R M Silver

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. doi request reprint Implications of the first cesarean: perinatal and future reproductive health and subsequent cesareans, placentation issues, uterine rupture risk, morbidity, and mortality
    Robert M Silver
    Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT 84132, USA
    Semin Perinatol 36:315-23. 2012
  2. doi request reprint Invited commentary: maternal stress and stillbirth: another piece of the puzzle
    Robert M Silver
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, School of Medicine, Salt Lake City, UT 84132, USA
    Am J Epidemiol 177:228-9. 2013
  3. doi request reprint Nomenclature for pregnancy outcomes: time for a change
    Robert M Silver
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Obstet Gynecol 118:1402-8. 2011
  4. pmc Prothrombin gene G20210A mutation and obstetric complications
    Robert M Silver
    Departments of Obstetrics and Gynecology at the University of Alabama at Birmingham, Birmingham, Alabama, USA
    Obstet Gynecol 115:14-20. 2010
  5. doi request reprint New anticoagulants and pregnancy
    Robert M Silver
    Department of Obstetrics and Gynecology at the University of Utah School of Medicine, Salt Lake City, UT, USA
    Obstet Gynecol 112:419-20. 2008
  6. ncbi request reprint Fetal death
    Robert M Silver
    Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT 84132, USA
    Obstet Gynecol 109:153-67. 2007
  7. doi request reprint Delivery after previous cesarean: long-term maternal outcomes
    Robert M Silver
    University of Utah School of Medicine, Department of Obstetrics and Gynecology, Salt Lake City, UT 84132, USA
    Semin Perinatol 34:258-66. 2010
  8. ncbi request reprint Immunology update: symposium on antiphospholipid antibodies
    R M Silver
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City 84132, USA
    J Reprod Immunol 32:269-72. 1997
  9. doi request reprint Obstetric antiphospholipid syndrome: current uncertainties should guide our way
    D W Branch
    University of Utah Health Sciences Center and Intermountain Healthcare, Salt Lake City, Utah, USA
    Lupus 19:446-52. 2010
  10. ncbi request reprint Heparin-induced thrombocytopenia is rare in pregnancy
    M B Fausett
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Am J Obstet Gynecol 185:148-52. 2001

Detail Information

Publications50

  1. doi request reprint Implications of the first cesarean: perinatal and future reproductive health and subsequent cesareans, placentation issues, uterine rupture risk, morbidity, and mortality
    Robert M Silver
    Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT 84132, USA
    Semin Perinatol 36:315-23. 2012
    ..The risk dramatically worsens in patients with multiple repeat cesarean deliveries. This article will summarize and highlight the implications of the rising cesarean rate on maternal and fetal morbidity and mortality...
  2. doi request reprint Invited commentary: maternal stress and stillbirth: another piece of the puzzle
    Robert M Silver
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, School of Medicine, Salt Lake City, UT 84132, USA
    Am J Epidemiol 177:228-9. 2013
    ..These data should spur additional investigation into the link between stress and stillbirth, hopefully leading to fewer fetal deaths...
  3. doi request reprint Nomenclature for pregnancy outcomes: time for a change
    Robert M Silver
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Obstet Gynecol 118:1402-8. 2011
    ..In this article, we propose a more useful nomenclature for pregnancy loss and preterm births that is informative and is based on developmental periods in gestation and shared pathophysiology...
  4. pmc Prothrombin gene G20210A mutation and obstetric complications
    Robert M Silver
    Departments of Obstetrics and Gynecology at the University of Alabama at Birmingham, Birmingham, Alabama, USA
    Obstet Gynecol 115:14-20. 2010
    ..To estimate whether maternal carriage of the prothrombin gene G20210A mutation is associated with pregnancy loss, preeclampsia, placental abruption, or small for gestational age (SGA) neonates in a low-risk, prospective cohort...
  5. doi request reprint New anticoagulants and pregnancy
    Robert M Silver
    Department of Obstetrics and Gynecology at the University of Utah School of Medicine, Salt Lake City, UT, USA
    Obstet Gynecol 112:419-20. 2008
  6. ncbi request reprint Fetal death
    Robert M Silver
    Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT 84132, USA
    Obstet Gynecol 109:153-67. 2007
    ..Outcomes may be improved in women with diabetes, hypertension, red cell alloimmunization, and antiphospholipid syndrome. However, there is considerable room for further reduction in the fetal death rate...
