Alcino Silva

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1
    Rui M Costa
    Departments of Neurobiology, Psychiatry and Psychology, BRI, University of California at Los Angeles, Los Angeles, California 90095 1761, USA
    Nature 415:526-30. 2002
  2. ncbi request reprint Molecular and cellular cognition; the unraveling of memory retrieval
    Robert Brown
    Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 117:3-4. 2004
  3. pmc Molecular and cellular approaches to memory allocation in neural circuits
    Alcino J Silva
    Department of Neurobiology, University of California, Los Angeles, 695 Charles Young Drive South, Los Angeles, CA 90095 1761, USA
    Science 326:391-5. 2009
  4. doi request reprint The science of research: the principles underlying the discovery of cognitive and other biological mechanisms
    Alcino J Silva
    Department of Neurobiology, UCLA, 695 Charles Young Drive South, Los Angeles, CA 90095 1761, United States
    J Physiol Paris 101:203-13. 2007
  5. ncbi request reprint Molecular and cellular cognitive studies of the role of synaptic plasticity in memory
    Alcino J Silva
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, 695 Charles Young Drive South, Los Angeles, California 90095, USA
    J Neurobiol 54:224-37. 2003
  6. ncbi request reprint The RAS effector RIN1 modulates the formation of aversive memories
    Ajay Dhaka
    Molecular Biology Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1737, USA
    J Neurosci 23:748-57. 2003
  7. ncbi request reprint Consolidation of CS and US representations in associative fear conditioning
    Paul W Frankland
    Departments of Neurobiology, Psychology and Psychiatry, University of California at Los Angeles, Los Angeles, California 90095 1761, USA
    Hippocampus 14:557-69. 2004
  8. ncbi request reprint Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction
    Inbal Israely
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Curr Biol 14:1657-63. 2004
  9. ncbi request reprint Increased neuronal excitability, synaptic plasticity, and learning in aged Kvbeta1.1 knockout mice
    Geoffrey G Murphy
    Departments of Neurobiology, Psychology, and Psychiatry, Brain Research Institute, University of California, Los Angeles, 2554 Gonda Center, Box 951761, Los Angeles, CA 90095, USA
    Curr Biol 14:1907-15. 2004
  10. ncbi request reprint The involvement of the anterior cingulate cortex in remote contextual fear memory
    Paul W Frankland
    Departments of Neurobiology, Psychiatry, Psychology and Brain Research Institute, UCLA, 695 Charles Young Drive South, Los Angeles, CA 90095 1761, USA
    Science 304:881-3. 2004

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1
    Rui M Costa
    Departments of Neurobiology, Psychiatry and Psychology, BRI, University of California at Los Angeles, Los Angeles, California 90095 1761, USA
    Nature 415:526-30. 2002
    ..Our findings have implications for the development of treatments for learning deficits associated with NF1...
  2. ncbi request reprint Molecular and cellular cognition; the unraveling of memory retrieval
    Robert Brown
    Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 117:3-4. 2004
    ..In this issue of Cell, use molecular genetic approaches combined with pharmacology to demonstrate that beta-adrenergic receptor function regulates retrieval of certain forms of memory...
  3. pmc Molecular and cellular approaches to memory allocation in neural circuits
    Alcino J Silva
    Department of Neurobiology, University of California, Los Angeles, 695 Charles Young Drive South, Los Angeles, CA 90095 1761, USA
    Science 326:391-5. 2009
    ..Results from these studies are likely to have a considerable impact on computer science, as well as on the understanding of memory and its disorders...
  4. doi request reprint The science of research: the principles underlying the discovery of cognitive and other biological mechanisms
    Alcino J Silva
    Department of Neurobiology, UCLA, 695 Charles Young Drive South, Los Angeles, CA 90095 1761, United States
    J Physiol Paris 101:203-13. 2007
    ..I will discuss both strategies to test this hypothesis and its implications for studies of cognitive function...
  5. ncbi request reprint Molecular and cellular cognitive studies of the role of synaptic plasticity in memory
    Alcino J Silva
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, 695 Charles Young Drive South, Los Angeles, California 90095, USA
    J Neurobiol 54:224-37. 2003
    ..Here, I will review this literature, with a special focus on studies of hippocampal-dependent learning and memory...
