James Simpkins

Summary

Affiliation: University of North Texas
Country: USA

Publications

  1. pmc Estrogen treatment following severe burn injury reduces brain inflammation and apoptotic signaling
    Joshua W Gatson
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Neuroinflammation 6:30. 2009
  2. ncbi request reprint Estrogens, progestins, menopause and neurodegeneration: basic and clinical studies
    J W Simpkins
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Cell Mol Life Sci 62:271-80. 2005
  3. pmc Psychopathology in multiple sclerosis: diagnosis, prevalence and treatment
    Ida S Haussleiter
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER Focused On Resources for her Health, Education and Research, University of North Texas Health Science Center, Fort Worth, TX, USA
    Ther Adv Neurol Disord 2:13-29. 2009
  4. ncbi request reprint Mitochondria play a central role in estrogen-induced neuroprotection
    James W Simpkins
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76102, USA
    Curr Drug Targets CNS Neurol Disord 4:69-83. 2005
  5. pmc Estrogen actions on mitochondria--physiological and pathological implications
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Mol Cell Endocrinol 290:51-9. 2008
  6. doi request reprint More than a decade of estrogen neuroprotection
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA
    Alzheimers Dement 4:S131-6. 2008
  7. ncbi request reprint Role of nonfeminizing estrogens in brain protection from cerebral ischemia: an animal model of Alzheimer's disease neuropathology
    James W Simpkins
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Ann N Y Acad Sci 1052:233-42. 2005
  8. pmc Phenolic compounds protect cultured hippocampal neurons against ethanol-withdrawal induced oxidative stress
    Katalin Prokai-Tatrai
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA
    Int J Mol Sci 10:1773-87. 2009
  9. pmc Role of protein phosphatases and mitochondria in the neuroprotective effects of estrogens
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science, Fort Worth, TX 76107, USA
    Front Neuroendocrinol 30:93-105. 2009
  10. doi request reprint Role of ethnicity in the expression of features of hot flashes
    James W Simpkins
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Maturitas 63:341-6. 2009

Research Grants

Collaborators

Detail Information

Publications77

  1. pmc Estrogen treatment following severe burn injury reduces brain inflammation and apoptotic signaling
    Joshua W Gatson
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Neuroinflammation 6:30. 2009
    ....
  2. ncbi request reprint Estrogens, progestins, menopause and neurodegeneration: basic and clinical studies
    J W Simpkins
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Cell Mol Life Sci 62:271-80. 2005
    ..Further clinical assessment of appropriate regimens of estrogens, progestins and their combination are supported by these data...
  3. pmc Psychopathology in multiple sclerosis: diagnosis, prevalence and treatment
    Ida S Haussleiter
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER Focused On Resources for her Health, Education and Research, University of North Texas Health Science Center, Fort Worth, TX, USA
    Ther Adv Neurol Disord 2:13-29. 2009
    ..In any event, psychiatric comorbidity in MS deserves greater clinical attention than has been previously paid, because the presence of psychopathology may have deleterious effects on the disease process and impair coping with disability...
  4. ncbi request reprint Mitochondria play a central role in estrogen-induced neuroprotection
    James W Simpkins
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76102, USA
    Curr Drug Targets CNS Neurol Disord 4:69-83. 2005
    ....
  5. pmc Estrogen actions on mitochondria--physiological and pathological implications
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Mol Cell Endocrinol 290:51-9. 2008
    ....
  6. doi request reprint More than a decade of estrogen neuroprotection
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA
    Alzheimers Dement 4:S131-6. 2008
    ....
  7. ncbi request reprint Role of nonfeminizing estrogens in brain protection from cerebral ischemia: an animal model of Alzheimer's disease neuropathology
    James W Simpkins
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Ann N Y Acad Sci 1052:233-42. 2005
    ....
  8. pmc Phenolic compounds protect cultured hippocampal neurons against ethanol-withdrawal induced oxidative stress
    Katalin Prokai-Tatrai
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA
    Int J Mol Sci 10:1773-87. 2009
    ....
