Research Topics
Genomes and Genes | Neal SilvermanSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
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Publications
Immunology. The right resident bugsNeal Silverman
Division of Infectious Disease, University of Massachusetts Medical School, Worcester, MA 01605, USA
Science 319:734-5. 2008- Immune activation of NF-kappaB and JNK requires Drosophila TAK1Neal Silverman
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Biol Chem 278:48928-34. 2003..Thus, JNK signaling appears to play an important role in the cellular immune response and the stress response... 
Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signalingNicholas Paquette
Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Mol Cell 37:172-82. 2010..Through its association with DIAP2, IMD is rapidly conjugated with K63-linked polyubiquitin chains. These results mechanistically connect caspase-mediated cleavage and K63 ubiquitination in immune-induced NF-kappaB signaling...- Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genesDeniz Erturk-Hasdemir
Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 106:9779-84. 2009..Instead they are critical for recruitment of RNA polymerase II and antimicrobial peptide gene induction, whereas IKK functions noncatalytically to support Dredd-mediated cleavage of Relish... - Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathwayKamna Aggarwal
Divison of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS Pathog 4:e1000120. 2008..These results show that Rudra is a critical component in a negative feedback loop, whereby immune-induced gene expression rapidly produces a potent inhibitor that binds and inhibits pattern recognition receptors... - PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycanTakashi Kaneko
Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nat Immunol 7:715-23. 2006..These data demonstrate that like mammals, drosophila use both extracellular and intracellular receptors, which have conserved signaling mechanisms, for innate immune recognition... - Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signalingNicholas Paquette
Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 109:12710-5. 2012..In addition, studies in mammalian cells show similar modification and inhibition of hTAK1. These data present evidence that TAK1 is a target for YopJ-mediated inhibition... - Positive and negative regulation of the Drosophila immune responseKamna Aggarwal
Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
BMB Rep 41:267-77. 2008..In this review, we focus on recent advances identifying and characterizing the negative regulators of these pathways... - NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogasterSandhya Ganesan
Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Curr Top Microbiol Immunol 349:25-60. 2011..Similarities and differences relative to their mammalian counterparts are discussed, and recent advances in our understanding of the intricate regulatory networks in these NF-κB signaling pathways are also highlighted... - YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transductionCharles R Sweet
Division of Infectious Diseases and Immunology, Departments of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell Microbiol 9:2700-15. 2007.... - Peptidoglycan recognition by the Drosophila Imd pathwayTakashi Kaneko
Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
J Endotoxin Res 11:383-9. 2005..These results also suggest that the heteromeric PGRP-LCa/LCx receptor complex recognizes monomeric Dap-type, but not Lys-type, PGN... - Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent mannerLukas Bossaller
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 189:5508-12. 2012..Hence, Fas controls a novel noncanonical IL-1β activation pathway in myeloid cells, which could play an essential role in inflammatory processes, tumor surveillance, and control of infectious diseases... 
Characterization of poxvirus-encoded proteins that regulate innate immune signaling pathwaysFlorentina Rus
Division of Infectious Disease, Department of Medicine, University of Massachusetts School of Medicine, Worcester, MA, USA
Methods Mol Biol 890:273-88. 2012..Novel poxviral innate immune inhibitors are being identified via several approaches and these techniques promise to identify further complexities in the way that poxviruses interact with the host innate immune system...- Eater: a big bite into phagocytosisDeniz Erturk-Hasdemir
Division of Infectious Disease, University of Massachusetts Medical School, Worcester 01605, USA
Cell 123:190-2. 2005..In this issue of Cell, Kocks et al. (2005) demonstrate that Eater, a scavenger receptor, plays an important role in the recognition and phagocytosis of bacteria in the fruit fly Drosophila... - Bacterial recognition and signalling by the Drosophila IMD pathwayTakashi Kaneko
Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell Microbiol 7:461-9. 2005..Throughout the article, the similarities and differences between Drosophila and mammalian innate immune pathways are discussed... - Flies kNOw how to signalNeal Silverman
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Road, Worcester, MA 01605, USA
Dev Cell 4:5-6. 2003..NO-mediated signaling was implicated in the communication between the site of a localized infection and the major immune organ of the fly, the fat body... - The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathwayAntonia Avila
