D H Silverman

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Estimation of paclitaxel biodistribution and uptake in human-derived xenografts in vivo with (18)F-fluoropaclitaxel
    Anne Gangloff
    Ahmanson Biological Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California
    J Nucl Med 46:1866-71. 2005
  2. ncbi request reprint Evaluating early dementia with and without assessment of regional cerebral metabolism by PET: a comparison of predicted costs and benefits
    Daniel H S Silverman
    Department of Molecular and Medical Pharmacology and Ahmanson Biological Imaging Center, UCLA School of Medicine, University of California, Los Angeles 90095 6942, USA
    J Nucl Med 43:253-66. 2002
  3. ncbi request reprint Brain 18F-FDG PET in the diagnosis of neurodegenerative dementias: comparison with perfusion SPECT and with clinical evaluations lacking nuclear imaging
    Daniel H S Silverman
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Nucl Med 45:594-607. 2004
  4. ncbi request reprint Prognostic value of regional cerebral metabolism in patients undergoing dementia evaluation: comparison to a quantifying parameter of subsequent cognitive performance and to prognostic assessment without PET
    Daniel H S Silverman
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, School of Medicine, Los Angeles, CA, USA
    Mol Genet Metab 80:350-5. 2003
  5. ncbi request reprint Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5-10 years after chemotherapy
    Daniel H S Silverman
    Department of Molecular and Medical Pharmacology, University of California, David Geffen School of Medicine, Los Angeles, CA 90095 6942, USA
    Breast Cancer Res Treat 103:303-11. 2007
  6. doi request reprint Positron emission tomography scans obtained for the evaluation of cognitive dysfunction
    Daniel H S Silverman
    David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Semin Nucl Med 38:251-61. 2008
  7. ncbi request reprint PET imaging in the assessment of normal and impaired cognitive function
    Daniel H S Silverman
    Neuroimaging Section, Nuclear Medicine Clinic, David Geffen School of Medicine, University of California at Los Angeles Medical Center, Los Angeles, CA 90095 6942, USA
    Radiol Clin North Am 43:67-77, x. 2005
  8. ncbi request reprint Prompt identification of Alzheimer's disease with brain PET imaging of a woman with multiple previous diagnoses of other neuropsychiatric conditions
    Daniel H S Silverman
    Department of Molecular and Medical Pharmacology, School of Medicine, University of California, Los Angeles 90095 6942, USA
    Am J Psychiatry 159:1482-8. 2002
  9. pmc Differences in regional brain metabolism associated with specific formulations of hormone therapy in postmenopausal women at risk for AD
    Daniel H S Silverman
    UCLA David Geffen School of Medicine, Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Clinic, CHS AR 144, University of California, Los Angeles School of Medicine, Los Angeles, CA 90095 6942, USA
    Psychoneuroendocrinology 36:502-13. 2011
  10. ncbi request reprint Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome
    D H Silverman
    Ahmanson Biological Imaging Center, CHS AR 144, Department of Molecular and Medical Pharmacology, University of California, Los Angeles School of Medicine, Los Angeles, CA 90095 6942, USA
    JAMA 286:2120-7. 2001

Research Grants

  1. Evaluation of Presynaptic Calcium Channels In Vivo
    Daniel Silverman; Fiscal Year: 2003

Detail Information

Publications45

  1. ncbi request reprint Estimation of paclitaxel biodistribution and uptake in human-derived xenografts in vivo with (18)F-fluoropaclitaxel
    Anne Gangloff
    Ahmanson Biological Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California
    J Nucl Med 46:1866-71. 2005
    ..We compared the PET data to data derived from direct harvesting and analysis of blood, organs, and breast carcinoma xenografts...
  2. ncbi request reprint Evaluating early dementia with and without assessment of regional cerebral metabolism by PET: a comparison of predicted costs and benefits
    Daniel H S Silverman
    Department of Molecular and Medical Pharmacology and Ahmanson Biological Imaging Center, UCLA School of Medicine, University of California, Los Angeles 90095 6942, USA
    J Nucl Med 43:253-66. 2002
    ..The precise diagnostic role of PET and its economic impact in this context, however, have not been systematically examined previously...