  9. pmc Role of protein phosphatases and mitochondria in the neuroprotective effects of estrogens
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science, Fort Worth, TX 76107, USA
    Front Neuroendocrinol 30:93-105. 2009
    ..Collectively, these multifaceted, coordinated action of estrogens leads to their potency in protecting neurons from a wide variety of acute insults as well as chronic neurodegenerative processes...
  10. doi request reprint Role of ethnicity in the expression of features of hot flashes
    James W Simpkins
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Maturitas 63:341-6. 2009
    ..Collectively, our results show more frequent and more bothersome HFs in African-American women and more frequent, but less intense and bothersome HFs in Hispanic women in comparison to Caucasian women...
  11. doi request reprint Commentary on "Alzheimer's Disease Drug Development and the Problem of the Blood-Brain Barrier"
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA
    Alzheimers Dement 5:433-4. 2009
    ....
  12. pmc The potential for estrogens in preventing Alzheimer's disease and vascular dementia
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER Focused On Resources for her Health, Education and Research, University of North Texas Health Science Center, Fort Worth, TX, USA
    Ther Adv Neurol Disord 2:31-49. 2009
    ..Several approaches to enhance brain specificity of estrogen action are now underway in an attempt to reduce the side effects of chronic estrogen therapy in AD...
  13. ncbi request reprint Mitochondrial mechanisms of estrogen neuroprotection
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, 3500 Camp Bowie Boul, Fort Worth, TX 76102, USA
    Brain Res Rev 57:421-30. 2008
    ....
  14. pmc Mitochondrial mechanisms of estrogen neuroprotection
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA
    Biochim Biophys Acta 1800:1113-20. 2010
    ..As such, estrogens and novel non-hormonal analogs have come to figure prominently in our efforts to protect neurons against both acute brain injury and chronic neurodegeneration...
  15. ncbi request reprint Estrogen-like compounds for ischemic neuroprotection
    James W Simpkins
    Department of Pharmacology and Neuroscience, 3500 Camp Bowie Blvd, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Stroke 35:2648-51. 2004
    ..These potent, nonfeminizing estrogen analogues are prime candidates for use in stroke neuroprotection...
  16. ncbi request reprint Neuroprotective effects of a novel non-receptor-binding estrogen analogue: in vitro and in vivo analysis
    Ran Liu
    Department of Pharmacology and Neuroscience, Health Science Center at Fort Worth, University of North Texas, 76107, USA
    Stroke 33:2485-91. 2002
    ..Estrogen analogues with neuroprotective function but lacking hormonal properties would be more attractive. The present study was undertaken to determine the neuroprotective effects of a novel 2-adamantyl estrogen analogue, ZYC3...
  17. ncbi request reprint Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats
    Yi Wen
    Department of Pharmacology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 279:22684-92. 2004
    ....
  18. ncbi request reprint Role of protein phosphatases in estrogen-mediated neuroprotection
    Kun Don Yi
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Neurosci 25:7191-8. 2005
    ..These results suggest that 17beta-estradiol may protect cells against glutamate-induced oxidative stress and excitotoxicity by activating a combination of protein phosphatases...
  19. pmc Mechanism of okadaic acid-induced neuronal death and the effect of estrogens
    Kun Don Yi
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    J Neurochem 108:732-40. 2009
    ....
  20. ncbi request reprint Oxidative damage to human lens epithelial cells in culture: estrogen protection of mitochondrial potential, ATP, and cell viability
    Xiaofei Wang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Invest Ophthalmol Vis Sci 44:2067-75. 2003
    ..In the present study, for the first time, the protective effect of estrogens against oxidative stress were tested in cultured human lens epithelial cells (HLECs)...
  21. pmc Protein phosphatase 1, protein phosphatase 2A, and calcineurin play a role in estrogen-mediated neuroprotection
    Kun Don Yi
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Endocrinology 149:5235-43. 2008
    ..Therefore, we conclude that in the face of cytotoxic challenges in vitro and in vivo, estrogens maintain the function of PP1, PP2A, and calcineurin...
