Tony J Simon

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Visuospatial and numerical cognitive deficits in children with chromosome 22q11.2 deletion syndrome
    Tony J Simon
    University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Cortex 41:145-55. 2005
  2. ncbi request reprint Evaluation of shape-based normalization in the corpus callosum for white matter connectivity analysis
    Hui Sun
    Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, USA
    Med Image Comput Comput Assist Interv 10:777-84. 2007
  3. pmc Structure-specific statistical mapping of white matter tracts
    Paul A Yushkevich
    Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
    Neuroimage 41:448-61. 2008
  4. ncbi request reprint Volumetric, connective, and morphologic changes in the brains of children with chromosome 22q11.2 deletion syndrome: an integrative study
    Tony J Simon
    Children s Hospital of Philadelphia, 3535 Market Street, Room 1425, Philadelphia, PA 19104, USA
    Neuroimage 25:169-80. 2005
  5. ncbi request reprint Maladaptive conflict monitoring as evidence for executive dysfunction in children with chromosome 22q11.2 deletion syndrome
    Joel P Bish
    Children s Hospital of Philadelphia, 3535 Market Street, Philadelphia, PA 19104, USA
    Dev Sci 8:36-43. 2005
  6. pmc Corpus callosum morphology and ventricular size in chromosome 22q11.2 deletion syndrome
    Alexei M C Machado
    Pontifical Catholic University of Minas Gerais, Av Dom Jose Gaspar, 500, PPGEE, Belo Horizonte, MG 30535 610, Brazil
    Brain Res 1131:197-210. 2007
  7. ncbi request reprint Thalamic reductions in children with chromosome 22q11.2 deletion syndrome
    Joel P Bish
    Children s Hospital of Philadelphia, 3535 Market St, Philadelphia, PA 19104, USA
    Neuroreport 15:1413-5. 2004
  8. ncbi request reprint Shape-based normalization of the corpus callosum for DTI connectivity analysis
    Hui Sun
    Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    IEEE Trans Med Imaging 26:1166-78. 2007
  9. pmc Domain specific attentional impairments in children with chromosome 22q11.2 deletion syndrome
    Joel P Bish
    Ursinus College, Department of Neuroscience, Thomas Hall, Collegeville, PA 19426, USA
    Brain Cogn 64:265-73. 2007
  10. ncbi request reprint Williams syndrome cognitive profile also characterizes Velocardiofacial/DiGeorge syndrome
    Carrie E Bearden
    Am J Med Genet 114:689-92. 2002

