ROSALIA C SIMMEN

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. pmc Krüppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis
    John Mark P Pabona
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, and the Arkansas Children s Nutrition Center, 15 Children s Way, Little Rock, Arkansas 72202, USA
    J Clin Endocrinol Metab 97:E376-92. 2012
  2. pmc The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression
    Frank A Simmen
    Department of Physiology and Biophysics, and the Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Reprod Biol Endocrinol 6:41. 2008
  3. pmc The planetary biology of cytochrome P450 aromatases
    Eric A Gaucher
    Foundation for Applied Molecular Evolution, 1115 NW 4th Street, Gainesville FL 32601 4256, USA
    BMC Biol 2:19. 2004
  4. ncbi request reprint Inhibition of NMU-induced mammary tumorigenesis by dietary soy
    Rosalia C M Simmen
    Arkansas Children s Nutrition Center, Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Cancer Lett 224:45-52. 2005
  5. ncbi request reprint Progesterone receptors and Sp/Krüppel-like family members in the uterine endometrium
    Rosalia C M Simmen
    Arkansas Children s Nutrition Center and Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Front Biosci 7:d1556-65. 2002
  6. pmc The emerging role of Krüppel-like factors in endocrine-responsive cancers of female reproductive tissues
    R C M Simmen
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    J Endocrinol 204:223-31. 2010
  7. ncbi request reprint Null mutation of Kruppel-like factor9/basic transcription element binding protein-1 alters peri-implantation uterine development in mice
    Michael C Velarde
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock AR 72202, USA
    Biol Reprod 73:472-81. 2005
  8. ncbi request reprint Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cells
    Michael C Velarde
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Mol Endocrinol 21:2988-3001. 2007
  9. ncbi request reprint Uterine phenotype of young adult rats exposed to dietary soy or genistein during development
    Renea R Eason
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Nutr Biochem 16:625-32. 2005
  10. ncbi request reprint Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Krüppel-like factor 9/basic transcription element binding protein-1
    Michael C Velarde
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences and Arkansas Children s Nutrition Center, Little Rock, 72202, USA
    Endocrinology 147:1969-78. 2006

Research Grants

  1. UTEROFERRIN GENE EXPRESSION DURING DEVELOPMENT
    ROSALIA SIMMEN; Fiscal Year: 2007
  2. UTEROFERRIN GENE EXPRESSION DURING DEVELOPMENT
    ROSALIA SIMMEN; Fiscal Year: 2007

