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Genomes and Genes | J Marc SimardSummaryAffiliation: University of Maryland Country: USA Publications
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Publications
Comparative effects of glibenclamide and riluzole in a rat model of severe cervical spinal cord injuryJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201 1595, USA
Exp Neurol 233:566-74. 2012..Differences in specificity, dose-limiting potency, or in spectrum of action may account for the apparent superiority of glibenclamide over riluzole in this model of severe SCI...- When replication teaches more than the original experiment--the saga of the unknown unknownJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Exp Neurol 233:623-4. 2012.... - Spinal cord injury with unilateral versus bilateral primary hemorrhage--effects of glibenclamideJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Exp Neurol 233:829-35. 2012..We conclude that glibenclamide is beneficial in different models of cervical SCI, with the magnitude of the benefit depending on the magnitude and extent of primary hemorrhage... - Sulfonylurea receptor 1 in central nervous system injury: a focused reviewJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
J Cereb Blood Flow Metab 32:1699-717. 2012.... - Transient receptor potential melastatin 4 and cell deathJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD 21201 1595, USA
Pflugers Arch 464:573-82. 2012..Future studies will be needed to determine whether TRPM4 also plays a role in regulated necrosis and apoptosis... - Does inhibiting Sur1 complement rt-PA in cerebral ischemia?J Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
Ann N Y Acad Sci 1268:95-107. 2012..Inhibition of Sur1 with injectable glyburide holds promise for ameliorating rt-PA-associated HT in stroke... - Non-selective cation channels, transient receptor potential channels and ischemic strokeJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Biochim Biophys Acta 1772:947-57. 2007..The nascent field of NC channels, including TRP channels, in ischemic stroke is poised to provide novel mechanistic insights and therapeutic strategies for this often devastating human condition... - Endothelial sulfonylurea receptor 1-regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injuryJ Marc Simard
Department of Neurosurgery, School of Medicine, University of Maryland at Baltimore, Baltimore, Maryland 21201 1595, USA
J Clin Invest 117:2105-13. 2007..We conclude that SUR1-regulated NC(Ca-ATP) channels in capillary endothelium are critical to development of PHN and constitute a major target for therapy in SCI... - Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implicationsJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA
Lancet Neurol 6:258-68. 2007.... - Drugs acting on SUR1 to treat CNS ischemia and traumaJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene St, Suite 12SD, Baltimore, MD 21201 1595, USA
Curr Opin Pharmacol 8:42-9. 2008.... - Sulfonylurea receptor 1 in the germinal matrix of premature infantsJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Pediatr Res 64:648-52. 2008..Our data suggest that the SUR1-regulated NCCa-ATP channel may be associated with GMH, and that pharmacological block of these channels could potentially reduce the incidence of this devastating complication of prematurity... - Protective effect of delayed treatment with low-dose glibenclamide in three models of ischemic strokeJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201 1595, USA
Stroke 40:604-9. 2009..However, the therapeutic window for treatment with glibenclamide has not been studied... - Key role of sulfonylurea receptor 1 in progressive secondary hemorrhage after brain contusionJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Neurotrauma 26:2257-67. 2009..Our findings provide novel insights into molecular mechanisms responsible for PSH associated with hemorrhagic contusions, and point to SUR1 as a potential therapeutic target in TBI... - Unfractionated heparin: multitargeted therapy for delayed neurological deficits induced by subarachnoid hemorrhageJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene St, Suite S12D, Baltimore, MD 21201 1595, USA
Neurocrit Care 13:439-49. 2010..Our review suggests that the use of prophylactic heparin following SAH may warrant formal study... - Molecular mechanisms of microvascular failure in central nervous system injury--synergistic roles of NKCC1 and SUR1/TRPM4J Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
J Neurosurg 113:622-9. 2010.... - Glibenclamide is superior to decompressive craniectomy in a rat model of malignant strokeJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
Stroke 41:531-7. 2010.... - Brief suppression of Abcc8 prevents autodestruction of spinal cord after traumaJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, MD 21201 1595, USA
Sci Transl Med 2:28ra29. 2010..Suppression of Abcc8 with antisense oligodeoxynucleotide after SCI presents an opportunity for reducing the devastating sequelae of SCI... - Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhageJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
J Cereb Blood Flow Metab 29:317-30. 2009..We conclude that block of SUR1 by glibenclamide may ameliorate several pathologic effects associated with inflammation that lead to cortical dysfunction after SAH... 
