint Dynamic relationships between the genome and exposures to environments as causes of common human diseases
    Charles F Sing
    Departments of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    World Rev Nutr Diet 93:77-91. 2004
  3. ncbi request reprint Genes, environment, and cardiovascular disease
    Charles F Sing
    Department of Human Genetics, University of Michigan, 1241 E Catherine St, 5928 Buhl Bldg, Ann Arbor, MI 48109 0618, USA
    Arterioscler Thromb Vasc Biol 23:1190-6. 2003
  4. pmc Impact of direct soil exposures from airborne dust and geophagy on human health
    David Sing
    Department of Human Genetics, University of Michigan Medical School, 1241 E Catherine Street, Ann Arbor, MI 48109 5618, USA
    Int J Environ Res Public Health 7:1205-23. 2010
  5. ncbi request reprint Genome-wide linkage analyses for hypertension genes in two ethnically and geographically diverse populations
    Sharon L R Kardia
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Am J Hypertens 16:154-7. 2003
  6. pmc Evidence for consistent intragenic and intergenic interactions between SNP effects in the APOA1/C3/A4/A5 gene cluster
    Sara C Hamon
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Hum Hered 61:87-96. 2006
  7. pmc Context-dependent associations between variation in risk of ischemic heart disease and variation in the 5' promoter region of the apolipoprotein E gene in Danish women
    Jari H Stengård
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 5618, USA
    Circ Cardiovasc Genet 3:22-30. 2010
  8. pmc Ethnic heterogeneity in the longitudinal effects of placental vascular blood flow on birthweight
    Vinod K Misra
    Division of Medical Genetics, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, USA
    Am J Obstet Gynecol 198:72.e1-8. 2008
  9. pmc An application of the patient rule-induction method for evaluating the contribution of the Apolipoprotein E and Lipoprotein Lipase genes to predicting ischemic heart disease
    Greg Dyson
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 0618, USA, and Department of Clinical Biochemistry, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Denmark
    Genet Epidemiol 31:515-27. 2007
  10. pmc Modifications to the Patient Rule-Induction Method that utilize non-additive combinations of genetic and environmental effects to define partitions that predict ischemic heart disease
    Greg Dyson
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 0618, USA
    Genet Epidemiol 33:317-24. 2009

