Scott E Sinclair

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. ncbi request reprint Augmented lung injury due to interaction between hyperoxia and mechanical ventilation
    Scott E Sinclair
    Departments of Medicine and Physiology, University of Tennessee, Memphis, TN 38163, USA
    Crit Care Med 32:2496-501. 2004
  2. ncbi request reprint Therapeutic hypercapnia and ventilation-perfusion matching in acute lung injury: low minute ventilation vs inspired CO2
    Scott E Sinclair
    Department of Medicine, University of Tennessee, 956 Court Ave, Room H314, Memphis, TN 38163, USA
    Chest 130:85-92. 2006
  3. pmc Positive end-expiratory pressure alters the severity and spatial heterogeneity of ventilator-induced lung injury: an argument for cyclical airway collapse
    Scott E Sinclair
    Department of Medicine, University of Tennessee, TN, USA
    J Crit Care 24:206-11. 2009
  4. pmc Deletion of apoptosis signal-regulating kinase-1 prevents ventilator-induced lung injury in mice
    Patrudu S Makena
    Department of Medicine, University of Tennessee Health Science Center, Memphis, USA
    Am J Respir Cell Mol Biol 46:461-9. 2012
  5. pmc CXCR4 regulates migration of lung alveolar epithelial cells through activation of Rac1 and matrix metalloproteinase-2
    Manik C Ghosh
    Department of Physiology, Univ of Tennessee Health Science Center, Memphis, TN 38163, USA
    Am J Physiol Lung Cell Mol Physiol 302:L846-56. 2012
  6. pmc Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH2-terminal kinase activation
    Patrudu S Makena
    Dept of Medicine, Univ of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Appl Physiol 111:1467-76. 2011
  7. ncbi request reprint Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injury
    Scott E Sinclair
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington, BB 1253 HSB Box 356522, Seattle, WA 98195 6522, USA
    Am J Respir Crit Care Med 166:403-8. 2002
  8. pmc Preexposure to hyperoxia causes increased lung injury and epithelial apoptosis in mice ventilated with high tidal volumes
    Patrudu S Makena
    Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Am J Physiol Lung Cell Mol Physiol 299:L711-9. 2010
  9. pmc Spatial distribution of sequential ventilation during mechanical ventilation of the uninjured lung: an argument for cyclical airway collapse and expansion
    Scott E Sinclair
    Department of Medicine, University of Tennessee Health Sciences Center, 956 Court Ave E222, Memphis, TN 38163 USA
    BMC Pulm Med 10:25. 2010
  10. pmc Insulin-like growth factor-I stimulates differentiation of ATII cells to ATI-like cells through activation of Wnt5a
    Manik C Ghosh
    Dept of Physiology, Univ of Tennessee Health Science Center, 894 Union Ave, 426 Nash, Memphis, TN 38163
    Am J Physiol Lung Cell Mol Physiol 305:L222-8. 2013

