Affiliation: University of Michigan
- Genes, environment, and cardiovascular diseaseCharles F Sing
Department of Human Genetics, University of Michigan, 1241 E Catherine St, 5928 Buhl Bldg, Ann Arbor, MI 48109 0618, USA
Arterioscler Thromb Vasc Biol 23:1190-6. 2003..We make recommendations for what needs to be done to cope with these complexities...
- Dynamic relationships between the genome and exposures to environments as causes of common human diseasesCharles F Sing
Departments of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
World Rev Nutr Diet 93:77-91. 2004
- Impact of direct soil exposures from airborne dust and geophagy on human healthDavid Sing
Department of Human Genetics, University of Michigan Medical School, 1241 E Catherine Street, Ann Arbor, MI 48109 5618, USA
Int J Environ Res Public Health 7:1205-23. 2010..We review the potential for soil exposure as an environmental source of epigenetic signals which may influence the function of our genome in determining health and disease...
- Genome-wide linkage analyses for hypertension genes in two ethnically and geographically diverse populationsSharon L R Kardia
Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
Am J Hypertens 16:154-7. 2003....
- Evidence for consistent intragenic and intergenic interactions between SNP effects in the APOA1/C3/A4/A5 gene clusterSara C Hamon
Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
Hum Hered 61:87-96. 2006..Evaluate the consistency of the contribution of interactions between single nucleotide polymorphism (SNP) genotype effects to variation in measures of lipid metabolism across ethnic strata within gender...
- Context-dependent associations between variation in risk of ischemic heart disease and variation in the 5' promoter region of the apolipoprotein E gene in Danish womenJari H Stengård
Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 5618, USA
Circ Cardiovasc Genet 3:22-30. 2010....
- Ethnic heterogeneity in the longitudinal effects of placental vascular blood flow on birthweightVinod K Misra
Division of Medical Genetics, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, USA
Am J Obstet Gynecol 198:72.e1-8. 2008....
- An application of the patient rule-induction method for evaluating the contribution of the Apolipoprotein E and Lipoprotein Lipase genes to predicting ischemic heart diseaseGreg Dyson
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 0618, USA, and Department of Clinical Biochemistry, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Denmark
Genet Epidemiol 31:515-27. 2007..An independent sample of 362 unrelated individuals also from the city of Copenhagen was used to test the model obtained for each of the hypothesized partitions...
- Complex adaptive system models and the genetic analysis of plasma HDL-cholesterol concentrationThomas J Rea
Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109-0618, USA
Perspect Biol Med 49:490-503. 2006....
- Modifications to the Patient Rule-Induction Method that utilize non-additive combinations of genetic and environmental effects to define partitions that predict ischemic heart diseaseGreg Dyson
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 0618, USA
Genet Epidemiol 33:317-24. 2009....
- The effects of maternal weight gain patterns on term birth weight in African-American womenVinod K Misra
Department of Pediatrics and Communicable Diseases, Division of Medical Genetics, The University of Michigan, Ann Arbor, Michigan, USA
J Matern Fetal Neonatal Med 23:842-9. 2010....
- Contribution of regulatory and structural variations in APOE to predicting dyslipidemiaJari H Stengård
National Public Health Institute, Helsinki, Finland
J Lipid Res 47:318-28. 2006..Our study suggests that both regulatory and structural variations should be considered when evaluating the utility of APOE for predicting dyslipidemia in the population at large...
- Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participantsKathy L E Klos
University of Texas Health Science Center at Houston, School of Public Health, Human Genetics Center, P O Box 20186, Houston, Texas 77225, USA
Arterioscler Thromb Vasc Biol 26:1828-36. 2006..To identify common variations in genes in the reverse cholesterol transport pathway with nongender-specific influence on plasma lipid and apolipoprotein levels...
- Contrasting multi-site genotypic distributions among discordant quantitative phenotypes: the APOA1/C3/A4/A5 gene cluster and cardiovascular disease risk factorsBret A Payseur
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA
Genet Epidemiol 30:508-18. 2006..Results indicate that this multi-site test can identify genotype-phenotype associations with reasonable power, including those generated by some simple epistatic models...
