Gabriel Silva

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Nanotechnology approaches for the regeneration and neuroprotection of the central nervous system
    Gabriel A Silva
    Department of Bioengineering, Whitaker Institute for Biomedical Engineering, University of California, San Diego, CA 92037 0946, USA
    Surg Neurol 63:301-6. 2005
  2. pmc Diffusion modeling of ATP signaling suggests a partially regenerative mechanism underlies astrocyte intercellular calcium waves
    Christopher L Macdonald
    Department of Bioengineering, University of California San Diego, La Jolla, CA, USA
    Front Neuroeng 1:1. 2008
  3. pmc Amyloid β-peptide directly induces spontaneous calcium transients, delayed intercellular calcium waves and gliosis in rat cortical astrocytes
    Siu Kei Chow
    Department of Bioengineering, University of California, San Diego, CA, U S A
    ASN Neuro 2:e00026. 2010
  4. ncbi request reprint Nanotechnologies for stimulating and recording excitable events in neurons and cardiomyocytes
    Gabriel A Silva
    Department of Bioengineering, University of California San Diego, La Jolla, California 92037, USA
    Discov Med 15:357-65. 2013
  5. ncbi request reprint Targeting the brain: advances in drug delivery
    James P Blumling Iii
    UCSD Jacobs Retina Center, 9415 Campus Point Drive, La Jolla, CA 92037 0946, USA
    Curr Pharm Biotechnol 13:2417-26. 2012
  6. pmc Mapping the spatiotemporal dynamics of calcium signaling in cellular neural networks using optical flow
    Marius Buibas
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Ann Biomed Eng 38:2520-31. 2010
  7. pmc Nanotechnology approaches to crossing the blood-brain barrier and drug delivery to the CNS
    Gabriel A Silva
    Departments of Bioengineering and Ophthalmology, and Neurosciences Program, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA 92037 0946, USA
    BMC Neurosci 9:S4. 2008
  8. doi request reprint Chapter 2 - Quantum dot nanotechnologies for neuroimaging
    Gabriel A Silva
    Department of Bioengineering, University of California, San Diego, CA, USA
    Prog Brain Res 180:19-34. 2009
  9. doi request reprint Nanotechnology applications and approaches for neuroregeneration and drug delivery to the central nervous system
    Gabriel A Silva
    Departments of Bioengineering, Ophthalmology and Neurosciences Program, University of California, San Diego, California, USA
    Ann N Y Acad Sci 1199:221-30. 2010
  10. ncbi request reprint Step response of mouse rod photoreceptors modeled in terms of elemental photic signals
    Gabriel A Silva
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA
    IEEE Trans Biomed Eng 51:3-12. 2004

Research Grants

Collaborators

  • Lingyun Cheng
  • F Wong-Staal
  • Marius Buibas
  • Diana Yu
  • Smita Pathak
  • Christopher L Macdonald
  • William R Freeman
  • James P Blumling Iii
  • Siu Kei Chow
  • Mahboubeh Hashemi
  • Iryna A Falkenstein
  • Igor Kozak
  • Marie C Davidson
  • Mai Ho
  • Krystal Nizar
  • Kim Nguyen
  • Lorenzo D'Amico
  • Rosa Tolentino
  • Erin Barron
  • Michelle Hysell
  • Ajay M Tammewar
  • Dehua Yu
  • Guohong Liu
  • Qi Xiang Li
  • James E Macdonald
  • Ning Ke
  • Erin C Barron
  • Marie C Davidsion
  • Elizabeth Cao
  • Sungho Jin

