Research Topics
| Jeffrey SimonSummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
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Detail Information
Publications
Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying putJeffrey A Simon
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
Mol Cell 49:808-24. 2013..The stage is now set to reveal fundamental epigenetic mechanisms that determine how Polycomb target genes are silenced and how Polycomb silence is preserved through cell-cycle progression...
Chromatin compaction at Hox loci: a polycomb tale beyond histone tailsJeffrey A Simon
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
Mol Cell 38:321-2. 2010..2010) implicates Polycomb repressive complex 1 (PRC1) in compacting Hox gene chromatin in mouse embryonic stem cells and suggests that compaction, rather than histone tail ubiquitylation, confers Hox gene silencing...- Mechanisms of polycomb gene silencing: knowns and unknownsJeffrey A Simon
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis 55455, USA
Nat Rev Mol Cell Biol 10:697-708. 2009..These findings have an impact on the epigenetic programming of gene expression in many biological systems... - Roles of the EZH2 histone methyltransferase in cancer epigeneticsJeffrey A Simon
Department of Genetics, University of Minnesota, Minneapolis, MN 55455, USA
Mutat Res 647:21-9. 2008..Finally, we review recent findings that link EZH2 roles in stem cells and cancer, and we consider prospects for integrating EZH2 blockade into strategies for developing epigenetic therapies... 
Comparative analysis of chromatin binding by Sex Comb on Midleg (SCM) and other polycomb group repressors at a Drosophila Hox geneLiangjun Wang
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
Mol Cell Biol 30:2584-93. 2010..We discuss these results in light of current models for recruitment of PcG complexes to chromatin targets...- Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexesCarrie S Ketel
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, 55455, USA
Mol Cell Biol 25:6857-68. 2005..Thus, although the fly and mammalian PcG complexes absolutely require SU(Z)12, the worm complex generates HMTase activity from a distinct partner set... - Requirement for sex comb on midleg protein interactions in Drosophila polycomb group repressionAidan J Peterson
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
Genetics 167:1225-39. 2004..These results suggest that SCM, although not a core component of PRC1, interacts and functions with PRC1 in gene silencing... - Polycomb group proteinsJeffrey A Simon
Department of Genetics, Cell Biology and Development, University of Minnesota, 321 Church St. SE, Minneapolis, MN 55455, USA
Curr Biol 13:R79-80. 2003 - Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexesJeffrey A Simon
Department of Genetics, Cell Biology and Development, University of Minnesota, 321 Church St, Minneapolis, Minnesota 55455, USA
Curr Opin Genet Dev 12:210-8. 2002.... - Drosophila histone deacetylase-3 controls imaginal disc size through suppression of apoptosisChangqi C Zhu
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, United States of America
PLoS Genet 4:e1000009. 2008..However, the specific HDACs implicated in tumor cell killing have not been identified. Our results indicate that protein deacetylation by HDAC3 plays a key role in suppression of apoptosis in Drosophila imaginal tissue... - Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2Shuai Chen
Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Nat Cell Biol 12:1108-14. 2010..These results demonstrate that CDK-mediated phosphorylation is a key mechanism governing EZH2 function and that there is a link between the cell-cycle machinery and epigenetic gene silencing... - Dominant alleles identify SET domain residues required for histone methyltransferase of Polycomb repressive complex 2Preeti Joshi
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minneapolis 55455, USA
J Biol Chem 283:27757-66. 2008..These results identify critical SET domain residues needed for PRC2 enzyme function, and they also emphasize functional inputs from outside the SET domain...
Research Grants
- TRANSCRIPTIONAL REPRESSION BY POLYCOMB GROUP PRODUCTSJeffrey Simon; Fiscal Year: 2007..Knowledge about PcG mechanisms in flies may thus improve understanding of normal blood cell development and processes that underlie these human cancers. ..
- TRANSCRIPTIONAL REPRESSION BY POLYCOMB GROUP PRODUCTSJeffrey Simon; Fiscal Year: 2003..Knowledge about the fly PcG components and mechanisms may contribute to a better understanding of normal blood cell development and processes that underlie certain human cancers. ..
- TRANSCRIPTIONAL REPRESSION BY POLYCOMB GROUP PRODUCTSJeffrey Simon; Fiscal Year: 1999..Since the mouse PcG homolog is an oncogene, this work may also provide insight into the basis of uncontrolled cell proliferation. ..
- TRANSCRIPTIONAL REPRESSION BY POLYCOMB GROUP PRODUCTSJeffrey A Simon; Fiscal Year: 2010..This research will advance basic understanding of gene regulatory mechanisms and provide knowledge that could impact stem cell applications in medicine and development of anti-cancer strategies. ..