Neal Silverman

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway
    Kamna Aggarwal
    Divison of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Pathog 4:e1000120. 2008
  2. doi request reprint Immunology. The right resident bugs
    Neal Silverman
    Division of Infectious Disease, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 319:734-5. 2008
  3. ncbi request reprint Immune activation of NF-kappaB and JNK requires Drosophila TAK1
    Neal Silverman
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 278:48928-34. 2003
  4. pmc Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling
    Nicholas Paquette
    Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 37:172-82. 2010
  5. ncbi request reprint PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan
    Takashi Kaneko
    Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 7:715-23. 2006
  6. pmc Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes
    Deniz Erturk-Hasdemir
    Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 106:9779-84. 2009
  7. pmc Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity
    Florentina Rus
    Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, MA, USA
    EMBO J 32:1626-38. 2013
  8. pmc Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling
    Nicholas Paquette
    Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 109:12710-5. 2012
  9. ncbi request reprint Positive and negative regulation of the Drosophila immune response
    Kamna Aggarwal
    Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    BMB Rep 41:267-77. 2008
  10. pmc NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster
    Sandhya Ganesan
    Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Top Microbiol Immunol 349:25-60. 2011

Collaborators

Detail Information

Publications32

  1. pmc Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway
    Kamna Aggarwal
    Divison of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Pathog 4:e1000120. 2008
    ..These results show that Rudra is a critical component in a negative feedback loop, whereby immune-induced gene expression rapidly produces a potent inhibitor that binds and inhibits pattern recognition receptors...
  2. doi request reprint Immunology. The right resident bugs
    Neal Silverman
    Division of Infectious Disease, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 319:734-5. 2008
  3. ncbi request reprint Immune activation of NF-kappaB and JNK requires Drosophila TAK1
    Neal Silverman
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 278:48928-34. 2003
    ..Thus, JNK signaling appears to play an important role in the cellular immune response and the stress response...
  4. pmc Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling
    Nicholas Paquette
    Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 37:172-82. 2010
    ..Through its association with DIAP2, IMD is rapidly conjugated with K63-linked polyubiquitin chains. These results mechanistically connect caspase-mediated cleavage and K63 ubiquitination in immune-induced NF-kappaB signaling...
  5. ncbi request reprint PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan
    Takashi Kaneko
    Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 7:715-23. 2006
    ..These data demonstrate that like mammals, drosophila use both extracellular and intracellular receptors, which have conserved signaling mechanisms, for innate immune recognition...
  6. pmc Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes
    Deniz Erturk-Hasdemir
    Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 106:9779-84. 2009
    ..Instead they are critical for recruitment of RNA polymerase II and antimicrobial peptide gene induction, whereas IKK functions noncatalytically to support Dredd-mediated cleavage of Relish...
  7. pmc Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity
    Florentina Rus
    Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, MA, USA
    EMBO J 32:1626-38. 2013
    ..Together, our results demonstrate that Drosophila use complex mechanisms to modulate innate immune responses, and identify a transcriptional hierarchy that integrates steroid signalling and immunity in animals...
  8. pmc Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling
    Nicholas Paquette
    Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 109:12710-5. 2012
    ..In addition, studies in mammalian cells show similar modification and inhibition of hTAK1. These data present evidence that TAK1 is a target for YopJ-mediated inhibition...
  9. ncbi request reprint Positive and negative regulation of the Drosophila immune response
    Kamna Aggarwal
    Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    BMB Rep 41:267-77. 2008
    ..In this review, we focus on recent advances identifying and characterizing the negative regulators of these pathways...
  10. pmc NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster
    Sandhya Ganesan
    Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Top Microbiol Immunol 349:25-60. 2011
