J Marc Simard

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc The sulfonylurea receptor 1 (Sur1)-transient receptor potential melastatin 4 (Trpm4) channel
    Seung Kyoon Woo
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 288:3655-67. 2013
  2. pmc Sulfonylurea receptor 1 expression in human cerebral infarcts
    Rupal I Mehta
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 1595, USA
    J Neuropathol Exp Neurol 72:871-83. 2013
  3. pmc Glibenclamide in cerebral ischemia and stroke
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene St, Suite S12D, Baltimore, MD, 21201 1595, USA
    Neurocrit Care 20:319-33. 2014
  4. pmc Heparin Reduces Neuroinflammation and Transsynaptic Neuronal Apoptosis in a Model of Subarachnoid Hemorrhage
    J Marc Simard
    Transl Stroke Res 3:155-165. 2012
  5. pmc Glibenclamide-10-h Treatment Window in a Clinically Relevant Model of Stroke
    J Marc Simard
    Transl Stroke Res 3:286-295. 2012
  6. pmc Spinal cord injury with unilateral versus bilateral primary hemorrhage--effects of glibenclamide
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Exp Neurol 233:829-35. 2012
  7. pmc Comparative effects of glibenclamide and riluzole in a rat model of severe cervical spinal cord injury
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201 1595, USA
    Exp Neurol 233:566-74. 2012
  8. pmc When replication teaches more than the original experiment--the saga of the unknown unknown
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Exp Neurol 233:623-4. 2012
  9. pmc Sulfonylurea receptor 1 in central nervous system injury: a focused review
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    J Cereb Blood Flow Metab 32:1699-717. 2012
  10. pmc Transient receptor potential melastatin 4 and cell death
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD 21201 1595, USA
    Pflugers Arch 464:573-82. 2012

Collaborators

Detail Information

Publications65

  1. pmc The sulfonylurea receptor 1 (Sur1)-transient receptor potential melastatin 4 (Trpm4) channel
    Seung Kyoon Woo
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 288:3655-67. 2013
    ..Our findings depart from the long-held view of an exclusive association between Sur1 and K(ATP) channels and reveal an unexpected molecular partnership with far-ranging implications for CNS injury...
  2. pmc Sulfonylurea receptor 1 expression in human cerebral infarcts
    Rupal I Mehta
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 1595, USA
    J Neuropathol Exp Neurol 72:871-83. 2013
    ..In conjunction with previous studies, these data suggest that Sur1 may be a promising treatment target in patients with acute cerebral infarction. ..
  3. pmc Glibenclamide in cerebral ischemia and stroke
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene St, Suite S12D, Baltimore, MD, 21201 1595, USA
    Neurocrit Care 20:319-33. 2014
    ..The findings reviewed here provide a strong foundation for a translational research program to study glibenclamide in patients with ischemic stroke...
  4. pmc Heparin Reduces Neuroinflammation and Transsynaptic Neuronal Apoptosis in a Model of Subarachnoid Hemorrhage
    J Marc Simard
    Transl Stroke Res 3:155-165. 2012
    ..We conclude that delayed IV infusion of low-dose unfractionated heparin may attenuate adverse neuroinflammatory effects of SAH...
  5. pmc Glibenclamide-10-h Treatment Window in a Clinically Relevant Model of Stroke
    J Marc Simard
    Transl Stroke Res 3:286-295. 2012
    ..8 ± 0.62 to 7.6 ± 0.70 or 8.4 ± 0.74 (both P < 0.01). We conclude that, in a clinically relevant model of stroke, the treatment window for glibenclamide extends to 10 h after onset of ischemia...
  6. pmc Spinal cord injury with unilateral versus bilateral primary hemorrhage--effects of glibenclamide
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Exp Neurol 233:829-35. 2012
    ..We conclude that glibenclamide is beneficial in different models of cervical SCI, with the magnitude of the benefit depending on the magnitude and extent of primary hemorrhage...
