Alan Sinaiko

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Relation of insulin resistance to blood pressure in childhood
    Alan R Sinaiko
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Hypertens 20:509-17. 2002
  2. ncbi request reprint The early natural history of nephropathy in Type 1 Diabetes: III. Predictors of 5-year urinary albumin excretion rate patterns in initially normoalbuminuric patients
    Julia M Steinke
    Division of Pediatric Nephrology, Department of Pediatrics, University of Minnesota, 420 Delaware St, SE, MMC 491, Minneapolis, MN 55455, USA
    Diabetes 54:2164-71. 2005
  3. pmc Modifiable risk factors associated with bone deficits in childhood cancer survivors
    Lynda E Polgreen
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    BMC Pediatr 12:40. 2012
  4. ncbi request reprint Influence of insulin resistance and body mass index at age 13 on systolic blood pressure, triglycerides, and high-density lipoprotein cholesterol at age 19
    Alan R Sinaiko
    Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minn 55455, USA
    Hypertension 48:730-6. 2006
  5. pmc Relation of blood pressure and body mass index during childhood to cardiovascular risk factor levels in young adults
    Erin R Rademacher
    Department of Pediatrics, University of Rochester, New York 14642, USA
    J Hypertens 27:1766-74. 2009
  6. ncbi request reprint Relation of leptin to insulin resistance syndrome in children
    Julia Steinberger
    Department of Pediatrics, University of Minnesota Medical School, University of Minnesota School of Public Health, Minneapolis, Minnesota 55455, USA
    Obes Res 11:1124-30. 2003
  7. ncbi request reprint Relation of birth weight to fasting insulin, insulin resistance, and body size in adolescence
    Maureen A Murtaugh
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    Diabetes Care 26:187-92. 2003
  8. pmc Benefits of Renin-Angiotensin blockade on retinopathy in type 1 diabetes vary with glycemic control
    Tasma Harindhanavudhi
    Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    Diabetes Care 34:1838-42. 2011
  9. pmc Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents
    Erica M Holt
    Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis, USA
    J Am Diet Assoc 109:414-21. 2009
  10. pmc Impact of pubertal development on endothelial function and arterial elasticity
    Kara L Marlatt
    Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, MN
    J Pediatr 163:1432-6. 2013