  3. ncbi request reprint Brain 18F-FDG PET in the diagnosis of neurodegenerative dementias: comparison with perfusion SPECT and with clinical evaluations lacking nuclear imaging
    Daniel H S Silverman
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Nucl Med 45:594-607. 2004
    ....
  4. ncbi request reprint Prognostic value of regional cerebral metabolism in patients undergoing dementia evaluation: comparison to a quantifying parameter of subsequent cognitive performance and to prognostic assessment without PET
    Daniel H S Silverman
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, School of Medicine, Los Angeles, CA, USA
    Mol Genet Metab 80:350-5. 2003
    ..4). These data indicate that evaluation of brain metabolism by PET in appropriately selected patients may improve the accuracy of clinical prognostic assessment...
  5. ncbi request reprint Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5-10 years after chemotherapy
    Daniel H S Silverman
    Department of Molecular and Medical Pharmacology, University of California, David Geffen School of Medicine, Los Angeles, CA 90095 6942, USA
    Breast Cancer Res Treat 103:303-11. 2007
    ..To explore the relationship of regional cerebral blood flow and metabolism with cognitive function and past exposure to chemotherapy for breast cancer...
  6. doi request reprint Positron emission tomography scans obtained for the evaluation of cognitive dysfunction
    Daniel H S Silverman
    David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Semin Nucl Med 38:251-61. 2008
    ....
  7. ncbi request reprint PET imaging in the assessment of normal and impaired cognitive function
    Daniel H S Silverman
    Neuroimaging Section, Nuclear Medicine Clinic, David Geffen School of Medicine, University of California at Los Angeles Medical Center, Los Angeles, CA 90095 6942, USA
    Radiol Clin North Am 43:67-77, x. 2005
    ..In certain pathologic circumstances, the normal coupling between blood flow and metabolic needs may be disturbed, and changes in oxygen extraction fraction can have significant prognostic value...
  8. ncbi request reprint Prompt identification of Alzheimer's disease with brain PET imaging of a woman with multiple previous diagnoses of other neuropsychiatric conditions
    Daniel H S Silverman
    Department of Molecular and Medical Pharmacology, School of Medicine, University of California, Los Angeles 90095 6942, USA
    Am J Psychiatry 159:1482-8. 2002
  9. pmc Differences in regional brain metabolism associated with specific formulations of hormone therapy in postmenopausal women at risk for AD
    Daniel H S Silverman
    UCLA David Geffen School of Medicine, Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Clinic, CHS AR 144, University of California, Los Angeles School of Medicine, Los Angeles, CA 90095 6942, USA
    Psychoneuroendocrinology 36:502-13. 2011
    ....
  10. ncbi request reprint Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome
    D H Silverman
    Ahmanson Biological Imaging Center, CHS AR 144, Department of Molecular and Medical Pharmacology, University of California, Los Angeles School of Medicine, Los Angeles, CA 90095 6942, USA
    JAMA 286:2120-7. 2001
    ..Deficits in cerebral glucose utilization have been identified in patients with cognitive dysfunction attributed to various disease processes, but their prognostic and diagnostic value remains to be defined...
  11. ncbi request reprint Impact of 18F-FDG PET on managing patients with colorectal cancer: the referring physician's perspective
    J Meta
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Clinic, and Nuclear Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, CA, USA
    J Nucl Med 42:586-90. 2001
    ....
  12. ncbi request reprint Usefulness of 3'-[F-18]fluoro-3'-deoxythymidine with positron emission tomography in predicting breast cancer response to therapy
    Betty S Pio
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA USA
    Mol Imaging Biol 8:36-42. 2006
    ..We examined side-by-side FDG and FLT imaging for monitoring and predicting tumor response to chemotherapy...