Regulation by sulfanylurea receptor type 1 of a non-selective cation channel involved in cytotoxic edema of reactive astrocytesJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Neurosurg Anesthesiol 16:98-9. 2004..These findings are consistent with participation of this channel in cation flux involved in cell swelling. This novel channel may play an important role in the pathogenesis of brain swelling...- Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic strokeJ Marc Simard
Department of Neurosurgery, School of Medicine, University of Maryland at Baltimore, 22 South Greene Street, Suite 12SD, Baltimore, Maryland 21201 1595, USA
Nat Med 12:433-40. 2006..Our findings indicate that the NC(Ca-ATP) channel is crucially involved in development of cerebral edema, and that targeting SUR1 may provide a new therapeutic approach to stroke... - Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat brainMingkui Chen
Department of Neurosurgery, University of Maryland at Baltimore, Baltimore, Maryland 21201, USA
J Neurosci 23:8568-77. 2003..Our data indicate that SUR1 is functionally coupled to the pore-forming portion of the NC(Ca-ATP) channel, providing the first demonstration of promiscuity of SUR1 outside of the K+ inward rectifier family of channels... - Sequential activation of hypoxia-inducible factor 1 and specificity protein 1 is required for hypoxia-induced transcriptional stimulation of Abcc8Seung Kyoon Woo
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
J Cereb Blood Flow Metab 32:525-36. 2012..Sequential gene activation in cerebral ischemia provides a plausible molecular explanation for the prolonged treatment window observed for inhibition of the end-target gene product, SUR1, by glibenclamide... - Early pathophysiological changes in cerebral vessels predisposing to strokeVolodymyr Gerzanich
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Clin Hemorheol Microcirc 29:291-4. 2003.... - The sulfonylurea receptor 1 (Sur1)-transient receptor potential melastatin 4 (Trpm4) channelSeung Kyoon Woo
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Biol Chem 288:3655-67. 2013..Our findings depart from the long-held view of an exclusive association between Sur1 and K(ATP) channels and reveal an unexpected molecular partnership with far-ranging implications for CNS injury... - Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscleVolodymyr Gerzanich
Department of Neurosurgery, University of Maryland at Baltimore, Baltimore, MD, USA
Circ Res 93:805-12. 2003..Our data identify a functional role for cGKIbeta in VSMCs previously ascribed exclusively to cGKIalpha. Ang-induced alternative splicing of cGKI represents a novel mechanism for reducing sensitivity to NO/cGMP... - De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injuryVolodymyr Gerzanich
Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, Maryland 21201 1595, USA
Nat Med 15:185-91. 2009..To our knowledge, this is the first example of a Trp channel that must undergo de novo expression for manifestation of central nervous system pathology... - Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscleAlexander Ivanov
Department of Neurosurgery, 22 S Greene Street, Suite 12SD, Baltimore, MD 21201 1595, USA
J Physiol 570:73-84. 2006.... - Mislocalization of eNOS and upregulation of cerebral vascular Ca2+ channel activity in angiotensin-hypertensionVolodymyr Gerzanich
Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201-1595, USA
Hypertension 41:1124-30. 2003..These data provide the first evidence linking Ang-induced eNOS mislocalization, eNOS dysfunction, and Ca2+ channel upregulation, and they provide novel mechanistic insights into pathological changes in LSAs associated with stroke... - Adenosine-A2a receptor down-regulates cerebral smooth muscle L-type Ca2+ channel activity via protein tyrosine phosphatase, not cAMP-dependent protein kinaseKatrina Murphy
Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene St, Baltimore MD 21201-1595, USA
Mol Pharmacol 64:640-9. 2003.... - Autocrine TGF-beta1 mediates angiotensin II-induced proliferative response of cerebral vessels in vivoVladimir V Yurovsky
Department of Neurosurgery, University of Maryland at Baltimore, Baltimore, Maryland 21201 1595, USA
Am J Hypertens 20:950-6. 2007..Here, we tested the hypothesis that Ang promotes proliferative and fibrogenic responses in cerebral vessels through autocrine production and signaling of TGF-beta1 by vascular smooth muscle cells (VSMC)... 
