Affiliation: University of Pennsylvania
- Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entryGraham Simmons
Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 102:11876-81. 2005..The requirement for cathepsin L proteolysis identifies a previously uncharacterized class of inhibitor for SARS-CoV infection...
- Proteolysis of the Ebola virus glycoproteins enhances virus binding and infectivityRachel L Kaletsky
Department of Microbiology, University of Pennsylvania School of Medicine, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
J Virol 81:13378-84. 2007..The influence of CatL in Ebola virus GP receptor binding should be useful in future studies characterizing the mechanism of Ebola virus entry...
- Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entryGraham Simmons
Department of Microbiology, University of Pennsylvania School of Medicine, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 101:4240-5. 2004..Together, these studies describe important tools that can be used to study SARS-CoV S glycoprotein structure and function, including approaches that can be used to identify inhibitors of the entry of SARS-CoV into target cells...
- Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entryZhaozhu Qiu
Department of Microbiology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 6076, USA
J Virol 80:5768-76. 2006....
- Expanded tropism and altered activation of a retroviral glycoprotein resistant to an entry inhibitor peptideSean M Amberg
Department of Microbiology, University of Pennsylvania School of Medicine, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104-6076, USA
J Virol 80:353-9. 2006..These observations depict a class of HR2 peptide-selected mutations with a reduced activation threshold, thereby allowing the utilization of alternative receptors for viral entry...
- Identification of murine T-cell epitopes in Ebola virus nucleoproteinGraham Simmons
Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6076, USA
Virology 318:224-30. 2004..The identification of these epitopes will facilitate studies of immune correlates of protection and the evaluation of vaccine strategies in murine models of Ebola infection...
- Folate receptor alpha and caveolae are not required for Ebola virus glycoprotein-mediated viral infectionGraham Simmons
Department of Microbiology. Abramson Family Cancer Research Institute, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104-6076, USA
J Virol 77:13433-8. 2003..Finally, a panel of ligands to and soluble analogues of FRalpha were unable to inhibit infection on a range of cell lines, questioning the role of FRalpha as an important factor for Ebola virus entry...
- Proteolysis of SARS-associated coronavirus spike glycoproteinGraham Simmons
University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Adv Exp Med Biol 581:235-40. 2006
- DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirusAndrea Marzi
Institute for Clinical and Molecular Virology, University Erlangen Nurnberg, Nikolaus Fiebiger Center, Glückstrasse 6, D 91054 Erlangen, Germany
J Virol 78:12090-5. 2004..SIGNR1, a murine DC-SIGN homologue, also enhanced infection driven by MARV and Ebola virus GP and could be targeted to assess the role of attachment factors in filovirus infection in vivo...
- Longitudinally profiling neutralizing antibody response to SARS coronavirus with pseudotypesNigel J Temperton
Wohl Virion Centre and Division of Infection and Immunity, University College London, 46 Cleveland St, London W1T 4JF, London, UK
Emerg Infect Dis 11:411-6. 2005..The pseudotype assay does not require handling live SARS virus; it is a useful tool to determine neutralizing titers during natural infection and the preclinical evaluation of candidate vaccines...