P J Simpson-Haidaris

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Tumors and fibrinogen. The role of fibrinogen as an extracellular matrix protein
    P J Simpson-Haidaris
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14620, USA
    Ann N Y Acad Sci 936:406-25. 2001
  2. ncbi Induction of fibrinogen expression in the lung epithelium during Pneumocystis carinii pneumonia
    P J Simpson-Haidaris
    Departments of Medicine Vascular Medicine Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Infect Immun 66:4431-9. 1998
  3. ncbi Polarized secretion of fibrinogen by lung epithelial cells
    G Guadiz
    Department of Medicine Vascular Medicine Unit, University of Rochester School of Medicine and Dentistry, New York
    Am J Respir Cell Mol Biol 17:60-9. 1997
  4. ncbi Cloning and characterization of a lung-specific cDNA corresponding to the gamma chain of hepatic fibrinogen
    P J Simpson-Haidaris
    Department of Medicine, Microbiology and Pathology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Gene 167:273-8. 1995
  5. ncbi Molecular characterization of mouse Pneumocystis carinii surface glycoprotein A
    C G Haidaris
    Department of Microbiology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    DNA Res 5:77-85. 1998
  6. ncbi Fibrinogen binding potentiates FGF-2 but not VEGF induced expression of u-PA, u-PAR, and PAI-1 in endothelial cells
    A Sahni
    Department of Medicine, Hematology Oncology Unit, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Thromb Haemost 2:1629-36. 2004
  7. ncbi Antigenic properties of recombinant glycosylated and nonglycosylated Pneumocystis carinii glycoprotein A polypeptides expressed in baculovirus-infected insect cells
    C G Haidaris
    Department of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry, NY 14642, USA
    Mol Biotechnol 9:91-7. 1998
  8. ncbi Fibrinogen assembly, secretion, and deposition into extracellular matrix by MCF-7 human breast carcinoma cells
    B J Rybarczyk
    Department of Pathology, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    Cancer Res 60:2033-9. 2000
  9. ncbi Fibrinogen modulates gene expression in wounded fibroblasts
    M Pereira
    Department of Medicine-Vascular Medicine Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Ann N Y Acad Sci 936:438-43. 2001
  10. ncbi Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2)
    A Sahni
    Hematology Oncology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Thromb Haemost 6:176-83. 2008