  13. ncbi request reprint Brain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetine
    A L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute and Hospital, Los Angeles, CA 90024, USA
    Psychiatry Res 91:127-39. 1999
    ..These findings implicate ventral prefrontal-subcortical brain circuitry in the mediation of response to serotonin reuptake inhibitors in MDD...
  14. pmc Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease
    G W Small
    Center on Aging and Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Proc Natl Acad Sci U S A 97:6037-42. 2000
    ..These results indicate that the combination of cerebral metabolic rates and genetic risk factors provides a means for preclinical AD detection that will assist in response monitoring during experimental treatments...
  15. ncbi request reprint Predicting seizure-free status for temporal lobe epilepsy patients undergoing surgery: prognostic value of quantifying maximal metabolic asymmetry extending over a specified proportion of the temporal lobe
    Tina W Lin
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 6942, USA
    J Nucl Med 48:776-82. 2007
    ..We aimed to develop an approach with which to quantitatively assess prognostically pertinent aspects of metabolic asymmetry in presurgical PET scans for forecasting postsurgical seizure-free clinical outcomes...
  16. ncbi request reprint Imaging proliferation in brain tumors with 18F-FLT PET: comparison with 18F-FDG
    Wei Chen
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    J Nucl Med 46:945-52. 2005
    ..We characterized (18)F-FLT PET of brain gliomas and compared (18)F-FLT with (18)F-FDG PET in side-by-side studies of the same patients...
  17. ncbi request reprint Breast cancer treatment and cognitive functioning: current status and future challenges in assessment
    Steven A Castellon
    Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA
    Breast Cancer Res Treat 92:199-206. 2005
  18. ncbi request reprint Semiautomated analysis of small-animal PET data
    Adam L Kesner
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 6942, USA
    J Nucl Med 47:1181-6. 2006
    ..The objective of the work reported here was to develop and test automated methods to calculate biodistribution of PET tracers using small-animal PET images...
  19. ncbi request reprint Effects of a 14-day healthy longevity lifestyle program on cognition and brain function
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
    Am J Geriatr Psychiatry 14:538-45. 2006
    ..The objective of this study was to determine the effects of a 14-day healthy longevity lifestyle program on cognition and cerebral metabolism in people with mild age-related memory complaints...
  20. ncbi request reprint 3,4-dihydroxy-6-[18f]-fluoro-L-phenylalanine positron emission tomography in patients with central motor disorders and in evaluation of brain and other tumors
    John P Seibyl
    Ahmanson Biological Imaging Division, UCLA Medical Center, Los Angeles, CA 90095 6942, USA
    Semin Nucl Med 37:440-50. 2007
    ....
  21. ncbi request reprint Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study
    Wei Chen
    Ahmanson Biological Imaging Division and the Department of Molecular and Medical Pharmacology, Biostatistics, Radiology, University of California, Los Angeles, Los Angeles, CA 90005 6942, USA
    J Clin Oncol 25:4714-21. 2007
    ....
  22. doi request reprint Advances in evaluation of primary brain tumors
    Wei Chen
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Semin Nucl Med 38:240-50. 2008
    ..Tracers for imaging hypoxia such as (18)F-FMISO have been studied and appear promising in providing prognostic information as well as planning treatment...
  23. ncbi request reprint Noninvasive quantification of bowel inflammation through positron emission tomography imaging of 2-deoxy-2-[18F]fluoro-D-glucose-labeled white blood cells
    Betty S Pio
    Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, and the Greater Los Angeles Veterans Affairs Hospital System, Los Angeles, CA 90095 6942, USA
    Mol Imaging Biol 5:271-7. 2003
    ..FDG-labeled WBC's, in conjunction with PET, can be used to provide quantitative assessment of bowel inflammation noninvasively, accurately, and rapidly...
  24. pmc Cognitive and cerebral metabolic effects of celecoxib versus placebo in people with age-related memory loss: randomized controlled study
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA 90024, USA
    Am J Geriatr Psychiatry 16:999-1009. 2008
    ....