  6. ncbi request reprint The RAS effector RIN1 modulates the formation of aversive memories
    Ajay Dhaka
    Molecular Biology Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1737, USA
    J Neurosci 23:748-57. 2003
    ..These results indicate that RIN1 serves as an inhibitory modulator of neuronal plasticity in aversive memory formation...
  7. ncbi request reprint Consolidation of CS and US representations in associative fear conditioning
    Paul W Frankland
    Departments of Neurobiology, Psychology and Psychiatry, University of California at Los Angeles, Los Angeles, California 90095 1761, USA
    Hippocampus 14:557-69. 2004
    ..Together, these data suggest that this approach is particularly suited for the characterization of molecular and cellular processes underlying the formation of stimulus representations...
  8. ncbi request reprint Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction
    Inbal Israely
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Curr Biol 14:1657-63. 2004
    ....
  9. ncbi request reprint Increased neuronal excitability, synaptic plasticity, and learning in aged Kvbeta1.1 knockout mice
    Geoffrey G Murphy
    Departments of Neurobiology, Psychology, and Psychiatry, Brain Research Institute, University of California, Los Angeles, 2554 Gonda Center, Box 951761, Los Angeles, CA 90095, USA
    Curr Biol 14:1907-15. 2004
    ....
  10. ncbi request reprint The involvement of the anterior cingulate cortex in remote contextual fear memory
    Paul W Frankland
    Departments of Neurobiology, Psychiatry, Psychology and Brain Research Institute, UCLA, 695 Charles Young Drive South, Los Angeles, CA 90095 1761, USA
    Science 304:881-3. 2004
    ..Accordingly, reversible inactivation of this structure in normal mice disrupts remote memory without affecting recent memory...
  11. ncbi request reprint Genetic approaches to molecular and cellular cognition: a focus on LTP and learning and memory
    Anna Matynia
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
    Annu Rev Genet 36:687-720. 2002
    ..Altogether, these findings not only demonstrate a role for plasticity in learning, they also lay down the foundations for the new field of molecular and cellular cognition...
  12. pmc Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
    Jian Feng
    Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Nat Neurosci 13:423-30. 2010
    ..We conclude that Dnmt1 and Dnmt3a are required for synaptic plasticity, learning and memory through their overlapping roles in maintaining DNA methylation and modulating neuronal gene expression in adult CNS neurons...
  13. ncbi request reprint Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice
    Stephan G Anagnostaras
    Department of Neurobiology, Brain Research Institute, 2554 Gonda Center, Box 951761, University of California, Los Angeles, California 90095 1761, USA
    Nat Neurosci 6:51-8. 2003
    ..Our results suggest that the M1 receptor is specifically involved in memory processes for which the cortex and hippocampus interact...
  14. ncbi request reprint Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory
    Adele P Chen
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, 90095 1761, USA
    J Neurosci Res 83:28-38. 2006
    ..Our findings demonstrate that B-raf plays a role in hippocampal ERK activation, synaptic plasticity, and L&M...
  15. ncbi request reprint Memory for context becomes less specific with time
    Brian J Wiltgen
    Departments of Neurobiology, Psychology, Psychiatry and the Brain Research Institute, UCLA, Los Angeles, California 90095, USA
    Learn Mem 14:313-7. 2007
    ..These results suggest that context memories are specific early after training when they require the hippocampus, and become more general as they are permanently stored in the cortex...
  16. ncbi request reprint Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning
    Yu Zhou
    Department of Neurobiology, Semel Institute, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
    J Neurosci 27:13843-53. 2007
    ..Together our results demonstrate the importance of interactions between CaMKII and NR2B for CaMKII activity, synaptic plasticity, and learning...
  17. pmc The molecular and cellular biology of enhanced cognition
    Yong Seok Lee
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, California 90095, USA
    Nat Rev Neurosci 10:126-40. 2009
    ..These findings represent the beginning of a fundamental new approach in the study of enhanced cognition...
  18. pmc CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala
    Yu Zhou
    Department of Neurobiology, University of California Los Angeles, Los Angeles, California, USA
    Nat Neurosci 12:1438-43. 2009
    ..Our findings demonstrate that CREB modulates the allocation of fear memory to specific cells in lateral amygdala and suggest that neuronal excitability is important in this process...
