Research Topics
| D H SilvermanSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Estimation of paclitaxel biodistribution and uptake in human-derived xenografts in vivo with (18)F-fluoropaclitaxelAnne Gangloff
Ahmanson Biological Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California
J Nucl Med 46:1866-71. 2005..CONCLUSION: PET studies with (18)F-FPAC can be used in conjunction with clinically practical quantification methods to yield estimates of PAC uptake in breast cancer tumors and normal organs noninvasively...- Evaluating early dementia with and without assessment of regional cerebral metabolism by PET: a comparison of predicted costs and benefitsDaniel H S Silverman
Department of Molecular and Medical Pharmacology and Ahmanson Biological Imaging Center, UCLA School of Medicine, University of California, Los Angeles 90095 6942, USA
J Nucl Med 43:253-66. 2002..The precise diagnostic role of PET and its economic impact in this context, however, have not been systematically examined previously... - Brain 18F-FDG PET in the diagnosis of neurodegenerative dementias: comparison with perfusion SPECT and with clinical evaluations lacking nuclear imagingDaniel H S Silverman
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Nucl Med 45:594-607. 2004.... - Prognostic value of regional cerebral metabolism in patients undergoing dementia evaluation: comparison to a quantifying parameter of subsequent cognitive performance and to prognostic assessment without PETDaniel H S Silverman
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, School of Medicine, Los Angeles, CA, USA
Mol Genet Metab 80:350-5. 2003..4). These data indicate that evaluation of brain metabolism by PET in appropriately selected patients may improve the accuracy of clinical prognostic assessment... - Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5-10 years after chemotherapyDaniel H S Silverman
Department of Molecular and Medical Pharmacology, University of California, David Geffen School of Medicine, Los Angeles, CA 90095 6942, USA
Breast Cancer Res Treat 103:303-11. 2007..To explore the relationship of regional cerebral blood flow and metabolism with cognitive function and past exposure to chemotherapy for breast cancer... 
Positron emission tomography scans obtained for the evaluation of cognitive dysfunctionDaniel H S Silverman
David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Semin Nucl Med 38:251-61. 2008....- PET imaging in the assessment of normal and impaired cognitive functionDaniel H S Silverman
Neuroimaging Section, Nuclear Medicine Clinic, David Geffen School of Medicine, University of California at Los Angeles Medical Center, Los Angeles, CA 90095 6942, USA
Radiol Clin North Am 43:67-77, x. 2005..In certain pathologic circumstances, the normal coupling between blood flow and metabolic needs may be disturbed, and changes in oxygen extraction fraction can have significant prognostic value... - Prompt identification of Alzheimer's disease with brain PET imaging of a woman with multiple previous diagnoses of other neuropsychiatric conditionsDaniel H S Silverman
Department of Molecular and Medical Pharmacology, School of Medicine, University of California, Los Angeles 90095-6942, USA
Am J Psychiatry 159:1482-8. 2002 
Differences in regional brain metabolism associated with specific formulations of hormone therapy in postmenopausal women at risk for ADDaniel H S Silverman
UCLA David Geffen School of Medicine, Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Clinic, CHS AR 144, University of California, Los Angeles School of Medicine, Los Angeles, CA 90095 6942, USA
Psychoneuroendocrinology 36:502-13. 2011....- Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcomeD H Silverman
Ahmanson Biological Imaging Center, CHS AR 144, Department of Molecular and Medical Pharmacology, University of California, Los Angeles School of Medicine, Los Angeles, CA 90095 6942, USA
JAMA 286:2120-7. 2001..Deficits in cerebral glucose utilization have been identified in patients with cognitive dysfunction attributed to various disease processes, but their prognostic and diagnostic value remains to be defined... - Impact of 18F-FDG PET on managing patients with colorectal cancer: the referring physician's perspectiveJ Meta
Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Clinic, and Nuclear Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, CA, USA