Increased transient receptor potential vanilloid type 1 (TRPV1) signaling in idiopathic overactive bladder urothelial cellsMingkai Li
Division of Urology, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Neurourol Urodyn 30:606-11. 2011..To measure transient receptor potential vanilloid type 1 (TRPV1) signaling in human bladder urothelial cells (BUC) from non-neurogenic overactive bladder (OAB) patients and control subjects (NB) BUC...- Trans-cellular proliferating cell nuclear antigen gene activation in cerebral vascular smooth muscle by endothelial oxidative injury in vivoVolodymyr Gerzanich
Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene St, Baltimore, MD 21201 1595, USA
Arterioscler Thromb Vasc Biol 23:2048-54. 2003..This study was undertaken to assess the role of vascular smooth muscle cell (VSMC) Ca2+ channels and Ca2+/calmodulin-dependent protein kinase II (CaMKII) in gene regulation after oxidative endothelial injury (OEI)... - Glial fibrillary acidic protein is highly correlated with brain injuryKimberly M Lumpkins
Division of Clinical and Outcomes Research, R Adams Cowley Shock Trauma Center, Baltimore, Maryland 21201, USA
J Trauma 65:778-82; discussion 782-4. 2008..Recent work has indicated that GFAP may serve as a serum marker of traumatic brain injury (TBI) that is released after central nervous system cell damage... - Comparative study of decompressive craniectomy after mass lesion evacuation in severe head injuryBizhan Aarabi
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Neurosurgery 64:927-39; discussion 939-40. 2009..This study was conducted to evaluate outcome after decompressive craniectomy (DC) in the setting of mass evacuation with or without intracranial pressure (ICP) monitoring... - Cytotoxic edema: mechanisms of pathological cell swellingDanny Liang
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
Neurosurg Focus 22:E2. 2007..A better understanding of these molecular mechanisms holds the promise of improved treatments of cerebral edema and of the secondary injury produced by this pathological process... - Glibenclamide reduces hippocampal injury and preserves rapid spatial learning in a model of traumatic brain injuryAshish D Patel
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Neuropathol Exp Neurol 69:1177-90. 2010..We conclude that glibenclamide may have long-term protective effects on the hippocampus after mild-to-moderate TBI... - Intramedullary lesion expansion on magnetic resonance imaging in patients with motor complete cervical spinal cord injuryBizhan Aarabi
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Neurosurg Spine 17:243-50. 2012.... - Chlorotoxin-sensitive Ca2+-activated Cl- channel in type R2 reactive astrocytes from adult rat brainStanislava Dalton
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Glia 42:325-39. 2003..Expression of a novel chlorotoxin-sensitive Cl(Ca) channel in a morphologically distinct subpopulation of NRAs distinguishes these cells as a new subtype of reactive astrocyte... - Transforming growth factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via phospholipase C and protein kinase C-delta in reactive astrocytes from adult rat brainPablo R Perillan
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Biol Chem 277:1974-80. 2002..Given the commonality of signaling involving PLC-PKC-delta, we speculate that TGF-beta(1)-evoked depolarization may be an early signaling event related to gene transcription in astrocytes... - Tandem insults of prenatal ischemia plus postnatal raised intrathoracic pressure in a novel rat model of encephalopathy of prematurityMichael T Koltz
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Neurosurg Pediatr 8:628-39. 2011..In this study, the authors evaluated a novel model using rats that featured tandem insults of transient prenatal intrauterine ischemia (IUI) plus transient postnatal raised intrathoracic pressure (RIP)... - Hemorrhagic progression of a contusion after traumatic brain injury: a reviewDavid Kurland