  7. pmc Comparative effects of glibenclamide and riluzole in a rat model of severe cervical spinal cord injury
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201 1595, USA
    Exp Neurol 233:566-74. 2012
    ..Differences in specificity, dose-limiting potency, or in spectrum of action may account for the apparent superiority of glibenclamide over riluzole in this model of severe SCI...
  8. pmc When replication teaches more than the original experiment--the saga of the unknown unknown
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Exp Neurol 233:623-4. 2012
    ....
  9. pmc Sulfonylurea receptor 1 in central nervous system injury: a focused review
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    J Cereb Blood Flow Metab 32:1699-717. 2012
    ....
  10. pmc Transient receptor potential melastatin 4 and cell death
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD 21201 1595, USA
    Pflugers Arch 464:573-82. 2012
    ..Future studies will be needed to determine whether TRPM4 also plays a role in regulated necrosis and apoptosis...
  11. pmc Does inhibiting Sur1 complement rt-PA in cerebral ischemia?
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Ann N Y Acad Sci 1268:95-107. 2012
    ..Inhibition of Sur1 with injectable glyburide holds promise for ameliorating rt-PA-associated HT in stroke...
  12. ncbi request reprint Regulation by sulfanylurea receptor type 1 of a non-selective cation channel involved in cytotoxic edema of reactive astrocytes
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Neurosurg Anesthesiol 16:98-9. 2004
    ..These findings are consistent with participation of this channel in cation flux involved in cell swelling. This novel channel may play an important role in the pathogenesis of brain swelling...
  13. pmc Protective effect of delayed treatment with low-dose glibenclamide in three models of ischemic stroke
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201 1595, USA
    Stroke 40:604-9. 2009
    ..However, the therapeutic window for treatment with glibenclamide has not been studied...
  14. pmc Sulfonylurea receptor 1 in the germinal matrix of premature infants
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Pediatr Res 64:648-52. 2008
    ..Our data suggest that the SUR1-regulated NCCa-ATP channel may be associated with GMH, and that pharmacological block of these channels could potentially reduce the incidence of this devastating complication of prematurity...
  15. pmc Unfractionated heparin: multitargeted therapy for delayed neurological deficits induced by subarachnoid hemorrhage
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene St, Suite S12D, Baltimore, MD 21201 1595, USA
    Neurocrit Care 13:439-49. 2010
    ..Our review suggests that the use of prophylactic heparin following SAH may warrant formal study...
  16. pmc Drugs acting on SUR1 to treat CNS ischemia and trauma
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene St, Suite 12SD, Baltimore, MD 21201 1595, USA
    Curr Opin Pharmacol 8:42-9. 2008
    ....
  17. pmc Endothelial sulfonylurea receptor 1-regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury
    J Marc Simard
    Department of Neurosurgery, School of Medicine, University of Maryland at Baltimore, Baltimore, Maryland 21201 1595, USA
    J Clin Invest 117:2105-13. 2007
    ..We conclude that SUR1-regulated NC(Ca-ATP) channels in capillary endothelium are critical to development of PHN and constitute a major target for therapy in SCI...
  18. pmc Glibenclamide is superior to decompressive craniectomy in a rat model of malignant stroke
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Stroke 41:531-7. 2010
    ....
  19. pmc Brief suppression of Abcc8 prevents autodestruction of spinal cord after trauma
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, MD 21201 1595, USA
    Sci Transl Med 2:28ra29. 2010
    ..Suppression of Abcc8 with antisense oligodeoxynucleotide after SCI presents an opportunity for reducing the devastating sequelae of SCI...
  20. pmc Non-selective cation channels, transient receptor potential channels and ischemic stroke
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochim Biophys Acta 1772:947-57. 2007
    ..The nascent field of NC channels, including TRP channels, in ischemic stroke is poised to provide novel mechanistic insights and therapeutic strategies for this often devastating human condition...
  21. pmc Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA
    Lancet Neurol 6:258-68. 2007
    ....
  22. pmc Key role of sulfonylurea receptor 1 in progressive secondary hemorrhage after brain contusion
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Neurotrauma 26:2257-67. 2009
    ..Our findings provide novel insights into molecular mechanisms responsible for PSH associated with hemorrhagic contusions, and point to SUR1 as a potential therapeutic target in TBI...