  7. doi request reprint Delivery after previous cesarean: long-term maternal outcomes
    Robert M Silver
    University of Utah School of Medicine, Department of Obstetrics and Gynecology, Salt Lake City, UT 84132, USA
    Semin Perinatol 34:258-66. 2010
    ..This chapter outlines these long term risks of cesarean delivery so that they may be factored into the risk:benefit ratio for women considering vaginal birth after cesarean delivery (VBAC)...
  8. ncbi request reprint Immunology update: symposium on antiphospholipid antibodies
    R M Silver
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City 84132, USA
    J Reprod Immunol 32:269-72. 1997
    ..The meeting was attended by over 230 people and was hosted by Azzudin E. Gharavi and Wendell A. Wilson. Workshops were also conducted on assays for lupus anticoagulant, antiphospholipid antibodies, and anti-endothelial cell antibodies...
  9. doi request reprint Obstetric antiphospholipid syndrome: current uncertainties should guide our way
    D W Branch
    University of Utah Health Sciences Center and Intermountain Healthcare, Salt Lake City, Utah, USA
    Lupus 19:446-52. 2010
    ..This brief commentary focuses on areas of uncertainty that we see as deserving of new or renewed study for the sake of improving our understanding of APS and best patient care...
  10. ncbi request reprint Heparin-induced thrombocytopenia is rare in pregnancy
    M B Fausett
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Am J Obstet Gynecol 185:148-52. 2001
    ..However, the incidence of heparin-induced thrombocytopenia during pregnancy is unknown. The purpose of this study was to compare the incidence of heparin-induced thrombocytopenia in pregnant and nonpregnant women...
  11. ncbi request reprint Histologic features of placentas and abortion specimens from women with antiphospholipid and antiphospholipid-like syndromes
    J T Van Horn
    University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Placenta 25:642-8. 2004
    ..The objective of our study was to determine whether patients with antiphospholipid and antiphospholipid-like syndromes share pathophysiology by comparing the histology of gestational tissues from these groups...
  12. doi request reprint The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis
    Sarah M Davis
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, USA
    Am J Obstet Gynecol 202:308.e1-8. 2010
    ..The objective of the study was to determine whether single-nucleotide polymorphisms (SNPs) that influence the maternal innate immune response are associated with puerperal group A streptococcal sepsis...
  13. ncbi request reprint Reliability of fetal middle cerebral artery velocity measurements: a randomized controlled trial of sonographer training
    Erin A S Clark
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Ultrasound Med 28:19-25. 2009
    ..The purpose of this study was to determine the reliability of fetal middle cerebral artery (MCA) peak systolic velocity (PSV) measurements at a tertiary care center and to evaluate the effect of targeted training for sonographers...
  14. ncbi request reprint The factor V Leiden and the G20210A prothrombin gene mutations are rare in women with fetal death
    Amy E Sullivan
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Am J Reprod Immunol 54:1-4. 2005
    ..To determine if there is an association between two commonly inherited thrombophilias, the factor V Leiden and the G20210A prothrombin mutations, and fetal death...
  15. doi request reprint Thromboprophylaxis and pregnancy outcomes in asymptomatic women with inherited thrombophilias
    Jennifer E Warren
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Am J Obstet Gynecol 200:281.e1-5. 2009
    ..Our objective was to evaluate the effect of thromboprophylaxis on pregnancy outcomes in asymptomatic women with inherited thrombophilias...
  16. doi request reprint Outcomes of expectantly managed preterm premature rupture of membranes occurring before 24 weeks of gestation
    Tracy A Manuck
    Department of Obstetrics and Gynecology and Intermountain Healthcare Maternal Fetal Medicine, University of Utah, Salt Lake City, Utah, USA
    Obstet Gynecol 114:29-37. 2009
    ..To assess contemporary outcomes in expectantly managed preterm premature rupture of membranes (PROM) before 24 weeks of gestation...