Collaborators

Detail Information

Publications24

  1. pmc Long-range autocorrelations of CpG islands in the human genome
    Benjamin Koester
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e29889. 2012
    ....
  2. ncbi request reprint Dynamic relationships between the genome and exposures to environments as causes of common human diseases
    Charles F Sing
    Departments of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    World Rev Nutr Diet 93:77-91. 2004
  3. ncbi request reprint Genes, environment, and cardiovascular disease
    Charles F Sing
    Department of Human Genetics, University of Michigan, 1241 E Catherine St, 5928 Buhl Bldg, Ann Arbor, MI 48109 0618, USA
    Arterioscler Thromb Vasc Biol 23:1190-6. 2003
    ..We make recommendations for what needs to be done to cope with these complexities...
  4. pmc Impact of direct soil exposures from airborne dust and geophagy on human health
    David Sing
    Department of Human Genetics, University of Michigan Medical School, 1241 E Catherine Street, Ann Arbor, MI 48109 5618, USA
    Int J Environ Res Public Health 7:1205-23. 2010
    ..We review the potential for soil exposure as an environmental source of epigenetic signals which may influence the function of our genome in determining health and disease...
  5. ncbi request reprint Genome-wide linkage analyses for hypertension genes in two ethnically and geographically diverse populations
    Sharon L R Kardia
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Am J Hypertens 16:154-7. 2003
    ....
  6. pmc Evidence for consistent intragenic and intergenic interactions between SNP effects in the APOA1/C3/A4/A5 gene cluster
    Sara C Hamon
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Hum Hered 61:87-96. 2006
    ..Evaluate the consistency of the contribution of interactions between single nucleotide polymorphism (SNP) genotype effects to variation in measures of lipid metabolism across ethnic strata within gender...
  7. pmc Context-dependent associations between variation in risk of ischemic heart disease and variation in the 5' promoter region of the apolipoprotein E gene in Danish women
    Jari H Stengård
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 5618, USA
    Circ Cardiovasc Genet 3:22-30. 2010
    ....
  8. pmc Ethnic heterogeneity in the longitudinal effects of placental vascular blood flow on birthweight
    Vinod K Misra
    Division of Medical Genetics, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, USA
    Am J Obstet Gynecol 198:72.e1-8. 2008
    ....
  9. pmc An application of the patient rule-induction method for evaluating the contribution of the Apolipoprotein E and Lipoprotein Lipase genes to predicting ischemic heart disease
    Greg Dyson
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 0618, USA, and Department of Clinical Biochemistry, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Denmark
    Genet Epidemiol 31:515-27. 2007
    ..An independent sample of 362 unrelated individuals also from the city of Copenhagen was used to test the model obtained for each of the hypothesized partitions...
  10. pmc Modifications to the Patient Rule-Induction Method that utilize non-additive combinations of genetic and environmental effects to define partitions that predict ischemic heart disease
    Greg Dyson
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 0618, USA
    Genet Epidemiol 33:317-24. 2009
    ....
  11. pmc The effects of maternal weight gain patterns on term birth weight in African-American women
    Vinod K Misra
    Department of Pediatrics and Communicable Diseases, Division of Medical Genetics, The University of Michigan, Ann Arbor, Michigan, USA
    J Matern Fetal Neonatal Med 23:842-9. 2010
    ....
  12. pmc Complex adaptive system models and the genetic analysis of plasma HDL-cholesterol concentration
    Thomas J Rea
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Perspect Biol Med 49:490-503. 2006
    ....
  13. pmc Understanding the accuracy of statistical haplotype inference with sequence data of known phase
    Aida M Andres
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA
    Genet Epidemiol 31:659-71. 2007
    ..Strategies to improve confidence in reconstructed haplotypes, and realistic alternatives to the analysis of inferred haplotypes, are discussed...
  14. pmc Subsets of SNPs define rare genotype classes that predict ischemic heart disease
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
    Hum Genet 120:865-77. 2007
    ..In conclusion, we present evidence that combinations of SNPs in APOE and LPL identify subgroups of individuals at substantially increased risk of IHD beyond that associated with smoking, diabetes and hypertension...
  15. ncbi request reprint Contrasting multi-site genotypic distributions among discordant quantitative phenotypes: the APOA1/C3/A4/A5 gene cluster and cardiovascular disease risk factors
    Bret A Payseur
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA
    Genet Epidemiol 30:508-18. 2006
    ..Results indicate that this multi-site test can identify genotype-phenotype associations with reasonable power, including those generated by some simple epistatic models...
  16. ncbi request reprint Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants
    Kathy L E Klos
    University of Texas Health Science Center at Houston, School of Public Health, Human Genetics Center, P O Box 20186, Houston, Texas 77225, USA
    Arterioscler Thromb Vasc Biol 26:1828-36. 2006
    ..To identify common variations in genes in the reverse cholesterol transport pathway with nongender-specific influence on plasma lipid and apolipoprotein levels...
  17. pmc Contribution of regulatory and structural variations in APOE to predicting dyslipidemia
    Jari H Stengård
    National Public Health Institute, Helsinki, Finland
    J Lipid Res 47:318-28. 2006
    ..Our study suggests that both regulatory and structural variations should be considered when evaluating the utility of APOE for predicting dyslipidemia in the population at large...
  18. pmc Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism
    Jari H Stengård
    National Public Health Institute, Helsinki, Finland
    Am J Hum Genet 71:501-17. 2002
    ....
  19. ncbi request reprint APOA5 polymorphisms influence plasma triglycerides in young, healthy African Americans and whites of the CARDIA Study
    Kathy L E Klos
    Human Genetics Center, University of Texas Health Science Center, Houston, TX, USA
    J Lipid Res 46:564-71. 2005
    ..46% among white males, and 0-0.69% among African American females. The results of our study suggest a small but replicable context-dependent influence of the APOA5 gene region on plasma TG levels in young, healthy individuals...
  20. pmc Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism
    Stefan Kammerer
    Sequenom, Inc, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:4066-71. 2003
    ..Age-stratified samples appear to be useful for screening SNPs to identify functional gene variants that have an impact on health...
  21. ncbi request reprint Gender- and age-specific contributions of additional DNA sequence variation in the 5' regulatory region of the APOE gene to prediction of measures of lipid metabolism
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Genet 115:331-45. 2004
    ..2059T --> C and g.2197C --> T SNPs doubled the estimate of genetic variance of high-density lipoprotein and apolipoprotein Al in middle-aged females...
  22. pmc Tree scanning: a method for using haplotype trees in phenotype/genotype association studies
    Alan R Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
    Genetics 169:441-53. 2005
    ..Overall, tree scanning is a simple, powerful, and flexible method for using haplotype trees to detect phenotype/genotype associations at candidate loci...
  23. pmc Mining genetic epidemiology data with Bayesian networks application to APOE gene variation and plasma lipid levels
    Andrei Rodin
    Human Genetics Center, University of Texas Health Science Center, 1200 Herman Pressler Drive, Houston, TX 77030, USA
    J Comput Biol 12:1-11. 2005
    ..These results document the utility of a Belief network approach for mining large scale genotype-phenotype association data...
  24. ncbi request reprint Impact of alcohol intake on measures of lipid metabolism depends on context defined by gender, body mass index, cigarette smoking, and apolipoprotein E genotype
    Suzanne Lussier-Cacan
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada cacans ircm qc ca
    Arterioscler Thromb Vasc Biol 22:824-31. 2002
    ..This study emphasizes the context dependency of the influence of alcohol on lipid metabolism and demonstrates how biological, environmental, and genetic factors interact to determine cardiovascular disease risk...

