Research Topics
| James SimpkinsSummaryAffiliation: University of North Texas Country: USA Publications
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Publications
Estrogen treatment following severe burn injury reduces brain inflammation and apoptotic signalingJoshua W Gatson
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Neuroinflammation 6:30. 2009....- Estrogens, progestins, menopause and neurodegeneration: basic and clinical studiesJ W Simpkins
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
Cell Mol Life Sci 62:271-80. 2005..Further clinical assessment of appropriate regimens of estrogens, progestins and their combination are supported by these data... - Psychopathology in multiple sclerosis: diagnosis, prevalence and treatmentIda S Haussleiter
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER Focused On Resources for her Health, Education and Research, University of North Texas Health Science Center, Fort Worth, TX, USA
Ther Adv Neurol Disord 2:13-29. 2009..In any event, psychiatric comorbidity in MS deserves greater clinical attention than has been previously paid, because the presence of psychopathology may have deleterious effects on the disease process and impair coping with disability... - Mitochondria play a central role in estrogen-induced neuroprotectionJames W Simpkins
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76102, USA
Curr Drug Targets CNS Neurol Disord 4:69-83. 2005.... - Estrogen actions on mitochondria--physiological and pathological implicationsJames W Simpkins
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
Mol Cell Endocrinol 290:51-9. 2008.... - More than a decade of estrogen neuroprotectionJames W Simpkins
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA
Alzheimers Dement 4:S131-6. 2008.... - Role of nonfeminizing estrogens in brain protection from cerebral ischemia: an animal model of Alzheimer's disease neuropathologyJames W Simpkins
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
Ann N Y Acad Sci 1052:233-42. 2005.... - Phenolic Compounds Protect Cultured Hippocampal Neurons against Ethanol-Withdrawal Induced Oxidative StressKatalin Prokai Tatrai
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA E Mails J W S M E J
Int J Mol Sci 10:1773-87. 2009.... - Role of protein phosphatases and mitochondria in the neuroprotective effects of estrogensJames W Simpkins
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science, Fort Worth, TX 76107, USA
Front Neuroendocrinol 30:93-105. 2009..Collectively, these multifaceted, coordinated action of estrogens leads to their potency in protecting neurons from a wide variety of acute insults as well as chronic neurodegenerative processes... - Role of ethnicity in the expression of features of hot flashesJames W Simpkins
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Maturitas 63:341-6. 2009..Collectively, our results show more frequent and more bothersome HFs in African-American women and more frequent, but less intense and bothersome HFs in Hispanic women in comparison to Caucasian women... - Commentary on "Alzheimer's Disease Drug Development and the Problem of the Blood-Brain Barrier"James W Simpkins
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA
Alzheimers Dement 5:433-4. 2009.... - The potential for estrogens in preventing Alzheimer's disease and vascular dementiaJames W Simpkins
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER Focused On Resources for her Health, Education and Research, University of North Texas Health Science Center, Fort Worth, TX, USA
Ther Adv Neurol Disord 2:31-49. 2009..Several approaches to enhance brain specificity of estrogen action are now underway in an attempt to reduce the side effects of chronic estrogen therapy in AD... - Mitochondrial mechanisms of estrogen neuroprotectionJames W Simpkins
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, 3500 Camp Bowie Boul, Fort Worth, TX 76102, USA
Brain Res Rev 57:421-30. 2008.... - Mitochondrial mechanisms of estrogen neuroprotectionJames W Simpkins
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA
Biochim Biophys Acta 1800:1113-20. 2010..As such, estrogens and novel non-hormonal analogs have come to figure prominently in our efforts to protect neurons against both acute brain injury and chronic neurodegeneration... - Estrogen-like compounds for ischemic neuroprotectionJames W Simpkins
Department of Pharmacology and Neuroscience, 3500 Camp Bowie Blvd, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Stroke 35:2648-51. 2004..These potent, nonfeminizing estrogen analogues are prime candidates for use in stroke neuroprotection... - Neuroprotective effects of a novel non-receptor-binding estrogen analogue: in vitro and in vivo analysisRan Liu