  23. pmc Molecular mechanisms of microvascular failure in central nervous system injury--synergistic roles of NKCC1 and SUR1/TRPM4
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    J Neurosurg 113:622-9. 2010
    ....
  24. pmc Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    J Cereb Blood Flow Metab 29:317-30. 2009
    ..We conclude that block of SUR1 by glibenclamide may ameliorate several pathologic effects associated with inflammation that lead to cortical dysfunction after SAH...
  25. pmc Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke
    J Marc Simard
    Department of Neurosurgery, School of Medicine, University of Maryland at Baltimore, 22 South Greene Street, Suite 12SD, Baltimore, Maryland 21201 1595, USA
    Nat Med 12:433-40. 2006
    ..Our findings indicate that the NC(Ca-ATP) channel is crucially involved in development of cerebral edema, and that targeting SUR1 may provide a new therapeutic approach to stroke...
  26. ncbi request reprint Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat brain
    Mingkui Chen
    Department of Neurosurgery, University of Maryland at Baltimore, Baltimore, Maryland 21201, USA
    J Neurosci 23:8568-77. 2003
    ..Our data indicate that SUR1 is functionally coupled to the pore-forming portion of the NC(Ca-ATP) channel, providing the first demonstration of promiscuity of SUR1 outside of the K+ inward rectifier family of channels...
  27. pmc Sequential activation of hypoxia-inducible factor 1 and specificity protein 1 is required for hypoxia-induced transcriptional stimulation of Abcc8
    Seung Kyoon Woo
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    J Cereb Blood Flow Metab 32:525-36. 2012
    ..Sequential gene activation in cerebral ischemia provides a plausible molecular explanation for the prolonged treatment window observed for inhibition of the end-target gene product, SUR1, by glibenclamide...
  28. pmc De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury
    Volodymyr Gerzanich
    Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, Maryland 21201 1595, USA
    Nat Med 15:185-91. 2009
    ..To our knowledge, this is the first example of a Trp channel that must undergo de novo expression for manifestation of central nervous system pathology...
  29. ncbi request reprint Early pathophysiological changes in cerebral vessels predisposing to stroke
    Volodymyr Gerzanich
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Hemorheol Microcirc 29:291-4. 2003
    ....
  30. ncbi request reprint Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle
    Volodymyr Gerzanich
    Department of Neurosurgery, University of Maryland at Baltimore, Baltimore, MD, USA
    Circ Res 93:805-12. 2003
    ..Our data identify a functional role for cGKIbeta in VSMCs previously ascribed exclusively to cGKIalpha. Ang-induced alternative splicing of cGKI represents a novel mechanism for reducing sensitivity to NO/cGMP...
  31. pmc Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle
    Alexander Ivanov
    Department of Neurosurgery, 22 S Greene Street, Suite 12SD, Baltimore, MD 21201 1595, USA
    J Physiol 570:73-84. 2006
    ....
  32. ncbi request reprint Mislocalization of eNOS and upregulation of cerebral vascular Ca2+ channel activity in angiotensin-hypertension
    Volodymyr Gerzanich
    Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201 1595, USA
    Hypertension 41:1124-30. 2003
    ..These data provide the first evidence linking Ang-induced eNOS mislocalization, eNOS dysfunction, and Ca2+ channel upregulation, and they provide novel mechanistic insights into pathological changes in LSAs associated with stroke...
  33. ncbi request reprint Autocrine TGF-beta1 mediates angiotensin II-induced proliferative response of cerebral vessels in vivo
    Vladimir V Yurovsky
    Department of Neurosurgery, University of Maryland at Baltimore, Baltimore, Maryland 21201 1595, USA
    Am J Hypertens 20:950-6. 2007
    ..Here, we tested the hypothesis that Ang promotes proliferative and fibrogenic responses in cerebral vessels through autocrine production and signaling of TGF-beta1 by vascular smooth muscle cells (VSMC)...