Detail Information

Publications26

  1. ncbi request reprint Nanotechnology approaches for the regeneration and neuroprotection of the central nervous system
    Gabriel A Silva
    Department of Bioengineering, Whitaker Institute for Biomedical Engineering, University of California, San Diego, CA 92037 0946, USA
    Surg Neurol 63:301-6. 2005
    ....
  2. pmc Diffusion modeling of ATP signaling suggests a partially regenerative mechanism underlies astrocyte intercellular calcium waves
    Christopher L Macdonald
    Department of Bioengineering, University of California San Diego, La Jolla, CA, USA
    Front Neuroeng 1:1. 2008
    ..These results suggest that seemingly conflicting data in the literature are actually complimentary, and represents a highly efficient and robustly engineered signaling mechanism...
  3. pmc Amyloid β-peptide directly induces spontaneous calcium transients, delayed intercellular calcium waves and gliosis in rat cortical astrocytes
    Siu Kei Chow
    Department of Bioengineering, University of California, San Diego, CA, U S A
    ASN Neuro 2:e00026. 2010
    ....
  4. ncbi request reprint Nanotechnologies for stimulating and recording excitable events in neurons and cardiomyocytes
    Gabriel A Silva
    Department of Bioengineering, University of California San Diego, La Jolla, California 92037, USA
    Discov Med 15:357-65. 2013
    ..In this review we introduce the reader to the key concepts and methods associated with nanotechnology and nanoengineering, and discuss the work of some of the key groups developing nanoscale stimulation and recording technologies. ..
  5. ncbi request reprint Targeting the brain: advances in drug delivery
    James P Blumling Iii
    UCSD Jacobs Retina Center, 9415 Campus Point Drive, La Jolla, CA 92037 0946, USA
    Curr Pharm Biotechnol 13:2417-26. 2012
    ....
  6. pmc Mapping the spatiotemporal dynamics of calcium signaling in cellular neural networks using optical flow
    Marius Buibas
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Ann Biomed Eng 38:2520-31. 2010
    ..We discuss the imaging requirements, parameter selection and threshold selection for reliable measurements, and offer perspectives on uses of the vector data...
  7. pmc Nanotechnology approaches to crossing the blood-brain barrier and drug delivery to the CNS
    Gabriel A Silva
    Departments of Bioengineering and Ophthalmology, and Neurosciences Program, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA 92037 0946, USA
    BMC Neurosci 9:S4. 2008
    ..This brief review introduces emerging work in this area and summarizes a number of example applications to CNS cancers, gene therapy, and analgesia...
  8. doi request reprint Chapter 2 - Quantum dot nanotechnologies for neuroimaging
    Gabriel A Silva
    Department of Bioengineering, University of California, San Diego, CA, USA
    Prog Brain Res 180:19-34. 2009
    ....
  9. doi request reprint Nanotechnology applications and approaches for neuroregeneration and drug delivery to the central nervous system
    Gabriel A Silva
    Departments of Bioengineering, Ophthalmology and Neurosciences Program, University of California, San Diego, California, USA
    Ann N Y Acad Sci 1199:221-30. 2010
    ..It also discusses developing platform technologies that may prove to have broad applications to medicine and physiology, including some being developed for rescuing or replacing anatomical and/or functional CNS structures...
  10. ncbi request reprint Step response of mouse rod photoreceptors modeled in terms of elemental photic signals
    Gabriel A Silva
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA
    IEEE Trans Biomed Eng 51:3-12. 2004
    ..The model yields a time-dependent function that describes the course of desensitization and putatively represents the cumulative dynamics of underlying biochemical processes involved in light adaptation of the rod...
  11. ncbi request reprint Neuroscience nanotechnology: progress, opportunities and challenges
    Gabriel A Silva
    Department of Bioengineering, University of California, San Diego, UCSD Jacobs Retina Center 0946, 9415 Campus Point Drive, La Jolla, California 92037 0946, USA
    Nat Rev Neurosci 7:65-74. 2006
    ....
  12. ncbi request reprint Selective differentiation of neural progenitor cells by high-epitope density nanofibers
    Gabriel A Silva
    Institute for Bioengineering and Nanoscience in Advanced Medicine, Northwestern University, Chicago, IL 60611, USA
    Science 303:1352-5. 2004
    ..This rapid selective differentiation is linked to the amplification of bioactive epitope presentation to cells by the nanofibers...
  13. ncbi request reprint What impact will nanotechnology have on neurology?
    Gabriel A Silva
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92037 0946, USA
    Nat Clin Pract Neurol 3:180-1. 2007