Department of Pharmacology and Neuroscience, Health Science Center at Fort Worth, University of North Texas, 76107, USA
Stroke 33:2485-91. 2002..It also suggests that both the neuroprotective and vasoactive effects of estrogen are receptor independent... - Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female ratsYi Wen
Department of Pharmacology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
J Biol Chem 279:22684-92. 2004.... - Role of protein phosphatases in estrogen-mediated neuroprotectionKun Don Yi
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
J Neurosci 25:7191-8. 2005..These results suggest that 17beta-estradiol may protect cells against glutamate-induced oxidative stress and excitotoxicity by activating a combination of protein phosphatases... - Mechanism of okadaic acid-induced neuronal death and the effect of estrogensKun Don Yi
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
J Neurochem 108:732-40. 2009.... - Oxidative damage to human lens epithelial cells in culture: estrogen protection of mitochondrial potential, ATP, and cell viabilityXiaofei Wang
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
Invest Ophthalmol Vis Sci 44:2067-75. 2003.... - Protein phosphatase 1, protein phosphatase 2A, and calcineurin play a role in estrogen-mediated neuroprotectionKun Don Yi
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
Endocrinology 149:5235-43. 2008..Therefore, we conclude that in the face of cytotoxic challenges in vitro and in vivo, estrogens maintain the function of PP1, PP2A, and calcineurin... - Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivoEvelyn Perez
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
Brain Res 1038:216-22. 2005..Further, in view of the now known toxicities of chronic feminizing estrogen use in older women, non-feminizing estrogens may be a useful alternative for estrogen-induced brain protection... - Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cellsXiaofei Wang
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
Mol Pharmacol 70:395-404. 2006..In conclusion, estrogens exert protective effects against oxidative stress by inhibiting lipid peroxidation and subsequently preserving Ca2+ homeostasis, mitochondrial membrane potential, and ATP levels... - Intermittent hypoxia conditioning prevents behavioral deficit and brain oxidative stress in ethanol-withdrawn ratsMarianna E Jung
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
J Appl Physiol 105:510-7. 2008..We conclude that IH conditioning during chronic ethanol consumption attenuates oxidative damage to the brain and mitigates behavioral abnormalities during subsequent EW. IH-induced ROS may evoke this powerful protection... - Neuroendocrine mechanism for tolerance to cerebral ischemia-reperfusion injury in male ratsShao-Hua Yang
Department of Pharmacology and Neuroscience, Health Science Center at Fort Worth, University of North Texas, Fort Worth, Texas 76107, USA
J Neurobiol 62:341-51. 2005..In summary, stress-induced testosterone reduction contributes to ischemia tolerance in cerebral ischemia-reperfusion injury in males, which could be related to the loss of inhibition by testosterone of Hsp70 and -90 expression... - Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivativeKatalin Prokai-Tatrai
Department of Pharmacology and Neuroscience, UNT Health Science Center, Fort Worth, TX 76107, USA
Steroids 73:280-8. 2008..Taken together, our report argues for a previously unrecognized antioxidant cycle for estrogen-derived compounds... - Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable mannerZhang Zhang
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Brain Res 1345:176-81. 2010..Our results show that cdk5 is involved in OA-induced tau hyperphosphorylation, and estrogens ameliorate the tau hyperphosphorylation, which may be mediated in part by ER... - Dose dependence and therapeutic window for the neuroprotective effects of 17beta-estradiol when administered after cerebral ischemiaRan Liu
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
Neurosci Lett 415:237-41. 2007..These findings suggest that postischemic treatment with estrogen affords protection against ischemic damage and that it acts within a clinically useful therapeutic window... - Estrogens as protectants of the neurovascular unit against ischemic strokeShao-Hua Yang
Department of Pharmacology and Neuroscience, Health Science Center, University of North Texas, Fort Worth, TX. 76123, USA
