PATRICIA JANET SIME

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β
    Robert Matthew Kottmann
    Department of Medicine, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Respir Crit Care Med 186:740-51. 2012
  2. doi request reprint The antifibrogenic potential of PPARgamma ligands in pulmonary fibrosis
    Patricia J Sime
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Investig Med 56:534-8. 2008
  3. pmc Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts
    Heather E Ferguson
    Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 41:722-30. 2009
  4. ncbi request reprint Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire
    Thomas H Thatcher
    Department of Microbiology and Immunology, Division of Pulmonary and Critical Care Medicine, University of Rochester, Rochester, New York 14642, USA
    Exp Lung Res 31:685-700. 2005
  5. ncbi request reprint PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis
    Heather A Burgess
    Department of Environmental Medicine, Univ of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1146-53. 2005
  6. pmc Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells
    Emily A Desmet
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Virology 400:224-32. 2010
  7. pmc A putative role for platelet-derived PPARγ in vascular homeostasis demonstrated by anti-PPARγ induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis
    Patricia J Simpson-Haidaris
    Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA pj
    J Biotechnol 150:417-27. 2010
  8. pmc Differences in the TGF-{beta}1-induced profibrotic response of anterior and posterior corneal keratocytes in vitro
    Holly B Hindman
    Flaum Eye Institute, University of Rochester Medical Center, Rochester, New York, USA
    Invest Ophthalmol Vis Sci 51:1935-42. 2010
  9. pmc Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism
    Heather E Ferguson
    Department of Environmental Medicine, University of Rochester, 601 Elmwood Ave, Box 692, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 297:L912-9. 2009
  10. ncbi request reprint Expression of CD154 (CD40 ligand) by human lung fibroblasts: differential regulation by IFN-gamma and IL-13, and implications for fibrosis
    Julia Kaufman
    Department of Microbiology and Immunology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 172:1862-71. 2004