  17. doi request reprint Polymorphisms in the promoter region of the interleukin-10 (IL-10) gene in women with cervical insufficiency
    Jennifer E Warren
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Am J Obstet Gynecol 201:372.e1-5. 2009
    ..Our objective was to determine whether polymorphisms in the promoter region of the interleukin-10 gene are more common in women with cervical insufficiency compared with controls...
  18. doi request reprint Preterm premature rupture of membranes: does the duration of latency influence perinatal outcomes?
    Tracy A Manuck
    Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA
    Am J Obstet Gynecol 201:414.e1-6. 2009
    ..We hypothesized that, when controlled for delivery gestational age, potential prolonged exposure to inflammation/infection could be harmful to the developing fetus...
  19. doi request reprint Array comparative genomic hybridization for genetic evaluation of fetal loss between 10 and 20 weeks of gestation
    Jennifer E Warren
    Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah, USA
    Obstet Gynecol 114:1093-102. 2009
    ..To estimate genomic copy number changes in fetal loss between 10 and 20 weeks of gestation using array comparative genomic hybridization...
  20. doi request reprint Stillbirth workup and delivery management
    Robert M Silver
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah, USA
    Clin Obstet Gynecol 53:681-90. 2010
    ..Induction of labor using prostaglandins or oxytocin is the most common method of delivery. However, under some circumstances, dilation and evacuation is a safe alternative during the second trimester...
  21. doi request reprint Correlation between stillbirth vital statistics and medical records
    Cara C Heuser
    Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah 84132, USA
    Obstet Gynecol 116:1296-301. 2010
    ..Our purposes were to compare stillbirth data recorded in vital statistics with those in the medical record and to investigate whether diagnostic evaluations differed in tertiary care and community hospitals...
  22. doi request reprint Second trimester termination of pregnancy: a review by site and procedure type
    David K Turok
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT 84132 2209, USA
    Contraception 77:155-61. 2008
    ..We hypothesized that complications for second trimester terminations are higher in a low-volume residency training program than in a high-volume private practice...
  23. ncbi request reprint Collagen 1Alpha1 and transforming growth factor-beta polymorphisms in women with cervical insufficiency
    Jennifer E Warren
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Obstet Gynecol 110:619-24. 2007
    ..To estimate whether polymorphisms in the collagen 1Alpha1 gene (COL1Alpha1) and the transforming growth factor-beta gene (TGF-beta;1) are more common in women with cervical insufficiency than in those without the condition...
  24. ncbi request reprint The aryl hydrocarbon receptor nuclear translocator gene polymorphism in patients with recurrent miscarriage
    Amy E Sullivan
    Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Utah Health Science Center, RM, SOM, UT 84132, USA
    Am J Reprod Immunol 55:51-3. 2006
    ..Knockout of ARNT is embryonic lethal. We thus hypothesized that some cases of recurrent miscarriage (RM) may be due to a polymorphism in the ARNT gene...
  25. ncbi request reprint Recurrent fetal aneuploidy and recurrent miscarriage
    Amy E Sullivan
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, 50 North Medical Drive, Salt Lake City, Utah 94132, USA
    Obstet Gynecol 104:784-8. 2004
    ..of this study was to investigate the relationship between fetal aneuploidy and recurrent miscarriage by estimating whether fetal aneuploidy is more common in patients with recurrent miscarriage than in patients with sporadic miscarriage..
  26. ncbi request reprint Maternal morbidity associated with multiple repeat cesarean deliveries
    Robert M Silver
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Obstet Gynecol 107:1226-32. 2006
    ..Our objective was to estimate the magnitude of increased maternal morbidity associated with increasing number of cesarean deliveries...
  27. ncbi request reprint The management of acardiac twins: a conservative approach
    Amy E Sullivan
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Room 2B200, 50 N Medical Drive, Salt Lake City, UT 84132, USA
    Am J Obstet Gynecol 189:1310-3. 2003
    ..Because of increased antenatal diagnosis, outcomes in expectantly managed cases may be better than reported. Our objective was to determine the outcome of expectantly managed acardiac twin pregnancies...
