G M Simpson

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Double-blind study of clozapine dose response in chronic schizophrenia
    G M Simpson
    Medical College of Pennsylvania Hahnemann University, Philadelphia, USA
    Am J Psychiatry 156:1744-50. 1999
  2. ncbi request reprint Six-month, blinded, multicenter continuation study of ziprasidone versus olanzapine in schizophrenia
    George M Simpson
    Department of Psychiatry and the Behavioral Sciences, LAC USC Medical Center, IRD RM 204, Psychiatric Outpatient Clinic, 2020 Zonal Ave, Los Angeles, CA 90033, USA
    Am J Psychiatry 162:1535-8. 2005
  3. ncbi request reprint Long-term improvement in efficacy and safety after switching to ziprasidone in stable outpatients with schizophrenia
    George M Simpson
    Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine University of Southern California, Los Angeles, CA, USA
    CNS Spectr 13:898-905. 2008
  4. ncbi request reprint Randomized, controlled, double-blind multicenter comparison of the efficacy and tolerability of ziprasidone and olanzapine in acutely ill inpatients with schizophrenia or schizoaffective disorder
    George M Simpson
    Department of Psychiatry and the Behavioral Sciences, LAC USC Medical Center, IRD RM 204, Psychiatric Outpatient Clinic, 2020 Zonal Ave, Los Angeles, CA 90033, USA
    Am J Psychiatry 161:1837-47. 2004
  5. ncbi request reprint The apparent effects of ziprasidone on plasma lipids and glucose
    S J Kingsbury
    Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    J Clin Psychiatry 62:347-9. 2001
  6. ncbi request reprint Effectiveness of switching to ziprasidone for stable but symptomatic outpatients with schizophrenia
    Peter J Weiden
    Department of Psychiatry, SUNY Downstate Medical Center State, Brooklyn, NY 11203, USA
    J Clin Psychiatry 64:580-8. 2003
  7. ncbi request reprint A 1-year double-blind study of 2 doses of long-acting risperidone in stable patients with schizophrenia or schizoaffective disorder
    George M Simpson
    Department of Psychiatry, Keck School of Medicine of the University of Southern California, Los Angeles, USA
    J Clin Psychiatry 67:1194-203. 2006
  8. ncbi request reprint Does clozapine decrease smoking?
    Jose de Leon
    Mental Health Research Center at Eastern State Hospital, 627 West Fourth St, Lexington, KY 40508, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:757-62. 2005
  9. ncbi request reprint Psychopharmacology: the need for effectiveness trials to inform evidence-based psychiatric practice
    Isabel T Lagomasino
    University of Southern California Keck School of Medicine, 2020 Zonal Avenue, IRD 218, Los Angeles, California 90033, USA
    Psychiatr Serv 56:649-51. 2005
  10. ncbi request reprint An 8-week open-label trial of a 6-day course of mifepristone for the treatment of psychotic depression
    George M Simpson
    Department of Psychiatry, Keck School of Medicine, University of Southern California, 2020 Zonal Avenue, IRD 202, Los Angeles, CA 90033, USA
    J Clin Psychiatry 66:598-602. 2005

Detail Information

Publications27

  1. ncbi request reprint Double-blind study of clozapine dose response in chronic schizophrenia
    G M Simpson
    Medical College of Pennsylvania Hahnemann University, Philadelphia, USA
    Am J Psychiatry 156:1744-50. 1999
    ..This study explored the relative efficacy of three different doses of clozapine...
  2. ncbi request reprint Six-month, blinded, multicenter continuation study of ziprasidone versus olanzapine in schizophrenia
    George M Simpson
    Department of Psychiatry and the Behavioral Sciences, LAC USC Medical Center, IRD RM 204, Psychiatric Outpatient Clinic, 2020 Zonal Ave, Los Angeles, CA 90033, USA
    Am J Psychiatry 162:1535-8. 2005
    ..The authors' goal was to compare the efficacy and tolerability of 6 months' treatment with flexible-dose ziprasidone and olanzapine in patients with schizophrenia or schizoaffective disorder...
  3. ncbi request reprint Long-term improvement in efficacy and safety after switching to ziprasidone in stable outpatients with schizophrenia
    George M Simpson
    Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine University of Southern California, Los Angeles, CA, USA
    CNS Spectr 13:898-905. 2008
    ....
