Alexander Simon


Affiliation: University of Arizona
Country: USA


  1. request reprint
    Simon A, McWhorter A. Role of connexin37 and connexin40 in vascular development. Cell Commun Adhes. 2003;10:379-85 pubmed
    ..In addition, Cx37 and Cx40 appear to be mutually dependent on each other for normal expression in vascular endothelium. ..
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    Simon A, Chen H, Jackson C. Cx37 and Cx43 localize to zona pellucida in mouse ovarian follicles. Cell Commun Adhes. 2006;13:61-77 pubmed
    ..We suggest that in addition to its role in oocyte-granulosa cell communication, Cx37 could enable a distinct communication pathway between those granulosa cells that are in direct contact with the oocyte. ..
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    Simon A, McWhorter A. Decreased intercellular dye-transfer and downregulation of non-ablated connexins in aortic endothelium deficient in connexin37 or connexin40. J Cell Sci. 2003;116:2223-36 pubmed
    ..Furthermore, Cx37 and Cx40 are codependent on each other for optimal expression in vascular endothelium. ..
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    Simon A, McWhorter A, Dones J, Jackson C, Chen H. Heart and head defects in mice lacking pairs of connexins. Dev Biol. 2004;265:369-83 pubmed
    ..Moreover, ablating different pairs of cardiac connexins results in distinct heart defects, suggesting both common and unique functions for Cx40, Cx43, and Cx37 during cardiac morphogenesis. ..
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    Simon A, McWhorter A, Chen H, Jackson C, Ouellette Y. Decreased intercellular communication and connexin expression in mouse aortic endothelium during lipopolysaccharide-induced inflammation. J Vasc Res. 2004;41:323-33 pubmed
    ..These results suggest that LPS mediates changes in endothelial gap junction-mediated communication, at least in part, through modulation of Cx40 and Cx37 levels. ..