  34. ncbi request reprint Adenosine-A2a receptor down-regulates cerebral smooth muscle L-type Ca2+ channel activity via protein tyrosine phosphatase, not cAMP-dependent protein kinase
    Katrina Murphy
    Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene St, Baltimore MD 21201 1595, USA
    Mol Pharmacol 64:640-9. 2003
    ....
  35. ncbi request reprint Trans-cellular proliferating cell nuclear antigen gene activation in cerebral vascular smooth muscle by endothelial oxidative injury in vivo
    Volodymyr Gerzanich
    Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene St, Baltimore, MD 21201 1595, USA
    Arterioscler Thromb Vasc Biol 23:2048-54. 2003
    ..This study was undertaken to assess the role of vascular smooth muscle cell (VSMC) Ca2+ channels and Ca2+/calmodulin-dependent protein kinase II (CaMKII) in gene regulation after oxidative endothelial injury (OEI)...
  36. doi request reprint Increased transient receptor potential vanilloid type 1 (TRPV1) signaling in idiopathic overactive bladder urothelial cells
    Mingkai Li
    Division of Urology, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Neurourol Urodyn 30:606-11. 2011
    ..To measure transient receptor potential vanilloid type 1 (TRPV1) signaling in human bladder urothelial cells (BUC) from non-neurogenic overactive bladder (OAB) patients and control subjects (NB) BUC...
  37. doi request reprint Pilot study of intravenous glyburide in patients with a large ischemic stroke
    Kevin N Sheth
    From the Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT K N S Division of Neurocritical Care and Emergency Neurology, Department of Neurology W T K and Division of Neuroradiology, Department of Radiology A J Y, Massachusetts General Hospital, Boston Department of Public Health Services, Medical University of South Carolina, Charleston J J E Department of Neurology, Michael E DeBakey VA Medical, Baylor College of Medicine, Houston, TX T A K, P M Department of Neurology, Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany G T Department of Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Australia B C, G A D, S M D Department of Neurology, Stanford University School of Medicine, CA G W A Remedy Pharmaceuticals, Inc, New York, NY S J and Departments of Neurosurgery J M S and Neurology B J S, University of Maryland School of Medicine, Baltimore
    Stroke 45:281-3. 2014
    ..We assessed the feasibility of recruiting and treating patients with severe stroke while obtaining preliminary information on the safety and tolerability of RP-1127 (glyburide for injection)...
  38. doi request reprint Glial fibrillary acidic protein is highly correlated with brain injury
    Kimberly M Lumpkins
    Division of Clinical and Outcomes Research, R Adams Cowley Shock Trauma Center, Baltimore, Maryland 21201, USA
    J Trauma 65:778-82; discussion 782-4. 2008
    ..Recent work has indicated that GFAP may serve as a serum marker of traumatic brain injury (TBI) that is released after central nervous system cell damage...
  39. pmc Tandem insults of prenatal ischemia plus postnatal raised intrathoracic pressure in a novel rat model of encephalopathy of prematurity
    Michael T Koltz
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Neurosurg Pediatr 8:628-39. 2011
    ..In this study, the authors evaluated a novel model using rats that featured tandem insults of transient prenatal intrauterine ischemia (IUI) plus transient postnatal raised intrathoracic pressure (RIP)...
  40. doi request reprint Glibenclamide reduces hippocampal injury and preserves rapid spatial learning in a model of traumatic brain injury
    Ashish D Patel
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Neuropathol Exp Neurol 69:1177-90. 2010
    ..We conclude that glibenclamide may have long-term protective effects on the hippocampus after mild-to-moderate TBI...
  41. pmc Cytotoxic edema: mechanisms of pathological cell swelling
    Danny Liang
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    Neurosurg Focus 22:E2. 2007
    ..A better understanding of these molecular mechanisms holds the promise of improved treatments of cerebral edema and of the secondary injury produced by this pathological process...
  42. doi request reprint Comparative study of decompressive craniectomy after mass lesion evacuation in severe head injury
    Bizhan Aarabi
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Neurosurgery 64:927-39; discussion 939-40. 2009
    ..This study was conducted to evaluate outcome after decompressive craniectomy (DC) in the setting of mass evacuation with or without intracranial pressure (ICP) monitoring...