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
J Neurotrauma 29:19-31. 2012..Here we review the topic of HPC, we examine data relevant to the concept of a coagulopathy, and we detail emerging data elucidating the mechanism of progressive microvascular failure that predisposes to HPC after head trauma... - Augmented bladder urothelial polyamine signaling and block of BK channel in the pathophysiology of overactive bladder syndromeMingkai Li
Department of Surgery, University of Maryland School of Medicine, Baltimore, 21201, USA
Am J Physiol Cell Physiol 297:C1445-51. 2009..Furthermore, polyamines in BUC block the BK channel. Targeting of bladder urothelial polyamine signaling may represent a novel approach for OAB treatment based on pathophysiologic mechanisms... - EGF and HB-EGF modulate inward potassium current in human bladder urothelial cells from normal and interstitial cystitis patientsYan Sun
Division of Urology, University of Maryland, 22 S Greene Street, S8D18, Baltimore, MD 21201, USA
Am J Physiol Cell Physiol 292:C106-14. 2007..These data show that the inward potassium current in BUC can be modulated by EGF and HB-EGF. Changes in BUC membrane potassium conductance caused by altered levels of EGF and HB-EGF may therefore play a role in the pathophysiology of IC... - Concomitant boost of stratified target area with gamma knife radiosurgery: a treatment planning studyLijun Ma
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore 21201, USA
Am J Clin Oncol 26:e100-5. 2003..As a result, we conclude that concomitant boost of a stratified target area is feasible for GKSRS... - Plasma levels of the beta chemokine regulated upon activation, normal T cell expressed, and secreted (RANTES) correlate with severe brain injuryKimberly Lumpkins
Division of Clinical Outcomes Research, R Adams Cowley Shock Trauma Center, Baltimore, Maryland, USA
J Trauma 64:358-61. 2008.... - Novel treatment targets for cerebral edemaBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Neurotherapeutics 9:65-72. 2012..A specific antagonist of the vasopressin V1A- and V2-receptor, conivaptan, promotes water excretion while sparing electrolytes through a process known as aquaresis... - Long-term outcome of Gamma Knife stereotactic radiosurgery for arteriovenous malformations graded by the Spetzler-Martin classificationMichael T Koltz
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
J Neurosurg 118:74-83. 2013..The object of this study was to assess outcomes in patients with arteriovenous malformations (AVMs) treated by Gamma Knife stereotactic radiosurgery (SRS); lesions were stratified by size, symptomatology, and Spetzler-Martin (S-M) grade... - Continuous hyperosmolar therapy for traumatic brain injury-associated cerebral edema: as good as it gets, or an iatrogenic secondary insult?Kristopher T Kahle
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Neurosci 20:30-1. 2013..This practice is highly controversial, is in widespread use, and lacks robust evidence for efficacy. Herein, we review details of the controversy regarding this practice... - Managing malignant cerebral infarctionJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene St, Suite S12D, Baltimore, MD, 21201 1595, USA
Curr Treat Options Neurol 13:217-29. 2011..Under appropriate circumstances, decompressive craniectomy may be warranted to improve outcome or to prevent death... - Increase in Cx45 gap junction channels in cerebral smooth muscle cells from SHRXing Li
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201-1595, USA
Hypertension 40:940-6. 2002..Overall, our data show increased Cx45 in SHR that is unlikely to be due to either elevated blood pressure or to angiotensin. Relative dominance of Cx45 over Cx43 in cerebral vessels may predispose SHR to ischemic stroke... - Traumatic brain injuryBizhan Aarabi
Department of Neurosurgery, University of Maryland School of Medicine, Maryland 21201, USA