    ..Similarities and differences relative to their mammalian counterparts are discussed, and recent advances in our understanding of the intricate regulatory networks in these NF-κB signaling pathways are also highlighted...
  11. ncbi request reprint YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction
    Charles R Sweet
    Division of Infectious Diseases and Immunology, Departments of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Microbiol 9:2700-15. 2007
    ....
  12. ncbi request reprint Eater: a big bite into phagocytosis
    Deniz Erturk-Hasdemir
    Division of Infectious Disease, University of Massachusetts Medical School, Worcester 01605, USA
    Cell 123:190-2. 2005
    ..In this issue of Cell, Kocks et al. (2005) demonstrate that Eater, a scavenger receptor, plays an important role in the recognition and phagocytosis of bacteria in the fruit fly Drosophila...
  13. ncbi request reprint Bacterial recognition and signalling by the Drosophila IMD pathway
    Takashi Kaneko
    Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Microbiol 7:461-9. 2005
    ..Throughout the article, the similarities and differences between Drosophila and mammalian innate immune pathways are discussed...
  14. ncbi request reprint Peptidoglycan recognition by the Drosophila Imd pathway
    Takashi Kaneko
    Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Endotoxin Res 11:383-9. 2005
    ..These results also suggest that the heteromeric PGRP-LCa/LCx receptor complex recognizes monomeric Dap-type, but not Lys-type, PGN...
  15. ncbi request reprint Flies kNOw how to signal
    Neal Silverman
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Road, Worcester, MA 01605, USA
    Dev Cell 4:5-6. 2003
    ..NO-mediated signaling was implicated in the communication between the site of a localized infection and the major immune organ of the fly, the fat body...
  16. pmc The Drosophila IMD pathway in the activation of the humoral immune response
    Anni Kleino
    Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA Electronic address
    Dev Comp Immunol 42:25-35. 2014
    ..Here, we summarize the current view of the IMD pathway focusing on how it regulates the humoral immune response of Drosophila. ..
  17. pmc The genome of Anopheles darlingi, the main neotropical malaria vector
    Osvaldo Marinotti
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA, Institute of Technology, Broad Institute of Harvard and Massachusetts, Cambridge, MA 02141, USA, Laboratório de Bioinformática do Laboratório Nacional de Computação Científica, Petropolis, RJ 25651 075, Brasil, Departamento de Tecnologia, Faculdade de Ciencias Agrarias e Veterinarias de Jaboticabal, UNESP Universidade Estadual Paulista, SP 14884 900, Brasil, Departamento de Biologia, Universidade Federal de Santa Maria, Santa Maria, RS 97105 900, Brasil, Departamento de Biologia Molecular e Biotecnologia, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 91501 970, Brasil, Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270901, Brasil, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA, Laboratório de Entomologia Médica IPEPATRO FIOCRUZ, Porto Velho, RO 76812 245, Brasil, Departamento de Microbiologia, Guildford
    Nucleic Acids Res 41:7387-400. 2013
    ..It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index.php/anopheles-darlingi. ..
  18. pmc Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner
    Lukas Bossaller
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 189:5508-12. 2012
    ..Hence, Fas controls a novel noncanonical IL-1β activation pathway in myeloid cells, which could play an essential role in inflammatory processes, tumor surveillance, and control of infectious diseases...
  19. doi request reprint Characterization of poxvirus-encoded proteins that regulate innate immune signaling pathways
    Florentina Rus
    Division of Infectious Disease, Department of Medicine, University of Massachusetts School of Medicine, Worcester, MA, USA
    Methods Mol Biol 890:273-88. 2012
    ..Novel poxviral innate immune inhibitors are being identified via several approaches and these techniques promise to identify further complexities in the way that poxviruses interact with the host innate immune system...
  20. pmc Hormonal regulation of the humoral innate immune response in Drosophila melanogaster
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    J Exp Biol 211:2712-24. 2008
    ..Our results suggest that 20E and JH play major roles in the regulation of gene expression in response to immune challenge...
  21. pmc The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway
    Antonia Avila
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
    Mol Cell Biol 22:8787-95. 2002
    ..Collectively, these results demonstrate the conservation of the p62-aPKC complex for the control of innate immunity signal transduction in Drosophila melanogaster...
  22. pmc Caspase-mediated processing of the Drosophila NF-kappaB factor Relish
