Fraser J Sim

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Statin treatment of adult human glial progenitors induces PPAR gamma-mediated oligodendrocytic differentiation
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, New York 14642, USA
    Glia 56:954-62. 2008
  2. ncbi Pleiotrophin Suppression of Receptor Protein Tyrosine Phosphatase-β/ζ Maintains the Self-Renewal Competence of Fetal Human Oligodendrocyte Progenitor Cells
    Crystal R McClain
    Departments of Neurology and Neurosurgery and Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642
    J Neurosci 32:15066-75. 2012
  3. ncbi CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA
    Nat Biotechnol 29:934-41. 2011
  4. ncbi Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, NY 14642, USA
    Ann Neurol 59:763-79. 2006
  5. ncbi Fate determination of adult human glial progenitor cells
    Fraser J Sim
    Center for Translational Neuromedicine, and the Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA
    Neuron Glia Biol 5:45-55. 2009
  6. ncbi Neurocytoma is a tumor of adult neuronal progenitor cells
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 26:12544-55. 2006
  7. ncbi Non-stem cell origin for oligodendroglioma
    Anders I Persson
    Department of Neurology, University of California, San Francisco, 94158, USA
    Cancer Cell 18:669-82. 2010
  8. ncbi Analysis of transforming growth factor β receptor expression and signaling in higher grade meningiomas
    Mahlon D Johnson
    Department of Pathology, Division of Neuropathology, University of Rochester Medical Center, 601 Elmwood Ave Box 626, Rochester, NY 14642, USA
    J Neurooncol 103:277-85. 2011
  9. ncbi Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting
    Su Wang
    Center for Translational Neuromedicine and the Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 30:14635-48. 2010
  10. ncbi The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation
    Fraser J Sim
    Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    J Neurosci 22:2451-9. 2002

Detail Information

Publications11

  1. ncbi Statin treatment of adult human glial progenitors induces PPAR gamma-mediated oligodendrocytic differentiation
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, New York 14642, USA
    Glia 56:954-62. 2008
    ..Thus, statins may promote oligodendrocyte lineage commitment by parenchymal glial progenitor cells; this might reduce the available progenitor pool, and hence degrade the long-term regenerative competence of the adult white matter...
  2. ncbi Pleiotrophin Suppression of Receptor Protein Tyrosine Phosphatase-β/ζ Maintains the Self-Renewal Competence of Fetal Human Oligodendrocyte Progenitor Cells
    Crystal R McClain
    Departments of Neurology and Neurosurgery and Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642
    J Neurosci 32:15066-75. 2012
    ..These observations suggest that pleiotrophin inhibition of PTPRZ1 contributes to the homeostatic self-renewal of OPCs and that this process is mediated by the tonic activation of β-catenin/TCF-dependent transcription...
  3. ncbi CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA
    Nat Biotechnol 29:934-41. 2011
    ..Microarray analysis of CD140a(+) cells revealed overexpression of the oligodendroglial marker CD9, suggesting that CD9(+)/CD140a(+) cells may constitute an even more highly enriched population of myelinogenic progenitor cells...
  4. ncbi Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, NY 14642, USA
    Ann Neurol 59:763-79. 2006
    ..As such, they provide targets by which to productively mobilize resident progenitor cells of the adult human brain...
  5. ncbi Fate determination of adult human glial progenitor cells
    Fraser J Sim
    Center for Translational Neuromedicine, and the Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA
    Neuron Glia Biol 5:45-55. 2009
    ....
  6. ncbi Neurocytoma is a tumor of adult neuronal progenitor cells
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 26:12544-55. 2006
    ..This strategy of comparing the gene expression of tumor cells to that of the purified native progenitors from which they derive may provide a focused approach to identifying transcripts important to stem and progenitor cell oncogenesis...
  7. ncbi Non-stem cell origin for oligodendroglioma
    Anders I Persson
    Department of Neurology, University of California, San Francisco, 94158, USA
    Cancer Cell 18:669-82. 2010
    ..Our results suggest that oligodendroglioma cells show hallmarks of OPCs, and that a progenitor rather than a NSC origin underlies improved prognosis in patients with this tumor...
  8. ncbi Analysis of transforming growth factor β receptor expression and signaling in higher grade meningiomas
    Mahlon D Johnson
    Department of Pathology, Division of Neuropathology, University of Rochester Medical Center, 601 Elmwood Ave Box 626, Rochester, NY 14642, USA
    J Neurooncol 103:277-85. 2011
    ..Nonetheless, restoring TGF-β inhibition of meningioma cell proliferation may be an important objective in the design of new chemotherapies for these tumors...
  9. ncbi Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting
    Su Wang
    Center for Translational Neuromedicine and the Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 30:14635-48. 2010
    ....
  10. ncbi The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation
    Fraser J Sim
    Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    J Neurosci 22:2451-9. 2002
    ....
  11. ncbi Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS
    Fraser J Sim
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
    Mol Cell Neurosci 20:669-82. 2002
    ....