Research Topics
| DONALD SIMONESummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
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Detail Information
Publications
Differential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptorsThaddeus S Brink
Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis 55455, USA
J Neurophysiol 107:1210-21. 2012....
Changes in response properties of nociceptive dorsal horn neurons in a murine model of cancer painDonald A Simone
Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
Sheng Li Xue Bao 60:635-44. 2008..Our findings show that sensitization of WDR neurons, but not HT neurons, contributes to tumor-evoked hyperalgesia...- Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuliDonald A Simone
Department of Oral Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurophysiol 91:213-22. 2004..We conclude that the STT neurons in our sample are more likely to contribute to pain, allodynia, and hyperalgesia than to itch and alloknesis... - Tumor-evoked hyperalgesia and sensitization of nociceptive dorsal horn neurons in a murine model of cancer painSergey G Khasabov
Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, 17 252 Moos Tower, 515 Delaware St, S E, Minneapolis, Minnesota 55455, USA
Brain Res 1180:7-19. 2007..Our findings show that sensitization of WDR neurons contributes to cancer pain and supports the notion that the mechanisms underlying cancer pain differ from those that contribute to inflammatory and neuropathic pain... - Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injuryLisa M Johanek
Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
Pain 109:432-42. 2004..Activation of this receptor in the periphery may attenuate pain without causing unwanted side effects mediated by central CB1 receptors... - Termination zones of functionally characterized spinothalamic tract neurons within the primate posterior thalamusSteve Davidson
Department of Neuroscience, School of Medicine, University of Minnesota, 6 145 Jackson Hall, 321 Church St SE, Minneapolis, MN, USA
J Neurophysiol 100:2026-37. 2008..Seventy-one percent responded to an intradermal injection of capsaicin. These data indicate that the primate STT transmits noxious and innocuous mechanical, thermal, and chemical information to multiple posterior thalamic nuclei... - Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neuronsSteve Davidson
University of Minnesota, Minneapolis, USA
Nat Neurosci 12:544-6. 2009.... - A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle painLois J Kehl
Department of Oral Science, School of Dentistry, University of Minnesota, Minneapolis, MN 55455-0217, USA
Pain 103:175-86. 2003.... - Cannabinoid modulation of cutaneous Adelta nociceptors during inflammationCarl Potenzieri
Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, 515 Delaware St SE, 17 252 Moos Tower, Minneapolis, MN 55455, USA
J Neurophysiol 100:2794-806. 2008..These results suggest that attenuation of mechanically evoked responses of Adelta nociceptors contributes to the behavioral antinociception produced by activation of peripheral CB(1) receptors during inflammation... - Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoidsDivyanshoo R Kohli
Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis 55455, USA
Blood 116:456-65. 2010..Importantly, cannabinoids attenuate pain in mice expressing HbS... - Excitation of cutaneous C nociceptors by intraplantar administration of anandamideCarl Potenzieri
Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA
Brain Res 1268:38-47. 2009..Our results indicate that anandamide excited cutaneous C nociceptors and produced nocifensive behaviors via activation of TRPV1 receptors... - Tumor-evoked sensitization of C nociceptors: a role for endothelinDarryl T Hamamoto
Department of Diagnostic and Biological Sciences, University of Minnesota, 515 Delaware St SE, 17 252 Moos Tower, Minneapolis, MN 55455, USA
J Neurophysiol 100:2300-11. 2008..We conclude that ET-1 at the tumor site contributes to tumor-evoked excitation and sensitization of C nociceptors through an ETA receptor mediated mechanism... - The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanismsCarl Potenzieri
Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
Brain Res 1215:69-75. 2008..These results suggest that peripherally-administered cannabinoids may be effective in attenuating cancer pain... - Spinal neurons that possess the substance P receptor are required for the development of central sensitizationSergey G Khasabov
Department of Preventive Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosci 22:9086-98. 2002..It appears that this relatively small population of neurons can regulate the physiological properties of other nociceptive neurons and drive central sensitization... - Cannabinoid agonist, CP 55,940, prevents capsaicin-induced sensitization of spinal cord dorsal horn neuronsLisa M Johanek
Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
J Neurophysiol 93:989-97. 2005..These studies demonstrate that cannabinoid application to the spinal cord prevents central sensitization... - The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neuronsSteve Davidson
Department of Neuroscience, Medical School, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosci 27:10007-14. 2007..Our results demonstrate that the spinothalamic tract contains mutually exclusive populations of neurons responsive to histamine or the nonhistaminergic itch-producing agent cowhage... - Acute and chronic administration of the cannabinoid receptor agonist CP 55,940 attenuates tumor-evoked hyperalgesiaDarryl T Hamamoto
Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
Eur J Pharmacol 558:73-87. 2007..These results suggest that cannabinoids may be a useful alternative or adjunct therapy for treating cancer pain... 