  25. ncbi request reprint Estrogen, tamoxifen, and the brain
    Patricia A Ganz
    University of California at Los Angeles UCLA School of Medicine, and Jonsson Comprehensive Cancer Center at UCLA, 90095 6900, USA
    J Natl Cancer Inst 94:547-9. 2002
  26. pmc Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects
    E C Mormino
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Brain 132:1310-23. 2009
    ..This pattern suggests that declining EM in older individuals may be caused by Abeta-induced hippocampus atrophy...
  27. ncbi request reprint 18F-FDOPA PET imaging of brain tumors: comparison study with 18F-FDG PET and evaluation of diagnostic accuracy
    Wei Chen
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    J Nucl Med 47:904-11. 2006
    ..We evaluated the amino acid and glucose metabolism of brain tumors by using PET with 3,4-dihydroxy-6-(18)F-fluoro-l-phenylalanine ((18)F-FDOPA) and (18)F-FDG...
  28. pmc Neuroimaging evidence of cerebellar involvement in premenstrual dysphoric disorder
    Andrea J Rapkin
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095 1740, USA
    Biol Psychiatry 69:374-80. 2011
    ..Despite a prevalence of up to 8% in women of reproductive age, few studies have investigated the brain mechanisms that underlie this disorder...
  29. ncbi request reprint The usefulness of F-18 deoxyglucose whole-body positron emission tomography (PET) for re-staging of renal cell cancer
    A Safaei
    Ahmanson Biological Imaging Clinic Nuclear Medicine, Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095 6948, USA
    Clin Nephrol 57:56-62. 2002
    ..The aim of the current study was to examine the diagnostic accuracy and clinical usefulness of whole-body PET imaging for re-staging of renal cell cancer...
  30. ncbi request reprint Functional imaging as a window to dementia: corticobasal degeneration
    Andreea L Seritan
    Department of Psychiatry and Behavioral Sciences, University of California, Davis, California, USA
    J Neuropsychiatry Clin Neurosci 16:393-9. 2004
  31. ncbi request reprint Recognition and treatment of Alzheimer's disease: a case-based review
    Dana M Marseille
    Neuronuclear Imaging Section, Division of Biological Imaging, David Geffen School of Medicine, University of California at Los Angeles Medical Center, Los Angeles, California, USA
    Am J Alzheimers Dis Other Demen 21:119-25. 2006
    ..In case 2, initiation of ChEI therapy is followed by substantial clinical improvement in the face of a complex medical picture, and neuroimaging revealing more neurodegenerative changes than could be accounted for by "pure" AD...
  32. ncbi request reprint Value of F-18 fluorodeoxyglucose positron emission tomography for predicting the clinical outcome of patients with aggressive lymphoma prior to and after autologous stem-cell transplantation
    Jean Emmanuel Filmont
    Ahmanson Biological Imaging Clinic, Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Chest 124:608-13. 2003
    ....
  33. ncbi request reprint Optimizing imaging protocols for overweight and obese patients: a lutetium orthosilicate PET/CT study
    Benjamin S Halpern
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, UCLA David Geffen School of Medicine, Los Angeles, California 90095 6942, USA
    J Nucl Med 46:603-7. 2005
    ..High photon attenuation and scatter in obese patients affect image quality. The purpose of the current study was to optimize lutetium orthosilicate (LSO) PET image acquisition protocols in patients weighing > or =91 kg (200 lb)...
  34. ncbi request reprint 18F-FDG PET for staging breast cancer in patients with inner-quadrant versus outer-quadrant tumors: comparison with long-term clinical outcome
    Amy Tran
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    J Nucl Med 46:1455-9. 2005
    ..This study examined whether (18)F-FDG PET findings were differentially associated with the location of primary tumors, and with long-term prognosis, in IQ and OQ patients...
  35. ncbi request reprint Biodistribution and predictive value of 18F-fluorocyclophosphamide in mice bearing human breast cancer xenografts
    Amanda L Kesner
    Ahmanson Biological Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 6942, USA
    J Nucl Med 48:2021-7. 2007
    ....