Research Grants32

  1. Modeling DNA Diversity in Reverse Cholesterol Transport
    CHARLES SING; Fiscal Year: 2009
    ..This research not only considers the individual effects of variation in each gene, but their interactions with other genes and with the environment. ..
  2. Modeling DNA Diversity in Reverse Cholesterol Transport
    Charles F Sing; Fiscal Year: 2010
    ..This research not only considers the individual effects of variation in each gene, but their interactions with other genes and with the environment. ..
  3. MODELING DNA DIVERSITY IN CARDIOVASCULAR HEALTH/DISEASE
    CHARLES SING; Fiscal Year: 2000
    ..These studies will provide an unprecedented ..
  4. GENETIC EPIDEMIOLOGY OF CORONARY ARTERY DISEASE
    CHARLES SING; Fiscal Year: 2001
    ....
  5. MODELING DNA DIVERSITY IN CARDIOVASCULAR HEALTH/DISEASE
    CHARLES SING; Fiscal Year: 2001
    ..These studies will provide an unprecedented ..
  6. GENETIC EPIDEMIOLOGY OF CORONARY ARTERY DISEASE
    CHARLES SING; Fiscal Year: 2002
    ....
  7. Modeling DNA Diversity in Reverse Cholesterol Transport
    CHARLES SING; Fiscal Year: 2003
    ..abstract_text> ..
  8. GENETIC EPIDEMIOLOGY OF CORONARY ARTERY DISEASE
    CHARLES SING; Fiscal Year: 2003
    ....
  9. Modeling DNA Diversity in Reverse Cholesterol Transport
    CHARLES SING; Fiscal Year: 2004
    ..abstract_text> ..
  10. GENETIC EPIDEMIOLOGY OF CORONARY ARTERY DISEASE
    CHARLES SING; Fiscal Year: 2004
    ....
  11. Modeling DNA Diversity in Reverse Cholesterol Transport
    CHARLES SING; Fiscal Year: 2005
    ..abstract_text> ..
  12. GENETIC EPIDEMIOLOGY OF CORONARY ARTERY DISEASE
    CHARLES SING; Fiscal Year: 2005
    ....
  13. Modeling DNA Diversity in Reverse Cholesterol Transport
    CHARLES SING; Fiscal Year: 2006
    ..abstract_text> ..
  14. GENETIC EPIDEMIOLOGY OF CORONARY ARTERY DISEASE
    CHARLES SING; Fiscal Year: 2000
    ....
  15. GENETIC EPIDEMIOLOGY OF CORONARY ARTERY DISEASE
    CHARLES SING; Fiscal Year: 1999
    ....
  16. GENETIC EPIDEMIOLOGY OF CORONARY ARTERY DISEASE
    CHARLES SING; Fiscal Year: 1992
    ....
  17. GENETIC EPIDEMIOLOGY OF CORONARY HEART DISEASE
    CHARLES SING; Fiscal Year: 1990
    ....
  18. GENETIC EPIDEMIOLOGY OF CORONARY HEART DISEASE
    CHARLES SING; Fiscal Year: 1991
    ....
  19. GENETIC EPIDEMIOLOGY OF CORONARY ARTERY DISEASE
    CHARLES SING; Fiscal Year: 1993
    ....
  20. MODELING DNA DIVERSITY IN CARDIOVASCULAR HEALTH/DISEASE
    CHARLES SING; Fiscal Year: 1999
    ..These studies will provide an unprecedented ..