Research Grants

Detail Information

Publications40

  1. ncbi request reprint Relation of insulin resistance to blood pressure in childhood
    Alan R Sinaiko
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Hypertens 20:509-17. 2002
    ..To determine the relation between blood pressure and insulin resistance in children and the differences between fasting insulin and the insulin clamp in that relation...
  2. ncbi request reprint The early natural history of nephropathy in Type 1 Diabetes: III. Predictors of 5-year urinary albumin excretion rate patterns in initially normoalbuminuric patients
    Julia M Steinke
    Division of Pediatric Nephrology, Department of Pediatrics, University of Minnesota, 420 Delaware St, SE, MMC 491, Minneapolis, MN 55455, USA
    Diabetes 54:2164-71. 2005
    ..Since 64% of the patients that developed microalbuminuria reverted to normoalbuminuria, the risk of diabetic nephropathy as defined by current microalbuminuria criteria is unclear...
  3. pmc Modifiable risk factors associated with bone deficits in childhood cancer survivors
    Lynda E Polgreen
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    BMC Pediatr 12:40. 2012
    ..To determine the prevalence and severity of bone deficits in a cohort of childhood cancer survivors (CCS) compared to a healthy sibling control group, and the modifiable factors associated with bone deficits in CCS...
  4. ncbi request reprint Influence of insulin resistance and body mass index at age 13 on systolic blood pressure, triglycerides, and high-density lipoprotein cholesterol at age 19
    Alan R Sinaiko
    Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minn 55455, USA
    Hypertension 48:730-6. 2006
    ..These results show an effect for insulin resistance that is independent of BMI, consistent with the hypothesis that reducing insulin resistance, in addition to weight, may be needed to reduce the prevalence of cardiovascular risk...
  5. pmc Relation of blood pressure and body mass index during childhood to cardiovascular risk factor levels in young adults
    Erin R Rademacher
    Department of Pediatrics, University of Rochester, New York 14642, USA
    J Hypertens 27:1766-74. 2009
    ..Although childhood BMI and blood pressure (BP) track into adulthood, how they influence adult cardiovascular risk independent of each other is not well defined...
  6. ncbi request reprint Relation of leptin to insulin resistance syndrome in children
    Julia Steinberger
    Department of Pediatrics, University of Minnesota Medical School, University of Minnesota School of Public Health, Minneapolis, Minnesota 55455, USA
    Obes Res 11:1124-30. 2003
    ..To examine the relation of leptin to insulin resistance, as measured by euglycemic insulin clamp, and insulin resistance syndrome factors in thin and heavy children...
  7. ncbi request reprint Relation of birth weight to fasting insulin, insulin resistance, and body size in adolescence
    Maureen A Murtaugh
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    Diabetes Care 26:187-92. 2003
    ..A relationship between birth weight and the insulin resistance syndrome has been reported in adults but has not been defined in adolescents...
  8. pmc Benefits of Renin-Angiotensin blockade on retinopathy in type 1 diabetes vary with glycemic control
    Tasma Harindhanavudhi
    Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    Diabetes Care 34:1838-42. 2011
    ..In the current study, we evaluate whether glycemic control influenced the benefit of RAS blockade on DR progression in type 1 diabetic patients...
  9. pmc Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents
    Erica M Holt
    Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis, USA
    J Am Diet Assoc 109:414-21. 2009
    ..Markers of inflammation and oxidative stress are predictors of coronary heart disease risk; however, it is unknown whether these markers are related to dietary flavonoid and antioxidant intake in youth...
  10. pmc Impact of pubertal development on endothelial function and arterial elasticity
    Kara L Marlatt
    Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, MN
    J Pediatr 163:1432-6. 2013
    ....
  11. doi request reprint Measurement of insulin sensitivity in children: comparison between the euglycemic-hyperinsulinemic clamp and surrogate measures
    Betsy Schwartz
    Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Diabetes Care 31:783-8. 2008
    ..e., homeostasis model assessment [HOMA], quantitative insulin sensitivity check index [QUICKI], and fasting glucose-to-insulin ratio [FGIR]) or triglycerides to the insulin clamp in a cohort of children/adolescents...
  12. pmc Renal and retinal effects of enalapril and losartan in type 1 diabetes
    Michael Mauer
    Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    N Engl J Med 361:40-51. 2009
    ..Nephropathy and retinopathy remain important complications of type 1 diabetes. It is unclear whether their progression is slowed by early administration of drugs that block the renin-angiotensin system...
  13. ncbi request reprint Plasma protein profiling: unique and stable features of individuals
    Gary L Nelsestuen
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    Proteomics 5:4012-24. 2005
    ....
  14. doi request reprint Top-down proteomic analysis by MALDI-TOF profiling: Concentration-independent biomarkers
    Gary L Nelsestuen
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA
    Proteomics Clin Appl 2:158-66. 2008