Curr Opin Crit Care 15:548-53. 2009..A broad effort is gaining momentum to unravel reasons behind failed therapeutic trials in TBI... - Low-angle Vascular Access for Neurovascular Procedures Using the Arstasis AXERA Access DeviceManuel Correa Fortes
Department of Radiology, University of Maryland Medical Center, 22 S Greene St, Room G2K14, Baltimore, MD 21201 Electronic address
J Vasc Interv Radiol 24:693-7. 2013..To evaluate the safety and efficacy of the Arstasis AXERA access device in patients undergoing neuroendovascular procedures... - Concomitant GRID boost for Gamma Knife radiosurgeryLijun Ma
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland 21210, USA
Med Phys 32:3419-23. 2005..e., the near region) were decreased for the GRID boost technique. In conclusion, we demonstrated a new technique for Gamma Knife radiosurgery that can escalate the dose to the target while sparing the adjacent normal brain tissue... - Fetal and ovarian radiation dose in patients undergoing gamma knife radiosurgeryVladimir Ioffe
Department of Radiation Oncology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21229, USA
Surg Neurol 58:32-41; discussion 41. 2002..We recommend pregnancy status assessment in women of reproductive age and treatment plan design using large volume shots in order to minimize treatment time... - Sulfonylureas improve outcome in patients with type 2 diabetes and acute ischemic strokeHagen Kunte
Department of Neurology, Center for Stroke Research, Humboldt University, Berlin, Germany
Stroke 38:2526-30. 2007..We hypothesized that patients with type 2 diabetes mellitus taking sulfonylurea agents both at the time of stroke and during hospitalization would have superior outcomes... - Vascular smooth muscle proliferation as a target for therapeutic interventionJ Marc Simard
Stroke 34:e108; author reply e108. 2003 - Recommendations of the National Heart, Lung, and Blood Institute working group on cerebrovascular biology and diseaseCostantino Iadecola
Weill Cornell Medical College, New York, NY, USA
Stroke 37:1578-81. 2006....
Research Grants
- Spinal cord injury, progressive hemorrhagic necrosis and the NC(Ca-ATP) channelJ Marc Simard; Fiscal Year: 2009..These studies will form the basis for novel future therapies for spinal cord injury. ..
- Sulfonylurea receptor 1 (SUR1)- A novel therapeutic target in ischemic strokeJ Marc Simard; Fiscal Year: 2007..End of Abstract) ..
- CEREBROVASCULAR ION CHANNELS IN HYPERTENSIONJ Marc Simard; Fiscal Year: 2007..abstract_text> ..
- Reactive astrocytes from gliotic capsuleJ Marc Simard; Fiscal Year: 2007..Overall, we expect that these studies will build on our recent discovery of the novel SURl-regulated NCca-ATPchannel, and will help to elucidate the function of R1 astrocytes in the inner zone of the gliotic capsule. ..
- Sulfonylurea receptor 1 (SUR1)- A novel therapeutic target in ischemic strokeJ Marc Simard; Fiscal Year: 2009..End of Abstract) ..
- Pathological role of the SUR1-regulated NC(Ca-ATP) channel in cortex after subaraJ Marc Simard; Fiscal Year: 2009..In this proposal, we will use a rat model of SAH to establish the essential role of the NC(Ca-ATP) channel in pathophysiology post-SAH. ..
- Sulfonylurea receptor 1 (SUR1)- A novel therapeutic target in ischemic strokeJ Marc Simard; Fiscal Year: 2010..End of Abstract) ..
- Spinal cord injury, progressive hemorrhagic necrosis and the NC(Ca-ATP) channelJ Marc Simard; Fiscal Year: 2010..These studies will form the basis for novel future therapies for spinal cord injury. ..
- CEREBROVASCULAR ION CHANNELS IN HYPERTENSIONJ Simard; Fiscal Year: 2002....
- PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELSJ Simard; Fiscal Year: 2004....
- Pathological role of the SUR1-regulated NC(Ca-ATP) channel in cortex after subaraJ Marc Simard; Fiscal Year: 2010..In this proposal, we will use a rat model of SAH to establish the essential role of the NC(Ca-ATP) channel in pathophysiology post-SAH. ..