Collaborators

Detail Information

Publications36

  1. pmc Krüppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis
    John Mark P Pabona
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, and the Arkansas Children s Nutrition Center, 15 Children s Way, Little Rock, Arkansas 72202, USA
    J Clin Endocrinol Metab 97:E376-92. 2012
    ..Whether loss of KLF9 expression contributes to progesterone resistance of eutopic endometrium of women with endometriosis is unknown...
  2. pmc The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression
    Frank A Simmen
    Department of Physiology and Biophysics, and the Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Reprod Biol Endocrinol 6:41. 2008
    ..This cell line provides a unique model for identifying KLF9 downstream gene targets and signaling pathways...
  3. pmc The planetary biology of cytochrome P450 aromatases
    Eric A Gaucher
    Foundation for Applied Molecular Evolution, 1115 NW 4th Street, Gainesville FL 32601 4256, USA
    BMC Biol 2:19. 2004
    ..This strategy expands systems biology to a planetary context, necessary for a notion of fitness to underlie (as it must) any discussion of function within a biomolecular system...
  4. ncbi request reprint Inhibition of NMU-induced mammary tumorigenesis by dietary soy
    Rosalia C M Simmen
    Arkansas Children s Nutrition Center, Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Cancer Lett 224:45-52. 2005
    ..Thus, dietary soy protects against mammary tumorigenesis induced by a direct-acting carcinogen and alters signaling pathways involving PR and HER-2/neu...
  5. ncbi request reprint Progesterone receptors and Sp/Krüppel-like family members in the uterine endometrium
    Rosalia C M Simmen
    Arkansas Children s Nutrition Center and Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Front Biosci 7:d1556-65. 2002
    ....
  6. pmc The emerging role of Krüppel-like factors in endocrine-responsive cancers of female reproductive tissues
    R C M Simmen
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    J Endocrinol 204:223-31. 2010
    ..We suggest that understanding the mode of actions of KLFs and their functional networks may lead to the development of novel therapeutics to improve current prospects for cancer prevention and cure...
  7. ncbi request reprint Null mutation of Kruppel-like factor9/basic transcription element binding protein-1 alters peri-implantation uterine development in mice
    Michael C Velarde
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock AR 72202, USA
    Biol Reprod 73:472-81. 2005
    ....
  8. ncbi request reprint Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cells
    Michael C Velarde
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Mol Endocrinol 21:2988-3001. 2007
    ..Our data identify KLF9 as a transcriptional repressor of ERalpha signaling and suggest that it may function at the node of PR and ER genomic pathways to influence cell proliferation...
  9. ncbi request reprint Uterine phenotype of young adult rats exposed to dietary soy or genistein during development
    Renea R Eason
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Nutr Biochem 16:625-32. 2005
    ..Given its limited influence on uterine phenotype of young adult females, GEN, when taken as part of soy foods or as supplement, should be favorably considered for other potential health benefits...
  10. ncbi request reprint Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Krüppel-like factor 9/basic transcription element binding protein-1
    Michael C Velarde
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences and Arkansas Children s Nutrition Center, Little Rock, 72202, USA
    Endocrinology 147:1969-78. 2006
    ..Our findings define a novel pathway for BTEB1/PR cross-talk to facilitate P-dependent gene transcription in endometrial epithelial cells...
  11. ncbi request reprint Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors
    Ying Su
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, and Arkansas Children s Nutrition Center, Little Rock, Arkansas 72202, USA
    Physiol Genomics 30:8-16. 2007
    ..Identification of distinct Gen and SPI responsive genes in mammary epithelial cells may define early events contributing to tumor protection by diet relevant to the prevention of breast and other types of cancer...
  12. ncbi request reprint Dysregulation of intestinal crypt cell proliferation and villus cell migration in mice lacking Kruppel-like factor 9
    Frank A Simmen
    Arkansas Children s Nutrition Center, 1120 Marshall St, Little Rock, AR 72202, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1757-69. 2007
    ..Results suggest that Klf9 controls the elaboration, from intestine smooth muscle, of molecular mediator(s) of crypt cell proliferation and lineage determination and of villus cell migration...
  13. ncbi request reprint Orchestrating the menstrual cycle: discerning the music from the noise
    Frank A Simmen
    Arkansas Children s Nutrition Center, 1120 Marshall Street, Little Rock, Arkansas 72202, USA