    ..Diagnosis by longitudinal analysis of the same individual might increase sensitivity of protein biomarkers by 20-fold or more. Protein changes that exceed the range of values found among healthy individuals may be uncommon...
  15. doi request reprint Changes in insulin resistance and cardiovascular risk during adolescence: establishment of differential risk in males and females
    Antoinette Moran
    Department of Pediatrics, University of Minnesota, 516 Delaware St SE, Minneapolis, MN 55454, USA
    Circulation 117:2361-8. 2008
    ..Developmental changes in insulin resistance and cardiovascular risk were studied in youths 11 to 19 years of age...
  16. pmc Circulating activated endothelial cells in pediatric obesity
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Pediatr 157:547-51. 2010
    ..We characterized the state of the vascular endothelium in pediatric obesity by comparing circulating endothelial cell (CEC) number and activation phenotype in severely obese children to that of normal weight, overweight, and obese children...
  17. pmc The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 S Second St, Suite 300, Minneapolis, MN 55454 1015, USA
    Hum Genet 125:21-8. 2009
    ..There are several other variants in ADIPOQ, ADIPOR1, and ADIPOR2 that may influence insulin sensitivity and these variants should be further investigated in other populations...
  18. pmc Influence of waist on adiponectin and insulin sensitivity in adolescence
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    Obesity (Silver Spring) 17:156-61. 2009
    ..These results support the hypothesis that adiponectin may contribute to the association of waist and insulin sensitivity...
  19. doi request reprint Albuminuria in children
    Erin R Rademacher
    Division of Pediatric Nephrology, Department of Pediatrics, University of Rochester, Rochester, New York 14642, USA
    Curr Opin Nephrol Hypertens 18:246-51. 2009
    ..Because the roots of these diseases extend back into childhood, assessment of albuminuria has become relevant to child and adolescent clinical care...
  20. pmc Relation of circulating oxidized LDL to obesity and insulin resistance in children
    Aaron S Kelly
    Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Pediatr Diabetes 11:552-5. 2010
    ..The purpose of this study was to assess the relation of oxidative stress, measured by circulating oxidized LDL, with measures of adiposity and insulin resistance in children...
  21. pmc Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin sensitivity in a mixed-age cohort
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454 1015, USA
    Metabolism 58:1369-71. 2009
    ..No significant associations were seen between rs7903146 and insulin sensitivity. Adjusted genotype means were consistent across races and generational subgroups...
  22. ncbi request reprint Effect of oral glucose loading on endothelial function in normal-weight and overweight children
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Sci (Lond) 112:493-8. 2007
    ..6 compared with 20.2+/-2.0% respectively; P=0.019). In conclusion, these results suggest that acute elevation of glucose and insulin in overweight and normal-weight children are not associated with impairment in endothelial function...
  23. ncbi request reprint Association between the insulin resistance of puberty and the insulin-like growth factor-I/growth hormone axis
    Antoinette Moran
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Clin Endocrinol Metab 87:4817-20. 2002
    ..04), whereas IGFBP-3 correlated positively with insulin resistance in boys (P = 0.0004) but not girls (P = 0.85). These data suggest that the GH/IGF-I axis is an important contributor to the insulin resistance of puberty...
  24. ncbi request reprint Relation of insulin resistance and body composition to left ventricular mass in children
    Julia Steinberger
    Department of Pediatrics, University of Minnesota Medical School, MMC 94, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Am J Cardiol 90:1177-80. 2002
  25. ncbi request reprint ACE-I and ARBs in early diabetic nephropathy
    Michael Mauer
    MMC 491, 420 SE Delaware St, Minneapolis, MN 55455, USA
    J Renin Angiotensin Aldosterone Syst 3:262-9. 2002
    ....
  26. ncbi request reprint Whole grain intake is associated with lower body mass and greater insulin sensitivity among adolescents
    Lyn M Steffen
    Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis 55454, USA
    Am J Epidemiol 158:243-50. 2003
    ..02). This relation was stronger among adolescents with higher BMIs (p = 0.001). Whole grain intake was associated with greater insulin sensitivity and lower BMI in adolescents, especially among the heaviest persons...
  27. ncbi request reprint Insulin resistance and cardiovascular disease risk factors in children of parents with the insulin resistance (metabolic) syndrome
    James S Pankow
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Diabetes Care 27:775-80. 2004
    ..To evaluate whether children of parents with the insulin resistance syndrome (IRS) themselves have greater insulin resistance and unfavorable patterns of cardiovascular disease (CVD) risk factors...
  28. ncbi request reprint Relation of body mass index and insulin resistance to cardiovascular risk factors, inflammatory factors, and oxidative stress during adolescence
    Alan R Sinaiko
    Department of Pediatrics, University of Minnesota Medical School, 420 Delaware St SE, Box 491 UMHC, Minneapolis, MN 55455, USA
    Circulation 111:1985-91. 2005