Variation in quantitative sensory testing and epidermal nerve fiber density in repeated measurementsMona M Selim
Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
Pain 151:575-81. 2010..18 ENFs/mm). Since some individuals had large unsystematic variations, unexpected test results should therefore alert clinicians to test additional locations...- A randomized, controlled, open-label study of the long-term effects of NGX-4010, a high-concentration capsaicin patch, on epidermal nerve fiber density and sensory function in healthy volunteersWilliam R Kennedy
Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Pain 11:579-87. 2010..The results help predict the long-term safety of NGX-4010 applications in patients... - A decrease in anandamide signaling contributes to the maintenance of cutaneous mechanical hyperalgesia in a model of bone cancer painIryna A Khasabova
Department of Diagnostic Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosci 28:11141-52. 2008..Together, the data provide evidence that manipulation of peripheral endocannabinoid signaling is a promising strategy for the management of bone cancer pain... - Characterization of cutaneous primary afferent fibers excited by acetic acid in a model of nociception in frogsDarryl T Hamamoto
Department of Diagnostic and Surgical Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurophysiol 90:566-77. 2003..The results of the present study suggest that the model of acetic acid-induced nociception in frogs may be useful for studying the mechanisms by which tissue acidosis produces pain... - SYM 2081, an agonist that desensitizes kainate receptors, attenuates capsaicin and inflammatory hyperalgesiaMichelle S Turner
Department of Oral Science, University of Minnesota, 17-252 Moos Tower, 515 Delaware Street S.E, Minneapolis, MN 55455, USA
Brain Res 973:252-64. 2003..The present study demonstrates that administration of a high-potency ligand that selectively desensitizes kainate receptors attenuates the development of mechanical and heat hyperalgesia and attenuates ongoing inflammatory hyperalgesia... - NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicinCholawat Pacharinsak
Department of Diagnostic and Biological Science, School of Dentistry, University of Minnesota, 515 Delaware Street SE, Minneapolis, MN 55455, USA
Pain 139:34-46. 2008..These findings suggest that the activation of NK-1 receptors in the RVM contributes to the hyperalgesia produced by capsaicin... - Re-organization of P2X3 receptor localization on epidermal nerve fibers in a murine model of cancer painLaura S Gilchrist
Physical Therapy Program, College of St. Catherine, Minneapolis, MN 55454, USA
Brain Res 1044:197-205. 2005..These studies demonstrate increased expression of P2X3 receptors on CGRP-ir ENFs during tumor growth and suggest a role for ATP in cancer-related pain... - Mechanism of cancer painBrian L Schmidt
Department of Oral and Maxillofacial Surgery, School of Dentistry, University of California San Francisco, USA
Mol Interv 10:164-78. 2010..As our understanding of the peripheral and central mechanisms that underlie cancer pain improves, targeted analgesics for the cancer patient will likely follow... - NK-1 receptors modulate the excitability of ON cells in the rostral ventromedial medullaDenes Budai
Department of Diagnostic and Biological Sciences, University of Minnesota, 515 Delaware Street SE, 17 252 Moos Tower, Minneapolis, MN 55455, USA
J Neurophysiol 97:1388-95. 2007..It is suggested that activation of NK-1 receptors in the RVM and the ensuing sensitization of on cells may contribute to the development of central sensitization and hyperalgesia after tissue injury and inflammation... - Chemical interactions between fibrosarcoma cancer cells and sensory neurons contribute to cancer painIryna A Khasabova
Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosci 27:10289-98. 2007..More broadly, this study provides a novel in vitro model to resolve the cellular and molecular mechanisms by which tumor cells drive functional changes in nociceptors... - Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculusSergey G Khasabov
Department of Oral Sciences, University of Minnesota, Minneapolis, MN 55455, USA
J Neurophysiol 93:998-1006. 2005..These results demonstrate that spinal neurons expressing the NK-1 receptor appear to play a pivotal role in regulating descending systems that modulate activity of nociceptive dorsal horn neurons...
Research Grants
- Neural Mechanisms of Cancer PainDONALD SIMONE; Fiscal Year: 2007..Results may have a direct impact on the future development of novel medications for cancer pain that act peripherally at the tumor/nerve level. ..
- CANNABINOID MODULATION OF HYPERALGESIADonald A Simone; Fiscal Year: 2010..This is a proposal to investigate whether peripheral administration of cannabinoids reduces pain and hyperalgesia from chemotherapy and to determine the underlying mechanisms. ..
- CANNABINOID MODULATION OF HYPERALGESIADONALD SIMONE; Fiscal Year: 2009..We will determine whether cancer cells modify cannabinoid receptor expression and cannabinoid receptor signaling in primary afferent neurons. ..
- Neural Mechanisms of Cancer PainDONALD SIMONE; Fiscal Year: 2005..Results may have a direct impact on the future development of novel medications for cancer pain that act peripherally at the tumor/nerve level. ..
- CANNABINOID MODULATION OF HYPERALGESIADONALD SIMONE; Fiscal Year: 2004..Peripheral cannabinoids may be very effective for managing certain chronic pains without undesirable side effects associated with traditional therapies. ..
- Neural Mechanisms of Cancer PainDonald A Simone; Fiscal Year: 2010..Results may have a direct impact on the future development of novel medications for cancer pain that act peripherally at the tumor/nerve level. ..