  22. ncbi request reprint Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo
    Evelyn Perez
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Brain Res 1038:216-22. 2005
    ..Further, in view of the now known toxicities of chronic feminizing estrogen use in older women, non-feminizing estrogens may be a useful alternative for estrogen-induced brain protection...
  23. ncbi request reprint Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells
    Xiaofei Wang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Mol Pharmacol 70:395-404. 2006
    ..In conclusion, estrogens exert protective effects against oxidative stress by inhibiting lipid peroxidation and subsequently preserving Ca2+ homeostasis, mitochondrial membrane potential, and ATP levels...
  24. pmc Intermittent hypoxia conditioning prevents behavioral deficit and brain oxidative stress in ethanol-withdrawn rats
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    J Appl Physiol 105:510-7. 2008
    ..We conclude that IH conditioning during chronic ethanol consumption attenuates oxidative damage to the brain and mitigates behavioral abnormalities during subsequent EW. IH-induced ROS may evoke this powerful protection...
  25. ncbi request reprint Neuroendocrine mechanism for tolerance to cerebral ischemia-reperfusion injury in male rats
    Shao Hua Yang
    Department of Pharmacology and Neuroscience, Health Science Center at Fort Worth, University of North Texas, Fort Worth, Texas 76107, USA
    J Neurobiol 62:341-51. 2005
    ..In summary, stress-induced testosterone reduction contributes to ischemia tolerance in cerebral ischemia-reperfusion injury in males, which could be related to the loss of inhibition by testosterone of Hsp70 and -90 expression...
  26. pmc Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivative
    Katalin Prokai-Tatrai
    Department of Pharmacology and Neuroscience, UNT Health Science Center, Fort Worth, TX 76107, USA
    Steroids 73:280-8. 2008
    ..Taken together, our report argues for a previously unrecognized antioxidant cycle for estrogen-derived compounds...
  27. pmc Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner
    Zhang Zhang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Brain Res 1345:176-81. 2010
    ..Our results show that cdk5 is involved in OA-induced tau hyperphosphorylation, and estrogens ameliorate the tau hyperphosphorylation, which may be mediated in part by ER...
  28. pmc Dose dependence and therapeutic window for the neuroprotective effects of 17beta-estradiol when administered after cerebral ischemia
    Ran Liu
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Neurosci Lett 415:237-41. 2007
    ..These findings suggest that postischemic treatment with estrogen affords protection against ischemic damage and that it acts within a clinically useful therapeutic window...
  29. ncbi request reprint Estrogens as protectants of the neurovascular unit against ischemic stroke
    Shao Hua Yang
    Department of Pharmacology and Neuroscience, Health Science Center, University of North Texas, Fort Worth, TX 76123, USA
    Curr Drug Targets CNS Neurol Disord 4:169-77. 2005
    ....
  30. ncbi request reprint Role of nonfeminizing estrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicity
    D Maneesh Kumar
    Department of Cell Biology and Genetics, UNT Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Free Radic Biol Med 38:1152-63. 2005
    ..The data support the hypothesis that estrogen analogues may be useful in the treatment of neurodegenerative diseases, particularly in neuroprotection of retinal ganglion cells in ocular pathologies such as glaucoma...
  31. ncbi request reprint Estrogen receptor-independent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activation
    Kun Don Yi
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    J Pharmacol Exp Ther 324:1188-95. 2008
    ....
  32. ncbi request reprint Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells
    Paul Aoun
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Invest Ophthalmol Vis Sci 44:2999-3004. 2003
    ..Glaucoma and other retinal disorders are some of the major complications in diabetes. In the present study, the role that PPAR-gamma ligands play in protecting retinal ganglion cells (RGC-5) against glutamate insult was explored...
