DONALD SIMONE

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Differential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptors
    Thaddeus S Brink
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis 55455, USA
    J Neurophysiol 107:1210-21. 2012
  2. ncbi request reprint Changes in response properties of nociceptive dorsal horn neurons in a murine model of cancer pain
    Donald A Simone
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Sheng Li Xue Bao 60:635-44. 2008
  3. ncbi request reprint Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli
    Donald A Simone
    Department of Oral Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurophysiol 91:213-22. 2004
  4. pmc Tumor-evoked hyperalgesia and sensitization of nociceptive dorsal horn neurons in a murine model of cancer pain
    Sergey G Khasabov
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, 17 252 Moos Tower, 515 Delaware St, S E, Minneapolis, Minnesota 55455, USA
    Brain Res 1180:7-19. 2007
  5. ncbi request reprint Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injury
    Lisa M Johanek
    Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Pain 109:432-42. 2004
  6. pmc Termination zones of functionally characterized spinothalamic tract neurons within the primate posterior thalamus
    Steve Davidson
    Department of Neuroscience, School of Medicine, University of Minnesota, 6 145 Jackson Hall, 321 Church St SE, Minneapolis, MN, USA
    J Neurophysiol 100:2026-37. 2008
  7. pmc Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons
    Steve Davidson
    University of Minnesota, Minneapolis, USA
    Nat Neurosci 12:544-6. 2009
  8. ncbi request reprint A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain
    Lois J Kehl
    Department of Oral Science, School of Dentistry, University of Minnesota, Minneapolis, MN 55455 0217, USA
    Pain 103:175-86. 2003
  9. pmc Cannabinoid modulation of cutaneous Adelta nociceptors during inflammation
    Carl Potenzieri
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, 515 Delaware St SE, 17 252 Moos Tower, Minneapolis, MN 55455, USA
    J Neurophysiol 100:2794-806. 2008
  10. pmc Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids
    Divyanshoo R Kohli
    Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis 55455, USA
    Blood 116:456-65. 2010

Research Grants

  1. Neural Mechanisms of Cancer Pain
    DONALD SIMONE; Fiscal Year: 2007
  2. CANNABINOID MODULATION OF HYPERALGESIA
    Donald A Simone; Fiscal Year: 2010
  3. CANNABINOID MODULATION OF HYPERALGESIA
    DONALD SIMONE; Fiscal Year: 2009
  4. Neural Mechanisms of Cancer Pain
    DONALD SIMONE; Fiscal Year: 2005
  5. CANNABINOID MODULATION OF HYPERALGESIA
    DONALD SIMONE; Fiscal Year: 2004
  6. Neural Mechanisms of Cancer Pain
    Donald A Simone; Fiscal Year: 2010