  19. pmc Molecular and cellular mechanisms of memory allocation in neuronetworks
    Jaejoon Won
    Department of Neurobiology, and the Brain Research Institute, UCLA, Los Angeles, CA 90095, USA
    Neurobiol Learn Mem 89:285-92. 2008
    ..Beyond CREB, there may be a host of other processes that dynamically modulate memory allocation in neuronetworks by shaping cooperation and competition among neurons...
  20. ncbi request reprint Notch to remember
    Rui M Costa
    Departments of Neurobiology, Psychiatry, and Psychology, University of California Los Angeles, 695 Young Drive South, Room 2554, Box 951761, Los Angeles, CA 90095 1761, USA
    Trends Neurosci 28:429-35. 2005
    ..We also consider the possible involvement of Notch signaling in cognitive disorders...
  21. ncbi request reprint Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning
    Ype Elgersma
    Department of Neurobiology, Department of Psychiatry, Department of Psychology, Brain Research Institute, University of California, Los Angeles, CA 90095, USA
    Neuron 36:493-505. 2002
    ..Mimicking inhibitory phosphorylation dramatically decreased the association of CaMKII with the PSD and blocked both LTP and learning. These data demonstrate that inhibitory phosphorylation has a critical role in plasticity and learning...
  22. ncbi request reprint Pharmacologically regulated induction of silent mutations (PRISM): combined pharmacological and genetic approaches for learning and memory
    Paul W Frankland
    Department of Neurobiology, University of California, Los Angeles, USA
    Neuroscientist 9:104-9. 2003
    ..This approach is easily set up and can be used to study the functional interactions between molecules in signaling pathways...
  23. ncbi request reprint The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1
    Weidong Li
    Department of Neurobiology, University of California, Los Angeles, Los Angeles, California 90095, USA
    Curr Biol 15:1961-7. 2005
    ..Therefore, these results demonstrate that lovastatin may prove useful in the treatment of Neurofibromatosis Type 1...
  24. ncbi request reprint Investigation of age-related cognitive decline using mice as a model system: behavioral correlates
    Geoffrey G Murphy
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, CA 90095 1761, USA
    Am J Geriatr Psychiatry 14:1004-11. 2006
    ....
  25. pmc Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis
    Dan Ehninger
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, 695 Charles E Young Drive South, Los Angeles, California 90095, USA
    Nat Med 14:843-8. 2008
    ....
  26. pmc Neurofibromin regulation of ERK signaling modulates GABA release and learning
    Yijun Cui
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 135:549-60. 2008
    ..Importantly, our results also revealed lasting increases in GABA release triggered by learning, indicating that the mechanisms uncovered here are of general importance for learning...
  27. ncbi request reprint New circuits for old memories: the role of the neocortex in consolidation
    Brian J Wiltgen
    Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Neuron 44:101-8. 2004
    ..The studies reviewed here represent the first exciting steps toward the understanding of the molecular, cellular, and systems mechanisms of how the brain stores our oldest and perhaps most defining memories...
  28. pmc DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation
    LEAH K HUTNICK
    Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, 695 Charles Young Drive South, Los Angeles, CA 90095, USA
    Hum Mol Genet 18:2875-88. 2009
    ..Our results suggest that DNA methylation, through its role in modulating neuronal gene expression, plays multiple roles in regulating cell survival and neuronal maturation in the CNS...
  29. ncbi request reprint A pharmacogenetic inducible approach to the study of NMDA/alphaCaMKII signaling in synaptic plasticity
    Masuo Ohno
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles 90095 1761, USA
    Curr Biol 12:654-6. 2002
    ..This ability to temporally induce recessive mutant phenotypes could be applicable to a broad range of problems and genetic systems...
  30. pmc Reversing neurodevelopmental disorders in adults
    Dan Ehninger
    Department of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology and the Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095 1761, USA
    Neuron 60:950-60. 2008
    ..These findings mark a paradigmatic change in the way we understand and envision treating neurodevelopmental disorders...