  33. pmc Mitochondrial localization of estrogen receptor beta
    Shao Hua Yang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Proc Natl Acad Sci U S A 101:4130-5. 2004
    ..In summary, this study demonstrated that ERbeta is localized to mitochondria, suggesting a role for mitochondrial ERbeta in estrogen effects on this important organelle...
  34. ncbi request reprint Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Brain Res 1008:147-54. 2004
    ..These studies also provide evidence that suppression of post-ischemic inflammation may play a critical role in estrogen-mediated neuroprotection...
  35. ncbi request reprint Estradiol protects against cerebellar damage and motor deficit in ethanol-withdrawn rats
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas HSC at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Alcohol 26:83-93. 2002
    ..These findings support the suggestion that E(2) exerts protective effects against withdrawal signs, cerebellar neuronal damage, and motoric impairment in subjects exposed to, and withdrawn from, chronic ethanol exposure...
  36. pmc Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds
    Laszlo Prokai
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Pharmacol Ther 114:1-12. 2007
    ..This review highlights recent structure-activity studies that revealed the importance of antioxidant effects for neuroprotective estrogen analogues and derivatives...
  37. ncbi request reprint Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Brain Res 1022:30-8. 2004
    ..Finally, our results also suggest that neuronal apoptosis may be a therapeutic target in preventing tauopathy-related neurodegenerative diseases...
  38. ncbi request reprint A prototypical Sigma-1 receptor antagonist protects against brain ischemia
    John A Schetz
    Department of Pharmacology and Neuroscience, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Brain Res 1181:1-9. 2007
    ....
  39. pmc Estrogens and progesterone as neuroprotectants: what animal models teach us
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Front Biosci 13:1083-9. 2008
    ....
  40. ncbi request reprint Subcellular distribution of native estrogen receptor alpha and beta subtypes in cultured human lens epithelial cells
    Patrick R Cammarata
    Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth, TX, USA
    Exp Eye Res 78:861-71. 2004
    ....
  41. doi request reprint Ethanol withdrawal provokes mitochondrial injury in an estrogen preventable manner
    Marianna E Jung
    Department of Pharmacology, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    J Bioenerg Biomembr 40:35-44. 2008
    ..These findings demonstrate that EW provokes oxidative injury to mitochondrial membranes in a manner that is exacerbated by estrogen deprivation...
  42. pmc Estrogens directly potentiate neuronal L-type Ca2+ channels
    Saumyendra N Sarkar
    Department of Pharmacology and Neuroscience and the Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Proc Natl Acad Sci U S A 105:15148-53. 2008
    ....
  43. pmc Ethanol withdrawal provokes opening of the mitochondrial membrane permeability transition pore in an estrogen-preventable manner
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    J Pharmacol Exp Ther 328:692-8. 2009
    ..These findings suggest that EW provokes PTP opening partly but not entirely through the pro-oxidant nature and that E2 counteracts EW-associated factors to protect against the PTP opening...
  44. pmc Estrogen receptor beta as a mitochondrial vulnerability factor
    Shao Hua Yang
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 284:9540-8. 2009
    ..These data demonstrate that ERbeta is expressed in mitochondria and function as a mitochondrial vulnerability factor involved in Deltapsim maintenance, potentially through a mitochondrial transcription dependent mechanism...
  45. ncbi request reprint Role of the GABAA system in behavioral, motoric, and cerebellar protection by estrogen during ethanol withdrawal
    Mridula Rewal
    Department of Pharmacology and Neuroscience, University of North Texas HSC at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Alcohol 31:49-61. 2003
    ..Also, results of the current study provide indirect evidence that the GABAergic system is involved in protective effects of E(2) against the EW syndrome...
  46. ncbi request reprint Role of protein kinase C in estrogen protection against apoptotic cerebellar cell death in ethanol-withdrawn rats
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas HSC at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Alcohol 31:39-48. 2003
    ....
  47. ncbi request reprint Role of parvalbumin in estrogen protection from ethanol withdrawal syndrome
    Mridula Rewal
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas 76107 2699, USA
    Alcohol Clin Exp Res 29:1837-44. 2005
    ..This study examined whether ethanol exposure and/or ethanol withdrawal (EW) alter the levels of PA in a manner that is protected by 17beta-estradiol (E2)...
