Hyagriv N Simhan

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Lower genital tract inflammatory milieu and the risk of subsequent preterm birth: an exploratory factor analysis
    Hyagriv N Simhan
    Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Hospital and University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Paediatr Perinat Epidemiol 25:277-82. 2011
  2. ncbi request reprint Low concentrations of thrombin-inhibitor complexes and the risk of preterm delivery
    David N Hackney
    Department of Obstetrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 203:184.e1-6. 2010
  3. pmc Maternal serum 25-hydroxyvitamin D and placental vascular pathology in a multicenter US cohort
    Alison D Gernand
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
    Am J Clin Nutr 98:383-8. 2013
  4. pmc Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women
    Lisa M Bodnar
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Nutr 140:999-1006. 2010
  5. pmc Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu
    Hyagriv N Simhan
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Obstet Gynecol 205:61.e1-7. 2011
  6. ncbi request reprint Mid-trimester cervical inflammatory milieu and sonographic cervical length
    Amanda M Kalan
    Department of Obstetrics and Gynecology, Magee Womens Hospital, Pittsburgh, PA 15213, USA
    Am J Obstet Gynecol 203:126.e1-5. 2010
  7. doi request reprint First trimester maternal concentrations of thrombin-inhibitor complexes and the presence of histologic placental lesions at delivery
    David N Hackney
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Matern Fetal Neonatal Med 22:837-42. 2009
  8. pmc Paternal race and bacterial vaginosis during the first trimester of pregnancy
    Hyagriv N Simhan
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 198:196.e1-4. 2008
  9. ncbi request reprint Host immune consequences of asymptomatic Trichomonas vaginalis infection in pregnancy
    Hyagriv N Simhan
    Division of Maternal Fetal Medicine, Magee Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 196:59.e1-5. 2007
  10. doi request reprint Genetic regulation of cervical antiinflammatory cytokine concentrations during pregnancy
    Hyagriv N Simhan
    Department of Obstetrics, Division of Maternal Fetal Medicine, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Pittsburgh, PA, USA
    Am J Obstet Gynecol 199:163.e1-163.e11. 2008

Detail Information

Publications68

  1. pmc Lower genital tract inflammatory milieu and the risk of subsequent preterm birth: an exploratory factor analysis
    Hyagriv N Simhan
    Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Hospital and University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Paediatr Perinat Epidemiol 25:277-82. 2011
    ....
  2. ncbi request reprint Low concentrations of thrombin-inhibitor complexes and the risk of preterm delivery
    David N Hackney
    Department of Obstetrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 203:184.e1-6. 2010
    ..The objective of this study was to evaluate the relationship between TAT in asymptomatic subjects at 24 and 28 weeks and spontaneous preterm birth (SPTB)...
  3. pmc Maternal serum 25-hydroxyvitamin D and placental vascular pathology in a multicenter US cohort
    Alison D Gernand
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
    Am J Clin Nutr 98:383-8. 2013
    ..Maternal vitamin D deficiency has been linked to fetal growth restriction, but the underlying mechanisms are unclear...
  4. pmc Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women
    Lisa M Bodnar
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Nutr 140:999-1006. 2010
    ..One SNP in the VDR gene among white women and 3 SNP in black women were significantly associated with SGA. Our results suggest that vitamin D has a complex relation with fetal growth that may vary by race...
  5. pmc Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu
    Hyagriv N Simhan
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Obstet Gynecol 205:61.e1-7. 2011
    ..Our objective was to explore the relation between serum folate vitamers and the lower genital tract inflammatory milieu...
  6. ncbi request reprint Mid-trimester cervical inflammatory milieu and sonographic cervical length
    Amanda M Kalan
    Department of Obstetrics and Gynecology, Magee Womens Hospital, Pittsburgh, PA 15213, USA
    Am J Obstet Gynecol 203:126.e1-5. 2010
    ..The purpose of this study was to explore the relation between the relative balance of pro- and antiinflammatory cytokines in cervical fluid and mid-trimester cervical length...
  7. doi request reprint First trimester maternal concentrations of thrombin-inhibitor complexes and the presence of histologic placental lesions at delivery
    David N Hackney
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Matern Fetal Neonatal Med 22:837-42. 2009
    ..The activation of thrombin may contribute to the development of thrombosis and inflammation, and can be assessed through the measurement of thrombin-inhibitor complexes...
