Tony Simon

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Young adult male carriers of the fragile X premutation exhibit genetically modulated impairments in visuospatial tasks controlled for psychomotor speed
    Ling M Wong
    MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California, Davis, 2825 50th Street, Sacramento, CA, 95817, USA
    J Neurodev Disord 4:26. 2012
  2. pmc A cross-sectional study of the development of volitional control of spatial attention in children with chromosome 22q11.2 deletion syndrome
    Heather M Shapiro
    MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California, Davis, 2825 50th Street, Sacramento, CA 95817, USA
    J Neurodev Disord 4:5. 2012
  3. pmc Impaired multiple object tracking in children with chromosome 22q11.2 deletion syndrome
    Margarita H Cabaral
    Department of Psychiatry and Behavioral Sciences and the Medical Investigation of Neurodevelopmental Disorders MIND Institute, University of California Davis Medical Center, 2825 50th Street, Sacramento, CA 95817, USA
    J Neurodev Disord 4:6. 2012
  4. pmc How might stress contribute to increased risk for schizophrenia in children with chromosome 22q11.2 deletion syndrome?
    Elliott A Beaton
    Department of Psychiatry and Behavioral Sciences and the M I N D Institute, University of California Davis, 2825 50th Street, Sacramento, CA 95817 USA
    J Neurodev Disord 3:68-75. 2011
  5. pmc Hippocampal volume reduction in children with chromosome 22q11.2 deletion syndrome is associated with cognitive impairment
    Tracy DeBoer
    M, I, N, d, Institute, Psychiatry and Behavioral Sciences, University of California, Davis, USA
    Behav Brain Funct 3:54. 2007
  6. pmc Overlapping numerical cognition impairments in children with chromosome 22q11.2 deletion or Turner syndromes
    T J Simon
    MIND Institute, University of California at Davis, 2825 50th Street, Sacramento, CA 95817, United States
    Neuropsychologia 46:82-94. 2008
  7. pmc Atypical cortical connectivity and visuospatial cognitive impairments are related in children with chromosome 22q11.2 deletion syndrome
    Tony J Simon
    M, I, N, d, Institute, University of California, Davis, 2825 50th Street, Sacramento, CA 95817, USA
    Behav Brain Funct 4:25. 2008
  8. pmc A new account of the neurocognitive foundations of impairments in space, time and number processing in children with chromosome 22q11.2 deletion syndrome
    Tony J Simon
    MIND Institute University of California Davis, Sacramento, CA 95817, USA
    Dev Disabil Res Rev 14:52-8. 2008
  9. pmc Clues to the foundations of numerical cognitive impairments: evidence from genetic disorders
    Tony J Simon
    MIND Institute, University of California Davis, Sacramento, California 95817, USA
    Dev Neuropsychol 36:788-805. 2011
  10. pmc Cognitive characteristics of children with genetic syndromes
    Tony J Simon
    University of California, Davis, M I N D Institute, Sacramento, CA 95817, USA
    Child Adolesc Psychiatr Clin N Am 16:599-616. 2007