  43. pmc Exposure of the thorax to a sublethal blast wave causes a hydrodynamic pulse that leads to perivenular inflammation in the brain
    J Marc Simard
    1 Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland
    J Neurotrauma 31:1292-304. 2014
    ..We conclude that blast injury to the thorax leads to perivenular inflammation, Sur1 up-regulation, and reactive astrocytosis resulting from the induction of a hydrodynamic pulse in the vasculature. ..
  44. ncbi request reprint Induced and sustained hypernatremia for the prevention and treatment of cerebral edema following brain injury
    Justine H Ryu
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA, 02114, USA
    Neurocrit Care 19:222-31. 2013
    ..Insufficient evidence exists to recommend pharmacologic induction of hypernatremia as a treatment for cerebral edema. The strategy of vigilant avoidance of hyponatremia is currently a safer, potentially more efficacious paradigm. ..
  45. pmc Hemorrhagic progression of a contusion after traumatic brain injury: a review
    David Kurland
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    J Neurotrauma 29:19-31. 2012
    ..Here we review the topic of HPC, we examine data relevant to the concept of a coagulopathy, and we detail emerging data elucidating the mechanism of progressive microvascular failure that predisposes to HPC after head trauma...
  46. ncbi request reprint Chlorotoxin-sensitive Ca2+-activated Cl- channel in type R2 reactive astrocytes from adult rat brain
    Stanislava Dalton
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Glia 42:325-39. 2003
    ..Expression of a novel chlorotoxin-sensitive Cl(Ca) channel in a morphologically distinct subpopulation of NRAs distinguishes these cells as a new subtype of reactive astrocyte...
  47. pmc Intramedullary lesion expansion on magnetic resonance imaging in patients with motor complete cervical spinal cord injury
    Bizhan Aarabi
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosurg Spine 17:243-50. 2012
    ....
  48. ncbi request reprint Transforming growth factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via phospholipase C and protein kinase C-delta in reactive astrocytes from adult rat brain
    Pablo R Perillan
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 277:1974-80. 2002
    ..Given the commonality of signaling involving PLC-PKC-delta, we speculate that TGF-beta(1)-evoked depolarization may be an early signaling event related to gene transcription in astrocytes...
  49. pmc Continuous hyperosmolar therapy for traumatic brain injury-associated cerebral edema: as good as it gets, or an iatrogenic secondary insult?
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Neurosci 20:30-1. 2013
    ..This practice is highly controversial, is in widespread use, and lacks robust evidence for efficacy. Herein, we review details of the controversy regarding this practice...
  50. ncbi request reprint EGF and HB-EGF modulate inward potassium current in human bladder urothelial cells from normal and interstitial cystitis patients
    Yan Sun
    Division of Urology, University of Maryland, 22 S Greene Street, S8D18, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 292:C106-14. 2007
    ..These data show that the inward potassium current in BUC can be modulated by EGF and HB-EGF. Changes in BUC membrane potassium conductance caused by altered levels of EGF and HB-EGF may therefore play a role in the pathophysiology of IC...
  51. pmc Augmented bladder urothelial polyamine signaling and block of BK channel in the pathophysiology of overactive bladder syndrome
    Mingkai Li
    Department of Surgery, University of Maryland School of Medicine, Baltimore, 21201, USA
    Am J Physiol Cell Physiol 297:C1445-51. 2009
    ..Furthermore, polyamines in BUC block the BK channel. Targeting of bladder urothelial polyamine signaling may represent a novel approach for OAB treatment based on pathophysiologic mechanisms...
  52. ncbi request reprint Concomitant boost of stratified target area with gamma knife radiosurgery: a treatment planning study
    Lijun Ma
    Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore 21201, USA
    Am J Clin Oncol 26:e100-5. 2003
    ..As a result, we conclude that concomitant boost of a stratified target area is feasible for GKSRS...