  8. pmc Paternal race and bacterial vaginosis during the first trimester of pregnancy
    Hyagriv N Simhan
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 198:196.e1-4. 2008
    ..The purpose of this study was to determine the joint effects of maternal and paternal race on risk of bacterial vaginosis (BV) during the first trimester...
  9. ncbi request reprint Host immune consequences of asymptomatic Trichomonas vaginalis infection in pregnancy
    Hyagriv N Simhan
    Division of Maternal Fetal Medicine, Magee Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 196:59.e1-5. 2007
    ..The purpose of this study was to define the impact of asymptomatic trichomoniasis on lower genital tract neutrophil activation in pregnancy...
  10. doi request reprint Genetic regulation of cervical antiinflammatory cytokine concentrations during pregnancy
    Hyagriv N Simhan
    Department of Obstetrics, Division of Maternal Fetal Medicine, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Pittsburgh, PA, USA
    Am J Obstet Gynecol 199:163.e1-163.e11. 2008
    ..The purpose of this study was to evaluate the contribution of maternal genotype to the concentration of interleukin (IL)-4, -10, and -13 in the cervix during the first trimester in the context of bacterial vaginosis and cigarette smoking...
  11. ncbi request reprint The vaginal inflammatory milieu and the risk of early premature preterm rupture of membranes
    Hyagriv N Simhan
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 192:213-8. 2005
    ..The purpose of this study was to determine the association of vaginal pH > or =5.0 and vaginal neutrophils >5 per oil field with preterm rupture of membranes (PPROM)...
  12. ncbi request reprint Maternal and fetal Toll-like receptor 4 genotype and chorionic plate inflammatory lesions
    Hyagriv N Simhan
    Division of Maternal Fetal Medicine, Magee Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 199:400.e1-4. 2008
    ..The objective of the study was to explore the relation between maternal and fetal genetic variation in Toll-like receptor 4 (TLR4) and chorionic plate inflammation..
  13. ncbi request reprint Maternal vitamin D deficiency increases the risk of preeclampsia
    Lisa M Bodnar
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, A742 Crabtree Hall, 130 DeSoto Street, Pittsburgh, Pennsylvania, 15261, USA
    J Clin Endocrinol Metab 92:3517-22. 2007
    ..Vitamin D has direct influence on molecular pathways proposed to be important in the pathogenesis of preeclampsia, yet the vitamin D-preeclampsia relation has not been studied...
  14. pmc Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy
    Lisa M Bodnar
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    J Nutr 139:1157-61. 2009
    ..Vitamin D deficiency is associated with BV and may contribute to the strong racial disparity in the prevalence of BV...
  15. pmc Maternal serum 25-hydroxyvitamin D and measures of newborn and placental weight in a U.S. multicenter cohort study
    Alison D Gernand
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 98:398-404. 2013
    ..Inconsistent associations between maternal vitamin D status and fetal size have been published in small studies...
  16. pmc Prepregnancy obesity predicts poor vitamin D status in mothers and their neonates
    Lisa M Bodnar
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    J Nutr 137:2437-42. 2007
    ..The rise in maternal obesity highlights that maternal and newborn vitamin D deficiency will continue to be a serious public health problem until steps are taken to identify and treat low 25(OH)D...
  17. ncbi request reprint First-trimester maternal plasma concentrations of C-reactive protein in low-risk patients and the subsequent development of chorioamnionitis
    David N Hackney
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Perinatol 25:407-11. 2008
    ..72). We concluded that the development of histological chorioamnionitis is not associated with elevations in maternal plasma CRP earlier in pregnancy...
  18. pmc Vitamin D may be a link to black-white disparities in adverse birth outcomes
    Lisa M Bodnar
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Obstet Gynecol Surv 65:273-84. 2010
    ..Understand the basic aspects of vitamin D metabolism. Become aware of recent literature linking inadequate vitamin D status and adverse pregnancy outcomes such as preeclampsia and preterm birth...
  19. ncbi request reprint Preterm premature rupture of membranes: diagnosis, evaluation and management strategies
    Hyagriv N Simhan
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, 300 Halket Street, Pittsburgh, PA 15213, USA
    BJOG 112:32-7. 2005
    ..Women with PPROM after 32 weeks of gestation should be considered for delivery, and after 34 weeks the benefits of delivery clearly outweigh the risks...
  20. pmc Maternal serum folate species in early pregnancy and risk of preterm birth
    Lisa M Bodnar
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Clin Nutr 92:864-71. 2010
    ..Poor maternal folate status has been associated with an increased risk of preterm birth. However, major gaps remain in our understanding of how individual folate species relate to preterm birth...