Collaborators

Detail Information

Publications28

  1. pmc Differential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptors
    Thaddeus S Brink
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis 55455, USA
    J Neurophysiol 107:1210-21. 2012
    ....
  2. ncbi request reprint Changes in response properties of nociceptive dorsal horn neurons in a murine model of cancer pain
    Donald A Simone
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Sheng Li Xue Bao 60:635-44. 2008
    ..Our findings show that sensitization of WDR neurons, but not HT neurons, contributes to tumor-evoked hyperalgesia...
  3. ncbi request reprint Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli
    Donald A Simone
    Department of Oral Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurophysiol 91:213-22. 2004
    ..We conclude that the STT neurons in our sample are more likely to contribute to pain, allodynia, and hyperalgesia than to itch and alloknesis...
  4. pmc Tumor-evoked hyperalgesia and sensitization of nociceptive dorsal horn neurons in a murine model of cancer pain
    Sergey G Khasabov
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, 17 252 Moos Tower, 515 Delaware St, S E, Minneapolis, Minnesota 55455, USA
    Brain Res 1180:7-19. 2007
    ..Our findings show that sensitization of WDR neurons contributes to cancer pain and supports the notion that the mechanisms underlying cancer pain differ from those that contribute to inflammatory and neuropathic pain...
  5. ncbi request reprint Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injury
    Lisa M Johanek
    Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Pain 109:432-42. 2004
    ..Activation of this receptor in the periphery may attenuate pain without causing unwanted side effects mediated by central CB1 receptors...
  6. pmc Termination zones of functionally characterized spinothalamic tract neurons within the primate posterior thalamus
    Steve Davidson
    Department of Neuroscience, School of Medicine, University of Minnesota, 6 145 Jackson Hall, 321 Church St SE, Minneapolis, MN, USA
    J Neurophysiol 100:2026-37. 2008
    ..Seventy-one percent responded to an intradermal injection of capsaicin. These data indicate that the primate STT transmits noxious and innocuous mechanical, thermal, and chemical information to multiple posterior thalamic nuclei...
  7. pmc Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons
    Steve Davidson
    University of Minnesota, Minneapolis, USA
    Nat Neurosci 12:544-6. 2009
    ....
  8. ncbi request reprint A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain
    Lois J Kehl
    Department of Oral Science, School of Dentistry, University of Minnesota, Minneapolis, MN 55455 0217, USA
    Pain 103:175-86. 2003
    ....
  9. pmc Cannabinoid modulation of cutaneous Adelta nociceptors during inflammation
    Carl Potenzieri
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, 515 Delaware St SE, 17 252 Moos Tower, Minneapolis, MN 55455, USA
    J Neurophysiol 100:2794-806. 2008
    ..These results suggest that attenuation of mechanically evoked responses of Adelta nociceptors contributes to the behavioral antinociception produced by activation of peripheral CB(1) receptors during inflammation...
  10. pmc Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids
    Divyanshoo R Kohli
    Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis 55455, USA
    Blood 116:456-65. 2010
    ..Importantly, cannabinoids attenuate pain in mice expressing HbS...
  11. pmc Excitation of cutaneous C nociceptors by intraplantar administration of anandamide
    Carl Potenzieri
    Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA
    Brain Res 1268:38-47. 2009
    ..Our results indicate that anandamide excited cutaneous C nociceptors and produced nocifensive behaviors via activation of TRPV1 receptors...
  12. pmc Tumor-evoked sensitization of C nociceptors: a role for endothelin
    Darryl T Hamamoto
    Department of Diagnostic and Biological Sciences, University of Minnesota, 515 Delaware St SE, 17 252 Moos Tower, Minneapolis, MN 55455, USA
    J Neurophysiol 100:2300-11. 2008
    ..We conclude that ET-1 at the tumor site contributes to tumor-evoked excitation and sensitization of C nociceptors through an ETA receptor mediated mechanism...
  13. pmc The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms
    Carl Potenzieri
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
    Brain Res 1215:69-75. 2008
    ..These results suggest that peripherally-administered cannabinoids may be effective in attenuating cancer pain...
  14. ncbi request reprint Spinal neurons that possess the substance P receptor are required for the development of central sensitization
    Sergey G Khasabov
    Department of Preventive Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 22:9086-98. 2002
    ..It appears that this relatively small population of neurons can regulate the physiological properties of other nociceptive neurons and drive central sensitization...
  15. ncbi request reprint Cannabinoid agonist, CP 55,940, prevents capsaicin-induced sensitization of spinal cord dorsal horn neurons
    Lisa M Johanek
    Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    J Neurophysiol 93:989-97. 2005
    ..These studies demonstrate that cannabinoid application to the spinal cord prevents central sensitization...
  16. pmc The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons
    Steve Davidson
    Department of Neuroscience, Medical School, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 27:10007-14. 2007
    ..Our results demonstrate that the spinothalamic tract contains mutually exclusive populations of neurons responsive to histamine or the nonhistaminergic itch-producing agent cowhage...
  17. pmc Acute and chronic administration of the cannabinoid receptor agonist CP 55,940 attenuates tumor-evoked hyperalgesia
    Darryl T Hamamoto
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
    Eur J Pharmacol 558:73-87. 2007
    ..These results suggest that cannabinoids may be a useful alternative or adjunct therapy for treating cancer pain...
  18. doi request reprint Variation in quantitative sensory testing and epidermal nerve fiber density in repeated measurements
    Mona M Selim
    Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    Pain 151:575-81. 2010
    ..18 ENFs/mm). Since some individuals had large unsystematic variations, unexpected test results should therefore alert clinicians to test additional locations...
  19. doi request reprint A randomized, controlled, open-label study of the long-term effects of NGX-4010, a high-concentration capsaicin patch, on epidermal nerve fiber density and sensory function in healthy volunteers
    William R Kennedy
    Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Pain 11:579-87. 2010
    ..NGX-4010 was generally well tolerated. Transient, mild warming or burning sensations at the site of application were common adverse effects...
  20. pmc A decrease in anandamide signaling contributes to the maintenance of cutaneous mechanical hyperalgesia in a model of bone cancer pain
    Iryna A Khasabova
    Department of Diagnostic Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 28:11141-52. 2008
    ..Together, the data provide evidence that manipulation of peripheral endocannabinoid signaling is a promising strategy for the management of bone cancer pain...
  21. ncbi request reprint Characterization of cutaneous primary afferent fibers excited by acetic acid in a model of nociception in frogs
    Darryl T Hamamoto
    Department of Diagnostic and Surgical Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurophysiol 90:566-77. 2003
    ..The results of the present study suggest that the model of acetic acid-induced nociception in frogs may be useful for studying the mechanisms by which tissue acidosis produces pain...
  22. ncbi request reprint SYM 2081, an agonist that desensitizes kainate receptors, attenuates capsaicin and inflammatory hyperalgesia
    Michelle S Turner
    Department of Oral Science, University of Minnesota, 17 252 Moos Tower, 515 Delaware Street S E, Minneapolis, MN 55455, USA
    Brain Res 973:252-64. 2003
    ..The present study demonstrates that administration of a high-potency ligand that selectively desensitizes kainate receptors attenuates the development of mechanical and heat hyperalgesia and attenuates ongoing inflammatory hyperalgesia...
  23. doi request reprint NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin
    Cholawat Pacharinsak
    Department of Diagnostic and Biological Science, School of Dentistry, University of Minnesota, 515 Delaware Street SE, Minneapolis, MN 55455, USA
    Pain 139:34-46. 2008
    ..These findings suggest that the activation of NK-1 receptors in the RVM contributes to the hyperalgesia produced by capsaicin...
  24. ncbi request reprint Re-organization of P2X3 receptor localization on epidermal nerve fibers in a murine model of cancer pain
    Laura S Gilchrist
    Physical Therapy Program, College of St Catherine, Minneapolis, MN 55454, USA
    Brain Res 1044:197-205. 2005
    ..These studies demonstrate increased expression of P2X3 receptors on CGRP-ir ENFs during tumor growth and suggest a role for ATP in cancer-related pain...
  25. pmc Mechanism of cancer pain
    Brian L Schmidt
    Department of Oral and Maxillofacial Surgery, School of Dentistry, University of California San Francisco, USA
    Mol Interv 10:164-78. 2010
    ..As our understanding of the peripheral and central mechanisms that underlie cancer pain improves, targeted analgesics for the cancer patient will likely follow...
  26. ncbi request reprint NK-1 receptors modulate the excitability of ON cells in the rostral ventromedial medulla
    Denes Budai
    Department of Diagnostic and Biological Sciences, University of Minnesota, 515 Delaware Street SE, 17 252 Moos Tower, Minneapolis, MN 55455, USA
    J Neurophysiol 97:1388-95. 2007
    ..It is suggested that activation of NK-1 receptors in the RVM and the ensuing sensitization of on cells may contribute to the development of central sensitization and hyperalgesia after tissue injury and inflammation...
  27. ncbi request reprint Chemical interactions between fibrosarcoma cancer cells and sensory neurons contribute to cancer pain
    Iryna A Khasabova
    Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 27:10289-98. 2007
    ..More broadly, this study provides a novel in vitro model to resolve the cellular and molecular mechanisms by which tumor cells drive functional changes in nociceptors...
  28. ncbi request reprint Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculus
    Sergey G Khasabov
    Department of Oral Sciences, University of Minnesota, Minneapolis, MN 55455, USA
    J Neurophysiol 93:998-1006. 2005
    ..These results demonstrate that spinal neurons expressing the NK-1 receptor appear to play a pivotal role in regulating descending systems that modulate activity of nociceptive dorsal horn neurons...

