Jeffrey Simon

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Drosophila histone deacetylase-3 controls imaginal disc size through suppression of apoptosis
    Changqi C Zhu
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS Genet 4:e1000009. 2008
  2. pmc Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put
    Jeffrey A Simon
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Cell 49:808-24. 2013
  3. ncbi request reprint Chromatin compaction at Hox loci: a polycomb tale beyond histone tails
    Jeffrey A Simon
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Cell 38:321-2. 2010
  4. doi request reprint Mechanisms of polycomb gene silencing: knowns and unknowns
    Jeffrey A Simon
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis 55455, USA
    Nat Rev Mol Cell Biol 10:697-708. 2009
  5. doi request reprint Roles of the EZH2 histone methyltransferase in cancer epigenetics
    Jeffrey A Simon
    Department of Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Mutat Res 647:21-9. 2008
  6. pmc Comparative analysis of chromatin binding by Sex Comb on Midleg (SCM) and other polycomb group repressors at a Drosophila Hox gene
    Liangjun Wang
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Mol Cell Biol 30:2584-93. 2010
  7. pmc Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes
    Carrie S Ketel
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, 55455, USA
    Mol Cell Biol 25:6857-68. 2005
  8. pmc Requirement for sex comb on midleg protein interactions in Drosophila polycomb group repression
    Aidan J Peterson
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Genetics 167:1225-39. 2004
  9. ncbi request reprint Polycomb group proteins
    Jeffrey A Simon
    Department of Genetics, Cell Biology and Development, University of Minnesota, 321 Church St SE, Minneapolis, MN 55455, USA
    Curr Biol 13:R79-80. 2003
  10. ncbi request reprint Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes
    Jeffrey A Simon
    Department of Genetics, Cell Biology and Development, University of Minnesota, 321 Church St, Minneapolis, Minnesota 55455, USA
    Curr Opin Genet Dev 12:210-8. 2002

Research Grants

Collaborators

Detail Information

Publications12

  1. pmc Drosophila histone deacetylase-3 controls imaginal disc size through suppression of apoptosis
    Changqi C Zhu
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS Genet 4:e1000009. 2008
    ..However, the specific HDACs implicated in tumor cell killing have not been identified. Our results indicate that protein deacetylation by HDAC3 plays a key role in suppression of apoptosis in Drosophila imaginal tissue...
  2. pmc Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put
    Jeffrey A Simon
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Cell 49:808-24. 2013
    ..The stage is now set to reveal fundamental epigenetic mechanisms that determine how Polycomb target genes are silenced and how Polycomb silence is preserved through cell-cycle progression...
  3. ncbi request reprint Chromatin compaction at Hox loci: a polycomb tale beyond histone tails
    Jeffrey A Simon
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Cell 38:321-2. 2010
    ..2010) implicates Polycomb repressive complex 1 (PRC1) in compacting Hox gene chromatin in mouse embryonic stem cells and suggests that compaction, rather than histone tail ubiquitylation, confers Hox gene silencing...
  4. doi request reprint Mechanisms of polycomb gene silencing: knowns and unknowns
    Jeffrey A Simon
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis 55455, USA
    Nat Rev Mol Cell Biol 10:697-708. 2009
    ..These findings have an impact on the epigenetic programming of gene expression in many biological systems...
  5. doi request reprint Roles of the EZH2 histone methyltransferase in cancer epigenetics
    Jeffrey A Simon
    Department of Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Mutat Res 647:21-9. 2008
    ..Finally, we review recent findings that link EZH2 roles in stem cells and cancer, and we consider prospects for integrating EZH2 blockade into strategies for developing epigenetic therapies...
  6. pmc Comparative analysis of chromatin binding by Sex Comb on Midleg (SCM) and other polycomb group repressors at a Drosophila Hox gene
    Liangjun Wang
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Mol Cell Biol 30:2584-93. 2010
    ..We discuss these results in light of current models for recruitment of PcG complexes to chromatin targets...
  7. pmc Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes
    Carrie S Ketel
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, 55455, USA
    Mol Cell Biol 25:6857-68. 2005
    ..Thus, although the fly and mammalian PcG complexes absolutely require SU(Z)12, the worm complex generates HMTase activity from a distinct partner set...
  8. pmc Requirement for sex comb on midleg protein interactions in Drosophila polycomb group repression
    Aidan J Peterson
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Genetics 167:1225-39. 2004
    ..These results suggest that SCM, although not a core component of PRC1, interacts and functions with PRC1 in gene silencing...
  9. ncbi request reprint Polycomb group proteins
    Jeffrey A Simon
    Department of Genetics, Cell Biology and Development, University of Minnesota, 321 Church St SE, Minneapolis, MN 55455, USA
    Curr Biol 13:R79-80. 2003
  10. ncbi request reprint Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes
    Jeffrey A Simon
    Department of Genetics, Cell Biology and Development, University of Minnesota, 321 Church St, Minneapolis, Minnesota 55455, USA
    Curr Opin Genet Dev 12:210-8. 2002
    ....
  11. pmc Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2
    Shuai Chen
    Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Nat Cell Biol 12:1108-14. 2010
    ..These results demonstrate that CDK-mediated phosphorylation is a key mechanism governing EZH2 function and that there is a link between the cell-cycle machinery and epigenetic gene silencing...
  12. pmc Dominant alleles identify SET domain residues required for histone methyltransferase of Polycomb repressive complex 2
    Preeti Joshi
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minneapolis 55455, USA
    J Biol Chem 283:27757-66. 2008
    ..These results identify critical SET domain residues needed for PRC2 enzyme function, and they also emphasize functional inputs from outside the SET domain...

Research Grants13

  1. TRANSCRIPTIONAL REPRESSION BY POLYCOMB GROUP PRODUCTS
    Jeffrey Simon; Fiscal Year: 1999
    ..Since the mouse PcG homolog is an oncogene, this work may also provide insight into the basis of uncontrolled cell proliferation. ..
  2. TRANSCRIPTIONAL REPRESSION BY POLYCOMB GROUP PRODUCTS
    Jeffrey Simon; Fiscal Year: 2003
    ..Knowledge about the fly PcG components and mechanisms may contribute to a better understanding of normal blood cell development and processes that underlie certain human cancers. ..
  3. TRANSCRIPTIONAL REPRESSION BY POLYCOMB GROUP PRODUCTS
    Jeffrey Simon; Fiscal Year: 2007
    ..Knowledge about PcG mechanisms in flies may thus improve understanding of normal blood cell development and processes that underlie these human cancers. ..
  4. TRANSCRIPTIONAL REPRESSION BY POLYCOMB GROUP PRODUCTS
    Jeffrey A Simon; Fiscal Year: 2010
    ..This research will advance basic understanding of gene regulatory mechanisms and provide knowledge that could impact stem cell applications in medicine and development of anti-cancer strategies. ..