- Subsets of SNPs define rare genotype classes that predict ischemic heart diseaseRuth Frikke-Schmidt
Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
Hum Genet 120:865-77. 2007..In conclusion, we present evidence that combinations of SNPs in APOE and LPL identify subgroups of individuals at substantially increased risk of IHD beyond that associated with smoking, diabetes and hypertension...
- Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolismJari H Stengård
National Public Health Institute, Helsinki, Finland
Am J Hum Genet 71:501-17. 2002....
- APOA5 polymorphisms influence plasma triglycerides in young, healthy African Americans and whites of the CARDIA StudyKathy L E Klos
Human Genetics Center, University of Texas Health Science Center, Houston, TX, USA
J Lipid Res 46:564-71. 2005..46% among white males, and 0-0.69% among African American females. The results of our study suggest a small but replicable context-dependent influence of the APOA5 gene region on plasma TG levels in young, healthy individuals...
- Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphismStefan Kammerer
Sequenom, Inc, San Diego, CA 92121, USA
Proc Natl Acad Sci U S A 100:4066-71. 2003..Age-stratified samples appear to be useful for screening SNPs to identify functional gene variants that have an impact on health...
- Understanding the accuracy of statistical haplotype inference with sequence data of known phaseAida M Andres
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA
Genet Epidemiol 31:659-71. 2007..Strategies to improve confidence in reconstructed haplotypes, and realistic alternatives to the analysis of inferred haplotypes, are discussed...
- Gender- and age-specific contributions of additional DNA sequence variation in the 5' regulatory region of the APOE gene to prediction of measures of lipid metabolismRuth Frikke-Schmidt
Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
Hum Genet 115:331-45. 2004..2059T --> C and g.2197C --> T SNPs doubled the estimate of genetic variance of high-density lipoprotein and apolipoprotein Al in middle-aged females...
- Tree scanning: a method for using haplotype trees in phenotype/genotype association studiesAlan R Templeton
Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
Genetics 169:441-53. 2005..Overall, tree scanning is a simple, powerful, and flexible method for using haplotype trees to detect phenotype/genotype associations at candidate loci...
- Mining genetic epidemiology data with Bayesian networks application to APOE gene variation and plasma lipid levelsAndrei Rodin
Human Genetics Center, University of Texas Health Science Center, 1200 Herman Pressler Drive, Houston, TX 77030, USA
J Comput Biol 12:1-11. 2005..These results document the utility of a Belief network approach for mining large scale genotype-phenotype association data...
- Impact of alcohol intake on measures of lipid metabolism depends on context defined by gender, body mass index, cigarette smoking, and apolipoprotein E genotypeSuzanne Lussier-Cacan
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada cacans ircm qc ca
Arterioscler Thromb Vasc Biol 22:824-31. 2002..This study emphasizes the context dependency of the influence of alcohol on lipid metabolism and demonstrates how biological, environmental, and genetic factors interact to determine cardiovascular disease risk...
- Modeling DNA Diversity in Reverse Cholesterol TransportCHARLES SING; Fiscal Year: 2009..This research not only considers the individual effects of variation in each gene, but their interactions with other genes and with the environment. ..
- Modeling DNA Diversity in Reverse Cholesterol TransportCharles F Sing; Fiscal Year: 2010..This research not only considers the individual effects of variation in each gene, but their interactions with other genes and with the environment. ..
- MODELING DNA DIVERSITY IN CARDIOVASCULAR HEALTH/DISEASECHARLES SING; Fiscal Year: 2001..These studies will provide an unprecedented ..
- GENETIC EPIDEMIOLOGY OF CORONARY ARTERY DISEASECHARLES SING; Fiscal Year: 2005....
- Modeling DNA Diversity in Reverse Cholesterol TransportCHARLES SING; Fiscal Year: 2006..abstract_text> ..
- GENETIC EPIDEMIOLOGY OF CORONARY ARTERY DISEASECHARLES SING; Fiscal Year: 2000....
- GENETIC EPIDEMIOLOGY OF CORONARY HEART DISEASECHARLES SING; Fiscal Year: 1991....
- GENETIC EPIDEMIOLOGY OF CORONARY ARTERY DISEASECHARLES SING; Fiscal Year: 1993....