Research Grants19

  1. Neural Mechanisms of Cancer Pain
    DONALD SIMONE; Fiscal Year: 2007
    ..Results may have a direct impact on the future development of novel medications for cancer pain that act peripherally at the tumor/nerve level. ..
  2. CANNABINOID MODULATION OF HYPERALGESIA
    Donald A Simone; Fiscal Year: 2010
    ..This is a proposal to investigate whether peripheral administration of cannabinoids reduces pain and hyperalgesia from chemotherapy and to determine the underlying mechanisms. ..
  3. CANNABINOID MODULATION OF HYPERALGESIA
    DONALD SIMONE; Fiscal Year: 2009
    ..We will determine whether cancer cells modify cannabinoid receptor expression and cannabinoid receptor signaling in primary afferent neurons. ..
  4. Neural Mechanisms of Cancer Pain
    DONALD SIMONE; Fiscal Year: 2005
    ..Results may have a direct impact on the future development of novel medications for cancer pain that act peripherally at the tumor/nerve level. ..
  5. CANNABINOID MODULATION OF HYPERALGESIA
    DONALD SIMONE; Fiscal Year: 2004
    ..Peripheral cannabinoids may be very effective for managing certain chronic pains without undesirable side effects associated with traditional therapies. ..
  6. Neural Mechanisms of Cancer Pain
    Donald A Simone; Fiscal Year: 2010
    ..Results may have a direct impact on the future development of novel medications for cancer pain that act peripherally at the tumor/nerve level. ..