Curr Drug Targets CNS Neurol Disord 4:169-77. 2005.... - Role of nonfeminizing estrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicityD Maneesh Kumar
Department of Cell Biology and Genetics, UNT Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
Free Radic Biol Med 38:1152-63. 2005..The data support the hypothesis that estrogen analogues may be useful in the treatment of neurodegenerative diseases, particularly in neuroprotection of retinal ganglion cells in ocular pathologies such as glaucoma... - Estrogen receptor-independent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activationKun Don Yi
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
J Pharmacol Exp Ther 324:1188-95. 2008.... - Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cellsPaul Aoun
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
Invest Ophthalmol Vis Sci 44:2999-3004. 2003..These results suggest that PPAR-gamma agonists, in addition to improving insulin sensitivity, may also provide a valuable antioxidant benefit that could prove valuable in targeting ocular complications including glaucoma... - Mitochondrial localization of estrogen receptor betaShao Hua Yang
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
Proc Natl Acad Sci U S A 101:4130-5. 2004..In summary, this study demonstrated that ERbeta is localized to mitochondria, suggesting a role for mitochondrial ERbeta in estrogen effects on this important organelle... - Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemiaYi Wen
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107-2699, USA
Brain Res 1008:147-54. 2004..These studies also provide evidence that suppression of post-ischemic inflammation may play a critical role in estrogen-mediated neuroprotection... - Estradiol protects against cerebellar damage and motor deficit in ethanol-withdrawn ratsMarianna E Jung
Department of Pharmacology and Neuroscience, University of North Texas HSC at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
Alcohol 26:83-93. 2002..These findings support the suggestion that E(2) exerts protective effects against withdrawal signs, cerebellar neuronal damage, and motoric impairment in subjects exposed to, and withdrawn from, chronic ethanol exposure... - Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compoundsLaszlo Prokai
Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Pharmacol Ther 114:1-12. 2007..This review highlights recent structure-activity studies that revealed the importance of antioxidant effects for neuroprotective estrogen analogues and derivatives... - Transient cerebral ischemia induces site-specific hyperphosphorylation of tau proteinYi Wen
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
Brain Res 1022:30-8. 2004..Finally, our results also suggest that neuronal apoptosis may be a therapeutic target in preventing tauopathy-related neurodegenerative diseases... - A prototypical Sigma-1 receptor antagonist protects against brain ischemiaJohn A Schetz
Department of Pharmacology and Neuroscience, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
Brain Res 1181:1-9. 2007.... - Estrogens and progesterone as neuroprotectants: what animal models teach usMeharvan Singh
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Front Biosci 13:1083-9. 2008.... - Subcellular distribution of native estrogen receptor alpha and beta subtypes in cultured human lens epithelial cellsPatrick R Cammarata
Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth, TX, USA
Exp Eye Res 78:861-71. 2004.... - Ethanol withdrawal provokes mitochondrial injury in an estrogen preventable mannerMarianna E Jung
Department of Pharmacology, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
J Bioenerg Biomembr 40:35-44. 2008..These findings demonstrate that EW provokes oxidative injury to mitochondrial membranes in a manner that is exacerbated by estrogen deprivation... - Estrogens directly potentiate neuronal L-type Ca2+ channelsSaumyendra N Sarkar
Department of Pharmacology and Neuroscience and the Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Proc Natl Acad Sci U S A 105:15148-53. 2008.... - Ethanol withdrawal provokes opening of the mitochondrial membrane permeability transition pore in an estrogen-preventable mannerMarianna E Jung
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
J Pharmacol Exp Ther 328:692-8. 2009..These findings suggest that EW provokes PTP opening partly but not entirely through the pro-oxidant nature and that E2 counteracts EW-associated factors to protect against the PTP opening... - Estrogen receptor beta as a mitochondrial vulnerability factorShao Hua Yang
