Robert U Simpson

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Antisense oligonucleotides targeted against protein kinase Cbeta and CbetaII block 1,25-(OH)2D3-induced differentiation
    R U Simpson
    Department of Pharmacology, The University of Michigan, Ann Arbor, Michigan 48109 0632, USA
    J Biol Chem 273:19587-91. 1998
  2. ncbi Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse
    Robert U Simpson
    Department of Pharmacology, University of Michigan, School of Medicine, 1301 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0632, USA
    J Steroid Biochem Mol Biol 103:521-4. 2007
  3. ncbi Characterization of vitamin D receptor (VDR) in lung adenocarcinoma
    So Hee Kim
    Division of Medical Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Lung Cancer 77:265-71. 2012
  4. ncbi 1,25-Dihydroxyvitamin-D3 treatment reduces cardiac hypertrophy and left ventricular diameter in spontaneously hypertensive heart failure-prone (cp/+) rats independent of changes in serum leptin
    Peter Mancuso
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Cardiovasc Pharmacol 51:559-64. 2008
  5. ncbi Functional vitamin D receptor (VDR) in the t-tubules of cardiac myocytes: VDR knockout cardiomyocyte contractility
    Daniel X Tishkoff
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Endocrinology 149:558-64. 2008
  6. ncbi Interaction between vitamin D receptor with caveolin-3 and regulation by 1,25-dihydroxyvitamin D3 in adult rat cardiomyocytes
    Guisheng Zhao
    Department of Pharmacology, University of Michigan, School of Medicine, Ann Arbor, MI 48109, USA
    J Steroid Biochem Mol Biol 121:159-63. 2010
  7. ncbi Membrane localization, Caveolin-3 association and rapid actions of vitamin D receptor in cardiac myocytes
    Guisheng Zhao
    Department of Pharmacology, University of Michigan, School of Medicine, Ann Arbor, MI 48109, USA
    Steroids 75:555-9. 2010
  8. ncbi 1,25(OH)2-vitamin D3 actions on cell proliferation, size, gene expression, and receptor localization, in the HL-1 cardiac myocyte
    Karl A Nibbelink
    Department of Pharmacology, University of Michigan School of Medicine, 1301 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0632, USA
    J Steroid Biochem Mol Biol 103:533-7. 2007
  9. ncbi CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma
    Guoan Chen
    Section of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 17:817-26. 2011
  10. ncbi Heart extracellular matrix gene expression profile in the vitamin D receptor knockout mice
    Ayesha Rahman
    Department of Pharmacology, University of Michigan Medical School, 1301 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0632, USA
    J Steroid Biochem Mol Biol 103:416-9. 2007

Research Grants

  1. Vitamin D regulation of ECM in model of heart failure
    Robert Simpson; Fiscal Year: 2007

Collaborators

  • David G Beer
  • Dafydd G Thomas
  • Lili Zhao
  • Peter D R Higgins
  • Peter Mancuso
  • Lin Lin
  • K T Weber
  • Amanda N King
  • Guisheng Zhao
  • So Hee Kim
  • Guoan Chen
  • Nithya Ramnath
  • Paul J Christensen
  • Daniel X Tishkoff
  • Karl A Nibbelink
  • Ayesha Rahman
  • Laura A Johnson
  • Dean E Brenner
  • Thomas J Giordano
  • John J Green
  • Bruce Hollis
  • Chae Kyung Jeon
  • Kay L Sauder
  • Eva S Rodansky
  • Zhuwen Wang
  • Kristina H Holmberg
  • Loredana Dandu
  • Karl Nibbelink
  • Salahuddin Ahmed
  • Stephen Hershey
  • Stephen D Hershey
  • Margaret V Westfall
  • Dustin A Robinson
  • G E Wilson