  4. ncbi request reprint Randomized, controlled, double-blind multicenter comparison of the efficacy and tolerability of ziprasidone and olanzapine in acutely ill inpatients with schizophrenia or schizoaffective disorder
    George M Simpson
    Department of Psychiatry and the Behavioral Sciences, LAC USC Medical Center, IRD RM 204, Psychiatric Outpatient Clinic, 2020 Zonal Ave, Los Angeles, CA 90033, USA
    Am J Psychiatry 161:1837-47. 2004
    ..The authors compared the efficacy and tolerability of ziprasidone and olanzapine in the treatment of acutely ill inpatients with schizophrenia or schizoaffective disorder...
  5. ncbi request reprint The apparent effects of ziprasidone on plasma lipids and glucose
    S J Kingsbury
    Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    J Clin Psychiatry 62:347-9. 2001
    ..Ziprasidone treatment appeared to have no significant effect on BMI or glucose level, perhaps due to the small number of subjects. CONCLUSION: Ziprasidone appears to independently lead to a lowering of serum lipid levels...
  6. ncbi request reprint Effectiveness of switching to ziprasidone for stable but symptomatic outpatients with schizophrenia
    Peter J Weiden
    Department of Psychiatry, SUNY Downstate Medical Center State, Brooklyn, NY 11203, USA
    J Clin Psychiatry 64:580-8. 2003
    ....
  7. ncbi request reprint A 1-year double-blind study of 2 doses of long-acting risperidone in stable patients with schizophrenia or schizoaffective disorder
    George M Simpson
    Department of Psychiatry, Keck School of Medicine of the University of Southern California, Los Angeles, USA
    J Clin Psychiatry 67:1194-203. 2006
    ..This study examined the effects of 2 doses of long-acting risperidone injection in patients with schizophrenia or schizoaffective disorder...
  8. ncbi request reprint Does clozapine decrease smoking?
    Jose de Leon
    Mental Health Research Center at Eastern State Hospital, 627 West Fourth St, Lexington, KY 40508, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:757-62. 2005
    ..New prospective longitudinal studies using repeated cotinine and clozapine levels are needed to explore whether clozapine may reduce smoking in some patients...
  9. ncbi request reprint Psychopharmacology: the need for effectiveness trials to inform evidence-based psychiatric practice
    Isabel T Lagomasino
    University of Southern California Keck School of Medicine, 2020 Zonal Avenue, IRD 218, Los Angeles, California 90033, USA
    Psychiatr Serv 56:649-51. 2005
  10. ncbi request reprint An 8-week open-label trial of a 6-day course of mifepristone for the treatment of psychotic depression
    George M Simpson
    Department of Psychiatry, Keck School of Medicine, University of Southern California, 2020 Zonal Avenue, IRD 202, Los Angeles, CA 90033, USA
    J Clin Psychiatry 66:598-602. 2005
    ..The goals of this study were to extend these findings by conducting an 8-week trial of mifepristone for subjects with psychotic depression who were taking no concomitant psychiatric medications...
  11. ncbi request reprint Plasma clozapine concentration coefficients of variation in a long-term study
    Francisco J Diaz
    Department of Statistics, Universidad Nacional, Medellin, Colombia
    Schizophr Res 72:131-5. 2005
    ..Clozapine CVs may be important in order to understand the importance of variations around the therapeutic range and to interpret drug interactions above the usual noise of measuring plasma concentrations...
  12. ncbi request reprint Psychopharmacology: principles for starting, stopping, or switching medications
    Steven J Kingsbury
    Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Psychiatr Serv 53:139-40. 2002
  13. ncbi request reprint Weight gain during a double-blind multidosage clozapine study
    Jose de Leon
    Mental Health Research Center, Eastern State Hospital, Lexington, KY 40508, USA
    J Clin Psychopharmacol 27:22-7. 2007
    ..32, n = 43), but seems to be strongly correlated in nonsmokers. Despite its limitations, this study indicates that baseline BMI, dosing, and, possibly, the African-American race may be major determinants of clozapine-induced weight gain...
  14. ncbi request reprint Possible individual and gender differences in the small increases in plasma prolactin levels seen during clozapine treatment
    Jose de Leon
    Clinical Research Center, Norristown State Hospital, Norristown, PA, USA
    Eur Arch Psychiatry Clin Neurosci 254:318-25. 2004
    ..6) correlation between clozapine and prolactin levels. This study suggests that clozapine has effects on prolactin levels but effects are small and may be more evident in some individuals, particularly females...
