J M Simard

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi Functional integrity of endothelium determines Ca2+ channel availability in smooth muscle: involvement of nitric oxide
    J M Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore 21201, USA
    Pflugers Arch 439:752-8. 2000
  2. pmc Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke
    J Marc Simard
    Department of Neurosurgery, School of Medicine, University of Maryland at Baltimore, 22 South Greene Street, Suite 12SD, Baltimore, Maryland 21201 1595, USA
    Nat Med 12:433-40. 2006
  3. ncbi Cell swelling and a nonselective cation channel regulated by internal Ca2+ and ATP in native reactive astrocytes from adult rat brain
    M Chen
    Department of Neurosurgery, University of Maryland at Baltimore, Baltimore, Maryland 21201, USA
    J Neurosci 21:6512-21. 2001
  4. ncbi Chronic nicotine alters NO signaling of Ca(2+) channels in cerebral arterioles
    V Gerzanich
    Departments of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201-1595, USA
    Circ Res 88:359-65. 2001
  5. ncbi Increase in functional Ca2+ channels in cerebral smooth muscle with renal hypertension
    J M Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore 21201, USA
    Circ Res 82:1330-7. 1998
  6. ncbi Doppel-induced apoptosis and counteraction by cellular prion protein in neuroblastoma and astrocytes
    K Qin
    Department of Pathology, University of Maryland School of Medicine, 10 South Pine Street, MSTF 700A, Baltimore, MD 21201, USA
    Neuroscience 141:1375-88. 2006
  7. pmc MRI evidence that glibenclamide reduces acute lesion expansion in a rat model of spinal cord injury
    J M Simard
    1 Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA 2 Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA 3 Department of Physiology, University of Maryland School of Medicine, Baltimore MD, USA
    Spinal Cord 51:823-7. 2013
  8. ncbi Connexin45 gap junction channels in rat cerebral vascular smooth muscle cells
    X Li
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Heart Circ Physiol 281:H1890-8. 2001

Collaborators

Detail Information

Publications8

  1. ncbi Functional integrity of endothelium determines Ca2+ channel availability in smooth muscle: involvement of nitric oxide
    J M Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore 21201, USA
    Pflugers Arch 439:752-8. 2000
    ....
  2. pmc Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke
    J Marc Simard
    Department of Neurosurgery, School of Medicine, University of Maryland at Baltimore, 22 South Greene Street, Suite 12SD, Baltimore, Maryland 21201 1595, USA
    Nat Med 12:433-40. 2006
    ..Our findings indicate that the NC(Ca-ATP) channel is crucially involved in development of cerebral edema, and that targeting SUR1 may provide a new therapeutic approach to stroke...
  3. ncbi Cell swelling and a nonselective cation channel regulated by internal Ca2+ and ATP in native reactive astrocytes from adult rat brain
    M Chen
    Department of Neurosurgery, University of Maryland at Baltimore, Baltimore, Maryland 21201, USA
    J Neurosci 21:6512-21. 2001
    ..We conclude that NRAs from adult rat brain express a 35 pS NC(Ca-ATP) channel that may play an important role in the pathogenesis of brain swelling...
  4. ncbi Chronic nicotine alters NO signaling of Ca(2+) channels in cerebral arterioles
    V Gerzanich
    Departments of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201-1595, USA
    Circ Res 88:359-65. 2001
    ..These findings elucidate a new pathophysiological mechanism involving altered Ca(2+) homeostasis in cerebral arterioles that may predispose to stroke...
  5. ncbi Increase in functional Ca2+ channels in cerebral smooth muscle with renal hypertension
    J M Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore 21201, USA
    Circ Res 82:1330-7. 1998
    ..We conclude that in the 2K1C model, availability of functional Ca2+ channels increases with BPsys with no change in channel properties and that measurable BPsys elevation occurs before the increase in functional channels...
  6. ncbi Doppel-induced apoptosis and counteraction by cellular prion protein in neuroblastoma and astrocytes
    K Qin
    Department of Pathology, University of Maryland School of Medicine, 10 South Pine Street, MSTF 700A, Baltimore, MD 21201, USA
    Neuroscience 141:1375-88. 2006
    ....
  7. pmc MRI evidence that glibenclamide reduces acute lesion expansion in a rat model of spinal cord injury
    J M Simard
    1 Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA 2 Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA 3 Department of Physiology, University of Maryland School of Medicine, Baltimore MD, USA
    Spinal Cord 51:823-7. 2013
    ..Experimental, controlled, animal study...
  8. ncbi Connexin45 gap junction channels in rat cerebral vascular smooth muscle cells
    X Li
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Heart Circ Physiol 281:H1890-8. 2001
    ..9 mV), consistent with block of Cx45. Our data suggest that Cx45 is transcribed, expressed, and forms functional gap junction channels in rat cerebral arterial smooth muscle...