    ..This study assessed the relation of fatness and insulin resistance and their interaction with cardiovascular risk factors, inflammatory factors, and oxidative stress in thin and heavy adolescents...
  29. ncbi request reprint Relation of C-reactive protein to insulin resistance and cardiovascular risk factors in youth
    Antoinette Moran
    Deprtment of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Diabetes Care 28:1763-8. 2005
    ..Insulin resistance and C-reactive protein (CRP) levels are strongly correlated in adults. This study explored the relationship in youth...
  30. ncbi request reprint Relation of increase in adiposity to increase in left ventricular mass from childhood to young adulthood
    Shanthi Sivanandam
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Am J Cardiol 98:411-5. 2006
    ....
  31. ncbi request reprint Obesity and inflammation in children
    Sarah Jane Schwarzenberg
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Paediatr Respir Rev 7:239-46. 2006
    ..The study of inflammation in the context of excessive adipose tissue is central to understanding obesity and modifying its impact on patients...
  32. doi request reprint Gender differences in vascular function and insulin sensitivity in young adults
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Sci (Lond) 120:153-60. 2011
    ..However, the lower EID observed in males could not be explained by artery diameter. Future studies need to continue to examine influence of gender on EID and other measures of vascular function...
  33. pmc Albumin excretion rate in normal adolescents: relation to insulin resistance and cardiovascular risk factors and comparisons to type 1 diabetes mellitus patients
    Erin Rademacher
    University of Minnesota, Department of Pediatrics, MMC 491, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Clin J Am Soc Nephrol 3:998-1005. 2008
    ....
  34. pmc Impact of treatment exposures on cardiovascular risk and insulin resistance in childhood cancer survivors
    K Scott Baker
    Authors Affiliations Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington University of California San Diego and Rady Children s Hospital, San Diego, California Children s Hospitals and Clinics of Minnesota and Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
    Cancer Epidemiol Biomarkers Prev 22:1954-63. 2013
    ..This study examines specific treatment exposures associated with cardiovascular risk factors and insulin resistance...
  35. pmc Diagnosis of cardiac disease in pediatric end-stage renal disease
    Blanche M Chavers
    Department of Pediatrics University of Minnesota Amplatz Children s Hospital, Minneapolis, MN, USA
    Nephrol Dial Transplant 26:1640-5. 2011
    ..This study aimed to report the frequency of cardiac disease diagnostic methods used in US pediatric maintenance hemodialysis patients...
  36. pmc The co-occurrence of obesity, elevated blood pressure, and acanthosis nigricans among American Indian school children: identifying individual heritage and environment-level correlates
    Mary O Hearst
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Am J Hum Biol 23:346-52. 2011
    ..To estimate the prevalence and explore the social and cultural etiologic roots of weight status, blood pressure, and acanthosis nigricans among American Indian children on a reservation in South Dakota...
  37. ncbi request reprint Troponin I levels in a hemolytic uremic syndrome patient with severe cardiac failure
    Varvara Askiti
    Division of Nephrology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Pediatr Nephrol 19:345-8. 2004
    ..1 microg/l), and peaked (140.6 microg/l) at 24 h. It then fell gradually and was normal at discharge. These results suggest that measurement of cTnI may be a useful predictor of cardiac involvement in severely affected children with HUS...
  38. ncbi request reprint The relation of ambulatory blood pressure and pulse rate to retinopathy in type 1 diabetes mellitus: the renin-angiotensin system study
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705 2397, USA
    Ophthalmology 113:2231-6. 2006
    ....
  39. ncbi request reprint The relationship of diabetic retinopathy to preclinical diabetic glomerulopathy lesions in type 1 diabetic patients: the Renin-Angiotensin System Study
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI, USA
    Diabetes 54:527-33. 2005
    ..These data demonstrate a significant association between diabetic retinopathy and preclinical morphologic changes of diabetic nephropathy in type 1 diabetic patients...
  40. doi request reprint Comparing the automated versus manual method of needle biopsy for renal histology artefacts
    Sandra Donnelly
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Nephrol Dial Transplant 23:2098-100. 2008

Research Grants13

  1. INFLUENCE OF INSULIN ON BP CHANGE DURING ADOLESCENCE
    Alan Sinaiko; Fiscal Year: 2003
    ....
  2. IINFLUENCE OF INSULIN ON BLOOD PRESSURE CHANGE DURING AD
    Alan Sinaiko; Fiscal Year: 1999
    ..Insulin resistance will be determined during euglycemic insulin clamp studies. Echocardiograms will be obtained using 2D-Echoguided M-mode imaging with Doppler to assess left ventricular measurements and total peripheral resistance. ..
  3. INFLUENCE OF INSULIN ON BP CHANGE DURING ADOLESCENCE
    Alan Sinaiko; Fiscal Year: 2007
    ..It can improve the health of the population by providing the scientific information required to develop prevention and intervention strategies that can be applied prior to establishment of the disease process. ..