Collaborators

Detail Information

Publications30

  1. pmc Young adult male carriers of the fragile X premutation exhibit genetically modulated impairments in visuospatial tasks controlled for psychomotor speed
    Ling M Wong
    MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California, Davis, 2825 50th Street, Sacramento, CA, 95817, USA
    J Neurodev Disord 4:26. 2012
    ..abstract:..
  2. pmc A cross-sectional study of the development of volitional control of spatial attention in children with chromosome 22q11.2 deletion syndrome
    Heather M Shapiro
    MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California, Davis, 2825 50th Street, Sacramento, CA 95817, USA
    J Neurodev Disord 4:5. 2012
    ..abstract:..
  3. pmc Impaired multiple object tracking in children with chromosome 22q11.2 deletion syndrome
    Margarita H Cabaral
    Department of Psychiatry and Behavioral Sciences and the Medical Investigation of Neurodevelopmental Disorders MIND Institute, University of California Davis Medical Center, 2825 50th Street, Sacramento, CA 95817, USA
    J Neurodev Disord 4:6. 2012
    ..abstract:..
  4. pmc How might stress contribute to increased risk for schizophrenia in children with chromosome 22q11.2 deletion syndrome?
    Elliott A Beaton
    Department of Psychiatry and Behavioral Sciences and the M I N D Institute, University of California Davis, 2825 50th Street, Sacramento, CA 95817 USA
    J Neurodev Disord 3:68-75. 2011
    ..2DS while suggesting possible early interventions. Childhood anxiety is treatable and stress coping skills can be developed thereby improving quality of life in the short-term and potentially mitigating the risk of developing psychosis...
  5. pmc Hippocampal volume reduction in children with chromosome 22q11.2 deletion syndrome is associated with cognitive impairment
    Tracy DeBoer
    M, I, N, d, Institute, Psychiatry and Behavioral Sciences, University of California, Davis, USA
    Behav Brain Funct 3:54. 2007
    ..abstract:..
  6. pmc Overlapping numerical cognition impairments in children with chromosome 22q11.2 deletion or Turner syndromes
    T J Simon
    MIND Institute, University of California at Davis, 2825 50th Street, Sacramento, CA 95817, United States
    Neuropsychologia 46:82-94. 2008
    ....
  7. pmc Atypical cortical connectivity and visuospatial cognitive impairments are related in children with chromosome 22q11.2 deletion syndrome
    Tony J Simon
    M, I, N, d, Institute, University of California, Davis, 2825 50th Street, Sacramento, CA 95817, USA
    Behav Brain Funct 4:25. 2008
    ..abstract:..
  8. pmc A new account of the neurocognitive foundations of impairments in space, time and number processing in children with chromosome 22q11.2 deletion syndrome
    Tony J Simon
    MIND Institute University of California Davis, Sacramento, CA 95817, USA
    Dev Disabil Res Rev 14:52-8. 2008
    ....
  9. pmc Clues to the foundations of numerical cognitive impairments: evidence from genetic disorders
    Tony J Simon
    MIND Institute, University of California Davis, Sacramento, California 95817, USA
    Dev Neuropsychol 36:788-805. 2011
    ..The question of what neural substrate might underlie these impairments is also addressed, as are the challenges for interpreting neural structure/cognitive function mapping in atypically developing populations...
  10. pmc Cognitive characteristics of children with genetic syndromes
    Tony J Simon
    University of California, Davis, M I N D Institute, Sacramento, CA 95817, USA
    Child Adolesc Psychiatr Clin N Am 16:599-616. 2007
    ..The importance of a developmental approach to understanding dysfunction is stressed...
  11. pmc A multilevel analysis of cognitive dysfunction and psychopathology associated with chromosome 22q11.2 deletion syndrome in children
    Tony J Simon
    University of California, Davis, Sacramento 95817, USA
    Dev Psychopathol 17:753-84. 2005
    ..Beyond that, we introduce the idea that variation in other genes may further explain the phenotypic variation in cognitive function and possibly the anomalies in brain development...
  12. pmc Mapping cortical thickness in children with 22q11.2 deletions
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
    Cereb Cortex 17:1889-98. 2007
    ..These brain maps reveal how haploinsufficiency for such genes can affect cortical development and suggest a possible underlying pathophysiology of the neurobehavioral phenotype...
  13. pmc Effects of COMT genotype on behavioral symptomatology in the 22q11.2 Deletion Syndrome
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Child Neuropsychol 11:109-17. 2005
    ....
  14. pmc Atypical functional brain activation during a multiple object tracking task in girls with Turner syndrome: neurocorrelates of reduced spatiotemporal resolution
    Elliott A Beaton
    M I N D Institute, University of California at Davis Medical Center, Sacramento, CA 95817, USA
    Am J Intellect Dev Disabil 115:140-56. 2010
    ..Task performance and atypical functional activation indicate anomalous development of cortical and subcortical temporal and spatial processing circuits in girls with Turner syndrome...
  15. pmc Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome
    Joel Stoddard
    Department of Psychiatry and Behavioral Sciences and The Medical Investigation of Neurodevelopmental Disorders Institute, University of California at Davis Health System, Institute, University of California, Davis, Sacramento, CA 95817, United States
    Schizophr Res 118:118-21. 2010
    ..Almost all presented with moderate to severe symptoms in the negative, disorganized, and general symptom domains...
  16. pmc Catechol-O-methyltransferase polymorphism modulates cognitive control in children with chromosome 22q11.2 deletion syndrome
    Yukari Takarae
    University of California, Davis, California, USA
    Cogn Affect Behav Neurosci 9:83-90. 2009
    ..Our results support that a single gene, COMT, could modulate PFC-dependent cognition...
  17. ncbi request reprint Volumetric, connective, and morphologic changes in the brains of children with chromosome 22q11.2 deletion syndrome: an integrative study
    Tony J Simon