  31. ncbi request reprint Investigation of age-related cognitive decline using mice as a model system: neurophysiological correlates
    Geoffrey G Murphy
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095 1761, USA
    Am J Geriatr Psychiatry 14:1012-21. 2006
    ..Here, the authors explore the possibility that age-related changes in neuronal function may be the result of deregulation of cytosolic free calcium homeostasis...
  32. pmc A high through-put reverse genetic screen identifies two genes involved in remote memory in mice
    Anna Matynia
    Department of Neurobiology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 3:e2121. 2008
    ..This study identifies some of the first genes required for remote memory, and suggests that screens of targeted mutants may be an efficient strategy to identify molecular requirements for this process...
  33. pmc Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex
    Megumi Kaneko
    Department of Physiology and the Keck Center for Integrative Neurosciences, University of California, San Francisco, CA 94143 0444, USA
    Proc Natl Acad Sci U S A 107:19026-31. 2010
    ..These findings demonstrate accelerated neocortical plasticity, which offers an avenue toward future therapies for many neurological and neuropsychiatric disorders...
  34. pmc Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway
    Steven A Kushner
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, California 90095 1761, USA
    J Neurosci 25:9721-34. 2005
    ..Together with previous invertebrate studies, these results demonstrate that presynaptic plasticity represents an important evolutionarily conserved mechanism for modulating learning and memory...
  35. ncbi request reprint Autophosphorylation of alphaCaMKII is required for ocular dominance plasticity
    Sharif Taha
    W M Keck Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 36:483-91. 2002
    ..These results confirm the importance of alphaCaMKII in visual cortical plasticity and suggest that synaptic changes induced by monocular deprivation are stored specifically in glutamatergic synapses made onto excitatory neurons...
  36. ncbi request reprint Molecular and cellular mechanisms underlying the cognitive deficits associated with neurofibromatosis 1
    Rui M Costa
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles 90095 1761, USA
    J Child Neurol 17:622-6; discussion 627-9, 646-51. 2002
    ..These findings have brought us closer than ever to the development of possible treatments for the learning disabilities associated with neurofibromatosis 1...
  37. ncbi request reprint Learning and memory deficits in Notch mutant mice
    Rui M Costa
    University of California, Los Angeles, Department of Neurobiology, and Brain Research Institute, 695 Young Drive South, Room 2554, Box 951761, Los Angeles, CA 90095 1761, USA
    Curr Biol 13:1348-54. 2003
    ....
  38. ncbi request reprint Mouse models of neurofibromatosis type I: bridging the GAP
    Rui M Costa
    Department of Neurobiology and Brain Research Institute, University of California, Los Angeles, Room 2554, 95 Young Drive South, 90095 1761, USA
    Trends Mol Med 9:19-23. 2003
    ..This knowledge will aid the development of treatments for the different pathological processes associated with NF1...
  39. ncbi request reprint Central nervous system myelination in mice with deficient expression of Notch1 receptor
    Maria I Givogri
    Neurobiochemistry Group, Mental Retardation Research Center, School of Medicine, University of California, Los Angeles, California 90024, USA
    J Neurosci Res 67:309-20. 2002
    ....
  40. pmc MAPK, CREB and zif268 are all required for the consolidation of recognition memory
    Bruno Bozon
    Laboratoire de Neurobiologie de l Apprentissage, de la Memoire et de la Communication, CNRS UMR 8620, Universite Paris Sud, 91405 Orsay, France
    Philos Trans R Soc Lond B Biol Sci 358:805-14. 2003
    ....
  41. ncbi request reprint Trafficking in emotions
    Dan Ehninger
    Nat Neurosci 8:548-50. 2005
  42. ncbi request reprint CREB required for the stability of new and reactivated fear memories
    Satoshi Kida
    Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture, Sakuragaoka, Setagaya Ku, Tokyo 156 8502, Japan
    Nat Neurosci 5:348-55. 2002
    ..The findings presented here delineate the memory processes that require CREB and demonstrate the power of LBD-inducible transgenic systems in the study of complex cognitive processes...
  43. ncbi request reprint Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory
    Vanja Nagy
    Fishberg Department of Neuroscience, The Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurosci 26:1923-34. 2006
    ..Together, these data reveal new functions for MMPs in synaptic and behavioral plasticity...