  21. doi request reprint Risk of morbid perinatal outcomes in small-for-gestational-age pregnancies: customized compared with conventional standards of fetal growth
    Jacob C Larkin
    Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Obstet Gynecol 119:21-7. 2012
    ..To estimate and compare the risk of morbid perinatal outcomes in pregnancies identified as small for gestational age (SGA) with customized compared with conventional standards of fetal growth...
  22. ncbi request reprint Prepregnancy body mass index, vaginal inflammation, and the racial disparity in preterm birth
    Hyagriv N Simhan
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Epidemiol 163:459-66. 2006
    ..7-fold increased risk for a high level of neutrophils and a high vaginal pH measurement, while those with a body mass index of 18 had a 1.3-fold increased risk...
  23. doi request reprint Plasma corticotropin-releasing hormone and cortisol concentrations and perceived stress among pregnant women with preterm and term birth
    Katherine P Himes
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh Medical Center, Magee Women s Hospital, Pittsburgh, Pennsylvania
    Am J Perinatol 28:443-8. 2011
    ..The factors contributing to the elevation in CRH that precedes some preterm birth are complex and poorly understood...
  24. doi request reprint Association of polymicrobial growth from urine culture with adverse pregnancy outcomes
    Amber Naresh
    Divisions of Reproductive Infectious Diseases and Immunology, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh Medical Center, 300 Halket Street, Pittsburgh, PA 15213, USA
    Am J Perinatol 28:537-42. 2011
    ..4% of those in the negative initial urine culture group had a positive culture later in the pregnancy ( P=0.21). There is no association between polymicrobial growth from screening urine culture and pyelonephritis or preterm delivery...
  25. doi request reprint The prevalence of preterm birth and season of conception
    Lisa M Bodnar
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Paediatr Perinat Epidemiol 22:538-45. 2008
    ..4%). Results were similar when indicated preterm births were included. These seasonal changes may increase our insight into the role of exposures with seasonal periodicity in the pathophysiology of preterm birth...
  26. doi request reprint Paternal race and preterm birth
    Hyagriv N Simhan
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 198:644.e1-6. 2008
    ..The purpose of this study was to describe the contribution of paternal race and parental racial discordance to preterm birth..
  27. pmc The impact of exposure misclassification on associations between prepregnancy BMI and adverse pregnancy outcomes
    Lisa M Bodnar
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 18:2184-90. 2010
    ..However, the majority of relations remained readily apparent. This analysis suggests that in this population, associations between self-reported prepregnancy BMI and pregnancy outcomes are slightly overestimated...
  28. pmc High rate of severe fetal outcomes associated with maternal parvovirus b19 infection in pregnancy
    Richard H Beigi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Magee Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Infect Dis Obstet Gynecol 2008:524601. 2008
    ..To augment the understanding of parvovirus B19 infection in pregnancy with respect to maternal characteristics and their corresponding fetal outcomes...
  29. pmc Maternal vitamin D status and the risk of mild and severe preeclampsia
    Lisa M Bodnar
    From the aDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA bDepartment of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, PA cMagee Womens Research Institute, Pittsburgh, PA dDepartment of Pediatrics and Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada eCenter for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Columbus, OH and fDepartment of Pediatrics, The Ohio State University College of Medicine, Columbus, OH
    Epidemiology 25:207-14. 2014
    ..We sought to determine the association between maternal vitamin D status at ≤26 weeks' gestation and the risk of preeclampsia by clinical subtype...
  30. pmc Relationship between 17-hydroxyprogesterone caproate concentrations and gestational age at delivery in twin gestation
    Steve N Caritis
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Am J Obstet Gynecol 207:396.e1-8. 2012
    ..We sought to evaluate in women with twin gestation the relationship between 17-hydroxyprogesterone caproate (17-OHPC) concentration and gestational age at delivery and select biomarkers of potential pathways of drug action...
  31. doi request reprint Maternal and fetal C-reactive protein genotype and first trimester CRP concentrations in maternal plasma
    David N Hackney
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Reprod Immunol 79:44-9. 2008
    ..Instead, differences in clinical factors probably have more influence on baseline maternal CRP concentrations...
  32. pmc Maternal cereal consumption and adequacy of micronutrient intake in the periconceptional period
    Meredith Snook Parrott
    Magee Womens Research Institute, Pittsburgh, PA, USA
    Public Health Nutr 12:1276-83. 2009
    ..To assess the adequacy of periconceptional intake of key micronutrients for perinatal health in relation to regular cereal consumption of pregnant women...
