Fraser J Sim

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi request reprint Statin treatment of adult human glial progenitors induces PPAR gamma-mediated oligodendrocytic differentiation
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, New York 14642, USA
    Glia 56:954-62. 2008
  2. pmc Pleiotrophin suppression of receptor protein tyrosine phosphatase-β/ζ maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells
    Crystal R McClain
    Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 32:15066-75. 2012
  3. pmc CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA
    Nat Biotechnol 29:934-41. 2011
  4. ncbi request reprint Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, NY 14642, USA
    Ann Neurol 59:763-79. 2006
  5. ncbi request reprint Neurocytoma is a tumor of adult neuronal progenitor cells
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 26:12544-55. 2006
  6. doi request reprint Fate determination of adult human glial progenitor cells
    Fraser J Sim
    Center for Translational Neuromedicine, and the Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA
    Neuron Glia Biol 5:45-55. 2009
  7. doi request reprint Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes
    Romane M Auvergne
    Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Rep 3:2127-41. 2013
  8. pmc Non-stem cell origin for oligodendroglioma
    Anders I Persson
    Department of Neurology, University of California, San Francisco, 94158, USA
    Cancer Cell 18:669-82. 2010
  9. pmc Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting
    Su Wang
    Center for Translational Neuromedicine and the Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 30:14635-48. 2010
  10. doi request reprint Analysis of transforming growth factor β receptor expression and signaling in higher grade meningiomas
    Mahlon D Johnson
    Department of Pathology, Division of Neuropathology, University of Rochester Medical Center, 601 Elmwood Ave Box 626, Rochester, NY 14642, USA
    J Neurooncol 103:277-85. 2011

Detail Information

Publications12

  1. doi request reprint Statin treatment of adult human glial progenitors induces PPAR gamma-mediated oligodendrocytic differentiation
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, New York 14642, USA
    Glia 56:954-62. 2008
    ..Thus, statins may promote oligodendrocyte lineage commitment by parenchymal glial progenitor cells; this might reduce the available progenitor pool, and hence degrade the long-term regenerative competence of the adult white matter...
  2. pmc Pleiotrophin suppression of receptor protein tyrosine phosphatase-β/ζ maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells
    Crystal R McClain
    Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 32:15066-75. 2012
    ..These observations suggest that pleiotrophin inhibition of PTPRZ1 contributes to the homeostatic self-renewal of OPCs and that this process is mediated by the tonic activation of β-catenin/TCF-dependent transcription...
  3. pmc CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA
    Nat Biotechnol 29:934-41. 2011
    ..Microarray analysis of CD140a(+) cells revealed overexpression of the oligodendroglial marker CD9, suggesting that CD9(+)/CD140a(+) cells may constitute an even more highly enriched population of myelinogenic progenitor cells...
  4. ncbi request reprint Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, NY 14642, USA
    Ann Neurol 59:763-79. 2006
    ..Glial progenitor cells are abundant in adult human white matter. This study was designed to identify signaling pathways regulating their self-renewal and fate...
  5. ncbi request reprint Neurocytoma is a tumor of adult neuronal progenitor cells
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 26:12544-55. 2006
    ..This strategy of comparing the gene expression of tumor cells to that of the purified native progenitors from which they derive may provide a focused approach to identifying transcripts important to stem and progenitor cell oncogenesis...
  6. doi request reprint Fate determination of adult human glial progenitor cells
    Fraser J Sim
    Center for Translational Neuromedicine, and the Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA
    Neuron Glia Biol 5:45-55. 2009
    ....
  7. doi request reprint Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes
    Romane M Auvergne
    Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Rep 3:2127-41. 2013
    ..By comparing the expression patterns of glioma TPCs with those of normal GPCs, we have identified a discrete set of pathways by which glial tumorigenesis may be better understood and more specifically targeted...
  8. pmc Non-stem cell origin for oligodendroglioma
    Anders I Persson
    Department of Neurology, University of California, San Francisco, 94158, USA
    Cancer Cell 18:669-82. 2010
    ..Our results suggest that oligodendroglioma cells show hallmarks of OPCs, and that a progenitor rather than a NSC origin underlies improved prognosis in patients with this tumor...
  9. pmc Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting
    Su Wang
    Center for Translational Neuromedicine and the Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 30:14635-48. 2010
    ....
  10. doi request reprint Analysis of transforming growth factor β receptor expression and signaling in higher grade meningiomas
    Mahlon D Johnson
    Department of Pathology, Division of Neuropathology, University of Rochester Medical Center, 601 Elmwood Ave Box 626, Rochester, NY 14642, USA
    J Neurooncol 103:277-85. 2011
    ..Nonetheless, restoring TGF-β inhibition of meningioma cell proliferation may be an important objective in the design of new chemotherapies for these tumors...
  11. ncbi request reprint The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation
    Fraser J Sim
    Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    J Neurosci 22:2451-9. 2002
    ....
  12. ncbi request reprint Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS
    Fraser J Sim
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
    Mol Cell Neurosci 20:669-82. 2002
    ....