  48. pmc Ethanol withdrawal posttranslationally decreases the activity of cytochrome c oxidase in an estrogen reversible manner
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Neurosci Lett 416:160-4. 2007
    ..Neither EW nor E2 altered the protein levels of the subunits. These findings suggest that a counteracting relationship exists between the effects of EW and E2 on the activity of COX in a subunit specific manner...
  49. ncbi request reprint Role of the GABA-A system in estrogen-induced protection against brain lipid peroxidation in ethanol-withdrawn rats
    Mridula Rewal
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Alcohol Clin Exp Res 28:1907-15. 2004
    ..In this study, we examined the effect of the GABA-A antagonist bicuculline on the neuroprotective effect of E2 by assessing the oxidative marker thiobarbituric acid reactive substances (TBARS) during ethanol withdrawal (EW)...
  50. ncbi request reprint Suppression of protein kinase Cepsilon mediates 17beta-estradiol-induced neuroprotection in an immortalized hippocampal cell line
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Neurochem 95:745-55. 2005
    ..These data suggest that the neuroprotective effects of estrogens are mediated in part by inhibition of PKCepsilon activity and membrane translocation...
  51. ncbi request reprint 17beta-Estradiol attenuates blood-brain barrier disruption induced by cerebral ischemia-reperfusion injury in female rats
    Ran Liu
    Department of Pharmacology and Neuroscience, University of North Texas, Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Brain Res 1060:55-61. 2005
    ..Our results suggest an important role of estrogens as multiple targeting protectants against ischemic stroke on cellular as well as vascular components of central nervous system...
  52. ncbi request reprint Menopausal Vasomotor Symptoms (MVS) survey for assessment of hot flashes
    Anna Ratka
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Womens Health (Larchmt) 15:77-89. 2006
    ..This study was performed to evaluate a new Menopausal Vasomotor Symptoms (MVS) survey as an instrument for a comprehensive and subjective assessment of hot flashes...
  53. ncbi request reprint Estrogen protects against brain lipid peroxidation in ethanol-withdrawn rats
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Pharmacol Biochem Behav 79:573-86. 2004
    ..These data suggest that EW rather than ethanol enhances brain lipid peroxidation that is transient and brain-region specific. Estrogens protect against the brain lipid peroxidation in a manner independent of blood ethanol concentrations...
  54. ncbi request reprint Novel mechanisms for estrogen-induced neuroprotection
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Exp Biol Med (Maywood) 231:514-21. 2006
    ..On the basis of this evidence, we discuss the clinical applicability of estrogens in treating various age-related disorders, including Alzheimer disease and stroke, and identify the caveats that must be considered...
  55. ncbi request reprint Correspondence regarding Schwend and Gustafsson, "False positives in MALDI-TOF detection of ERbeta in mitochondria"
    Shao Hua Yang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Biochem Biophys Res Commun 345:917-8. 2006
    ..Therefore, the claim by Gustafsson's laboratory about false positives in MALDI-TOF detection of ERbeta in mitochondria has no relevance to our report...
  56. ncbi request reprint A nonfeminizing estrogen analog protects against ethanol withdrawal toxicity in immortalized hippocampal cells
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    J Pharmacol Exp Ther 319:543-50. 2006
    ..Therefore, ZYC26 can be a potential alternative estrogen therapy for a cellular and oxidative imbalance associated with ethanol withdrawal...
  57. ncbi request reprint Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female rats
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    FEBS Lett 579:4591-9. 2005
    ..These results suggest that ischemia/reperfusion cerebral damage induces signalings at the G1/S cell-cycle transition, and may constitute a critical step in the neuronal apoptotic pathway in ischemia/reperfusion induced neuronal damage...
