Rebecca A Simmons

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Developmental origins of adult metabolic disease: concepts and controversies
    Rebecca Simmons
    Department of Pediatrics Children s Hospital Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Trends Endocrinol Metab 16:390-4. 2005
  2. ncbi request reprint Role of metabolic programming in the pathogenesis of beta-cell failure in postnatal life
    Rebecca A Simmons
    Department of Pediatrics, Children s Hospital Philadelphia and University of Pennsylvania School of Medicine, BRB II III, Rm 1308, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Rev Endocr Metab Disord 8:95-104. 2007
  3. pmc Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1
    Jun H Park
    Department of Pediatrics, Children s Hospital of Philadelphia, Department of Medicine, and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:2316-24. 2008
  4. pmc Developmental origins of diabetes: The role of oxidative stress
    Rebecca A Simmons
    Department of Pediatrics, Children s Hospital Philadelphia and University of Pennsylvania, Philadelphia, Philadelphia, PA 19104, USA
    Best Pract Res Clin Endocrinol Metab 26:701-8. 2012
  5. doi request reprint Epigenetics and maternal nutrition: nature v. nurture
    Rebecca Simmons
    Department of Pediatrics, Children s Hospital Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Nutr Soc 70:73-81. 2011
  6. pmc Developmental origins of adult disease
    Rebecca A Simmons
    Department of Pediatrics, Children s Hospital, Philadelphia, PA, USA
    Pediatr Clin North Am 56:449-66, Table of Contents. 2009
  7. pmc Perinatal programming of obesity
    Rebecca Simmons
    Department of Pediatrics, Children s Hospital Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Semin Perinatol 32:371-4. 2008
  8. ncbi request reprint Developmental origins of diabetes: the role of epigenetic mechanisms
    Rebecca A Simmons
    Department of Pediatrics, Children s Hospital Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Endocrinol Diabetes Obes 14:13-6. 2007
  9. ncbi request reprint Developmental origins of beta-cell failure in type 2 diabetes: the role of epigenetic mechanisms
    Rebecca A Simmons
    Department of Pediatrics Children s Hospital Philadelphia, University of Pennsylvania, PA 19104, USA
    Pediatr Res 61:64R-67R. 2007
  10. ncbi request reprint Developmental origins of diabetes: the role of oxidative stress
    Rebecca A Simmons
    Department of Pediatrics, Children s Hospital Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA
    Free Radic Biol Med 40:917-22. 2006