    Children s Hospital of Philadelphia, 3535 Market Street, Room 1425, Philadelphia, PA 19104, USA
    Neuroimage 25:169-80. 2005
    ....
  18. ncbi request reprint Brief report: methods for acquiring structural MRI data in very young children with autism without the use of sedation
    Christine Wu Nordahl
    M I N D Institute and Department of Psychiatry and Behavioral Sciences, University of California at Davis, 2805 50th Street, Sacramento, CA, 95817, USA
    J Autism Dev Disord 38:1581-90. 2008
    ..Scanning very young children with autism, typical development, and developmental delays without the use of sedation or anesthesia was possible in the majority of cases...
  19. pmc Increased incidence and size of cavum septum pellucidum in children with chromosome 22q11.2 deletion syndrome
    Elliott A Beaton
    Department of Psychiatry, University of California, Davis, CA, USA UC Davis M I N D Institute, University of California, Davis, Sacramento, CA, USA
    Psychiatry Res 181:108-13. 2010
    ..2DS, large CSP may be a biomarker of atypical brain development. The implication of these larger CSP for cognitive and behavioral development is a topic in need of further investigation...
  20. ncbi request reprint Williams syndrome cognitive profile also characterizes Velocardiofacial/DiGeorge syndrome
    Carrie E Bearden
    Am J Med Genet 114:689-92. 2002
  21. ncbi request reprint Visuospatial and numerical cognitive deficits in children with chromosome 22q11.2 deletion syndrome
    Tony J Simon
    University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Cortex 41:145-55. 2005
    ..Instead, our findings are supportive of the hypothesis that visuospatial and numerical deficits in children with the chromosome 22q11.2 deletion are due, at least in part, to posterior parietal dysfunction...
  22. pmc Corpus callosum morphology and ventricular size in chromosome 22q11.2 deletion syndrome
    Alexei M C Machado
    Pontifical Catholic University of Minas Gerais, Av Dom Jose Gaspar, 500, PPGEE, Belo Horizonte, MG 30535 610, Brazil
    Brain Res 1131:197-210. 2007
    ..These novel findings reveal intricate relationships between genetic and disease-specific factors in the callosal anatomy and the potential impact of those changes on cognitive functions...
  23. pmc Domain specific attentional impairments in children with chromosome 22q11.2 deletion syndrome
    Joel P Bish
    Ursinus College, Department of Neuroscience, Thomas Hall, Collegeville, PA 19426, USA
    Brain Cogn 64:265-73. 2007
    ..Finally, the children with DS22q11.2 demonstrated an intact inhibition of return system, however, it appears to be delayed developmentally...
  24. ncbi request reprint Regional brain abnormalities in 22q11.2 deletion syndrome: association with cognitive abilities and behavioral symptoms
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90095, USA
    Neurocase 10:198-206. 2004
    ..Although preliminary,these findings suggest a possible underlying pathophysiology of the cognitive deficits seen in this syndrome,and provide insight into complex gene-brain-behavior relationships...
  25. ncbi request reprint Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome
    Joel P Bish
    Children s Hospital of Philadelphia, USA
    Neurosci Lett 399:245-8. 2006
    ..These results suggest that the morphological changes of specific portions of the cerebellum may be an important underlying substrate of cognitive impairments and increased incidence of psychopathology in this group...
  26. ncbi request reprint Shape-based normalization of the corpus callosum for DTI connectivity analysis
    Hui Sun
    Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    IEEE Trans Med Imaging 26:1166-78. 2007
    ..These results suggest that cm-rep is an appropriate tool for normalizing the corpus callosum in white matter studies...
  27. ncbi request reprint Maladaptive conflict monitoring as evidence for executive dysfunction in children with chromosome 22q11.2 deletion syndrome
    Joel P Bish
    Children s Hospital of Philadelphia, 3535 Market Street, Philadelphia, PA 19104, USA
    Dev Sci 8:36-43. 2005
    ..2, a problem that is also present in schizophrenia. The findings of specific executive dysfunction in this group may provide a linkage between particular genetic abnormalities and the development of psychopathology...
  28. ncbi request reprint Effects of a functional COMT polymorphism on prefrontal cognitive function in patients with 22q11.2 deletion syndrome
    Carrie E Bearden
    Children s Hospital of Philadelphia, Department of Child Development, USA
    Am J Psychiatry 161:1700-2. 2004
    ..The goal of the present study was to examine COMT genotype as a predictor of prefrontal cognitive function in patients with 22q11.2 deletion syndrome...
  29. ncbi request reprint Thalamic reductions in children with chromosome 22q11.2 deletion syndrome
    Joel P Bish
    Children s Hospital of Philadelphia, 3535 Market St, Philadelphia, PA 19104, USA
    Neuroreport 15:1413-5. 2004
    ..These results provide the first evidence for a potential relationship between posterior thalamic reductions and the characteristic visuo-spatial deficits demonstrated in this group...
  30. ncbi request reprint Evaluation of shape-based normalization in the corpus callosum for white matter connectivity analysis
    Hui Sun
    Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, USA
    Med Image Comput Comput Assist Interv 10:777-84. 2007
    ..These results suggest that cm-rep is an appropriate tool for normalizing the MSCC in white matter studies...

Research Grants17

  1. Visuospatial Cognitive Deficit in Del22q11.2 Syndrome
    Tony Simon; Fiscal Year: 2009
    ....
  2. Visuospatial Cognitive Deficit in Del22q11.2 Syndrome
    Tony Simon; Fiscal Year: 2009
    ....
  3. Numerical Deficits Across Multiple Genetic Disorders
    Tony Simon; Fiscal Year: 2007
    ..It should be possible to use these results to develop interventions for children with numerical disabilities and improved teaching methods in the numerical domain for typically developing children. ..
  4. Visuospatial Cognitive Deficit in Del22q11.2 Syndrome
    Tony J Simon; Fiscal Year: 2010
    ....