Michael J Simmons
Affiliation: University of Minnesota
Simmons M, Thorp M, Buschette J, Becker J. Transposon regulation in Drosophila: piRNA-producing P elements facilitate repression of hybrid dysgenesis by a P element that encodes a repressor polypeptide. Mol Genet Genomics. 2015;290:127-40 pubmed publisher
..Because the effect is seen only when a TP was present in the mother's genotype, maternally generated P-element piRNAs could facilitate regulation by the KP repressor polypeptide. ..
Simmons M, Peterson M, Thorp M, Buschette J, Diprima S, Harter C, et al
. piRNA-mediated transposon regulation and the germ-line mutation rate in Drosophila melanogaster males. Mutat Res. 2015;773:16-21 pubmed publisher
Simmons M, Grimes C, Czora C. Cytotype Regulation Facilitates Repression of Hybrid Dysgenesis by Naturally Occurring KP Elements in Drosophila melanogaster. G3 (Bethesda). 2016;6:1891-7 pubmed publisher
..In nature, repression by the KP polypeptide may therefore be facilitated by cytotype-mediating piRNAs. ..
Simmons M, Raymond J, Niemi J, Stuart J, Merriman P. The P cytotype in Drosophila melanogaster: a maternally transmitted regulatory state of the germ line associated with telomeric P elements. Genetics. 2004;166:243-54 pubmed
..Regulation by telomeric P elements appears to be epistatic to regulation by repressor P polypeptides. ..
Niemi J, Raymond J, Patrek R, Simmons M. Establishment and maintenance of the P cytotype associated with telomeric P elements in Drosophila melanogaster. Genetics. 2004;166:255-64 pubmed
..However, some of the stocks do not attain the regulatory ability of the original population. ..
Simmons M, Ryzek D, Lamour C, Goodman J, Kummer N, Merriman P. Cytotype regulation by telomeric P elements in Drosophila melanogaster: evidence for involvement of an RNA interference gene. Genetics. 2007;176:1945-55 pubmed
..Cytotype regulation by telomeric P elements may be tied to a system that uses RNAi to regulate the activities of telomeric retrotransposons in Drosophila. ..