  53. doi request reprint Treatment of cerebral aneurysms-surgical clipping or endovascular coiling: the guiding principles
    Ravishankar Shivashankar
    Division of Interventional Neuroradiology, University of Maryland Medical Center, Baltimore, Maryland
    Semin Neurol 33:476-87. 2013
    ..The treatment of intracranial aneurysms is best performed at high volume centers that utilize a multidisciplinary, team-based approach. ..
  54. doi request reprint Low-angle vascular access for neurovascular procedures using the Arstasis AXERA access device
    Manuel Correa Fortes
    Department of Radiology, University of Maryland Medical Center, Baltimore, MD 21201, USA
    J Vasc Interv Radiol 24:693-7. 2013
    ..To evaluate the safety and efficacy of the Arstasis AXERA access device in patients undergoing neuroendovascular procedures...
  55. ncbi request reprint Plasma levels of the beta chemokine regulated upon activation, normal T cell expressed, and secreted (RANTES) correlate with severe brain injury
    Kimberly Lumpkins
    Division of Clinical Outcomes Research, R Adams Cowley Shock Trauma Center, Baltimore, Maryland, USA
    J Trauma 64:358-61. 2008
    ....
  56. pmc Novel treatment targets for cerebral edema
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neurotherapeutics 9:65-72. 2012
    ..A specific antagonist of the vasopressin V1A- and V2-receptor, conivaptan, promotes water excretion while sparing electrolytes through a process known as aquaresis...
  57. doi request reprint Long-term outcome of Gamma Knife stereotactic radiosurgery for arteriovenous malformations graded by the Spetzler-Martin classification
    Michael T Koltz
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    J Neurosurg 118:74-83. 2013
    ..The object of this study was to assess outcomes in patients with arteriovenous malformations (AVMs) treated by Gamma Knife stereotactic radiosurgery (SRS); lesions were stratified by size, symptomatology, and Spetzler-Martin (S-M) grade...
  58. pmc Managing malignant cerebral infarction
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene St, Suite S12D, Baltimore, MD, 21201 1595, USA
    Curr Treat Options Neurol 13:217-29. 2011
    ..Under appropriate circumstances, decompressive craniectomy may be warranted to improve outcome or to prevent death...
  59. ncbi request reprint Increase in Cx45 gap junction channels in cerebral smooth muscle cells from SHR
    Xing Li
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201 1595, USA
    Hypertension 40:940-6. 2002
    ..Overall, our data show increased Cx45 in SHR that is unlikely to be due to either elevated blood pressure or to angiotensin. Relative dominance of Cx45 over Cx43 in cerebral vessels may predispose SHR to ischemic stroke...
  60. doi request reprint Traumatic brain injury
    Bizhan Aarabi
    Department of Neurosurgery, University of Maryland School of Medicine, Maryland 21201, USA
    Curr Opin Crit Care 15:548-53. 2009
    ..A broad effort is gaining momentum to unravel reasons behind failed therapeutic trials in TBI...
  61. ncbi request reprint Fetal and ovarian radiation dose in patients undergoing gamma knife radiosurgery
    Vladimir Ioffe
    Department of Radiation Oncology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21229, USA
    Surg Neurol 58:32-41; discussion 41. 2002
    ....
  62. ncbi request reprint Concomitant GRID boost for Gamma Knife radiosurgery
    Lijun Ma
    Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland 21210, USA
    Med Phys 32:3419-23. 2005
    ..e., the near region) were decreased for the GRID boost technique. In conclusion, we demonstrated a new technique for Gamma Knife radiosurgery that can escalate the dose to the target while sparing the adjacent normal brain tissue...
  63. pmc Sulfonylureas improve outcome in patients with type 2 diabetes and acute ischemic stroke
    Hagen Kunte
    Department of Neurology, Center for Stroke Research, Humboldt University, Berlin, Germany
    Stroke 38:2526-30. 2007
    ..We hypothesized that patients with type 2 diabetes mellitus taking sulfonylurea agents both at the time of stroke and during hospitalization would have superior outcomes...
  64. pmc Recommendations of the National Heart, Lung, and Blood Institute working group on cerebrovascular biology and disease
    Costantino Iadecola
    Weill Cornell Medical College, New York, NY, USA
    Stroke 37:1578-81. 2006
    ....