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
Mol Cell Biol 22:8787-95. 2002..Collectively, these results demonstrate the conservation of the p62-aPKC complex for the control of innate immunity signal transduction in Drosophila melanogaster... - Caspase-mediated processing of the Drosophila NF-kappaB factor RelishSvenja Stoven
Umea Centre for Molecular Pathogenesis, Umea University, S 901 87 Umea, Sweden
Proc Natl Acad Sci U S A 100:5991-6. 2003..Finally, an N-terminal serine-rich region in Relish and the PEST domain were found to negatively regulate Relish activation... - Hormonal regulation of the humoral innate immune response in Drosophila melanogasterThomas Flatt
Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
J Exp Biol 211:2712-24. 2008..Our results suggest that 20E and JH play major roles in the regulation of gene expression in response to immune challenge... - Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathwayTakashi Kaneko
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
Immunity 20:637-49. 2004..Recognition of monomeric and polymeric peptidoglycan required different PGRP-LC splice isoforms, while lipid A recognition required an unidentified soluble factor in the hemolymph of Bombyx morii... - DUBbing down innate immunityNeal Silverman
Nat Immunol 5:1010-2. 2004 - Autophagic control of listeria through intracellular innate immune recognition in drosophilaTamaki Yano
Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
Nat Immunol 9:908-16. 2008..Autophagy induction occurred independently of the Toll and IMD innate signaling pathways. Our findings define a pathway leading from the intracellular pattern-recognition receptors to the induction of autophagy to host defense... - Aging of the innate immune response in Drosophila melanogasterMelissa Zerofsky
Brown University, Division of Biology and Medicine, Providence, RI 02912, USA
Aging Cell 4:103-8. 2005..Consequently, maximum reproduction will occur when the immune response is tightly controlled in young females, even if this increases infection risk at later ages... - Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuliZi-Heng Zhuang
Signal Transduction Lab of Institute of Health Sciences, Shanghai Institutes for Biological Sciences [corrected] Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine [corrected] PR China
Cell Signal 18:441-8. 2006..Stimulation of UV and PGN activates D-p38 through D-MEKK1, heat shock-induced activation of D-p38 signals through both D-MEKK1 and D-ASK1. On the other hand, maximal activation of D-p38 by NaCl requires the expression of four MAP3Ks... - The role of ubiquitination in Drosophila innate immunityRui Zhou
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
J Biol Chem 280:34048-55. 2005..These studies reveal an evolutionarily conserved role of ubiquitination in IKK activation, and provide new insights into the hierarchy of signaling components in the Drosophila antibacterial immunity pathway... - Host-pathogen interactions in drosophila: new tricks from an old friendSara Cherry
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Nat Immunol 7:911-7. 2006..This review discusses advances in these exciting new areas of drosophila immunity... - TOLLing away in BrazilJane A Mitchell
Cardiothoracic Pharmacology, Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
Nat Immunol 7:675-9. 2006 - Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteinsJae Hong Lim
Center for Biomolecular Recognition and Division of Molecular and Life Science, Department of Life Science, Pohang University of Science and Technology, Pohang, Kyungbuk 790 784, Korea
J Biol Chem 281:8286-95. 2006..A sequence comparison suggests that TCT induces heterodimerization of the ectodomains of PGRP-LCx and -LCa in a closely analogous manner to prime the IMD signaling pathway, except that the heterodimer formation is nonperpetuating... - Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs)Chittoor P Swaminathan
Center for Advanced Research in Biotechnology, W M Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, Rockville, MD 20850, USA
Proc Natl Acad Sci U S A 103:684-9. 2006..The plasticity of the PGRP-binding site revealed by these mutants suggests an intrinsic capacity of the innate immune system to rapidly evolve specificities to meet new microbial challenges...
Research Grants
- Genetic and molecular analysis of Yersinia YopJNeal Silverman; Fiscal Year: 2003..By identifying the true targets of YopJ, new therapeutic means to treat the plague can be devised, thus reducing the potential impact of a bioterrorist attack. ..
- Intracellular Bacterial Recognition in the Drosophila Innate Immune ResponseNeal Silverman; Fiscal Year: 2010....
- Activation of Insect Immunity by Gram-negative BactriaNeal Silverman; Fiscal Year: 2010..Such an understanding is critical to our ability to devise more effective therapies against inflammatory disease. ..
- Intracellular Bacterial Recognition in the Drosophila Innate Immune ResponseNeal Silverman; Fiscal Year: 2009....
- Inhibiting the Inhibitor: Small Molecule Screening with Small Pox N1LNeal Silverman; Fiscal Year: 2007..Inhibitors of smallpox would be essential if vaccine-escape mutants of smallpox were disseminated. Finally compounds that inhibit vaccinia virus would theoretically prevent vaccine (vaccinia) side effects. ..