J Nucl Med 42:586-90. 2001.... - Usefulness of 3'-[F-18]fluoro-3'-deoxythymidine with positron emission tomography in predicting breast cancer response to therapyBetty S Pio
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA USA
Mol Imaging Biol 8:36-42. 2006..29 (r = 0.93, P = 0.003). CONCLUSION: A 10-minute FLT-PET scan acquired two weeks after the end of the first course of chemotherapy is useful for predicting longer-term efficacy of chemotherapy regimens for women with breast cancer... - Brain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetineA L Brody
UCLA Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute and Hospital, Los Angeles, CA 90024, USA
Psychiatry Res 91:127-39. 1999..These findings implicate ventral prefrontal-subcortical brain circuitry in the mediation of response to serotonin reuptake inhibitors in MDD... - Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's diseaseG W Small
Center on Aging and Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024, USA
Proc Natl Acad Sci U S A 97:6037-42. 2000..These results indicate that the combination of cerebral metabolic rates and genetic risk factors provides a means for preclinical AD detection that will assist in response monitoring during experimental treatments... - Predicting seizure-free status for temporal lobe epilepsy patients undergoing surgery: prognostic value of quantifying maximal metabolic asymmetry extending over a specified proportion of the temporal lobeTina W Lin
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 6942, USA
J Nucl Med 48:776-82. 2007..We aimed to develop an approach with which to quantitatively assess prognostically pertinent aspects of metabolic asymmetry in presurgical PET scans for forecasting postsurgical seizure-free clinical outcomes... - Imaging proliferation in brain tumors with 18F-FLT PET: comparison with 18F-FDGWei Chen
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
J Nucl Med 46:945-52. 2005..We characterized (18)F-FLT PET of brain gliomas and compared (18)F-FLT with (18)F-FDG PET in side-by-side studies of the same patients... - Breast cancer treatment and cognitive functioning: current status and future challenges in assessmentSteven A Castellon
Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA
Breast Cancer Res Treat 92:199-206. 2005 - Semiautomated analysis of small-animal PET dataAdam L Kesner
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 6942, USA
J Nucl Med 47:1181-6. 2006..The objective of the work reported here was to develop and test automated methods to calculate biodistribution of PET tracers using small-animal PET images... - Effects of a 14-day healthy longevity lifestyle program on cognition and brain functionGary W Small
Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
Am J Geriatr Psychiatry 14:538-45. 2006..The objective of this study was to determine the effects of a 14-day healthy longevity lifestyle program on cognition and cerebral metabolism in people with mild age-related memory complaints... - 3,4-dihydroxy-6-[18f]-fluoro-L-phenylalanine positron emission tomography in patients with central motor disorders and in evaluation of brain and other tumorsJohn P Seibyl
Ahmanson Biological Imaging Division, UCLA Medical Center, Los Angeles, CA 90095 6942, USA
Semin Nucl Med 37:440-50. 2007.... - Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot studyWei Chen
Ahmanson Biological Imaging Division and the Department of Molecular and Medical Pharmacology, Biostatistics, Radiology, University of California, Los Angeles, Los Angeles, CA 90005 6942, USA
J Clin Oncol 25:4714-21. 2007.... - Advances in evaluation of primary brain tumorsWei Chen
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
Semin Nucl Med 38:240-50. 2008..Tracers for imaging hypoxia such as (18)F-FMISO have been studied and appear promising in providing prognostic information as well as planning treatment... - Noninvasive quantification of bowel inflammation through positron emission tomography imaging of 2-deoxy-2-[18F]fluoro-D-glucose-labeled white blood cellsBetty S Pio
Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, and the Greater Los Angeles Veterans Affairs Hospital System, Los Angeles, CA 90095 6942, USA