  33. doi request reprint A customized standard of large size for gestational age to predict intrapartum morbidity
    Jacob C Larkin
    Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, PA, USA
    Am J Obstet Gynecol 204:499.e1-10. 2011
    ..The purpose of this study was to determine whether a customized standard of large-for-gestational age (LGA) identifies pregnancies with increased perinatal risk...
  34. doi request reprint Risk of recurrent preterm birth and placental pathology
    Katherine P Himes
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Obstet Gynecol 112:121-6. 2008
    ..To estimate whether placental pathological lesions from an index preterm birth are associated with an increased risk of recurrent preterm birth and to estimate whether certain pathologic lesions recur in a woman's next delivery...
  35. ncbi request reprint Prevention of preterm delivery
    Hyagriv N Simhan
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, USA
    N Engl J Med 357:477-87. 2007
  36. ncbi request reprint Untreated asymptomatic group B streptococcal bacteriuria early in pregnancy and chorioamnionitis at delivery
    Brenna L Anderson
    Division of Reproductive Infectious Diseases and Immunology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Obstet Gynecol 196:524.e1-5. 2007
    ..The objective of the study was to determine the frequency of adverse pregnancy outcomes in women with untreated asymptomatic group B beta-hemolytic streptococcal (GBS) bacteriuria during pregnancy...
  37. doi request reprint Comprehensive analysis of the transcriptional response of human decidual cells to lipopolysaccharide stimulation
    Katherine P Himes
    Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Maternal Fetal Medicine, University of Pittsburgh, PA 15213, USA
    J Reprod Immunol 93:17-27. 2012
    ..Our novel, preliminary findings provide insight into possible mechanisms via which the host inflammatory response could contribute to preterm birth and warrant further investigation in preterm samples...
  38. ncbi request reprint Cervical anti-inflammatory cytokine concentrations among first-trimester pregnant smokers
    Hyagriv N Simhan
    Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Pittsburgh, PA, USA
    Am J Obstet Gynecol 193:1999-2003. 2005
    ..We examined the impact of cigarette smoking in pregnancy on the detection of the 3 most important anti-inflammatory cytokines (interleukin-4, -10, and -13) in the cervix...
  39. ncbi request reprint High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates
    Lisa M Bodnar
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    J Nutr 137:447-52. 2007
    ..Higher-dose supplementation is needed to improve maternal and neonatal vitamin D nutriture...
  40. ncbi request reprint An evidence-based approach to the evaluation and treatment of premature rupture of membranes: Part II
    Timothy P Canavan
    Magee Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obstet Gynecol Surv 59:678-89. 2004
    ..This review presents the available evidence and grades it according to the U.S. Preventative Task Force recommendations...
  41. ncbi request reprint The safety of prolonged indomethacin therapy
    Ashlyn H Savage
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Perinatol 24:207-13. 2007
    ..Prolonged indomethacin therapy rarely is associated with ductal constriction and oligohydramnios...
  42. doi request reprint Can we communicate gravidity and parity better?
    Mitchell D Creinin
    Department of Obstetrics, Gynecology and Reproductive Sciences and Magee Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 3180, USA
    Obstet Gynecol 113:709-11. 2009
    ..In this article, we discuss the pitfalls of current systems used for describing a woman's reproductive history and recommend new and simple nomenclature to enhance our ability to communicate properly...
  43. doi request reprint First-trimester cervical inflammatory milieu and subsequent early preterm birth
    Hyagriv N Simhan
    Department of Obstetrics and Gynecology, Magee Womens Hospital, Pittsburgh, PA, USA
    Am J Obstet Gynecol 200:377.e1-4. 2009
    ..Our objective was to explore the relation between the pro- and antiinflammatory cervical cytokine balance in early pregnancy and subsequent early preterm birth...
  44. pmc Human decidual cell Toll-like receptor signaling in response to endotoxin: the effect of progestins
    Hyagriv N Simhan
    Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 198:119.e1-4. 2008
    ..The purpose of this study was to determine whether progesterone, 17-alpha-hydroxyprogesterone, and 17-alpha hydroxyprogesterone caproate modulate the Toll-like receptor (TLR) pathway in the response of decidua to lipopolysaccharide...
  45. ncbi request reprint Interleukin-6 promoter -174 polymorphism and spontaneous preterm birth
    Hyagriv N Simhan
    University of Pittsburgh School of Medicine, Department of Obstetrics, Magee Womens Research Institute, Pittsburgh, PA, USA
    Am J Obstet Gynecol 189:915-8. 2003
    ..We assessed the relationship between interleukin-6 (IL-6) promoter -174 polymorphism and spontaneous preterm birth (sPTB) less than 34 weeks and the relationship of polymorphism status with race...