Research Grants

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Augmented lung injury due to interaction between hyperoxia and mechanical ventilation
    Scott E Sinclair
    Departments of Medicine and Physiology, University of Tennessee, Memphis, TN 38163, USA
    Crit Care Med 32:2496-501. 2004
    ..Mechanical overdistension and hyperoxia can independently cause lung injury, yet little is known about their combined effects. We hypothesized that hyperoxia exacerbates lung injury caused by large tidal volume ventilation...
  2. ncbi request reprint Therapeutic hypercapnia and ventilation-perfusion matching in acute lung injury: low minute ventilation vs inspired CO2
    Scott E Sinclair
    Department of Medicine, University of Tennessee, 956 Court Ave, Room H314, Memphis, TN 38163, USA
    Chest 130:85-92. 2006
    ..We hypothesized the presence of hypercapnic acidosis from inspired carbon dioxide (ICD) would improve gas exchange in ALI and would be superior to that of low minute ventilation (LVe) produced by reduced respiratory rate, rather than Vt...
  3. pmc Positive end-expiratory pressure alters the severity and spatial heterogeneity of ventilator-induced lung injury: an argument for cyclical airway collapse
    Scott E Sinclair
    Department of Medicine, University of Tennessee, TN, USA
    J Crit Care 24:206-11. 2009
    ..We hypothesized that mechanical ventilation in the absence of positive end-expiratory pressure (PEEP) causes VILI to be more severe and regionally variable as compared with PEEP = 8 cm H(2)O...
  4. pmc Deletion of apoptosis signal-regulating kinase-1 prevents ventilator-induced lung injury in mice
    Patrudu S Makena
    Department of Medicine, University of Tennessee Health Science Center, Memphis, USA
    Am J Respir Cell Mol Biol 46:461-9. 2012
    ..ASK-1 is an important regulator of lung injury and apoptosis in this model. Further study is needed to determine the mechanism of lung injury and apoptosis by ASK-1 and its downstream mediators in the lung...
  5. pmc CXCR4 regulates migration of lung alveolar epithelial cells through activation of Rac1 and matrix metalloproteinase-2
    Manik C Ghosh
    Department of Physiology, Univ of Tennessee Health Science Center, Memphis, TN 38163, USA
    Am J Physiol Lung Cell Mol Physiol 302:L846-56. 2012
    ..Similar results were obtained with shRNA knockdown of CXCR4. These findings may help identify a therapeutic target for augmenting epithelial repair following acute lung injury...
  6. pmc Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH2-terminal kinase activation
    Patrudu S Makena
    Dept of Medicine, Univ of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Appl Physiol 111:1467-76. 2011
    ..NAC protects lung injury and apoptosis by inhibiting ROS-mediated activation of JNK and downstream proapoptotic signaling...
  7. ncbi request reprint Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injury
    Scott E Sinclair
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington, BB 1253 HSB Box 356522, Seattle, WA 98195 6522, USA
    Am J Respir Crit Care Med 166:403-8. 2002
    ..18 x 10(5) versus 2.84 x 10(5) +/- 0.28 x 10(5) nucleated cells/ml; p = 0.021), and injury score (7.0 +/- 3.3 versus 0.7 +/- 0.9; p < 0.0001). We conclude that hypercapnic acidosis is protective against VILI in this model...
  8. pmc Preexposure to hyperoxia causes increased lung injury and epithelial apoptosis in mice ventilated with high tidal volumes
    Patrudu S Makena
    Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Am J Physiol Lung Cell Mol Physiol 299:L711-9. 2010
    ..Immunohistochemistry and in vitro stretch studies showed caspase cleavage in alveolar epithelial cells. In conclusion, preexposure to HO followed by HV produced severe lung injury associated with alveolar epithelial cell apoptosis...
  9. pmc Spatial distribution of sequential ventilation during mechanical ventilation of the uninjured lung: an argument for cyclical airway collapse and expansion
    Scott E Sinclair
    Department of Medicine, University of Tennessee Health Sciences Center, 956 Court Ave E222, Memphis, TN 38163 USA
    BMC Pulm Med 10:25. 2010
    ..This regional injury heterogeneity was abolished by the application of PEEP = 8 cm H2O. We hypothesized that the spatial distribution of lung injury correlates with areas in which cyclical airway collapse and recruitment occurs...
  10. pmc Insulin-like growth factor-I stimulates differentiation of ATII cells to ATI-like cells through activation of Wnt5a
    Manik C Ghosh
    Dept of Physiology, Univ of Tennessee Health Science Center, 894 Union Ave, 426 Nash, Memphis, TN 38163
    Am J Physiol Lung Cell Mol Physiol 305:L222-8. 2013
    ..Treatment of wounded cells with either IGF-I or Wnt5a stimulated wound closure. These results suggest that IGF-I promotes differentiation of ATII to ATI cells through the activation of a noncanonical Wnt pathway. ..
  11. doi request reprint Prolonged glucocorticoid treatment and secondary prevention in acute respiratory distress syndrome
    G Umberto Meduri
    Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center and Memphis Veterans Affairs Medical Center 111, 1030 Jefferson Avenue, Suite Room CW444, Memphis, TN 38104, USA
    Expert Rev Respir Med 4:201-10. 2010
    ....
  12. pmc Regulation and function of the two-pore-domain (K2P) potassium channel Trek-1 in alveolar epithelial cells
    Andreas Schwingshackl
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee 38111, USA
    Am J Physiol Lung Cell Mol Physiol 302:L93-L102. 2012
    ....
  13. ncbi request reprint Hyperoxia in the intensive care unit: why more is not always better
    William A Altemeier
    Department of Medicine, University of Washington, Seattle, Washington 98195 6522, USA
    Curr Opin Crit Care 13:73-8. 2007
    ..This review identifies relevant new findings regarding hyperoxic lung injury in the context of providing guidance for future clinical studies...
  14. pmc Airway strain during mechanical ventilation in an intact animal model
    Scott E Sinclair
    Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Nash 426, Memphis, TN 38163, USA
    Am J Respir Crit Care Med 176:786-94. 2007
    ..Little direct evidence exists regarding the deformation of airways in vivo during mechanical ventilation, or in the presence of positive end-expiratory pressure (PEEP)...
  15. ncbi request reprint High tidal volume mechanical ventilation with hyperoxia alters alveolar type II cell adhesion
    Leena P Desai
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Am J Physiol Lung Cell Mol Physiol 293:L769-78. 2007
    ..Mechanical ventilation with hyperoxia promotes changes in focal adhesion proteins and RhoA in AT2 cells that may be deleterious for cell adhesion and migration...
  16. doi request reprint Activation and regulation of systemic inflammation in ARDS: rationale for prolonged glucocorticoid therapy
    G Umberto Meduri
    Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Chest 136:1631-43. 2009
    ..75; 95% CI, 0.63 to 0.89; p < 0.001; I(2), 43%) and for those treated before day 14 (RR, 0.71; 95% CI, 0.59 to 0.85; p < 0.001; I(2), 40%)...
  17. pmc Balance of life and death in alveolar epithelial type II cells: proliferation, apoptosis, and the effects of cyclic stretch on wound healing
    Lynn M Crosby
    Department of Physiology, University of Tennessee Health Science Center, Memphis, USA
    Am J Physiol Lung Cell Mol Physiol 301:L536-46. 2011
    ..Our results suggest that CS alters several mechanisms of epithelial repair and that an imbalance occurs between cell death and proliferation that must be overcome to restore the epithelial barrier...
  18. ncbi request reprint Cyclic mechanical strain increases reactive oxygen species production in pulmonary epithelial cells
    Kenneth E Chapman
    Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA
    Am J Physiol Lung Cell Mol Physiol 289:L834-41. 2005
    ..NADPH oxidase activity was increased after 2 h of CMS, contributing to the production of O2-. Increased ROS production in lung epithelial cells in response to elevated stretch may contribute to the onset of VILI...

Research Grants1

  1. Ventilator-Induced Lung Injury:Mechanisms & Consequences
    Scott Sinclair; Fiscal Year: 2005
    ..Aim 3A: Document cyclical airway collapse and reopening via changes in regional ventilation distribution. Aim 3B: Validate a method to estimate appropriate PEEP level to prevent cyclical airway collapse. ..