Research Grants

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Developmental origins of adult metabolic disease: concepts and controversies
    Rebecca Simmons
    Department of Pediatrics Children s Hospital Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Trends Endocrinol Metab 16:390-4. 2005
    ..Emerging data indicates that epigenetic regulation of gene expression might also play a crucial role in the pathogenesis of type 2 diabetes in individuals who are growth retarded at birth...
  2. ncbi request reprint Role of metabolic programming in the pathogenesis of beta-cell failure in postnatal life
    Rebecca A Simmons
    Department of Pediatrics, Children s Hospital Philadelphia and University of Pennsylvania School of Medicine, BRB II III, Rm 1308, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Rev Endocr Metab Disord 8:95-104. 2007
    ..Future research will be directed at elucidating the mechanisms underlying epigenetic modifications in offspring...
  3. pmc Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1
    Jun H Park
    Department of Pediatrics, Children s Hospital of Philadelphia, Department of Medicine, and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:2316-24. 2008
    ..These results provide insight into the development of type 2 diabetes following IUGR and we believe they are the first to describe the ontogeny of chromatin remodeling in vivo from the fetus to the onset of disease in adulthood...
  4. pmc Developmental origins of diabetes: The role of oxidative stress
    Rebecca A Simmons
    Department of Pediatrics, Children s Hospital Philadelphia and University of Pennsylvania, Philadelphia, Philadelphia, PA 19104, USA
    Best Pract Res Clin Endocrinol Metab 26:701-8. 2012
    ..Emerging data suggests that oxidative stress and mitochondrial dysfunction may also play a critical role in the pathogenesis of type 2 diabetes in individuals who were growth retarded at birth...
  5. doi request reprint Epigenetics and maternal nutrition: nature v. nurture
    Rebecca Simmons
    Department of Pediatrics, Children s Hospital Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Nutr Soc 70:73-81. 2011
    ..The contributions of histone acetylation, histone methylation and DNA methylation to the process of adipogenesis in vivo remain to be evaluated...
  6. pmc Developmental origins of adult disease
    Rebecca A Simmons
    Department of Pediatrics, Children s Hospital, Philadelphia, PA, USA
    Pediatr Clin North Am 56:449-66, Table of Contents. 2009
    ..Future research will be directed at elucidating the mechanisms underlying epigenetic modifications in offspring...
  7. pmc Perinatal programming of obesity
    Rebecca Simmons
    Department of Pediatrics, Children s Hospital Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Semin Perinatol 32:371-4. 2008
    ..Thus, both excess and reduced nutrient availability during fetal development can lead to the later development of obesity. This review summarizes both human and animal studies relating fetal exposures to later obesity...
  8. ncbi request reprint Developmental origins of diabetes: the role of epigenetic mechanisms
    Rebecca A Simmons
    Department of Pediatrics, Children s Hospital Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Endocrinol Diabetes Obes 14:13-6. 2007
    ..The purpose of this article is to review basic epigenetic mechanisms and familiarize the reader with the latest research linking epigenetics, fetal programming, and the development of type 2 diabetes...
  9. ncbi request reprint Developmental origins of beta-cell failure in type 2 diabetes: the role of epigenetic mechanisms
    Rebecca A Simmons
    Department of Pediatrics Children s Hospital Philadelphia, University of Pennsylvania, PA 19104, USA
    Pediatr Res 61:64R-67R. 2007
    ..It is postulated that these epigenetic changes result in the observed increase in gene expression of GR and PPARgamma. Future research will be directed at elucidating the mechanisms underlying epigenetic modifications in offspring...
  10. ncbi request reprint Developmental origins of diabetes: the role of oxidative stress
    Rebecca A Simmons
    Department of Pediatrics, Children s Hospital Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA
    Free Radic Biol Med 40:917-22. 2006
    ..Emerging data suggest that oxidative stress and mitochondrial dysfunction may also play critical roles in the pathogenesis of type 2 diabetes in individuals who were growth retarded at birth...
  11. ncbi request reprint Developmental origins of adult metabolic disease
    Rebecca Simmons
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Endocrinol Metab Clin North Am 35:193-204, viii. 2006
  12. ncbi request reprint Perinatal programming of obesity
    Rebecca Simmons
    Department of Pediatrics Children s Hospital Philadelphia and University of Pennsylvania School of Medicine, BRB II III, Rm 1308, 421 Curie Blvd, Pennsylvania, Philadelphia, PA 19104, USA
    Exp Gerontol 40:863-6. 2005
  13. ncbi request reprint Intrauterine growth retardation leads to the development of type 2 diabetes in the rat
    R A Simmons
    Division of Neonatology, Department of Pediatrics, University of Pennsylvania and Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Diabetes 50:2279-86. 2001
    ..05). The data presented here support the hypothesis that an abnormal intrauterine milieu can induce permanent changes in glucose homeostasis after birth and lead to type 2 diabetes in adulthood...
  14. ncbi request reprint Progressive accumulation of mitochondrial DNA mutations and decline in mitochondrial function lead to beta-cell failure
    Rebecca A Simmons
    Department of Pediatrics Children s Hospital Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 280:28785-91. 2005
    ..A self-reinforcing cycle of progressive deterioration in mitochondrial function leads to a corresponding decline in beta-cell function. Finally, a threshold in mitochondrial dysfunction and ROS production is reached, and diabetes ensues...
  15. pmc Neonatal exendin-4 treatment reduces oxidative stress and prevents hepatic insulin resistance in intrauterine growth-retarded rats
    Elisabeth L Raab
    Department of Pediatrics, Children s Hospital Los Angeles, Los Angeles, California, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1785-94. 2009
