Genomes and Genes
Matthew D Silverman
Affiliation: University of Michigan
- Homocysteine upregulates vascular cell adhesion molecule-1 expression in cultured human aortic endothelial cells and enhances monocyte adhesionMatthew D Silverman
Laboratory of Cell Biology, Department of Medicine, University of Wisconsin Medical School, Milwaukee, USA
Arterioscler Thromb Vasc Biol 22:587-92. 2002..These data support the notion that the proinflammatory effects of homocysteine may have important implications in atherogenesis...
- Differential E-selectin expression by iris versus retina microvascular endothelial cells cultured from the same individualsMatthew D Silverman
Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA
Microvasc Res 70:32-42. 2005..Thus, cultured EC derived from adjacent microvascular beds are biologically distinct. Such endothelial diversity could play a role in the pathogenesis of tissue-specific inflammation, infection, neovascularization, and malignancy...
- The role of vascular cell adhesion molecule 1/ very late activation antigen 4 in endothelial progenitor cell recruitment to rheumatoid arthritis synoviumMatthew D Silverman
University of Michigan Health System, Internal Medicine Department, Ann Arbor, MI 48109 2200, USA
Arthritis Rheum 56:1817-26. 2007..This study was undertaken to investigate the hypothesis that EPCs selectively home to inflamed joint tissue and may perpetuate synovial neovascularization...
- Constitutive and inflammatory mediator-regulated fractalkine expression in human ocular tissues and cultured cellsMatthew D Silverman
Department of Ophthalmology, Casey Eye Institute, Oregon Health and Sciences University, Portland, Oregon 97201, USA
Invest Ophthalmol Vis Sci 44:1608-15. 2003..In the current study, constitutive expression of FKN was identified in human iris and retina, and its regulation by various cytokines in endothelial cells (ECs) and stromal cells from human iris, retina, and choroid was investigated...
- Down-regulation of myeloid cell leukemia 1 by epigallocatechin-3-gallate sensitizes rheumatoid arthritis synovial fibroblasts to tumor necrosis factor alpha-induced apoptosisSalahuddin Ahmed
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
Arthritis Rheum 60:1282-93. 2009..This study was undertaken to evaluate the efficacy of epigallocatechin-3-gallate (EGCG) in down-regulating Mcl-1 expression and its mechanism of RA synovial fibroblast sensitization to TNFalpha-induced apoptosis...