  14. ncbi request reprint Nanotechnology approaches for drug and small molecule delivery across the blood brain barrier
    Gabriel A Silva
    Department of Bioengineering, University of California, San Diego, CA 92037, USA
    Surg Neurol 67:113-6. 2007
    ..This review discusses some of the main technical challenges associated with the development of nanotechnologies for delivery across the blood brain barrier and summarizes ongoing work...
  15. ncbi request reprint Quantum dot applications to neuroscience: new tools for probing neurons and glia
    Smita Pathak
    Materials Science and Engineering Program, University of California, San Diego, La Jolla, California 92037 0946, USA
    J Neurosci 26:1893-5. 2006
  16. ncbi request reprint A framework for simulating and estimating the state and functional topology of complex dynamic geometric networks
    Marius Buibas
    Department of Bioengineering, University of California, San Diego, LaJolla, CA 92037, U S A
    Neural Comput 23:183-214. 2011
    ..Computationally, the framework can simulate cellular network signaling close to or faster than real time. We further propose a standard test set of networks to measure performance and compare different mapping algorithms...
  17. pmc Stem cell sources and therapeutic approaches for central nervous system and neural retinal disorders
    Diana Yu
    Department of Bioengineering, University of California, San Diego, USA
    Neurosurg Focus 24:E11. 2008
    ..Nonetheless, stem cells present tremendous promise in the treatment of a variety of neurodegenerative diseases...
  18. ncbi request reprint Quantum dot labeling and imaging of glial fibrillary acidic protein intermediate filaments and gliosis in the rat neural retina and dissociated astrocytes
    Smita Pathak
    Materials Science and Engineering Graduate Program, University of California, San Diego 92037 0946, USA
    J Nanosci Nanotechnol 9:5047-54. 2009
    ..The presence of these structures in situ and in vivo as well as any potential functions remain to be determined, but their identification should be greatly facilitated by quantum dot labeling protocols...
  19. pmc Automated detection of intercellular signaling in astrocyte networks using the converging squares algorithm
    Mahboubeh Hashemi
    Department of Bioengineering, University of California, San Diego, La Jolla CA 92037, United States
    J Neurosci Methods 170:294-9. 2008
    ..It is robust to noise and performs comparably to manual cell signal identification, but is much faster and efficient. This is the first reported application of this algorithm to glial networks that we are aware of...
  20. pmc Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186
    Iryna A Falkenstein
    Joan and Irwin Jacobs Retina Center, Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, California, USA
    Curr Eye Res 33:599-609. 2008
    ..To investigate the intraocular properties and toxicity of IMS2186, a small molecule developed as an anti-choroidal neovascularization (anti-CNV) drug...
  21. ncbi request reprint Characterization of the functional binding properties of antibody conjugated quantum dots
    Smita Pathak
    Materials Science and Engineering Graduate Program, Department of Bioengineering, University of California, San Diego, La Jolla, California 92037 0946, USA
    Nano Lett 7:1839-45. 2007
    ..These results may suggest potential strategies for improving quantum dot labeling of biological preparations...
  22. ncbi request reprint Introduction to nanotechnology and its applications to medicine
    Gabriel A Silva
    Department of Bioengineering, Whitaker Institute for Biomedical Engineering and Neurosciences Program, University of California, San Diego, LaJolla, California, USA
    Surg Neurol 61:216-20. 2004
    ..In this review the main scientific and technical aspects of nanotechnology are introduced and some of its potential clinical applications are discussed...
  23. ncbi request reprint Testing of intraocular drugs for clinical use
    Igor Kozak
    Jacobs Retina Center at the Shiley Eye Center, University of California San Diego, La Jolla, CA 92093, USA
    Invest Ophthalmol Vis Sci 48:4861-3. 2007
  24. ncbi request reprint Comparison of standard surface chemistries for culturing mesenchymal stem cells prior to neural differentiation
    Mai Ho
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92037 0946, USA
    Biomaterials 27:4333-9. 2006
    ..Expansion of BMSCs on PDL-laminin-1 coated glass resulted in expression of nestin, a marker associated with neuronal and other progenitor cells, and therefore may confound experimental results if used as a pre-differentiation surface...

Research Grants5

  1. High Throughput Mapping of Neuronal and Glial Networks
    Gabriel Silva; Fiscal Year: 2007
    ....
  2. High Throughput Mapping of Neuronal and Glial Networks
    Gabriel A Silva; Fiscal Year: 2010
    ..abstract_text> ..