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
J Biol Chem 284:9540-8. 2009..These data demonstrate that ERbeta is expressed in mitochondria and function as a mitochondrial vulnerability factor involved in Deltapsim maintenance, potentially through a mitochondrial transcription dependent mechanism... - Role of the GABAA system in behavioral, motoric, and cerebellar protection by estrogen during ethanol withdrawalMridula Rewal
Department of Pharmacology and Neuroscience, University of North Texas HSC at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
Alcohol 31:49-61. 2003..Also, results of the current study provide indirect evidence that the GABAergic system is involved in protective effects of E(2) against the EW syndrome... - Role of protein kinase C in estrogen protection against apoptotic cerebellar cell death in ethanol-withdrawn ratsMarianna E Jung
Department of Pharmacology and Neuroscience, University of North Texas HSC at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
Alcohol 31:39-48. 2003.... - Role of parvalbumin in estrogen protection from ethanol withdrawal syndromeMridula Rewal
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas 76107 2699, USA
Alcohol Clin Exp Res 29:1837-44. 2005..This study examined whether ethanol exposure and/or ethanol withdrawal (EW) alter the levels of PA in a manner that is protected by 17beta-estradiol (E2)... - Ethanol withdrawal posttranslationally decreases the activity of cytochrome c oxidase in an estrogen reversible mannerMarianna E Jung
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
Neurosci Lett 416:160-4. 2007..Neither EW nor E2 altered the protein levels of the subunits. These findings suggest that a counteracting relationship exists between the effects of EW and E2 on the activity of COX in a subunit specific manner... - Role of the GABA-A system in estrogen-induced protection against brain lipid peroxidation in ethanol-withdrawn ratsMridula Rewal
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
Alcohol Clin Exp Res 28:1907-15. 2004..In this study, we examined the effect of the GABA-A antagonist bicuculline on the neuroprotective effect of E2 by assessing the oxidative marker thiobarbituric acid reactive substances (TBARS) during ethanol withdrawal (EW)... - Suppression of protein kinase Cepsilon mediates 17beta-estradiol-induced neuroprotection in an immortalized hippocampal cell lineMarianna E Jung
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
J Neurochem 95:745-55. 2005..These data suggest that the neuroprotective effects of estrogens are mediated in part by inhibition of PKCepsilon activity and membrane translocation... - 17beta-Estradiol attenuates blood-brain barrier disruption induced by cerebral ischemia-reperfusion injury in female ratsRan Liu
Department of Pharmacology and Neuroscience, University of North Texas, Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
Brain Res 1060:55-61. 2005..Our results suggest an important role of estrogens as multiple targeting protectants against ischemic stroke on cellular as well as vascular components of central nervous system... - Menopausal Vasomotor Symptoms (MVS) survey for assessment of hot flashesAnna Ratka
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
J Womens Health (Larchmt) 15:77-89. 2006..This study was performed to evaluate a new Menopausal Vasomotor Symptoms (MVS) survey as an instrument for a comprehensive and subjective assessment of hot flashes... - Estrogen protects against brain lipid peroxidation in ethanol-withdrawn ratsMarianna E Jung
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
Pharmacol Biochem Behav 79:573-86. 2004..These data suggest that EW rather than ethanol enhances brain lipid peroxidation that is transient and brain-region specific. Estrogens protect against the brain lipid peroxidation in a manner independent of blood ethanol concentrations... - Novel mechanisms for estrogen-induced neuroprotectionMeharvan Singh
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Exp Biol Med (Maywood) 231:514-21. 2006..On the basis of this evidence, we discuss the clinical applicability of estrogens in treating various age-related disorders, including Alzheimer disease and stroke, and identify the caveats that must be considered... - Correspondence regarding Schwend and Gustafsson, "False positives in MALDI-TOF detection of ERbeta in mitochondria"Shao Hua Yang