Research Grants

Collaborators

Detail Information

Publications27

  1. pmc Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β
    Robert Matthew Kottmann
    Department of Medicine, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Respir Crit Care Med 186:740-51. 2012
    ..Idiopathic pulmonary fibrosis (IPF) is a complex disease for which the pathogenesis is poorly understood. In this study, we identified lactic acid as a metabolite that is elevated in the lung tissue of patients with IPF...
  2. doi request reprint The antifibrogenic potential of PPARgamma ligands in pulmonary fibrosis
    Patricia J Sime
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Investig Med 56:534-8. 2008
    ....
  3. pmc Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts
    Heather E Ferguson
    Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 41:722-30. 2009
    ..As the inhibitory concentration causing a 50% decrease in aSMA for CDDO is 400-fold lower than that in rosiglitazone, the translational potential of CDDO for treatment of fibrotic diseases is high...
  4. ncbi request reprint Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire
    Thomas H Thatcher
    Department of Microbiology and Immunology, Division of Pulmonary and Critical Care Medicine, University of Rochester, Rochester, New York 14642, USA
    Exp Lung Res 31:685-700. 2005
    ..In fact, there is no difference in the inflammatory or fibrotic response to bleomycin between TCRbeta transgenic and control mice. Thus, if T cells are required for fibrogenesis, it must involve an antigen-independent mechanism...
  5. ncbi request reprint PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis
    Heather A Burgess
    Department of Environmental Medicine, Univ of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1146-53. 2005
    ..Thus PPARgamma agonists have novel and potent antifibrotic effects in human lung fibroblasts and may have potential for therapy of fibrotic diseases in the lung and other tissues...
  6. pmc Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells
    Emily A Desmet
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Virology 400:224-32. 2010
    ..These findings support a role for MLK3 in viral production during influenza infection...
  7. pmc A putative role for platelet-derived PPARγ in vascular homeostasis demonstrated by anti-PPARγ induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis
    Patricia J Simpson-Haidaris
    Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA pj
    J Biotechnol 150:417-27. 2010
    ..Furthermore, a major pitfall associated with MoAb production against closely related molecules is that monoclonicity does not guarantee monospecificity, an issue worth further scientific scrutiny...
  8. pmc Differences in the TGF-{beta}1-induced profibrotic response of anterior and posterior corneal keratocytes in vitro
    Holly B Hindman
    Flaum Eye Institute, University of Rochester Medical Center, Rochester, New York, USA
    Invest Ophthalmol Vis Sci 51:1935-42. 2010
    ..This heterogeneity of keratocyte response may impact wound closure after mechanical wounding...
  9. pmc Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism
    Heather E Ferguson
    Department of Environmental Medicine, University of Rochester, 601 Elmwood Ave, Box 692, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 297:L912-9. 2009
    ....
  10. ncbi request reprint Expression of CD154 (CD40 ligand) by human lung fibroblasts: differential regulation by IFN-gamma and IL-13, and implications for fibrosis
    Julia Kaufman
    Department of Microbiology and Immunology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 172:1862-71. 2004
    ..We speculate that fibroblast-derived CD40L plays a role in promoting fibroblast activation and possibly in interaction with CD40 bearing cells...
  11. ncbi request reprint Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema
    Carolyn J Baglole
    Univ of Rochester School of Medicine and Dentistry, Dept of Environmental Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 291:L19-29. 2006
    ..Variations in the sensitivity of fibroblasts to cigarette smoke may account for the fact that only some smokers develop emphysema...
  12. ncbi request reprint Isolation and phenotypic characterization of lung fibroblasts
    Carolyn J Baglole
    Department of Environmental Medicine, University of Rochester, NY, USA
    Methods Mol Med 117:115-27. 2005
    ..These subsets can then be used for experimentation to determine functional differences between fibroblasts derived from normal and pathological tissue such as scarred lung...
  13. ncbi request reprint Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation
    Heather F Lakatos
    Department of Environmental Medicine and Lung Biology and Disease Program, University of Rochester, Rochester, New York 14642, USA
    Exp Lung Res 32:181-99. 2006
    ..Oropharyngeal aspiration should be considered as an alternative to intratracheal instillation of silica and other particulates in studies of respiratory toxicity and lung disease...
  14. pmc The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB
    Carolyn J Baglole
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 283:28944-57. 2008
    ..The association between RelB and AhR may represent a new therapeutic and more selective target with which to combat inflammation-associated diseases...
  15. pmc Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB
    Thomas H Thatcher
    Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    Am J Pathol 170:855-64. 2007
    ....
  16. ncbi request reprint Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis
    Katherine M A O'Reilly
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1010-6. 2005
    ..Moreover, they suggest a mechanism to explain the differing fibrogenic potential of CS and AS. The molecules COX-2, PGE synthase, and PGE2 are identified as effectors in silicosis...
  17. pmc Cigarette smoke-induced expression of heme oxygenase-1 in human lung fibroblasts is regulated by intracellular glutathione
    Carolyn J Baglole
    University of Rochester School of Medicine and Dentistry, Dept of Environmental Medicine, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 295:L624-36. 2008
    ..These data support the concept that changes in the cellular redox status brought on by cigarette smoke induce HO-1 in fibroblasts. This increase in HO-1 may help protect against cigarette smoke-induced inflammation and/or cell death...
  18. pmc RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke
    Se Ran Yang
    Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 40:147-58. 2009
    ..Rapid degradation of RelB signals for RelA/p65 activation and loss of its protective ability to suppress the proinflammatory cytokine release in lymphoid B cells...
  19. ncbi request reprint More than structural cells, fibroblasts create and orchestrate the tumor microenvironment
    Carolyn J Baglole
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, and Lymphoma Biology Program, James P Wilmot Cancer Center, Rochester, New York 14642, USA
    Immunol Invest 35:297-325. 2006
    ..This review will highlight the emerging role of the complex fibroblastic stroma in establishing a microenvironment supporting malignant transformation, tumor growth and attenuation of host anti-tumor immune responses...
  20. pmc High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function
    Thomas H Thatcher
    Department of Medicine, Univ of Rochester, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 295:L412-21. 2008
    ....
  21. ncbi request reprint A novel ELISpot method for adherent cells
    Chantal K Turner
    Department of Environmental Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Immunol Methods 291:63-70. 2004
    ..Moreover, the assay is suitable for normal human adherent cells that are often short-lived and difficult to cultivate...
  22. doi request reprint PPARgamma: a novel molecular target in lung disease
    C Michael Hart
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University Medical Centers, Atlanta, GA, USA
    J Investig Med 56:515-7. 2008
    ..This brief introduction to the symposium will provide background information about PPARs to facilitate the general reader's appreciation of the more in-depth and disease-specific discussions that follow...
  23. ncbi request reprint Antenatal Ureaplasma urealyticum respiratory tract infection stimulates proinflammatory, profibrotic responses in the preterm baboon lung
    Rose M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Pediatr Res 60:141-6. 2006
    ..Collectively, these data suggest that a prolonged proinflammatory response initiated by intrauterine Ureaplasma infection contributes to early fibrosis and altered developmental signaling in the immature lung...
  24. ncbi request reprint Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer
    Christine A Martey
    Chemistry Department, Shippensburg University, Pennsylvania 17257, USA
    Am J Physiol Lung Cell Mol Physiol 287:L981-91. 2004
    ..This chronic inflammatory state may act as one of the first steps towards epithelial transformation...
  25. pmc Titration of non-replicating adenovirus as a vector for transducing active TGF-beta1 gene expression causing inflammation and fibrogenesis in the lungs of C57BL/6 mice
    G Sakuntala Warshamana
    Lung Biology Program, Department of Pathology, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Int J Exp Pathol 83:183-201. 2002
    ..Thus, this model system helps us to understand some quantitative aspects of TGF-beta1 biological activity and allows us to manipulate this potent factor as a mediator of interstitial fibrogenesis...
  26. ncbi request reprint Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains
    Martin Kolb
    Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 27:141-50. 2002
    ....
  27. pmc A new direction in the pathogenesis of idiopathic pulmonary fibrosis?
    Jack Gauldie
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Respir Res 3:1. 2002
    ..Altered microenvironment and involvement of epithelial cell/mesenchymal cell interaction are the most likely contributors to the pathogenesis of this chronic progressive disorder...