Mol Imaging Biol 5:271-7. 2003..FDG-labeled WBC's, in conjunction with PET, can be used to provide quantitative assessment of bowel inflammation noninvasively, accurately, and rapidly... - Cognitive and cerebral metabolic effects of celecoxib versus placebo in people with age-related memory loss: randomized controlled studyGary W Small
Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA 90024, USA
Am J Geriatr Psychiatry 16:999-1009. 2008.... - Estrogen, tamoxifen, and the brainPatricia A Ganz
University of California at Los Angeles (UCLA) School of Medicine, and Jonsson Comprehensive Cancer Center at UCLA, 90095-6900, USA
J Natl Cancer Inst 94:547-9. 2002 - Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjectsE C Mormino
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
Brain 132:1310-23. 2009..This pattern suggests that declining EM in older individuals may be caused by Abeta-induced hippocampus atrophy... - 18F-FDOPA PET imaging of brain tumors: comparison study with 18F-FDG PET and evaluation of diagnostic accuracyWei Chen
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
J Nucl Med 47:904-11. 2006..18)F-FDOPA PET may prove especially useful for imaging of recurrent low-grade tumors and for distinguishing tumor recurrence from radiation necrosis... - Neuroimaging evidence of cerebellar involvement in premenstrual dysphoric disorderAndrea J Rapkin
Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095 1740, USA
Biol Psychiatry 69:374-80. 2011..Despite a prevalence of up to 8% in women of reproductive age, few studies have investigated the brain mechanisms that underlie this disorder... - The usefulness of F-18 deoxyglucose whole-body positron emission tomography (PET) for re-staging of renal cell cancerA Safaei
Ahmanson Biological Imaging Clinic/Nuclear Medicine, Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095-6948, USA
Clin Nephrol 57:56-62. 2002..These findings suggest that PET is useful in characterizing anatomic lesions of unknown significance in patients with renal cell cancer... - Functional imaging as a window to dementia: corticobasal degenerationAndreea L Seritan
Department of Psychiatry and Behavioral Sciences, University of California, Davis, California, USA
J Neuropsychiatry Clin Neurosci 16:393-9. 2004 - Recognition and treatment of Alzheimer's disease: a case-based reviewDana M Marseille
Neuronuclear Imaging Section, Division of Biological Imaging, David Geffen School of Medicine, University of California at Los Angeles Medical Center, Los Angeles, California, USA
Am J Alzheimers Dis Other Demen 21:119-25. 2006..In case 2, initiation of ChEI therapy is followed by substantial clinical improvement in the face of a complex medical picture, and neuroimaging revealing more neurodegenerative changes than could be accounted for by "pure" AD... - Value of F-18 fluorodeoxyglucose positron emission tomography for predicting the clinical outcome of patients with aggressive lymphoma prior to and after autologous stem-cell transplantationJean-Emmanuel Filmont
Ahmanson Biological Imaging Clinic, Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Chest 124:608-13. 2003..05). CONCLUSIONS: PET findings but not CT results were strongly correlated with disease-free survival (p < 0.01). Our results show that FDG-PET can be used to predict the post-ASCT outcome of lymphoma patients with high accuracy... - Optimizing imaging protocols for overweight and obese patients: a lutetium orthosilicate PET/CT studyBenjamin S Halpern
Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, UCLA David Geffen School of Medicine, Los Angeles, California 90095-6942, USA
J Nucl Med 46:603-7. 2005..Thus, 5 min/bed position scans are sufficient for optimal lesion detection with LSO PET/CT in obese patients... - 18F-FDG PET for staging breast cancer in patients with inner-quadrant versus outer-quadrant tumors: comparison with long-term clinical outcomeAmy Tran
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
J Nucl Med 46:1455-9. 2005..Patients with IQ tumors could be vulnerable to understaging with conventional staging approaches and may particularly benefit from PET during the staging process... - Biodistribution and predictive value of 18F-fluorocyclophosphamide in mice bearing human breast cancer xenograftsAmanda L Kesner
Ahmanson Biological Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 6942, USA