  44. ncbi request reprint Neurofibromatosis type 1: new insights into neurocognitive issues
    Maria T Acosta
    Department of Neurology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Curr Neurol Neurosci Rep 6:136-43. 2006
    ..This review focuses on these advances, as well as recent preclinical studies that point towards potential pharmacologic interventions for NF1 patients...
  45. pmc Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses
    Mohammad Reza Hojjati
    Department of Neuroscience, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Nat Neurosci 10:1125-7. 2007
    ..These results indicate that alphaCaMKII has a nonenzymatic role in short-term presynaptic plasticity at hippocampal CA3-CA1 synapses...
  46. ncbi request reprint Neuronal competition and selection during memory formation
    Jin Hee Han
    Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Science 316:457-60. 2007
    ..Our results suggest a competitive model underlying memory formation, in which eligible neurons are selected to participate in amemorytrace as a function of their relative CREB activity at the time of learning...
  47. ncbi request reprint Memory reconsolidation and extinction have distinct temporal and biochemical signatures
    Akinobu Suzuki
    Department of Agricultural Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156 8502, Japan
    J Neurosci 24:4787-95. 2004
    ..These studies demonstrate the dynamic nature of memory processing after retrieval and represent a first step toward a molecular dissection of underlying mechanisms...
  48. pmc The antimetabolite ara-CTP blocks long-term memory of conditioned taste aversion
    Jianpeng Wang
    Department of Biology, University of Puerto Rico, San Juan 00931 3360, Puerto Rico, USA
    Learn Mem 10:503-9. 2003
    ..We suggest that DNA ligase-mediated DNA recombination and repair processes are necessary for the expression of LTM in the brain...
  49. ncbi request reprint The molecules of forgetfulness
    Alcino J Silva
    Nature 418:929-30. 2002
  50. pmc Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trial
    Lianne C Krab
    Department of General Pediatrics, Erasmus MC University Medical Center, Sophia Children s Hospital, Rotterdam, The Netherlands
    JAMA 300:287-94. 2008
    ..Recently, it was shown that statin-mediated inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase restores the cognitive deficits in an NF1 mouse model...
  51. ncbi request reprint Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of alphaCaMKII in mice
    Masuo Ohno
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
    Learn Mem 12:211-5. 2005
    ..These results indicate that hippocampal signaling mechanisms that underlie temporal associative learning as assessed by trace eyeblink conditioning may differ from those of spatial and contextual learning...
  52. pmc Stability of recent and remote contextual fear memory
    Paul W Frankland
    Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Learn Mem 13:451-7. 2006
    ..Furthermore, the dissociation between the effects of systemically and centrally administered ANI on remote memory suggests that stability is due, in part, to the distributed nature of remote contextual fear memories...
  53. ncbi request reprint Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability
    Masuo Ohno
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611 3008, USA
    Eur J Neurosci 23:2235-40. 2006
    ..Our findings suggest that alphaCaMKII signaling may function to suppress learning-unrelated changes during training, thereby allowing hippocampal CA1 neurons to increase their excitability appropriately for encoding spatial memories...

Research Grants31

  1. AGE RELATED LEARNING AND MEMORY IMPROVEMENTS
    Alcino Silva; Fiscal Year: 2003
    ..Additionally, these studies will further our understanding of the possible connections between sAHP, LTP and L&M. ..
  2. Mechanisms for Neurological Dysfunction in NF1
    Alcino Silva; Fiscal Year: 2004
    ..Importantly, they will also be crucial for developing targeted treatments for the debilitating learning disabilities associated with Neurofibromatosis Type I. ..
  3. GENE TARGETING APPROACHES TO LEARNING AND MEMORY STUDIES
    Alcino Silva; Fiscal Year: 2004
    ..The studies proposed here will not only further our understanding of the role of a-CaMKII in synaptic plasticity and in L&M, but they will also be critical for insights into cognitive deficits, such as those associated with aging. ..
  4. Mechanisms for Neurological Dysfunction in NF1
    Alcino Silva; Fiscal Year: 2005
    ..Importantly, they will also be crucial for developing targeted treatments for the debilitating learning disabilities associated with Neurofibromatosis Type I. ..
  5. Forward Genetic Approaches to Mechanisms of Cortical Plasticity
    Alcino Silva; Fiscal Year: 2007
    ....