Collaborators

Detail Information

Publications14

  1. ncbi Tumors and fibrinogen. The role of fibrinogen as an extracellular matrix protein
    P J Simpson-Haidaris
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14620, USA
    Ann N Y Acad Sci 936:406-25. 2001
    ..This review focuses on FBG within tumors and its relationship with other tumor constituents, ultimately focusing on the role of FBG in breast cancer...
  2. ncbi Induction of fibrinogen expression in the lung epithelium during Pneumocystis carinii pneumonia
    P J Simpson-Haidaris
    Departments of Medicine Vascular Medicine Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Infect Immun 66:4431-9. 1998
    ..carinii to the lung epithelium...
  3. ncbi Polarized secretion of fibrinogen by lung epithelial cells
    G Guadiz
    Department of Medicine Vascular Medicine Unit, University of Rochester School of Medicine and Dentistry, New York
    Am J Respir Cell Mol Biol 17:60-9. 1997
    ..These data provide evidence that FBG is secreted by lung alveolar epithelial cells vectorially toward the basement membrane, which may reflect in vivo processes associated with local injury, inflammation, and repair mechanisms...
  4. ncbi Cloning and characterization of a lung-specific cDNA corresponding to the gamma chain of hepatic fibrinogen
    P J Simpson-Haidaris
    Department of Medicine, Microbiology and Pathology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Gene 167:273-8. 1995
    ..Since expression of FBG is up-regulated 2-10-fold in the liver during an inflammatory event, it is possible that lung-specific gamma FBG expression occurs predominantly during lung disease or injury...
  5. ncbi Molecular characterization of mouse Pneumocystis carinii surface glycoprotein A
    C G Haidaris
    Department of Microbiology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    DNA Res 5:77-85. 1998
    ..carinii demonstrated 156 identical residues, including 46 cysteines, further supporting the hypothesis for conserved secondary structure, as well as function, for gpA from all P. carinii...
  6. ncbi Fibrinogen binding potentiates FGF-2 but not VEGF induced expression of u-PA, u-PAR, and PAI-1 in endothelial cells
    A Sahni
    Department of Medicine, Hematology Oncology Unit, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Thromb Haemost 2:1629-36. 2004
    ..We conclude that fibrinogen increases the capacity of FGF-2, but not of VEGF, to up-regulate u-PA, u-PAR, and PAI-1 in endothelial cells and that fibrinogen-bound FGF-2 requires alphaVbeta3 binding to up-regulate endothelial cell u-PA...
  7. ncbi Antigenic properties of recombinant glycosylated and nonglycosylated Pneumocystis carinii glycoprotein A polypeptides expressed in baculovirus-infected insect cells
    C G Haidaris
    Department of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry, NY 14642, USA
    Mol Biotechnol 9:91-7. 1998
    ..carinii surface glycoprotein were conserved in the recombinant polypeptide, and to investigate its glycosylation by insect cells. B-cell epitopes were retained, but the insect cells appeared to hyperglycosylate the recombinant protein...
  8. ncbi Fibrinogen assembly, secretion, and deposition into extracellular matrix by MCF-7 human breast carcinoma cells
    B J Rybarczyk
    Department of Pathology, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    Cancer Res 60:2033-9. 2000
    ..Taken together, the data suggest that endogenous synthesis and secretion of FBG is, at least in part, the source of FBG deposition in the ECM of breast cell carcinomas...
  9. ncbi Fibrinogen modulates gene expression in wounded fibroblasts
    M Pereira
    Department of Medicine-Vascular Medicine Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Ann N Y Acad Sci 936:438-43. 2001
    ..Taken together, these data suggest that FBG may function independently of hemostasis in cellular adhesive interactions to modulate cellular signaling processes during wound repair...
  10. ncbi Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2)
    A Sahni
    Hematology Oncology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Thromb Haemost 6:176-83. 2008
    ..Fibrinogen and fibrin bind to FGF-2 and modulate FGF-2 functions. Furthermore, we have shown that extrahepatic epithelial cells are capable of endogenous production of fibrinogen...
  11. ncbi Integrin alphavbeta3-mediated endocytosis of immobilized fibrinogen by A549 lung alveolar epithelial cells
    T M Odrljin
    Departments of Medicine/Vascular Medicine Unit, Microbiology and Immunology, Center for Oral Biology, Pediatrics, and Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Respir Cell Mol Biol 24:12-21. 2001
    ..Together, these results suggest that endocytosis of matrix-associated FBG by alveolar epithelial cells may be involved in the processes of alveolar tissue repair and matrix remodeling...
  12. ncbi Fibrinogen naples I (B beta A68T) nonsubstrate thrombin-binding capacities
    D A Meh
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53201-2178, USA
    Thromb Res 103:63-73. 2001
    ..Thus, reduced high-affinity thrombin binding to homozygotic Naples I fibrin may be related to the absence of low-affinity binding sites...
  13. ncbi Plasma fibrinogen gamma' chain content in the thrombotic microangiopathy syndrome
    M W Mosesson
    The Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 5:62-9. 2007
    ..Together, the gamma'(423P) and gamma'(427L) chains comprise the total plasma fibrinogen gamma' chain content...
  14. ncbi Cloning of the complete coding sequence of rat fibrinogen B beta chain cDNA: interspecies conservation of fibrin beta 15-42 primary structure
    M A Courtney
    Department of Medicine Hematology Unit, University of Rochester School of Medicine and Dentistry, NY 14642
    Blood Coagul Fibrinolysis 5:487-96. 1994
    ....