  65. ncbi request reprint Vascular smooth muscle proliferation as a target for therapeutic intervention
    J Marc Simard
    Stroke 34:e108; author reply e108. 2003

Research Grants30

  1. Spinal cord injury, progressive hemorrhagic necrosis and the NC(Ca-ATP) channel
    J Marc Simard; Fiscal Year: 2009
    ..These studies will form the basis for novel future therapies for spinal cord injury. ..
  2. Reactive astrocytes from gliotic capsule
    J Simard; Fiscal Year: 2005
    ..Overall, we expect that these studies will build on our recent discovery of the novel SURl-regulated NCca-ATPchannel, and will help to elucidate the function of R1 astrocytes in the inner zone of the gliotic capsule. ..
  3. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Simard; Fiscal Year: 2000
    ....
  4. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Simard; Fiscal Year: 2006
    ..abstract_text> ..
  5. Reactive astrocytes from gliotic capsule
    J Simard; Fiscal Year: 2006
    ..Overall, we expect that these studies will build on our recent discovery of the novel SURl-regulated NCca-ATPchannel, and will help to elucidate the function of R1 astrocytes in the inner zone of the gliotic capsule. ..
  6. PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELS
    J Simard; Fiscal Year: 2001
    ....
  7. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Simard; Fiscal Year: 2005
    ..abstract_text> ..
  8. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Simard; Fiscal Year: 1999
    ....
  9. Pathological role of the SUR1-regulated NC(Ca-ATP) channel in cortex after subara
    J Marc Simard; Fiscal Year: 2009
    ..In this proposal, we will use a rat model of SAH to establish the essential role of the NC(Ca-ATP) channel in pathophysiology post-SAH. ..
  10. Sulfonylurea receptor 1 (SUR1)- A novel therapeutic target in ischemic stroke
    J Marc Simard; Fiscal Year: 2010
    ..End of Abstract) ..
  11. Reactive astrocytes from gliotic capsule
    J Marc Simard; Fiscal Year: 2007
    ..Overall, we expect that these studies will build on our recent discovery of the novel SURl-regulated NCca-ATPchannel, and will help to elucidate the function of R1 astrocytes in the inner zone of the gliotic capsule. ..
  12. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Marc Simard; Fiscal Year: 2007
    ..abstract_text> ..
  13. Spinal cord injury, progressive hemorrhagic necrosis and the NC(Ca-ATP) channel
    J Marc Simard; Fiscal Year: 2010
    ..These studies will form the basis for novel future therapies for spinal cord injury. ..
  14. Pathological role of the SUR1-regulated NC(Ca-ATP) channel in cortex after subara
    J Marc Simard; Fiscal Year: 2010
    ..In this proposal, we will use a rat model of SAH to establish the essential role of the NC(Ca-ATP) channel in pathophysiology post-SAH. ..
  15. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Simard; Fiscal Year: 2001
    ....
  16. PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELS
    J Simard; Fiscal Year: 2002
    ....
  17. PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELS
    J Simard; Fiscal Year: 2003
    ....
  18. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Simard; Fiscal Year: 2004
    ..abstract_text> ..
  19. PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELS
    J Simard; Fiscal Year: 2004
    ....
  20. Sulfonylurea receptor 1 (SUR1)- A novel therapeutic target in ischemic stroke
    J Marc Simard; Fiscal Year: 2007
    ..End of Abstract) ..
  21. Sulfonylurea receptor 1 (SUR1)- A novel therapeutic target in ischemic stroke
    J Marc Simard; Fiscal Year: 2009
    ..End of Abstract) ..
  22. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Simard; Fiscal Year: 2002
    ....
  23. PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELS
    J Simard; Fiscal Year: 2000
    ....
  24. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Simard; Fiscal Year: 1999
    ....
  25. Sulfonylurea receptor 1 (SUR1)- A novel therapeutic target in ischemic stroke
    J Marc Simard; Fiscal Year: 2006
    ..End of Abstract) ..