  6. GENE TARGETING APPROACHES TO LEARNING AND MEMORY STUDIES
    Alcino Silva; Fiscal Year: 2007
    ....
  7. Mechanisms for Neurological Dysfunction in NF1
    Alcino Silva; Fiscal Year: 2007
    ..Importantly, they will also be crucial for developing targeted treatments for the debilitating learning disabilities associated with Neurofibromatosis Type I. ..
  8. AGE RELATED LEARNING AND MEMORY IMPROVEMENTS
    Alcino Silva; Fiscal Year: 2004
    ..Additionally, these studies will further our understanding of the possible connections between sAHP, LTP and L&M. ..
  9. GENE TARGETING APPROACHES TO LEARNING AND MEMORY STUDIES
    Alcino Silva; Fiscal Year: 2003
    ..The studies proposed here will not only further our understanding of the role of a-CaMKII in synaptic plasticity and in L&M, but they will also be critical for insights into cognitive deficits, such as those associated with aging. ..
  10. AGE RELATED LEARNING AND MEMORY IMPROVEMENTS
    Alcino Silva; Fiscal Year: 2003
    ..Additionally, these studies will further our understanding of the possible connections between sAHP, LTP and L&M. ..
  11. MECHANISMS FOR NEUROLOGICAL DYSFUNCTION IN NFI
    Alcino Silva; Fiscal Year: 1999
    ....
  12. GENE TARGETING APPROACHES TO LEARNING AND MEMORY STUDIES
    Alcino Silva; Fiscal Year: 1999
    ..To determine whether the alpha CaMKII+/- mutation disrupts memory formation. ..
  13. AGE RELATED LEARNING AND MEMORY IMPROVEMENTS
    Alcino Silva; Fiscal Year: 2000
    ..Additionally, these studies will further our understanding of the possible connections between sAHP, LTP and L&M. ..
  14. PHENOTYPING THE MOUSE NERVOUS SYSTEM AND BEHAVIOR
    Alcino Silva; Fiscal Year: 2000
    ..abstract_text> ..
  15. MECHANISMS FOR NEUROLOGICAL DYSFUNCTION IN NFI
    Alcino Silva; Fiscal Year: 2000
    ....
  16. PHENOTYPING THE MOUSE NERVOUS SYSTEM AND BEHAVIOR
    Alcino Silva; Fiscal Year: 2001
    ..abstract_text> ..
  17. AGE RELATED LEARNING AND MEMORY IMPROVEMENTS
    Alcino Silva; Fiscal Year: 2001
    ..Additionally, these studies will further our understanding of the possible connections between sAHP, LTP and L&M. ..
  18. MECHANISMS FOR NEUROLOGICAL DYSFUNCTION IN NFI
    Alcino Silva; Fiscal Year: 2001
    ....
  19. GENE TARGETING APPROACHES TO LEARNING AND MEMORY STUDIES
    Alcino Silva; Fiscal Year: 2001
    ..The studies proposed here will not only further our understanding of the role of a-CaMKII in synaptic plasticity and in L&M, but they will also be critical for insights into cognitive deficits, such as those associated with aging. ..
  20. PHENOTYPING THE MOUSE NERVOUS SYSTEM AND BEHAVIOR
    Alcino Silva; Fiscal Year: 2002
    ..abstract_text> ..
  21. AGE RELATED LEARNING AND MEMORY IMPROVEMENTS
    Alcino Silva; Fiscal Year: 2002
    ..Additionally, these studies will further our understanding of the possible connections between sAHP, LTP and L&M. ..
  22. GENE TARGETING APPROACHES TO LEARNING AND MEMORY STUDIES
    Alcino Silva; Fiscal Year: 2002
    ..The studies proposed here will not only further our understanding of the role of a-CaMKII in synaptic plasticity and in L&M, but they will also be critical for insights into cognitive deficits, such as those associated with aging. ..
  23. Mechanisms for Neurological Dysfunction in NF1 and Noonan Syndrome
    Alcino J Silva; Fiscal Year: 2010
    ..Additionally, the drug studies proposed could be the preface for clinical trials of cognitive deficits associated with NS, and other mental health disorders, including learning disabilities, autism and schizophrenia. ..