Research Grants13

  1. TGFB AND GENE THERAPY IN SILICA INDUCED LUNG FIBROSIS
    Patricia Sime; Fiscal Year: 2005
    ..In conjunction with a formal education program me this should allow her to successfully develop as an independent investigator, while yielding new insights into the pathogenesis and treatment of fibrotic pathologies. ..
  2. Modulation of Silica-Induced Pulmonary Fibrosis
    Patricia Sime; Fiscal Year: 2009
    ..These aims will identify the mechanism of action of PPARy agonists as anti-fibrotics and will generate exciting evidence supporting their utility as novel and efficacious therapies for scarring of the lungs, as well as other organs. ..
  3. Role of the Aryl Hydrocarbon Receptor in Lung Inflammation
    Patricia Sime; Fiscal Year: 2009
    ..Despite the fact that smoking causes lung diseases, remarkably little is known of the mechanisms whereby smoke generates inflammation and how the inflammatory responses are regulated. The fibroblast is a ..
  4. Role of the Aryl Hydrocarbon Receptor in Lung Inflammation
    PATRICIA JANET SIME; Fiscal Year: 2010
    ..Our studies will determine the mechanisms by which the AhR acts to dampen lung inflammation. This new knowledge can be exploited to develop new treatments for patients with lung inflammatory diseases. ..
  5. Modulation of Silica-Induced Pulmonary Fibrosis
    Patricia Sime; Fiscal Year: 2007
    ..These aims will identify the mechanism of action of PPARy agonists as anti-fibrotics and will generate exciting evidence supporting their utility as novel and efficacious therapies for scarring of the lungs, as well as other organs. ..
  6. Role of the Aryl Hydrocarbon Receptor in Lung Inflammation
    PATRICIA JANET SIME; Fiscal Year: 2011
    ..Our studies will determine the mechanisms by which the AhR acts to dampen lung inflammation. This new knowledge can be exploited to develop new treatments for patients with lung inflammatory diseases. ..