  28. ncbi request reprint Preconception counseling for women with thrombophilia
    Robert M Silver
    Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah 84132, USA
    Clin Obstet Gynecol 49:906-19. 2006
    ..Although relatively common, the association between hyperhomocysteinemia and associated mutations (such as the C677 T methylenetetrahydro-folate reductase) and obstetric complications is controversial...
  29. pmc Work-up of stillbirth: a review of the evidence
    Robert M Silver
    University of Utah, Department of Obstetrics and Gynecology, Salt Lake City, UT 84132, USA
    Am J Obstet Gynecol 196:433-44. 2007
    ....
  30. ncbi request reprint Do antiphospholipid antibodies cause preeclampsia and HELLP syndrome?
    Erin A S Clark
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, 30 North 1900 East, Room 2B200 SOM, Salt Lake City, UT 84132, USA
    Curr Rheumatol Rep 9:219-25. 2007
    ..Current evidence does not justify inclusion of preeclampsia as a major criterion for APS, but preeclampsia could reasonably be included as a secondary or minor criterion in diagnosis when a patient has other clinical features of APS...
  31. ncbi request reprint The use of cDNA microarray to identify differentially expressed labor-associated genes within the human myometrium during labor
    M Sean Esplin
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Utah Health Science Center, Salt Lake City, UT 84108, USA
    Am J Obstet Gynecol 193:404-13. 2005
    ..Microarray technology was used to comprehensively analyze gene expression during human labor in the myometrium...
  32. doi request reprint Optimal management strategies for placenta accreta
    A G Eller
    Department of Obstetrics and Gynecology, Divisions of Maternal Fetal Medicine and Gynecologic Oncology, University of Utah, Salt Lake City, UT 84132, USA
    BJOG 116:648-54. 2009
    ..To determine which interventions for managing placenta accreta were associated with reduced maternal morbidity...
  33. ncbi request reprint Poor obstetric outcome in subsequent pregnancies in women with prior fetal death
    Antonio E Frias
    University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Obstet Gynecol 104:521-6. 2004
    ..Thus, it is difficult for clinicians to optimally counsel, evaluate, and manage women with previous unexplained fetal death. Our objective was to ascertain the outcome of subsequent pregnancies in patients with prior fetal death...
  34. doi request reprint Genetics of pregnancy loss
    Jennifer E Warren
    Departments of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Utah, Salt Lake City, Utah, USA
    Clin Obstet Gynecol 51:84-95. 2008
    ..This review focuses on the genetic abnormalities that may contribute to this clinical problem and delineates strategies for genetic evaluation and clinical management in subsequent pregnancies...
  35. doi request reprint Hyperemesis in pregnancy: an evaluation of treatment strategies with maternal and neonatal outcomes
    Calla Holmgren
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Am J Obstet Gynecol 198:56.e1-4. 2008
    ....
  36. doi request reprint Leptin and leptin receptor polymorphisms and recurrent pregnancy loss
    J R Chin
    Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA
    J Perinatol 33:589-92. 2013
    ..Conclusion:Although leptin signaling is critical to many aspects of reproduction, the maternal leptin and leptin receptor SNPs evaluated in this study are unlikely to have a clinically meaningful role in RPL. ..
  37. ncbi request reprint Monocyte chemotactic protein-1 expression is increased in human gestational tissues during term and preterm labor
    M Sean Esplin
    Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Utah Health Science Center, Salt Lake City, 84132, USA
    Placenta 26:661-71. 2005
    ..Microarray analysis was used to characterize the labor-selective transcriptome of the human myometrium during labor. One highly up-regulated transcript, monocyte chemotactic protein-1 (MCP-1), was further characterized...
  38. pmc Bacterial lipopolysaccharide-mediated fetal death. Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide
    R M Silver
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City 84132
    J Clin Invest 95:725-31. 1995
    ..Since LPS-mediated fetal death is markedly diminished by pretreatment with indomethacin, COX-2-mediated eicosanoid production is likely a key pathophysiologic event in LPS-mediated fetal death...