  46. ncbi request reprint Clinical utility of fetal fibronectin for predicting preterm birth
    Geeta K Swamy
    Department of Obstetrics, Duke University School of Medicine, Durham, North Carolina, USA
    J Reprod Med 50:851-6. 2005
    ..To determine if fetal fibronectin can be used in a clinical setting to predict preterm birth and guide clinical management...
  47. ncbi request reprint Tumor necrosis factor-alpha promoter gene polymorphism -308 and chorioamnionitis
    Hyagriv N Simhan
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Obstet Gynecol 102:162-6. 2003
    ..The TNFA2 allele is associated with increased production of tumor necrosis factor alpha. The purpose of this study is to assess the relationship between carriage of the TNFA2 allele and clinical chorioamnionitis...
  48. ncbi request reprint The effect of the anti-inflammatory cytokines interleukin-4 and interleukin-10 on lipopolysaccharide-stimulated production of prostaglandin E2 by cultured human decidual cells
    Hyagriv N Simhan
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, 300 Halket Street, Pittsburgh, PA 15213, USA
    J Reprod Immunol 64:1-7. 2004
    ..We hypothesized that interleukin-4 (IL-4) and interleukin-10 (IL-10) diminish production of PGE2 by lipopolysaccharide (LPS)-stimulated cultured human decidual cells...
  49. pmc Improving universal prenatal screening for human immunodeficiency virus
    Brenna L Anderson
    Magee Womens Hospital, Maternal Fetal Medicine and Reproductive Infectious Diseases, University of Pittsburgh School of Medicine, PA 15213, USA
    Infect Dis Obstet Gynecol 12:115-20. 2004
    ..To evaluate the effect of implementation of a human immunodeficiency virus (HIV) educational intervention on universal screening for HIV in a prenatal clinic setting...
  50. doi request reprint Sonographic cervical length, vaginal bleeding, and the risk of preterm birth
    Devon M Ramaeker
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Obstet Gynecol 206:224.e1-4. 2012
    ..We sought to evaluate the contributions of vaginal bleeding and cervical length to the risk of preterm birth...
  51. doi request reprint Rate of sonographic cervical shortening and the risk of spontaneous preterm birth
    Leslie A Moroz
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Obstet Gynecol 206:234.e1-5. 2012
    ..We hypothesized that change in cervical length (CL) on serial ultrasounds is associated with spontaneous preterm birth (SPTB) <36 weeks for women with a short cervix (CL <25 mm)...
  52. ncbi request reprint Systemic immune response to Trichomonas vaginalis infection during pregnancy
    Brenna L Anderson
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Research Institute, Magee Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Sex Transm Dis 34:392-6. 2007
    ..The objective of this study was to characterize the systemic immune response in women with trichomoniasis in pregnancy as compared with uninfected women...
  53. doi request reprint First-trimester pregnancy-associated plasma protein A and subsequent abnormalities of fetal growth
    Suzanne E Peterson
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 198:e43-5. 2008
    ..The purpose of this study was to describe the relationship between first-trimester pregnancy-associated plasma protein A (PAPP-A) and birthweight along its continuum and at its extremes...
  54. ncbi request reprint Elevated vaginal pH and neutrophils are associated strongly with early spontaneous preterm birth
    Hyagriv N Simhan
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Research Institute, University of Pittsburgh School of Medicine, PA, USA
    Am J Obstet Gynecol 189:1150-4. 2003
    ..All women were tested for sexually transmitted infections and vaginal pH. Gram-stained smears were used for the detection of neutrophils...
  55. doi request reprint Genetic susceptibility to infection-mediated preterm birth
    Katherine P Himes
    Division of Maternal Fetal Medicine, University of Pittsburgh Medical Center, Magee Womens Hospital, Pittsburgh, PA 15213, USA
    Infect Dis Clin North Am 22:741-53, vii. 2008
    ..Given this, methodological considerations are emphasized to improve our understanding of the genetic susceptibility to infection-mediated preterm birth...
  56. doi request reprint Labor induction process improvement: a patient quality-of-care initiative
    John M Fisch
    Magee Womens Hospital, and Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Maternal Fetal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Obstet Gynecol 113:797-803. 2009
    ..To examine the effects that medical staff education and a new process for scheduling inductions had on decreasing inappropriate inductions...