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Biochem Biophys Res Commun 345:917-8. 2006..Therefore, the claim by Gustafsson's laboratory about false positives in MALDI-TOF detection of ERbeta in mitochondria has no relevance to our report... - A nonfeminizing estrogen analog protects against ethanol withdrawal toxicity in immortalized hippocampal cellsMarianna E Jung
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
J Pharmacol Exp Ther 319:543-50. 2006..Therefore, ZYC26 can be a potential alternative estrogen therapy for a cellular and oxidative imbalance associated with ethanol withdrawal... - Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female ratsYi Wen
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107-2699, USA
FEBS Lett 579:4591-9. 2005..These results suggest that ischemia/reperfusion cerebral damage induces signalings at the G1/S cell-cycle transition, and may constitute a critical step in the neuronal apoptotic pathway in ischemia/reperfusion induced neuronal damage... - Ethanol withdrawal reduces cerebellar parvalbumin expression in a manner reversed by estrogensMridula Rewal
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
Neurosci Lett 377:44-8. 2005..These data suggest that E2 treatment protects against the PA-suppression associated with EW toxicity... - Testosterone increases neurotoxicity of glutamate in vitro and ischemia-reperfusion injury in an animal modelShao-Hua Yang
Department of Pharmacology and Neuroscience, Health Science Center at Fort Worth, University of North Texas, Fort Worth, Texas 76107, USA
J Appl Physiol 92:195-201. 2002..Our in vitro and in vivo studies suggest that sex differences in response to brain injury are partly due to the consequence of damaging effects of testosterone... - Neuroprotective effects of PPARgamma agonists against oxidative insults in HT-22 cellsPaul Aoun
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107-2699, USA
Eur J Pharmacol 472:65-71. 2003..Our results demonstrate neuroprotective effects of 15d-PGJ2 and troglitazone that are likely independent of PPARgamma... - Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic strokeRan Liu
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
J Pharmacol Exp Ther 332:1006-12. 2010..Collectively, the present study suggests that estrogen could be a candidate for combination therapy with rtPA to attenuate its side effect and hence expand its short therapeutic window for treatment of ischemic stroke... - Estrogens and neuroprotection in retinal diseasesD Maneesh Kumar
Department of Cell Biology, UNT Health Science Center, Fort Worth, TX 76107, USA
Mol Vis 14:1480-6. 2008.... - The use of estrogens and related compounds in the treatment of damage from cerebral ischemiaShao-Hua Yang
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
Ann N Y Acad Sci 1007:101-7. 2003..Collectively, these data indicate that estrogens could prove to be useful therapies in preventing brain damage from strokes... - Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female ratsYi Wen
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Biochim Biophys Acta 1772:473-83. 2007..We conclude that Cdk5 may be the principal protein kinase responsible for tau hyperphosphorylation and may be a hallmark of the tauopathies in this stroke model... - Estrogen protects the inner retina from apoptosis and ischemia-induced loss of Vesl-1L/Homer 1c immunoreactive synaptic connectionsSimon Kaja
University of North Texas Health Science Center at Fort Worth, Department of Pharmacology and Neuroscience, Fort Worth, Texas 76107-2699, USA
Invest Ophthalmol Vis Sci 44:3155-62. 2003..The present results suggest that estrogen protects neurons in the GCL including RGCs from both apoptosis and early changes in synaptic connections associated with ischemia and potentially preceding apoptosis... - nNOS is involved in estrogen mediated neuroprotection in neuroblastoma cellsYi Wen
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107l, USA
Neuroreport 15:1515-8. 2004..In SK-N-SH cells, the major estrogen receptor isoforms is estrogen receptor beta. Our current study suggests that increased activity of nNOS may be involved in the neuroprotection conferred by 17beta-estradiol... - Increased severity of acute cerebral ischemic injury correlates with enhanced stem cell induction as well as with predictive behavioral profilingZhen He
Department of Pharmacology, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Curr Neurovasc Res 1:399-409. 2004..In conclusion, severe ischemia correlates with vigorous induction of the hippocampal progenitor cells in rats while behavioral profiling of posture changes permits prediction of severity of damage... - Proestrus levels of estradiol during transient global cerebral ischemia improves the histological outcome of the hippocampal CA1 region: perfusion-dependent and-independent mechanismsZhen He