J Nucl Med 48:2021-7. 2007.... - Time-course of effects of external beam radiation on [18F]FDG uptake in healthy tissue and bone marrowAdam L Kesner
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 6942, USA
J Appl Clin Med Phys 9:2747. 2008.... - Radiation dose estimates for [18F]5-fluorouracil derived from PET-based and tissue-based methods in ratsAdam L Kesner
Molecular and Medical Pharmacology, Ahmanson Biological Imaging Division, UCLA Medical Center, Los Angeles, CA 90095 6942, USA
Mol Imaging Biol 10:341-8. 2008..In the current manuscript, normal-tissue absorbed dose estimates for the 18F-labeled chemotherapy agent [18F]5-fluorouracil ([18F]5-FU) were derived by PET imaging- and by tissue harvesting-based methods in rats... - Conventional imaging and 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography for predicting the clinical outcome of patients with previously treated Hodgkin's diseaseJean-Emmanuel Filmont
Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Clinic, UCLA School of Medicine, Los Angeles, CA, USA
Mol Imaging Biol 6:47-54. 2004..Moreover, FDG-PET predicted patient outcome with a higher predictive accuracy than CI. This superior prognostic accuracy was achieved with a single FDG-PET study vs. 2.9+/-1.2 CI procedures/patient... - Comparison between 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography and positron emission tomography/computed tomography hardware fusion for staging of patients with lymphomaMartin Allen-Auerbach
Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, UCLA David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-6942 USA
Mol Imaging Biol 6:411-6. 2004..PET/CT correctly upstaged two and downstaged five patients. Overall staging was accurate in 93% with PET/CT and 84% with PET (P = 0.03). CONCLUSION: Lymphoma is staged with higher accuracy using PET/CT than PET alone... - Accuracy of early diagnosis and its impact on the management and course of Alzheimer's diseaseCarol Y Chang
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Expert Rev Mol Diagn 4:63-9. 2004..Early recognition and intervention facilitates optimal care of Alzheimer's patients and delays the morbidity associated with this progressive illness... - Predicting chemotherapy response to paclitaxel with 18F-Fluoropaclitaxel and PETWei-Ann Hsueh
Ahmanson Biological Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-6942, USA
J Nucl Med 47:1995-9. 2006..In combination with approaches for examining other aspects of resistance, such quantification could prove useful in helping to predict subsequent resistance to paclitaxel chemotherapy of breast cancer... - Conventional imaging and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography for predicting the clinical outcome of previously treated non-Hodgkin's lymphoma patientsJean-Emmanuel Filmont
Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Clinic UCLA School of Medicine, Los Angeles, CA 90095, USA
Mol Imaging Biol 5:232-9. 2003..Moreover, FDG-PET predicted patient outcome with a higher predictive accuracy than conventional imaging. This superior prognostic accuracy was achieved with a single FDG-PET study versus multiple conventional imaging procedures/patient... - Improving influx constant and ratio estimation in FDOPA brain PET analysis for Parkinson's diseaseXiao-Bo Pan
Siemens Molecular Imaging, Oxford, United Kingdom
J Nucl Med 46:1737-44. 2005..Influx constant values computed using our analysis technique closely correlated to values computed with ratio methods using this general approach... - Radiation dosimetry results for Zevalin radioimmunotherapy of rituximab-refractory non-Hodgkin lymphomaGregory A Wiseman
Division of Nuclear Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
Cancer 94:1349-57. 2002..The purpose of this trial was to perform (111)In-Zevalin imaging in patients with rituximab-refractory tumors to determine normal organ dosimetry... - Evaluating pathology in the brain with nuclear medicineDaniel H S Silverman
Semin Nucl Med 38:225-6. 2008
Research Grants
- Evaluation of Presynaptic Calcium Channels In VivoDaniel Silverman; Fiscal Year: 2003..A possible peripheral benefit of this work lies in its potential to bring us closer to an effective CNS delivery system for calcium channel antagonists which are under clinical development as therapeutic agents. ..