Graham Simmons

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
    Graham Simmons
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:11876-81. 2005
  2. pmc Proteolysis of the Ebola virus glycoproteins enhances virus binding and infectivity
    Rachel L Kaletsky
    Department of Microbiology, University of Pennsylvania School of Medicine, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Virol 81:13378-84. 2007
  3. pmc Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry
    Graham Simmons
    Department of Microbiology, University of Pennsylvania School of Medicine, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:4240-5. 2004
  4. pmc Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry
    Zhaozhu Qiu
    Department of Microbiology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 6076, USA
    J Virol 80:5768-76. 2006
  5. pmc Expanded tropism and altered activation of a retroviral glycoprotein resistant to an entry inhibitor peptide
    Sean M Amberg
    Department of Microbiology, University of Pennsylvania School of Medicine, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Virol 80:353-9. 2006
  6. ncbi request reprint Identification of murine T-cell epitopes in Ebola virus nucleoprotein
    Graham Simmons
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6076, USA
    Virology 318:224-30. 2004
  7. pmc Folate receptor alpha and caveolae are not required for Ebola virus glycoprotein-mediated viral infection
    Graham Simmons
    Department of Microbiology Abramson Family Cancer Research Institute, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104 6076, USA
    J Virol 77:13433-8. 2003
  8. ncbi request reprint Proteolysis of SARS-associated coronavirus spike glycoprotein
    Graham Simmons
    University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Adv Exp Med Biol 581:235-40. 2006
  9. pmc DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus
    Andrea Marzi
    Institute for Clinical and Molecular Virology, University Erlangen Nurnberg, Nikolaus Fiebiger Center, Glückstrasse 6, D 91054 Erlangen, Germany
    J Virol 78:12090-5. 2004
  10. pmc Longitudinally profiling neutralizing antibody response to SARS coronavirus with pseudotypes
    Nigel J Temperton
    Wohl Virion Centre and Division of Infection and Immunity, University College London, 46 Cleveland St, London W1T 4JF, London, UK
    Emerg Infect Dis 11:411-6. 2005

Collaborators

Detail Information

Publications10

  1. pmc Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
    Graham Simmons
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:11876-81. 2005
    ..The requirement for cathepsin L proteolysis identifies a previously uncharacterized class of inhibitor for SARS-CoV infection...
  2. pmc Proteolysis of the Ebola virus glycoproteins enhances virus binding and infectivity
    Rachel L Kaletsky
    Department of Microbiology, University of Pennsylvania School of Medicine, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Virol 81:13378-84. 2007
    ..The influence of CatL in Ebola virus GP receptor binding should be useful in future studies characterizing the mechanism of Ebola virus entry...
  3. pmc Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry
    Graham Simmons
    Department of Microbiology, University of Pennsylvania School of Medicine, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:4240-5. 2004
    ..Together, these studies describe important tools that can be used to study SARS-CoV S glycoprotein structure and function, including approaches that can be used to identify inhibitors of the entry of SARS-CoV into target cells...
  4. pmc Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry
    Zhaozhu Qiu
    Department of Microbiology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 6076, USA
    J Virol 80:5768-76. 2006
    ....
  5. pmc Expanded tropism and altered activation of a retroviral glycoprotein resistant to an entry inhibitor peptide
    Sean M Amberg
    Department of Microbiology, University of Pennsylvania School of Medicine, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Virol 80:353-9. 2006
    ..These observations depict a class of HR2 peptide-selected mutations with a reduced activation threshold, thereby allowing the utilization of alternative receptors for viral entry...
  6. ncbi request reprint Identification of murine T-cell epitopes in Ebola virus nucleoprotein
    Graham Simmons
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6076, USA
    Virology 318:224-30. 2004
    ..The identification of these epitopes will facilitate studies of immune correlates of protection and the evaluation of vaccine strategies in murine models of Ebola infection...
  7. pmc Folate receptor alpha and caveolae are not required for Ebola virus glycoprotein-mediated viral infection
    Graham Simmons
    Department of Microbiology Abramson Family Cancer Research Institute, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104 6076, USA
    J Virol 77:13433-8. 2003
    ..Finally, a panel of ligands to and soluble analogues of FRalpha were unable to inhibit infection on a range of cell lines, questioning the role of FRalpha as an important factor for Ebola virus entry...
  8. ncbi request reprint Proteolysis of SARS-associated coronavirus spike glycoprotein
    Graham Simmons
    University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Adv Exp Med Biol 581:235-40. 2006
  9. pmc DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus
    Andrea Marzi
    Institute for Clinical and Molecular Virology, University Erlangen Nurnberg, Nikolaus Fiebiger Center, Glückstrasse 6, D 91054 Erlangen, Germany
    J Virol 78:12090-5. 2004
    ..SIGNR1, a murine DC-SIGN homologue, also enhanced infection driven by MARV and Ebola virus GP and could be targeted to assess the role of attachment factors in filovirus infection in vivo...
  10. pmc Longitudinally profiling neutralizing antibody response to SARS coronavirus with pseudotypes
    Nigel J Temperton
    Wohl Virion Centre and Division of Infection and Immunity, University College London, 46 Cleveland St, London W1T 4JF, London, UK
    Emerg Infect Dis 11:411-6. 2005
    ..The pseudotype assay does not require handling live SARS virus; it is a useful tool to determine neutralizing titers during natural infection and the preclinical evaluation of candidate vaccines...