Research Topics
| Alcino SilvaSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1Rui M Costa
Departments of Neurobiology, Psychiatry and Psychology, BRI, University of California at Los Angeles, Los Angeles, California 90095 1761, USA
Nature 415:526-30. 2002..Our findings have implications for the development of treatments for learning deficits associated with NF1...- Molecular and cellular cognition; the unraveling of memory retrievalRobert Brown
Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095, USA
Cell 117:3-4. 2004..In this issue of Cell, use molecular genetic approaches combined with pharmacology to demonstrate that beta-adrenergic receptor function regulates retrieval of certain forms of memory... 
Molecular and cellular approaches to memory allocation in neural circuitsAlcino J Silva
Department of Neurobiology, University of California, Los Angeles, 695 Charles Young Drive South, Los Angeles, CA 90095 1761, USA
Science 326:391-5. 2009..Results from these studies are likely to have a considerable impact on computer science, as well as on the understanding of memory and its disorders...
The science of research: the principles underlying the discovery of cognitive and other biological mechanismsAlcino J Silva
Department of Neurobiology, UCLA, 695 Charles Young Drive South, Los Angeles, CA 90095 1761, United States
J Physiol Paris 101:203-13. 2007..I will discuss both strategies to test this hypothesis and its implications for studies of cognitive function...- Molecular and cellular cognitive studies of the role of synaptic plasticity in memoryAlcino J Silva
Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, 695 Charles Young Drive South, Los Angeles, California 90095, USA
J Neurobiol 54:224-37. 2003..Here, I will review this literature, with a special focus on studies of hippocampal-dependent learning and memory... - The RAS effector RIN1 modulates the formation of aversive memoriesAjay Dhaka
Molecular Biology Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1737, USA
J Neurosci 23:748-57. 2003..These results indicate that RIN1 serves as an inhibitory modulator of neuronal plasticity in aversive memory formation... - Consolidation of CS and US representations in associative fear conditioningPaul W Frankland
Departments of Neurobiology, Psychology and Psychiatry, University of California at Los Angeles, Los Angeles, California 90095-1761, USA
Hippocampus 14:557-69. 2004..Together, these data suggest that this approach is particularly suited for the characterization of molecular and cellular processes underlying the formation of stimulus representations... - Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunctionInbal Israely
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
Curr Biol 14:1657-63. 2004.... - Increased neuronal excitability, synaptic plasticity, and learning in aged Kvbeta1.1 knockout miceGeoffrey G Murphy
Departments of Neurobiology, Psychology, and Psychiatry, Brain Research Institute, University of California, Los Angeles, 2554 Gonda Center, Box 951761, Los Angeles, CA 90095, USA
Curr Biol 14:1907-15. 2004.... - The involvement of the anterior cingulate cortex in remote contextual fear memoryPaul W Frankland
Departments of Neurobiology, Psychiatry, Psychology and Brain Research Institute, UCLA, 695 Charles Young Drive South, Los Angeles, CA 90095 1761, USA
Science 304:881-3. 2004..Accordingly, reversible inactivation of this structure in normal mice disrupts remote memory without affecting recent memory... - Genetic approaches to molecular and cellular cognition: a focus on LTP and learning and memoryAnna Matynia
Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
Annu Rev Genet 36:687-720. 2002..Altogether, these findings not only demonstrate a role for plasticity in learning, they also lay down the foundations for the new field of molecular and cellular cognition... - Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neuronsJian Feng
Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
Nat Neurosci 13:423-30. 2010..We conclude that Dnmt1 and Dnmt3a are required for synaptic plasticity, learning and memory through their overlapping roles in maintaining DNA methylation and modulating neuronal gene expression in adult CNS neurons... - Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant miceStephan G Anagnostaras
Department of Neurobiology, Brain Research Institute, 2554 Gonda Center, Box 951761, University of California, Los Angeles, California 90095 1761, USA
Nat Neurosci 6:51-8. 2003..Our results suggest that the M1 receptor is specifically involved in memory processes for which the cortex and hippocampus interact... - Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memoryAdele P Chen
Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, 90095 1761, USA
J Neurosci Res 83:28-38. 2006..Our findings demonstrate that B-raf plays a role in hippocampal ERK activation, synaptic plasticity, and L&M... - Memory for context becomes less specific with timeBrian J Wiltgen
Departments of Neurobiology, Psychology, Psychiatry and the Brain Research Institute, UCLA, Los Angeles, California 90095, USA
Learn Mem 14:313-7. 2007..These results suggest that context memories are specific early after training when they require the hippocampus, and become more general as they are permanently stored in the cortex... - Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learningYu Zhou
Department of Neurobiology, Semel Institute, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
J Neurosci 27:13843-53. 2007..Together our results demonstrate the importance of interactions between CaMKII and NR2B for CaMKII activity, synaptic plasticity, and learning... - The molecular and cellular biology of enhanced cognitionYong Seok Lee
Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, California 90095, USA
Nat Rev Neurosci 10:126-40. 2009..These findings represent the beginning of a fundamental new approach in the study of enhanced cognition... - CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdalaYu Zhou