  15. ncbi request reprint Improvement in cognitive function following a switch to ziprasidone from conventional antipsychotics, olanzapine, or risperidone in outpatients with schizophrenia
    Philip D Harvey
    Mt Sinai School of Medicine, New York University, 1425 Madison Avenue, Fourth Floor, New York, NY 10029, USA
    Schizophr Res 66:101-13. 2004
    ....
  16. doi request reprint Paliperidone extended-release tablets in schizophrenia patients previously treated with risperidone
    Carla M Canuso
    Ortho McNeil Janssen Scientific Affairs LLC, Titusville, NJ, USA
    Int Clin Psychopharmacol 23:209-15. 2008
    ..4% with placebo. In patients who had received risperidone previously but remained sufficiently symptomatic for enrollment, paliperidone ER was significantly more effective than placebo in reducing symptoms and producing functional gains...
  17. ncbi request reprint Sertraline as monotherapy in the treatment of psychotic and nonpsychotic depression
    George M Simpson
    Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Clin Psychiatry 64:959-65. 2003
    ..The purpose of the present study was to examine the response to sertraline for patients with and without psychotic features using standard criteria such as recovery and remission...
  18. ncbi request reprint Serum antimuscarinic activity during clozapine treatment
    Jose de Leon
    Mental Health Research Center, Eastern State Hospital, 627 West Fourth Street, Lexington, KY 40508, USA
    J Clin Psychopharmacol 23:336-41. 2003
    ..In vitro studies and new clinical studies are needed to verify whether norclozapine may significantly contribute to antimuscarinic activity during clozapine treatment...
  19. ncbi request reprint The National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project: schizophrenia trial design and protocol development
    T Scott Stroup
    Department of Psychiatry, University of North Carolina School of Medicine, Neurosciences Hospital, Chapel Hill 27599 7160, USA
    Schizophr Bull 29:15-31. 2003
    ..If the phase 2 study drug is discontinued, subjects may enter phase 3, in which clinicians help subjects select an open-label treatment based on individuals' experiences in phases 1 and 2...
  20. ncbi request reprint Underuse of evidence-based pharmacotherapies for affective disorders
    Megan Dwight-Johnson
    Department of Psychiatry and Behavioral Science, University of Southern California Keck School of Medicine, Los Angeles, 91604, USA
    Psychiatr Serv 54:1076-8. 2003
  21. ncbi request reprint Delirium in HIV-associated dementia
    Suad Kapetanovic
    J Am Acad Child Adolesc Psychiatry 45:767-8; reply 768-9. 2006
  22. ncbi request reprint Review of antipsychotics in children and adolescents
    Suad Kapetanovic
    University of Southern California Keck School of Medicine, Department of Psychiatry, Division of Child and Adolescent Psychiatry, 2020 Zonal Avenue, IRD Building, Room 13, Los Angeles, California 90033, USA
    Expert Opin Pharmacother 7:1871-85. 2006
    ..The review ends with the authors' opinion on the clinical and research implications for the field and future directions...
  23. ncbi request reprint Atypical antipsychotics and the burden of disease
    George M Simpson
    Department of Psychiatry and the Behavioral Sciences, LAC USC Medical Center, Los Angeles, CA 90033, USA
    Am J Manag Care 11:S235-41. 2005
    ..Because of their improved tolerability, the atypicals offer the prospect of improved compliance and reduced risk of relapse, thus decreasing costs by the need for less hospitalization...
  24. ncbi request reprint Cross-cultural psychopharmacology: a current clinical perspective
    Edmond H Pi
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Psychiatr Serv 56:31-3. 2005
  25. ncbi request reprint Patients' preference for conventional antipsychotic medications
    Osama Abulseoud
    Department of Psychiatry and Behavioral Sciences of the Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Psychiatr Serv 53:537-8, 547. 2002
  26. ncbi request reprint Postmortem clozapine levels
    Jose de Leon
    J Clin Psychopharmacol 24:100-1. 2004
  27. ncbi request reprint Haloperidol half-life after chronic dosing
    Jose de Leon
    Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA
    J Clin Psychopharmacol 24:656-60. 2004
    ..This study suggests that haloperidol half-life following repeated drug administration is substantially more prolonged than what has been observed after acute haloperidol administration...