Detail Information

Publications14

  1. ncbi Antisense oligonucleotides targeted against protein kinase Cbeta and CbetaII block 1,25-(OH)2D3-induced differentiation
    R U Simpson
    Department of Pharmacology, The University of Michigan, Ann Arbor, Michigan 48109 0632, USA
    J Biol Chem 273:19587-91. 1998
    ..D.) but had no effect on 1,25-(OH)2D3 inhibition of cellular proliferation. These results indicate that the effects of 1,25-(OH)2D3 on HL-60 cell differentiation and proliferation can be dissociated by blocking PKCbetaII expression...
  2. ncbi Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse
    Robert U Simpson
    Department of Pharmacology, University of Michigan, School of Medicine, 1301 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0632, USA
    J Steroid Biochem Mol Biol 103:521-4. 2007
    ..Data presented here reveal that ablation of the VDR signaling system results in profound changes in heart structure. We propose that calcitriol acts directly on the heart as a tranquilizer by blunting cardiomyocyte hypertrophy...
  3. ncbi Characterization of vitamin D receptor (VDR) in lung adenocarcinoma
    So Hee Kim
    Division of Medical Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Lung Cancer 77:265-71. 2012
    ..In the present study, we characterized VDR expression in lung adenocarcinoma (AC)...
  4. ncbi 1,25-Dihydroxyvitamin-D3 treatment reduces cardiac hypertrophy and left ventricular diameter in spontaneously hypertensive heart failure-prone (cp/+) rats independent of changes in serum leptin
    Peter Mancuso
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Cardiovasc Pharmacol 51:559-64. 2008
    ..These studies suggest that 1,25(OH)2D3 treatment may prevent the development of cardiac hypertrophy, an important contributing factor in the progression of congestive heart failure...
  5. ncbi Functional vitamin D receptor (VDR) in the t-tubules of cardiac myocytes: VDR knockout cardiomyocyte contractility
    Daniel X Tishkoff
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Endocrinology 149:558-64. 2008
    ..This novel discovery is fundamentally important in understanding 1,25(OH)(2)D(3) signal transduction in heart cells and provides further evidence that the VDR plays a role in heart structure and function...
  6. ncbi Interaction between vitamin D receptor with caveolin-3 and regulation by 1,25-dihydroxyvitamin D3 in adult rat cardiomyocytes
    Guisheng Zhao
    Department of Pharmacology, University of Michigan, School of Medicine, Ann Arbor, MI 48109, USA
    J Steroid Biochem Mol Biol 121:159-63. 2010
    ....
  7. ncbi Membrane localization, Caveolin-3 association and rapid actions of vitamin D receptor in cardiac myocytes
    Guisheng Zhao
    Department of Pharmacology, University of Michigan, School of Medicine, Ann Arbor, MI 48109, USA
    Steroids 75:555-9. 2010
    ....
  8. ncbi 1,25(OH)2-vitamin D3 actions on cell proliferation, size, gene expression, and receptor localization, in the HL-1 cardiac myocyte
    Karl A Nibbelink
    Department of Pharmacology, University of Michigan School of Medicine, 1301 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0632, USA
    J Steroid Biochem Mol Biol 103:533-7. 2007
    ..1,25D treatment also increased expression and nuclear localization of the VDR in these cardiac myocytes. Thus 1,25D is an important hormone involved in modulating and maintaining heart cell structure and function...
  9. ncbi CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma
    Guoan Chen
    Section of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 17:817-26. 2011
    ..The purpose of our study was to assess CYP24A1 as a prognostic marker and to study its relevance to antiproliferative activity of 1,25-D(3) in lung AC cells...
  10. ncbi Heart extracellular matrix gene expression profile in the vitamin D receptor knockout mice
    Ayesha Rahman
    Department of Pharmacology, University of Michigan Medical School, 1301 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0632, USA
    J Steroid Biochem Mol Biol 103:416-9. 2007
    ..This data supports a role for 1,25D in heart ECM metabolism and suggests that MMPs and TIMPs expression may be modulated by vitamin D...
  11. ncbi CARD-024, a vitamin D analog, attenuates the pro-fibrotic response to substrate stiffness in colonic myofibroblasts
    Laura A Johnson
    University of Michigan, Department of Internal Medicine, Ann Arbor, MI 48109 0682, United States
    Exp Mol Pathol 93:91-8. 2012
    ..In summary, CARD-024 attenuated the pro-fibrotic response of colonic myofibroblasts to high matrix stiffness, suggesting that vitamin D analogs such as CARD-024 may ameliorate intestinal fibrosis...
  12. ncbi Calcitriol modulation of cardiac contractile performance via protein kinase C
    John J Green
    Department of Surgery, Cardiac Surgery Section, Ann Arbor, MI 48109, USA
    J Mol Cell Cardiol 41:350-9. 2006
    ..Phosphorylation of key Ca(2+) regulatory proteins by this kinase contributes to the enhanced relaxation observed in response to acute, but not chronic calcitriol...
  13. ncbi The vitamin D/CYP24A1 story in cancer
    Amanda N King
    Department of Medicine, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Anticancer Agents Med Chem 10:213-24. 2010
    ..The following review summarizes the available literature on CYP24A1 as it relates to 1,25(OH)(2)D(3) in cancer and outlines potential ways to inhibit CYP24A1 in an effort to improve the efficacy of exogenous 1,25(OH)(2)D(3)...
  14. ncbi Vitamin D and calcium dyshomoeostasis-associated heart failure
    Karl T Weber
    Heart 94:540-1. 2008

Research Grants4

  1. Vitamin D regulation of ECM in model of heart failure
    Robert Simpson; Fiscal Year: 2007
    ..Moreover, it will determine if decreased vitamin D metabolite levels correlate with changes in heart collagen and MMP in an established model of heart failure. ..