Department of Neurosurgery, College of Medicine, University of Florida, USA
J Neurol Sci 193:79-87. 2002..In conclusion, proestrus levels of 17beta-estradiol protect hippocampal CA1 neurons against transient global ischemia, through mechanisms that appear to involve improvement of perfusion and inhibition of caspase-3 activity... - Glutamate receptor activation evokes calpain-mediated degradation of Sp3 and Sp4, the prominent Sp-family transcription factors in neuronsXianrong Mao
Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
J Neurochem 100:1300-14. 2007..These data provide details of an impact of glutamate-receptor activation on molecular events connected to gene expression... - Noninvasive monitoring of estrogen effects against ischemic stroke in rats by near-infrared spectroscopyMengna Xia
Joint Program of Biomedical Engineering, University of Texas at Arlington, University of Texas Southwestern Medical Center, 501 West First, Arlington, Texas 76019, USA
Appl Opt 46:8315-21. 2007..e., to detect focal cerebral ischemia and to monitor cerebral responses to therapy against vascular dysfunction in animal models... - Quinol-based cyclic antioxidant mechanism in estrogen neuroprotectionLaszlo Prokai
Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610 0485, USA
Proc Natl Acad Sci U S A 100:11741-6. 2003..These findings may establish the foundation for a rational design of neuroprotective antioxidants focusing on steroidal quinols as unique molecular leads... - Increased beta-secretase activity and expression in rats following transient cerebral ischemiaYi Wen
Department of Pharmacology and Neuroscience, University of North Texas, Health Science Center Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
Brain Res 1009:1-8. 2004.... - 17beta-Estradiol extends ischemic thresholds and exerts neuroprotective effects in cerebral subcortex against transient focal cerebral ischemia in ratsTao Fan
Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL, USA
Brain Res 993:10-7. 2003..Further, this study indicates that estrogens could be used as a neuroprotectant to prolong the therapeutic window of thrombolysis and prolong the time of cerebral circulation intervention for neurosurgical procedure... - Pyruvate enhances neurological recovery following cardiopulmonary arrest and resuscitationArti B Sharma
Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
Resuscitation 76:108-19. 2008..This study tested whether acute pyruvate treatment during cardiopulmonary resuscitation can prevent neurological dysfunction and cerebral injury following cardiac arrest... - Consortium for the Assessment of Research on Progestins and Estrogens (CARPE) Fort Worth, Texas August 1-3, 2003James W Simpkins
J Womens Health (Larchmt) 13:1165-8. 2004 - Hippocampal progenitor cells express nestin following cerebral ischemia in ratsZhen He
Department of Pharmacology, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
Neuroreport 16:1541-4. 2005..eight-vessel occlusion, respectively). Confocal microscopy verified that a subset of the bromedeoxyuridine-positive cells expressed nestin. In conclusion, severe ischemia elicits nestin expression in hippocampal progenitor cells in rats... - Depletion of GGA3 stabilizes BACE and enhances beta-secretase activityGiuseppina Tesco
Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuron 54:721-37. 2007..In summary, we have elucidated a GGA3-dependent mechanism regulating BACE levels and beta-secretase activity. This mechanism may explain increased cerebral levels of BACE and Abeta following cerebral ischemia and existing in AD...
Research Grants
- TRAINING IN THE NEUROBIOLOGY OF AGINGJames Simpkins; Fiscal Year: 2007..This program will help fill the need for the next generation of scientists to deal with the prevention, treatment and cure of age-related diseases of the nervous system. ..
- System Gene Delivery for Alzheimer's Disease- SupplementJames Simpkins; Fiscal Year: 2007..These novel hypotheses will be investigated using an approach focusing on plasmid based vectors; if supported by our results, they may lead to a new type of vectors for researchers in the gene therapy of AD. ..
- Estrogens for Alcoholism & Its Neurological ConsequencesJames Simpkins; Fiscal Year: 2007..Collectively, the proposed studies will provide new knowledge on the mechanism of estrogen protection from the consequences of EW and determine if estrogens are potential pharmacotherapies for alcoholism and its consequences ..