    ..These results indicate that exposure to exendin-4 in the newborn period reverses the adverse consequences of fetal programming and prevents the development of hepatic insulin resistance...
  16. pmc Epigenetic mechanisms in the development of type 2 diabetes
    Sara E Pinney
    Department of Pediatrics, The Children s Hospital Philadelphia, Philadelphia, PA 19104, USA
    Trends Endocrinol Metab 21:223-9. 2010
    ....
  17. pmc Exendin-4 normalizes islet vascularity in intrauterine growth restricted rats: potential role of VEGF
    J Nina Ham
    Department of Medicine and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Pediatr Res 66:42-6. 2009
    ....
  18. ncbi request reprint Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats
    Iyalla E Peterside
    Department of Pediatrics, Children s Hospital and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Endocrinol Metab 285:E1258-66. 2003
    ....
  19. ncbi request reprint Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat
    Doris A Stoffers
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Clinical Research Building 611B, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Diabetes 52:734-40. 2003
    ..These results indicate that exposure to Ex-4 in the newborn period reverses the adverse consequences of fetal programming and prevents the development of diabetes in adulthood...
  20. ncbi request reprint Gestational diabetes leads to the development of diabetes in adulthood in the rat
    Judd Boloker
    Division of Neonatology, Department of Pediatrics, University of Pennsylvania and Children s Hospital of Philadelphia, Philadelphia, Pennsylvani, USA
    Diabetes 51:1499-506. 2002
    ..These data demonstrate that the altered metabolic milieu of the diabetic pregnancy causes permanent defects in glucose homeostasis in the offspring that lead to the development of diabetes later in life...
  21. doi request reprint Neonatal exendin-4 leads to protection from reperfusion injury and reduced rates of oxidative phosphorylation in the adult rat heart
    Suzanne B Brown
    Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Cardiovasc Drugs Ther 24:197-205. 2010
    ..We sought to evaluate whether neonatal Ex-4 can exert the same effect in the normal rat heart, as well as whether Ex-4 could affect susceptibility to cardiac reperfusion injury...
  22. ncbi request reprint Impaired oxidative phosphorylation in skeletal muscle of intrauterine growth-retarded rats
    Mary A Selak
    Department of Pediatrics, Children s Hospital of Philadelphia and University of Pennsylvania, 19104, USA
    Am J Physiol Endocrinol Metab 285:E130-7. 2003
    ..Impaired ATP synthesis in muscle compromises energy-dependent GLUT4 recruitment to the cell surface, glucose transport, and glycogen synthesis, which contribute to insulin resistance and hyperglycemia of type 2 diabetes...
  23. pmc Oxidative stress disrupts oligodendrocyte maturation
    Heather Morein French
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Neurosci Res 87:3076-87. 2009
    ..Both of these mechanisms result in the arrest of oligodendrocyte differentiation without an increase in cell death...
  24. doi request reprint Metabolic programming, epigenetics, and gestational diabetes mellitus
    Sara E Pinney
    Division of Endocrinology and Diabetes, Department of Pediatrics, The Children s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Diab Rep 12:67-74. 2012
    ....
  25. pmc Maternal antioxidant supplementation prevents adiposity in the offspring of Western diet-fed rats
    Sarbattama Sen
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 59:3058-65. 2010
    ....
  26. pmc Delayed myelination in an intrauterine growth retardation model is mediated by oxidative stress upregulating bone morphogenetic protein 4
    Mary V Reid
    Department of Neurology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Neuropathol Exp Neurol 71:640-53. 2012
    ..Together, these findings suggest that IUGR results in delayed myelination through the generation of oxidative stress that leads to BMP4 upregulation...
  27. pmc Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes
    Vargheese Chennathukuzhi
    Center for Research on Reproduction and Women s Health, School of Medicine, Department of Biology, University of Pennsylvania, 1310 Biomedical Research Building II III, 421 Curie Boulevard, Philadelphia, PA 19104 6142, USA
    Mol Cell Biol 23:6419-34. 2003
    ..Behavioral abnormalities were also seen. Compared to littermates, the TB-RBP-null mice appeared docile and exhibited reduced Rota-Rod performance...
  28. ncbi request reprint Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism
    Francis M Hoe
    Divisions of Endocrinology and Neonatology, Department of Pediatrics, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Pediatr 148:207-12. 2006
    ..To characterize the clinical features and insulin regulation in infants with hypoglycemia due to prolonged neonatal hyperinsulinism...
  29. ncbi request reprint Placental expression of insulin-like growth factor receptor-1 and insulin receptor in the growth-restricted fetal rat
    Gregory J Reid
    Department of Obstetrics and Gynecology, Northwestern University Medical School, Children s Memorial Hospital, Chicago, Illinois, USA
    J Soc Gynecol Investig 9:210-4. 2002
    ..The regulation of fetal growth by IGFs and insulin might reflect their actions on the placenta. This study compared the placental expression of IGF-R1 and INS-R in growth-restricted and normal pregnancies...

Research Grants13

  1. MECHANISMS BY WHICH IUGR LEADS TO DIABETES
    Rebecca Simmons; Fiscal Year: 2007
    ....
  2. Mechanisms by which GDM Leads to Diabetes in Offspring
    Rebecca Simmons; Fiscal Year: 2005
    ..non-F2 animals. ..
  3. MECHANISMS BY WHICH IUGR LEADS TO DIABETES
    Rebecca Simmons; Fiscal Year: 2003
    ..insufficiency to the beta-cell phenotype observed in type II diabetes, the investigators will induce beta-cell failure in vitro by transferring damaged mitochondria from IUGR animals into beta-cells from unaffected, non-IUGR animals ..
  4. Mechanisms by which Obesity in Pregnancy Leads to Obesity in Offspring
    Rebecca A Simmons; Fiscal Year: 2010
    ..Since the incidence of obesity is rapidly increasing in the United States, these studies will have great impact on health. ..