  57. ncbi request reprint Time from cervical conization to pregnancy and preterm birth
    Katherine P Himes
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal Fetal Medicine, University of Pittsburgh School of Medicine, 300 Halket Street, Pittsburgh, PA 15213, USA
    Obstet Gynecol 109:314-9. 2007
    ..To estimate whether the time interval between cervical conization and subsequent pregnancy is associated with risk of preterm birth...
  58. ncbi request reprint Innate immune function of the human decidual cell at the maternal-fetal interface
    Timothy P Canavan
    University of Pittsburgh School of Medicine, Magee Womens Hospital, Department of Obstetrics, Gynecology and Reproductive Sciences, 300 Halket Street, Pittsburgh, PA 15213, USA
    J Reprod Immunol 74:46-52. 2007
    ..Decidual cells from women at term have innate immune function and are capable of producing Interleukin responses to bacterial ligands...
  59. ncbi request reprint Serum biomarkers of spontaneous preterm birth
    Hyagriv N Simhan
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal Fetal Medicine and Reproductive Infectious Diseases, University of Pittsburgh School of Medicine, PA 15213, USA
    Acta Obstet Gynecol Scand 84:545-6. 2005
  60. ncbi request reprint Prenatal Midtrimester Fetal Long Bone Measurements and the Prediction of Small-for-Gestational-Age Fetuses at Term
    Paul D Speer
    Division of Ultrasound, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Am J Perinatol 31:231-6. 2014
    ..001). There was no single LB that proved to be superior in predicting an SGA newborn. Conclusion There is a significant association between LB-to-GA ratio at midtrimester and the probability of SGA at term. ..
  61. ncbi request reprint Short ultrasonographic cervical length in women with low-risk obstetric history
    Francesca L Facco
    Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
    Obstet Gynecol 122:858-62. 2013
    ..To understand the relationship between cervical length and the risk of prematurity in parous women without a history of preterm delivery...
  62. pmc Reproductive health of women electing bariatric surgery
    Gabriella G Gosman
    University of Pittsburgh, School of Medicine, Magee Womens Hospital, Pittsburgh, Pennsylvania 15213, USA
    Fertil Steril 94:1426-31. 2010
    ..To describe the reproductive health history and characteristics of women having bariatric surgery and to determine whether this differs by age of onset of obesity...
  63. pmc Gestational weight gain, early pregnancy maternal adiposity distribution, and maternal hyperglycemia
    Laura E Tomedi
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, 130 DeSoto Street, Pittsburgh, PA, 15261, USA
    Matern Child Health J 18:1265-70. 2014
    ..Independent of pre-pregnancy BMI, high early pregnancy GWG and maternal subcutaneous body fat may be positively associated with maternal glucose concentrations at 24-28 weeks...
  64. ncbi request reprint Decreased cervical proinflammatory cytokines permit subsequent upper genital tract infection during pregnancy
    Hyagriv N Simhan
    Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Am J Obstet Gynecol 189:560-7. 2003
    ....
  65. ncbi request reprint Focused assessment of surgical performance: difficulty with faculty compliance
    Gabriella G Gosman
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 193:1811-6. 2005
    ..This study evaluated faculty compliance in the use of the global surgical rating scale of the Objective Structured Assessment of Technical Skills to rate resident surgical performance after every endoscopic procedure...
  66. ncbi request reprint Introduction of an obstetric-specific medical emergency team for obstetric crises: implementation and experience
    Gabriella G Gosman
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 198:367.e1-7. 2008
    ..We describe the implementation and experience with adding an obstetric-specific medical emergency team (called Condition O for obstetric crisis) to an existing rapid response system at Magee-Womens Hospital...
  67. ncbi request reprint An evidence-based approach to the evaluation and treatment of premature rupture of membranes: Part I
    Timothy P Canavan
    Magee Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obstet Gynecol Surv 59:669-77. 2004
    ..In part II, the management, treatment, neonatal outcome, and the maternal and fetal evaluation of women with PPROM in the presence of cerclage and medical complications is reviewed...
  68. ncbi request reprint Effect of tocolytics on interleukin-8 production by human amniotic and decidual cells
    Michel A Makhlouf
    Department of Obstetrics, Gynecology and Reproductive Sciences, Magee Womens Hosptial, University of Pittsburgh, PA 15213, USA
    J Reprod Immunol 69:1-7. 2006
    ..The cellular mechanisms of this suppression and its clinical relevance in the setting of preterm labor merit further investigation...