    Svenja Stoven
    Umea Centre for Molecular Pathogenesis, Umea University, S 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 100:5991-6. 2003
    ..Finally, an N-terminal serine-rich region in Relish and the PEST domain were found to negatively regulate Relish activation...
  23. pmc Autophagic control of listeria through intracellular innate immune recognition in drosophila
    Tamaki Yano
    Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
    Nat Immunol 9:908-16. 2008
    ..Autophagy induction occurred independently of the Toll and IMD innate signaling pathways. Our findings define a pathway leading from the intracellular pattern-recognition receptors to the induction of autophagy to host defense...
  24. ncbi request reprint Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway
    Takashi Kaneko
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 20:637-49. 2004
    ..Recognition of monomeric and polymeric peptidoglycan required different PGRP-LC splice isoforms, while lipid A recognition required an unidentified soluble factor in the hemolymph of Bombyx morii...
  25. ncbi request reprint DUBbing down innate immunity
    Neal Silverman
    Nat Immunol 5:1010-2. 2004
  26. ncbi request reprint Aging of the innate immune response in Drosophila melanogaster
    Melissa Zerofsky
    Brown University, Division of Biology and Medicine, Providence, RI 02912, USA
    Aging Cell 4:103-8. 2005
    ..Consequently, maximum reproduction will occur when the immune response is tightly controlled in young females, even if this increases infection risk at later ages...
  27. ncbi request reprint Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli
    Zi Heng Zhuang
    Signal Transduction Lab of Institute of Health Sciences, Shanghai Institutes for Biological Sciences corrected Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine corrected PR China
    Cell Signal 18:441-8. 2006
    ..Stimulation of UV and PGN activates D-p38 through D-MEKK1, heat shock-induced activation of D-p38 signals through both D-MEKK1 and D-ASK1. On the other hand, maximal activation of D-p38 by NaCl requires the expression of four MAP3Ks...
  28. ncbi request reprint The role of ubiquitination in Drosophila innate immunity
    Rui Zhou
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Biol Chem 280:34048-55. 2005
    ..These studies reveal an evolutionarily conserved role of ubiquitination in IKK activation, and provide new insights into the hierarchy of signaling components in the Drosophila antibacterial immunity pathway...
  29. pmc Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs)
    Chittoor P Swaminathan
    Center for Advanced Research in Biotechnology, W M Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 103:684-9. 2006
    ..The plasticity of the PGRP-binding site revealed by these mutants suggests an intrinsic capacity of the innate immune system to rapidly evolve specificities to meet new microbial challenges...
  30. ncbi request reprint Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins
    Jae Hong Lim
    Center for Biomolecular Recognition and Division of Molecular and Life Science, Department of Life Science, Pohang University of Science and Technology, Pohang, Kyungbuk 790 784, Korea
    J Biol Chem 281:8286-95. 2006
    ..A sequence comparison suggests that TCT induces heterodimerization of the ectodomains of PGRP-LCx and -LCa in a closely analogous manner to prime the IMD signaling pathway, except that the heterodimer formation is nonperpetuating...
  31. ncbi request reprint TOLLing away in Brazil
    Jane A Mitchell
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Nat Immunol 7:675-9. 2006
  32. ncbi request reprint Host-pathogen interactions in drosophila: new tricks from an old friend
    Sara Cherry
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 7:911-7. 2006
    ..This review discusses advances in these exciting new areas of drosophila immunity...

Research Grants14

  1. Genetic and molecular analysis of Yersinia YopJ
    Neal Silverman; Fiscal Year: 2003
    ..By identifying the true targets of YopJ, new therapeutic means to treat the plague can be devised, thus reducing the potential impact of a bioterrorist attack. ..
  2. Intracellular Bacterial Recognition in the Drosophila Innate Immune Response
    Neal Silverman; Fiscal Year: 2010
    ....
  3. Activation of Insect Immunity by Gram-negative Bactria
    Neal Silverman; Fiscal Year: 2010
    ..Such an understanding is critical to our ability to devise more effective therapies against inflammatory disease. ..
  4. Intracellular Bacterial Recognition in the Drosophila Innate Immune Response
    Neal Silverman; Fiscal Year: 2009
    ....
  5. Inhibiting the Inhibitor: Small Molecule Screening with Small Pox N1L
    Neal Silverman; Fiscal Year: 2007
    ..Inhibitors of smallpox would be essential if vaccine-escape mutants of smallpox were disseminated. Finally compounds that inhibit vaccinia virus would theoretically prevent vaccine (vaccinia) side effects. ..