  58. ncbi request reprint Ethanol withdrawal reduces cerebellar parvalbumin expression in a manner reversed by estrogens
    Mridula Rewal
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Neurosci Lett 377:44-8. 2005
    ..These data suggest that E2 treatment protects against the PA-suppression associated with EW toxicity...
  59. ncbi request reprint Testosterone increases neurotoxicity of glutamate in vitro and ischemia-reperfusion injury in an animal model
    Shao Hua Yang
    Department of Pharmacology and Neuroscience, Health Science Center at Fort Worth, University of North Texas, Fort Worth, Texas 76107, USA
    J Appl Physiol 92:195-201. 2002
    ..Our in vitro and in vivo studies suggest that sex differences in response to brain injury are partly due to the consequence of damaging effects of testosterone...
  60. ncbi request reprint Neuroprotective effects of PPARgamma agonists against oxidative insults in HT-22 cells
    Paul Aoun
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Eur J Pharmacol 472:65-71. 2003
    ..Our results demonstrate neuroprotective effects of 15d-PGJ2 and troglitazone that are likely independent of PPARgamma...
  61. pmc Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke
    Ran Liu
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    J Pharmacol Exp Ther 332:1006-12. 2010
    ..Collectively, the present study suggests that estrogen could be a candidate for combination therapy with rtPA to attenuate its side effect and hence expand its short therapeutic window for treatment of ischemic stroke...
  62. pmc Estrogens and neuroprotection in retinal diseases
    D Maneesh Kumar
    Department of Cell Biology, UNT Health Science Center, Fort Worth, TX 76107, USA
    Mol Vis 14:1480-6. 2008
    ....
  63. ncbi request reprint The use of estrogens and related compounds in the treatment of damage from cerebral ischemia
    Shao Hua Yang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Ann N Y Acad Sci 1007:101-7. 2003
    ..Collectively, these data indicate that estrogens could prove to be useful therapies in preventing brain damage from strokes...
  64. ncbi request reprint Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Biochim Biophys Acta 1772:473-83. 2007
    ..We conclude that Cdk5 may be the principal protein kinase responsible for tau hyperphosphorylation and may be a hallmark of the tauopathies in this stroke model...
  65. ncbi request reprint Estrogen protects the inner retina from apoptosis and ischemia-induced loss of Vesl-1L/Homer 1c immunoreactive synaptic connections
    Simon Kaja
    University of North Texas Health Science Center at Fort Worth, Department of Pharmacology and Neuroscience, Fort Worth, Texas 76107 2699, USA
    Invest Ophthalmol Vis Sci 44:3155-62. 2003
    ..The present study quantitatively analyzed effects of estrogen administration on synaptic connections of neurons in the ganglion cell layer (GCL) of the retina...
  66. ncbi request reprint nNOS is involved in estrogen mediated neuroprotection in neuroblastoma cells
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107l, USA
    Neuroreport 15:1515-8. 2004
    ..In SK-N-SH cells, the major estrogen receptor isoforms is estrogen receptor beta. Our current study suggests that increased activity of nNOS may be involved in the neuroprotection conferred by 17beta-estradiol...
  67. ncbi request reprint Increased severity of acute cerebral ischemic injury correlates with enhanced stem cell induction as well as with predictive behavioral profiling
    Zhen He
    Department of Pharmacology, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Curr Neurovasc Res 1:399-409. 2004
    ..In conclusion, severe ischemia correlates with vigorous induction of the hippocampal progenitor cells in rats while behavioral profiling of posture changes permits prediction of severity of damage...
  68. ncbi request reprint Proestrus levels of estradiol during transient global cerebral ischemia improves the histological outcome of the hippocampal CA1 region: perfusion-dependent and-independent mechanisms
    Zhen He
    Department of Neurosurgery, College of Medicine, University of Florida, USA
    J Neurol Sci 193:79-87. 2002
    ..In conclusion, proestrus levels of 17beta-estradiol protect hippocampal CA1 neurons against transient global ischemia, through mechanisms that appear to involve improvement of perfusion and inhibition of caspase-3 activity...
