PATRICIA JANET SIME
Affiliation: University of Rochester
Thatcher T, Woeller C, McCarthy C, Sime P. Quenching the fires: Pro-resolving mediators, air pollution, and smoking. Pharmacol Ther. 2019;: pubmed publisher
Kottmann R, Sharp J, Owens K, Salzman P, Xiao G, Phipps R, et al
. Second harmonic generation microscopy reveals altered collagen microstructure in usual interstitial pneumonia versus healthy lung. Respir Res. 2015;16:61 pubmed publisher
Kottmann R, Trawick E, Judge J, Wahl L, Epa A, Owens K, et al
. Pharmacologic inhibition of lactate production prevents myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol. 2015;309:L1305-12 pubmed publisher
..These data support the hypothesis that pharmacologic inhibition of LDH may play an important role in the treatment of pulmonary fibrosis. ..
Hsiao H, Thatcher T, Colas R, Serhan C, Phipps R, Sime P. Resolvin D1 Reduces Emphysema and Chronic Inflammation. Am J Pathol. 2015;185:3189-201 pubmed publisher
Sime P. The antifibrogenic potential of PPARgamma ligands in pulmonary fibrosis. J Investig Med. 2008;56:534-8 pubmed publisher
Hsiao H, Thatcher T, Levy E, Fulton R, Owens K, Phipps R, et al
. Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1. J Immunol. 2014;193:4980-7 pubmed publisher
..In this article, we present the idea that RvD1 has the potential to be used as an anti-inflammatory and proresolving agent, possibly in the context of exuberant host responses to damaging respirable agents such as viruses. ..
McCarthy C, Duffney P, Gelein R, Thatcher T, Elder A, Phipps R, et al
. Dung biomass smoke activates inflammatory signaling pathways in human small airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2016;311:L1222-L1233 pubmed publisher
..We propose that the inflammatory responses of lung cells exposed to dung biomass smoke contribute to the development of respiratory diseases. ..
McCarthy C, Duffney P, Wyatt J, Thatcher T, Phipps R, Sime P. Comparison of in vitro toxicological effects of biomass smoke from different sources of animal dung. Toxicol In Vitro. 2017;43:76-86 pubmed publisher