  36. ncbi request reprint Time-course of effects of external beam radiation on [18F]FDG uptake in healthy tissue and bone marrow
    Adam L Kesner
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 6942, USA
    J Appl Clin Med Phys 9:2747. 2008
    ....
  37. doi request reprint Radiation dose estimates for [18F]5-fluorouracil derived from PET-based and tissue-based methods in rats
    Adam L Kesner
    Molecular and Medical Pharmacology, Ahmanson Biological Imaging Division, UCLA Medical Center, Los Angeles, CA 90095 6942, USA
    Mol Imaging Biol 10:341-8. 2008
    ..In the current manuscript, normal-tissue absorbed dose estimates for the 18F-labeled chemotherapy agent [18F]5-fluorouracil ([18F]5-FU) were derived by PET imaging- and by tissue harvesting-based methods in rats...
  38. ncbi request reprint Conventional imaging and 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography for predicting the clinical outcome of patients with previously treated Hodgkin's disease
    Jean Emmanuel Filmont
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Clinic, UCLA School of Medicine, Los Angeles, CA, USA
    Mol Imaging Biol 6:47-54. 2004
    ..The aim of this study was to determine the ability of 2-deoxy-2-[(18)F]fluoro-d-glucose positron emission tomography (FDG-PET) to predict the clinical outcome of previously treated patients with Hodgkin's Disease (HD)...
  39. ncbi request reprint Comparison between 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography and positron emission tomography/computed tomography hardware fusion for staging of patients with lymphoma
    Martin Allen-Auerbach
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, UCLA David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6942 USA
    Mol Imaging Biol 6:411-6. 2004
    ..We sought to determine whether integrated (hardware) fused PET/CT imaging results in further improvements in staging accuracy...
  40. ncbi request reprint Accuracy of early diagnosis and its impact on the management and course of Alzheimer's disease
    Carol Y Chang
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Expert Rev Mol Diagn 4:63-9. 2004
    ..Early recognition and intervention facilitates optimal care of Alzheimer's patients and delays the morbidity associated with this progressive illness...
  41. ncbi request reprint Predicting chemotherapy response to paclitaxel with 18F-Fluoropaclitaxel and PET
    Wei Ann Hsueh
    Ahmanson Biological Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 6942, USA
    J Nucl Med 47:1995-9. 2006
    ....
  42. ncbi request reprint Conventional imaging and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography for predicting the clinical outcome of previously treated non-Hodgkin's lymphoma patients
    Jean Emmanuel Filmont
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Clinic UCLA School of Medicine, Los Angeles, CA 90095, USA
    Mol Imaging Biol 5:232-9. 2003
    ....
  43. ncbi request reprint Improving influx constant and ratio estimation in FDOPA brain PET analysis for Parkinson's disease
    Xiao bo Pan
    Siemens Molecular Imaging, Oxford, United Kingdom
    J Nucl Med 46:1737-44. 2005
    ..We propose a method for improving the consistency with which scans obtained by either of these techniques are analyzed. The method is based on a fully 3-dimensional analysis of the images...
  44. ncbi request reprint Radiation dosimetry results for Zevalin radioimmunotherapy of rituximab-refractory non-Hodgkin lymphoma
    Gregory A Wiseman
    Division of Nuclear Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Cancer 94:1349-57. 2002
    ..The purpose of this trial was to perform (111)In-Zevalin imaging in patients with rituximab-refractory tumors to determine normal organ dosimetry...
  45. doi request reprint Evaluating pathology in the brain with nuclear medicine
    Daniel H S Silverman
    Semin Nucl Med 38:225-6. 2008

Research Grants1

  1. Evaluation of Presynaptic Calcium Channels In Vivo
    Daniel Silverman; Fiscal Year: 2003
    ..A possible peripheral benefit of this work lies in its potential to bring us closer to an effective CNS delivery system for calcium channel antagonists which are under clinical development as therapeutic agents. ..