    Endocrinology 147:1094-6. 2006
  14. ncbi request reprint Soy protein isolate and protection against cancer
    Thomas M Badger
    Arkansas Children s Nutrition Center and Department of Physiology Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Am Coll Nutr 24:146S-149S. 2005
    ..The purpose of this presentation was to evaluate the potential of soy protein to prevent occurrence of prostate, breast and colon cancer...
  15. ncbi request reprint Subfertility, uterine hypoplasia, and partial progesterone resistance in mice lacking the Kruppel-like factor 9/basic transcription element-binding protein-1 (Bteb1) gene
    Rosalia C M Simmen
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    J Biol Chem 279:29286-94. 2004
    ..These results identify Bteb1 as a functionally relevant PR-interacting protein and suggest its selective modulation of cellular processes that are regulated by PR-A in the uterine stroma...
  16. ncbi request reprint In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesis
    Ying Su
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, 1120 Marshall Street, Little Rock, AR 72202, USA
    Carcinogenesis 28:1046-51. 2007
    ..Preventative strategies against mammary and other types of cancer might be uncovered by refinement of the developmental window for dietary factor exposure...
  17. doi request reprint Delayed parturition and altered myometrial progesterone receptor isoform A expression in mice null for Krüppel-like factor 9
    Zhaoyang Zeng
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, and Arkansas Children s Nutrition Center, Little Rock, Arkansas 72202, USA
    Biol Reprod 78:1029-37. 2008
    ..The present study highlights the potential utility of Klf9 null mice to investigate the pathophysiology of parturition defects involving PGR signaling...
  18. doi request reprint Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase
    Rijin Xiao
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Am J Physiol Gastrointest Liver Physiol 294:G868-76. 2008
    ....
  19. doi request reprint In utero and lactational exposure to blueberry via maternal diet promotes mammary epithelial differentiation in prepubescent female rats
    Xianli Wu
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Nutr Res 29:802-11. 2009
    ..Our studies identify developing mammary glands as early targets of blueberry-associated bioactive components, possibly through systemic effects on epithelial PTEN signaling...
  20. doi request reprint Enhanced mammary progesterone receptor-A isoform activity in the promotion of mammary tumor progression by dietary soy in rats
    Bhuvanesh Dave
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, and Arkansas Children s Nutrition Center, Little Rock, AR 72202, USA
    Nutr Cancer 62:774-82. 2010
    ..Thus, soy-rich diets may influence the development of more aggressive tumors by enhancing PR-A-dependent signaling in premalignant breast tissues...
  21. ncbi request reprint Tp53-associated growth arrest and DNA damage repair gene expression is attenuated in mammary epithelial cells of rats fed whey proteins
    Bhuvanesh Dave
    Arkansas Children s Nutrition Center and Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Nutr 136:1156-60. 2006
    ..Results indicate that mammary glands of rats fed a WPH diet are more protected from endogenous DNA damage than are those of CAS-fed rats, and identify MCP-1 as a potential serum biomarker for the positive effects of healthy diets...
  22. pmc Functional differentiation of uterine stromal cells involves cross-regulation between bone morphogenetic protein 2 and Kruppel-like factor (KLF) family members KLF9 and KLF13
    John Mark P Pabona
    Department of Physiology and Biophysics, and Arkansas Children s Nutrition Center, 15 Children s Way, Little Rock, AR 72202, USA
    Endocrinology 151:3396-406. 2010
    ....
  23. ncbi request reprint The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN
    Bhuvanesh Dave
    Arkansas Children s Nutrition Center, Little Rock, AR 72202, USA
    Carcinogenesis 26:1793-803. 2005
    ....
  24. ncbi request reprint Tumor-protective and tumor-promoting actions of dietary whey proteins in an N-methyl-N-nitrosourea model of rat mammary carcinogenesis
    Renea R Eason
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, AR 72202, USA
    Nutr Cancer 55:171-7. 2006
    ....
  25. doi request reprint Early soy exposure via maternal diet regulates rat mammary epithelial differentiation by paracrine signaling from stromal adipocytes
    Ying Su
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Nutr 139:945-51. 2009
    ....
  26. doi request reprint Paracrine-acting adiponectin promotes mammary epithelial differentiation and synergizes with genistein to enhance transcriptional response to estrogen receptor β signaling
    Omar M Rahal
    Interdisciplinary Biomedical Sciences Program, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Endocrinology 152:3409-21. 2011
    ....
  27. pmc PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation
    Omar M Rahal