  39. ncbi request reprint Immunoglobulin A anti-beta2-glycoprotein antibodies in women who experience unexplained recurrent spontaneous abortion and unexplained fetal death
    R M Lee
    Department of Obstetrics and Gynecology, University of California at Irvine, Orange, USA
    Am J Obstet Gynecol 185:748-53. 2001
    ..It is unclear whether these antibodies are directly pathogenic, a result of the pregnancy losses, or markers for an underlying, yet uncharacterized autoimmune disorder...
  40. ncbi request reprint Plasmapheresis for the treatment of intrahepatic cholestasis of pregnancy refractory to medical treatment
    Jennifer E Warren
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, 84132, USA
    Am J Obstet Gynecol 192:2088-9. 2005
    ..We report a case of intractable ICP that was successfully treated with plasmapheresis. Plasmapheresis should be considered for ICP that is refractory to traditional therapies...
  41. ncbi request reprint Autoimmune disease in pregnancy: systemic lupus erythematosus and antiphospholipid syndrome
    Jennifer B Warren
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, 50 North Medical Drive, 2B200, Salt Lake City, UT 84132, USA
    Obstet Gynecol Clin North Am 31:345-72, vi-vii. 2004
    ..This article focuses on SLE,which is often considered to be the "classic" autoimmune disease,and antiphospholipid syndrome (APS), which is associated with pregnancy loss and placental insufficiency...
  42. ncbi request reprint Homocysteine levels in women with antiphospholipid syndrome and normal fertile controls
    Richard M Lee
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, 50 N Medical Dr Room 2B200, Salt Lake City, UT 84132, USA
    J Reprod Immunol 63:23-30. 2004
    ..Thus, our purpose was to determine if hyperhomocysteinemia is more common in patients with APS than normal fertile controls...
  43. doi request reprint Idiopathic recurrent pregnancy loss recurs at similar gestational ages
    Cara Heuser
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, USA
    Am J Obstet Gynecol 203:343.e1-5. 2010
    ..To determine whether a correlation exists between gestational ages of idiopathic recurrent pregnancy loss (iRPL)...
  44. doi request reprint Effect of aspirin treatment on TNFalpha production by women with a history of preterm birth
    Morgan R Peltier
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Reprod Immunol 80:109-14. 2009
    ....
  45. doi request reprint Genetics of the cervix in relation to preterm birth
    Jennifer E Warren
    Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT 84132, USA
    Semin Perinatol 33:308-11. 2009
    ..However, it is becoming clear that, at least in part, a genetic predisposition to CI plays a role in the condition. Specifically, genes related to connective tissue metabolism and inflammation have been shown to be associated with CI...
  46. doi request reprint Group A streptococcal puerperal sepsis: initial characterization of virulence factors in association with clinical parameters
    Janice L B Byrne
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, USA
    J Reprod Immunol 82:74-83. 2009
    ..We conclude that in this initial characterization, morbidity among women with GAS puerperal infection is associated with M-types 1 and 28, but not speB genotype...
  47. doi request reprint Maternal coagulation disorders and postpartum hemorrhage
    Robert M Silver
    Department of Obstetrics and Gynecology, University of Utah Medical Center, Salt Lake City, Utah, USA
    Clin Obstet Gynecol 53:252-64. 2010
    ..Diagnosis of a coagulation disorder often requires a high index of suspicion and should not be overlooked in the evaluation of obstetric hemorrhage...
  48. ncbi request reprint Maternal autoimmune diseases and immunologically induced embryonic and fetoplacental damage
    Asher Ornoy
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Birth Defects Res A Clin Mol Teratol 70:371-81. 2004
    ..We also describe experimental models that help to understand the etiology and pathogenesis of the effects of this maternal disease on the developing embryo, fetus and placenta...
  49. ncbi request reprint Immune activation early in pregnancy: trouble down the road?
    Robert M Silver
    Am J Obstet Gynecol 199:327-8. 2008
  50. ncbi request reprint Anticardiolipin and anti-beta2-glycoprotein-I antibodies in preeclampsia
    Richard M Lee
    Phoenix Perinatal Associates, Obstetrix Medical Group, Phoenix, Arizona, USA
    Obstet Gynecol 102:294-300. 2003
    ..To estimate whether antiphospholipid antibodies, specifically anticardiolipin and anti-beta(2)-glycoprotein-I antibodies, are associated with preeclampsia...