Detail Information

Publications19

  1. ncbi request reprint Visuospatial and numerical cognitive deficits in children with chromosome 22q11.2 deletion syndrome
    Tony J Simon
    University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Cortex 41:145-55. 2005
    ..Instead, our findings are supportive of the hypothesis that visuospatial and numerical deficits in children with the chromosome 22q11.2 deletion are due, at least in part, to posterior parietal dysfunction...
  2. ncbi request reprint Evaluation of shape-based normalization in the corpus callosum for white matter connectivity analysis
    Hui Sun
    Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, USA
    Med Image Comput Comput Assist Interv 10:777-84. 2007
    ..These results suggest that cm-rep is an appropriate tool for normalizing the MSCC in white matter studies...
  3. pmc Structure-specific statistical mapping of white matter tracts
    Paul A Yushkevich
    Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
    Neuroimage 41:448-61. 2008
    ..The framework is demonstrated in a study of white matter differences in pediatric chromosome 22q11.2 deletion syndrome...
  4. ncbi request reprint Volumetric, connective, and morphologic changes in the brains of children with chromosome 22q11.2 deletion syndrome: an integrative study
    Tony J Simon
    Children s Hospital of Philadelphia, 3535 Market Street, Room 1425, Philadelphia, PA 19104, USA
    Neuroimage 25:169-80. 2005
    ....
  5. ncbi request reprint Maladaptive conflict monitoring as evidence for executive dysfunction in children with chromosome 22q11.2 deletion syndrome
    Joel P Bish
    Children s Hospital of Philadelphia, 3535 Market Street, Philadelphia, PA 19104, USA
    Dev Sci 8:36-43. 2005
    ..2, a problem that is also present in schizophrenia. The findings of specific executive dysfunction in this group may provide a linkage between particular genetic abnormalities and the development of psychopathology...
  6. pmc Corpus callosum morphology and ventricular size in chromosome 22q11.2 deletion syndrome
    Alexei M C Machado
    Pontifical Catholic University of Minas Gerais, Av Dom Jose Gaspar, 500, PPGEE, Belo Horizonte, MG 30535 610, Brazil
    Brain Res 1131:197-210. 2007
    ..These novel findings reveal intricate relationships between genetic and disease-specific factors in the callosal anatomy and the potential impact of those changes on cognitive functions...
  7. ncbi request reprint Thalamic reductions in children with chromosome 22q11.2 deletion syndrome
    Joel P Bish
    Children s Hospital of Philadelphia, 3535 Market St, Philadelphia, PA 19104, USA
    Neuroreport 15:1413-5. 2004
    ..These results provide the first evidence for a potential relationship between posterior thalamic reductions and the characteristic visuo-spatial deficits demonstrated in this group...
  8. ncbi request reprint Shape-based normalization of the corpus callosum for DTI connectivity analysis
    Hui Sun
    Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    IEEE Trans Med Imaging 26:1166-78. 2007
    ..These results suggest that cm-rep is an appropriate tool for normalizing the corpus callosum in white matter studies...
  9. pmc Domain specific attentional impairments in children with chromosome 22q11.2 deletion syndrome
    Joel P Bish
    Ursinus College, Department of Neuroscience, Thomas Hall, Collegeville, PA 19426, USA
    Brain Cogn 64:265-73. 2007
    ..Finally, the children with DS22q11.2 demonstrated an intact inhibition of return system, however, it appears to be delayed developmentally...
  10. ncbi request reprint Williams syndrome cognitive profile also characterizes Velocardiofacial/DiGeorge syndrome
    Carrie E Bearden
    Am J Med Genet 114:689-92. 2002
  11. pmc Mapping cortical thickness in children with 22q11.2 deletions
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
    Cereb Cortex 17:1889-98. 2007
    ..These brain maps reveal how haploinsufficiency for such genes can affect cortical development and suggest a possible underlying pathophysiology of the neurobehavioral phenotype...
  12. ncbi request reprint Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome
    Joel P Bish
    Children s Hospital of Philadelphia, USA
    Neurosci Lett 399:245-8. 2006
    ..These results suggest that the morphological changes of specific portions of the cerebellum may be an important underlying substrate of cognitive impairments and increased incidence of psychopathology in this group...
  13. pmc A multilevel analysis of cognitive dysfunction and psychopathology associated with chromosome 22q11.2 deletion syndrome in children
    Tony J Simon
    University of California, Davis, Sacramento 95817, USA
    Dev Psychopathol 17:753-84. 2005
    ..Beyond that, we introduce the idea that variation in other genes may further explain the phenotypic variation in cognitive function and possibly the anomalies in brain development...
  14. pmc A new account of the neurocognitive foundations of impairments in space, time and number processing in children with chromosome 22q11.2 deletion syndrome
    Tony J Simon
    MIND Institute University of California Davis, Sacramento, CA 95817, USA
    Dev Disabil Res Rev 14:52-8. 2008
    ....
  15. pmc Cognitive characteristics of children with genetic syndromes
    Tony J Simon
    University of California, Davis, M I N D Institute, Sacramento, CA 95817, USA
    Child Adolesc Psychiatr Clin N Am 16:599-616. 2007
    ..The importance of a developmental approach to understanding dysfunction is stressed...
  16. pmc Effects of COMT genotype on behavioral symptomatology in the 22q11.2 Deletion Syndrome
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Child Neuropsychol 11:109-17. 2005
    ....
  17. ncbi request reprint Regional brain abnormalities in 22q11.2 deletion syndrome: association with cognitive abilities and behavioral symptoms
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90095, USA
    Neurocase 10:198-206. 2004
    ..Although preliminary,these findings suggest a possible underlying pathophysiology of the cognitive deficits seen in this syndrome,and provide insight into complex gene-brain-behavior relationships...
  18. ncbi request reprint Brief report: methods for acquiring structural MRI data in very young children with autism without the use of sedation
    Christine Wu Nordahl
    M I N D Institute and Department of Psychiatry and Behavioral Sciences, University of California at Davis, 2805 50th Street, Sacramento, CA, 95817, USA
    J Autism Dev Disord 38:1581-90. 2008
    ..Scanning very young children with autism, typical development, and developmental delays without the use of sedation or anesthesia was possible in the majority of cases...
  19. ncbi request reprint Effects of a functional COMT polymorphism on prefrontal cognitive function in patients with 22q11.2 deletion syndrome
    Carrie E Bearden
    Children s Hospital of Philadelphia, Department of Child Development, USA
    Am J Psychiatry 161:1700-2. 2004
    ..The goal of the present study was to examine COMT genotype as a predictor of prefrontal cognitive function in patients with 22q11.2 deletion syndrome...