  69. pmc Glutamate receptor activation evokes calpain-mediated degradation of Sp3 and Sp4, the prominent Sp-family transcription factors in neurons
    Xianrong Mao
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Neurochem 100:1300-14. 2007
    ..These data provide details of an impact of glutamate-receptor activation on molecular events connected to gene expression...
  70. pmc Noninvasive monitoring of estrogen effects against ischemic stroke in rats by near-infrared spectroscopy
    Mengna Xia
    Joint Program of Biomedical Engineering, University of Texas at Arlington, University of Texas Southwestern Medical Center, 501 West First, Arlington, Texas 76019, USA
    Appl Opt 46:8315-21. 2007
    ..e., to detect focal cerebral ischemia and to monitor cerebral responses to therapy against vascular dysfunction in animal models...
  71. pmc Quinol-based cyclic antioxidant mechanism in estrogen neuroprotection
    Laszlo Prokai
    Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610 0485, USA
    Proc Natl Acad Sci U S A 100:11741-6. 2003
    ..These findings may establish the foundation for a rational design of neuroprotective antioxidants focusing on steroidal quinols as unique molecular leads...
  72. ncbi request reprint Increased beta-secretase activity and expression in rats following transient cerebral ischemia
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas, Health Science Center Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Brain Res 1009:1-8. 2004
    ....
  73. ncbi request reprint 17beta-Estradiol extends ischemic thresholds and exerts neuroprotective effects in cerebral subcortex against transient focal cerebral ischemia in rats
    Tao Fan
    Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL, USA
    Brain Res 993:10-7. 2003
    ..Further, this study indicates that estrogens could be used as a neuroprotectant to prolong the therapeutic window of thrombolysis and prolong the time of cerebral circulation intervention for neurosurgical procedure...
  74. pmc Pyruvate enhances neurological recovery following cardiopulmonary arrest and resuscitation
    Arti B Sharma
    Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Resuscitation 76:108-19. 2008
    ..This study tested whether acute pyruvate treatment during cardiopulmonary resuscitation can prevent neurological dysfunction and cerebral injury following cardiac arrest...
  75. ncbi request reprint Consortium for the Assessment of Research on Progestins and Estrogens (CARPE) Fort Worth, Texas August 1-3, 2003
    James W Simpkins
    J Womens Health (Larchmt) 13:1165-8. 2004
  76. ncbi request reprint Hippocampal progenitor cells express nestin following cerebral ischemia in rats
    Zhen He
    Department of Pharmacology, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
    Neuroreport 16:1541-4. 2005
    ..eight-vessel occlusion, respectively). Confocal microscopy verified that a subset of the bromedeoxyuridine-positive cells expressed nestin. In conclusion, severe ischemia elicits nestin expression in hippocampal progenitor cells in rats...
  77. pmc Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity
    Giuseppina Tesco
    Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuron 54:721-37. 2007
    ..In summary, we have elucidated a GGA3-dependent mechanism regulating BACE levels and beta-secretase activity. This mechanism may explain increased cerebral levels of BACE and Abeta following cerebral ischemia and existing in AD...

Research Grants10

  1. TRAINING IN THE NEUROBIOLOGY OF AGING
    James Simpkins; Fiscal Year: 2007
    ..This program will help fill the need for the next generation of scientists to deal with the prevention, treatment and cure of age-related diseases of the nervous system. ..
  2. System Gene Delivery for Alzheimer's Disease- Supplement
    James Simpkins; Fiscal Year: 2007
    ..These novel hypotheses will be investigated using an approach focusing on plasmid based vectors; if supported by our results, they may lead to a new type of vectors for researchers in the gene therapy of AD. ..
  3. Estrogens for Alcoholism & Its Neurological Consequences
    James Simpkins; Fiscal Year: 2007
    ..Collectively, the proposed studies will provide new knowledge on the mechanism of estrogen protection from the consequences of EW and determine if estrogens are potential pharmacotherapies for alcoholism and its consequences ..