    University of Arkansas for Medical Sciences, USA
    Carcinogenesis 31:1491-500. 2010
    ....
  28. ncbi request reprint Dietary exposure to whey proteins alters rat mammary gland proliferation, apoptosis, and gene expression during postnatal development
    Renea R Eason
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Nutr 134:3370-7. 2004
    ....
  29. ncbi request reprint Direct interaction of the Krüppel-like family (KLF) member, BTEB1, and PR mediates progesterone-responsive gene expression in endometrial epithelial cells
    Daying Zhang
    Interdisciplinary Concentration in Animal Molecular and Cell Biology, Department of Animal Sciences, University of Florida, Shealy Drive, Gainesville, FL 32611 0910, USA
    Endocrinology 143:62-73. 2002
    ....
  30. ncbi request reprint Molecular markers of endometrial epithelial cell mitogenesis mediated by the Sp/Krüppel-like factor BTEB1
    Rosalia C M Simmen
    Department of Animal Sciences and Interdisciplinary Concentration in Animal Molecular and Cell Biology, University of Florida, Gainesville, Florida 32611 0910, USA
    DNA Cell Biol 21:115-28. 2002
    ..Taken together, the results suggest that BTEB1 mediates the expression of growth-associated genes through direct and indirect transactivation mechanisms, one of which may involve the participation of a JNK family member...
  31. ncbi request reprint Selective interactions of Kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells
    Xue Lian Zhang
    Interdisciplinary Concentration in Animal Molecular and Cell Biology, University of Florida, Gainesville, FL 32611 0910, USA
    J Biol Chem 278:21474-82. 2003
    ..Our results suggest a novel mechanism for the divergent physiological consequences of PR-A and PR-B on progesterone-dependent gene transcription in the uterus involving select KLF members...
  32. ncbi request reprint Uterine androgen receptors: roles in estrogen-mediated gene expressionand DNA synthesis
    Andrés A Kowalski
    Interdisciplinary Concentration in Animal Molecular and Cell Biology, University of Florida, Gainesville, Florida 32611 0910, USA
    Biol Reprod 70:1349-57. 2004
    ..Further elucidation of the role of androgens and their receptor in early pregnancy events may be relevant to an understanding of peri-implantation embryo loss...
  33. ncbi request reprint Molecular cloning of porcine estrogen receptor-beta complementary DNAs and developmental expression in periimplantation embryos
    Andrés A Kowalski
    Interdisciplinary Concentration in Animal Molecular and Cell Biology, Department of Animal Sciences, University of Florida, Gainesville, Florida 32611 0910, USA
    Biol Reprod 66:760-9. 2002
    ..These studies taken together suggest that embryonic ER-beta likely mediates the autocrine functions of estrogens in the dynamic regulation of embryonic growth and development at periimplantation...
  34. ncbi request reprint Secretory leukocyte protease inhibitor mediates proliferation of human endometrial epithelial cells by positive and negative regulation of growth-associated genes
    Daying Zhang
    Interdisciplinary Concentration in Animal Molecular and Cell Biology and the Department of Animal Sciences, University of Florida, Gainesville, Florida 32611 0910, USA
    J Biol Chem 277:29999-30009. 2002
    ..Because expression of SLPI is generally high in epithelial cells exhibiting abnormal proliferation such as in carcinomas, SLPI may define a novel pathway by which cellular growth is modulated...
  35. ncbi request reprint Enhancer- and silencer-like sequences that mediate insulin-like growth factor-binding protein-2 gene expression in uterine cells of pregnancy
    Inseok Kwak
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    DNA Cell Biol 25:6-18. 2006
    ..Results identify novel DNA motifs that regulate the IGFBP-2 gene promoter in uterine endometrium in pregnancy-associated fashion...
  36. ncbi request reprint Altered levels of growth-related and novel gene transcripts in reproductive and other tissues of female mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT)
    Seok Hong Min
    Interdisciplinary Concentration in Animal Molecular and Cell Biology, Genetics Institute, and Department of Animal Sciences, University of Florida, Gainesville, Florida 32611 0910, USA
    J Biol Chem 277:3647-57. 2002
    ..The data suggest that SSAT and polyamines are important for the control of molecular pathways underlying reproductive tract tissue growth, phenotype, and function...

Research Grants3

  1. UTEROFERRIN GENE EXPRESSION DURING DEVELOPMENT
    ROSALIA SIMMEN; Fiscal Year: 2007
    ..This research will provide novel mechanistic insights into PR signaling involving PR coregulators that have relevance to human subfertility and hormone-dependent gynecological diseases. ..
  2. UTEROFERRIN GENE EXPRESSION DURING DEVELOPMENT
    ROSALIA SIMMEN; Fiscal Year: 2007
    ..This research will provide novel mechanistic insights into PR signaling involving PR co- regulators that have relevance to human subfertility and hormone-dependent gynecological diseases. ..