Department of Neurobiology, University of California Los Angeles, Los Angeles, California, USA
Nat Neurosci 12:1438-43. 2009..Our findings demonstrate that CREB modulates the allocation of fear memory to specific cells in lateral amygdala and suggest that neuronal excitability is important in this process... - Molecular and cellular mechanisms of memory allocation in neuronetworksJaejoon Won
Department of Neurobiology, and the Brain Research Institute, UCLA, Los Angeles, CA 90095, USA
Neurobiol Learn Mem 89:285-92. 2008..Beyond CREB, there may be a host of other processes that dynamically modulate memory allocation in neuronetworks by shaping cooperation and competition among neurons... - Notch to rememberRui M Costa
Departments of Neurobiology, Psychiatry, and Psychology, University of California-Los Angeles, 695 Young Drive South, Room 2554, Box 951761, Los Angeles, CA 90095-1761, USA
Trends Neurosci 28:429-35. 2005..We also consider the possible involvement of Notch signaling in cognitive disorders... - Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learningYpe Elgersma
Department of Neurobiology, Department of Psychiatry, Department of Psychology, Brain Research Institute, University of California, Los Angeles, CA 90095, USA
Neuron 36:493-505. 2002..Mimicking inhibitory phosphorylation dramatically decreased the association of CaMKII with the PSD and blocked both LTP and learning. These data demonstrate that inhibitory phosphorylation has a critical role in plasticity and learning... - Pharmacologically regulated induction of silent mutations (PRISM): combined pharmacological and genetic approaches for learning and memoryPaul W Frankland
Department of Neurobiology, University of California, Los Angeles, USA
Neuroscientist 9:104-9. 2003..This approach is easily set up and can be used to study the functional interactions between molecules in signaling pathways... - The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1Weidong Li
Department of Neurobiology, University of California, Los Angeles, Los Angeles, California 90095, USA
Curr Biol 15:1961-7. 2005..Therefore, these results demonstrate that lovastatin may prove useful in the treatment of Neurofibromatosis Type 1... - Investigation of age-related cognitive decline using mice as a model system: behavioral correlatesGeoffrey G Murphy
Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, CA 90095-1761, USA
Am J Geriatr Psychiatry 14:1004-11. 2006..It is expected that similar benefits can be realized by developing mouse models for age-related cognitive decline... - Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosisDan Ehninger
Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, 695 Charles E Young Drive South, Los Angeles, California 90095, USA
Nat Med 14:843-8. 2008.... - Neurofibromin regulation of ERK signaling modulates GABA release and learningYijun Cui
Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
Cell 135:549-60. 2008..Importantly, our results also revealed lasting increases in GABA release triggered by learning, indicating that the mechanisms uncovered here are of general importance for learning... - New circuits for old memories: the role of the neocortex in consolidationBrian J Wiltgen
Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095, USA
Neuron 44:101-8. 2004..The studies reviewed here represent the first exciting steps toward the understanding of the molecular, cellular, and systems mechanisms of how the brain stores our oldest and perhaps most defining memories... - DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturationLEAH K HUTNICK
Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, 695 Charles Young Drive South, Los Angeles, CA 90095, USA
Hum Mol Genet 18:2875-88. 2009..Our results suggest that DNA methylation, through its role in modulating neuronal gene expression, plays multiple roles in regulating cell survival and neuronal maturation in the CNS... - A pharmacogenetic inducible approach to the study of NMDA/alphaCaMKII signaling in synaptic plasticityMasuo Ohno
Department of Neurobiology, Brain Research Institute, University of California, Los Angeles 90095 1761, USA
Curr Biol 12:654-6. 2002..This ability to temporally induce recessive mutant phenotypes could be applicable to a broad range of problems and genetic systems... - Reversing neurodevelopmental disorders in adultsDan Ehninger
Department of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology and the Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095 1761, USA
Neuron 60:950-60. 2008..These findings mark a paradigmatic change in the way we understand and envision treating neurodevelopmental disorders... - Investigation of age-related cognitive decline using mice as a model system: neurophysiological correlatesGeoffrey G Murphy
Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095-1761, USA
Am J Geriatr Psychiatry 14:1012-21. 2006..It is expected that similar benefits can be realized by developing mouse models for age-related cognitive decline... - A high through-put reverse genetic screen identifies two genes involved in remote memory in miceAnna Matynia
Department of Neurobiology, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 3:e2121. 2008..This study identifies some of the first genes required for remote memory, and suggests that screens of targeted mutants may be an efficient strategy to identify molecular requirements for this process... - Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortexMegumi Kaneko
Department of Physiology and the Keck Center for Integrative Neurosciences, University of California, San Francisco, CA 94143 0444, USA
Proc Natl Acad Sci U S A 107:19026-31. 2010..These findings demonstrate accelerated neocortical plasticity, which offers an avenue toward future therapies for many neurological and neuropsychiatric disorders... - Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathwaySteven A Kushner
Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, California 90095 1761, USA
J Neurosci 25:9721-34. 2005..Together with previous invertebrate studies, these results demonstrate that presynaptic plasticity represents an important evolutionarily conserved mechanism for modulating learning and memory... - Autophosphorylation of alphaCaMKII is required for ocular dominance plasticitySharif Taha
W M Keck Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 36:483-91. 2002..These results confirm the importance of alphaCaMKII in visual cortical plasticity and suggest that synaptic changes induced by monocular deprivation are stored specifically in glutamatergic synapses made onto excitatory neurons... - Molecular and cellular mechanisms underlying the cognitive deficits associated with neurofibromatosis 1Rui M Costa
Department of Neurobiology, Brain Research Institute, University of California, Los Angeles 90095-1761, USA
J Child Neurol 17:622-6; discussion 627-9, 646-51. 2002..These findings have brought us closer than ever to the development of possible treatments for the learning disabilities associated with neurofibromatosis 1... - Learning and memory deficits in Notch mutant miceRui M Costa
University of California, Los Angeles, Department of Neurobiology, and Brain Research Institute, 695 Young Drive South, Room 2554, Box 951761, Los Angeles, CA 90095 1761, USA
Curr Biol 13:1348-54. 2003.... - Mouse models of neurofibromatosis type I: bridging the GAPRui M Costa
Department of Neurobiology and Brain Research Institute, University of California, Los Angeles, Room 2554, 95 Young Drive South, 90095-1761, USA
Trends Mol Med 9:19-23. 2003..This knowledge will aid the development of treatments for the different pathological processes associated with NF1... - Central nervous system myelination in mice with deficient expression of Notch1 receptorMaria I Givogri
Neurobiochemistry Group, Mental Retardation Research Center, School of Medicine, University of California, Los Angeles, California 90024, USA
J Neurosci Res 67:309-20. 2002.... - MAPK, CREB and zif268 are all required for the consolidation of recognition memoryBruno Bozon
Laboratoire de Neurobiologie de l'Apprentissage, , CNRS UMR 8620, , 91405 Orsay, France
Philos Trans R Soc Lond B Biol Sci 358:805-14. 2003.... - Trafficking in emotionsDan Ehninger
Nat Neurosci 8:548-50. 2005 - CREB required for the stability of new and reactivated fear memoriesSatoshi Kida
Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture, Sakuragaoka, Setagaya Ku, Tokyo 156 8502, Japan
Nat Neurosci 5:348-55. 2002..The findings presented here delineate the memory processes that require CREB and demonstrate the power of LBD-inducible transgenic systems in the study of complex cognitive processes... - Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memoryVanja Nagy
Fishberg Department of Neuroscience, The Mount Sinai School of Medicine, New York, New York 10029 6574, USA
J Neurosci 26:1923-34. 2006..Together, these data reveal new functions for MMPs in synaptic and behavioral plasticity... - Neurofibromatosis type 1: new insights into neurocognitive issuesMaria T Acosta
Department of Neurology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
Curr Neurol Neurosci Rep 6:136-43. 2006..This review focuses on these advances, as well as recent preclinical studies that point towards potential pharmacologic interventions for NF1 patients... - Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapsesMohammad Reza Hojjati
Department of Neuroscience, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Nat Neurosci 10:1125-7. 2007..These results indicate that alphaCaMKII has a nonenzymatic role in short-term presynaptic plasticity at hippocampal CA3-CA1 synapses... - Neuronal competition and selection during memory formationJin Hee Han
Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
Science 316:457-60. 2007..Our results suggest a competitive model underlying memory formation, in which eligible neurons are selected to participate in amemorytrace as a function of their relative CREB activity at the time of learning... - Memory reconsolidation and extinction have distinct temporal and biochemical signaturesAkinobu Suzuki
Department of Agricultural Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156-8502, Japan
J Neurosci 24:4787-95. 2004..These studies demonstrate the dynamic nature of memory processing after retrieval and represent a first step toward a molecular dissection of underlying mechanisms... - The antimetabolite ara-CTP blocks long-term memory of conditioned taste aversionJianpeng Wang
Department of Biology, University of Puerto Rico, San Juan 00931 3360, Puerto Rico, USA
Learn Mem 10:503-9. 2003..We suggest that DNA ligase-mediated DNA recombination and repair processes are necessary for the expression of LTM in the brain... - The molecules of forgetfulnessAlcino J Silva
Nature 418:929-30. 2002 - Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trialLianne C Krab
Department of General Pediatrics, Erasmus MC University Medical Center, Sophia Children s Hospital, Rotterdam, The Netherlands
JAMA 300:287-94. 2008..Recently, it was shown that statin-mediated inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase restores the cognitive deficits in an NF1 mouse model... - Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of alphaCaMKII in miceMasuo Ohno
Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
Learn Mem 12:211-5. 2005..These results indicate that hippocampal signaling mechanisms that underlie temporal associative learning as assessed by trace eyeblink conditioning may differ from those of spatial and contextual learning... - Stability of recent and remote contextual fear memoryPaul W Frankland
Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
Learn Mem 13:451-7. 2006..Furthermore, the dissociation between the effects of systemically and centrally administered ANI on remote memory suggests that stability is due, in part, to the distributed nature of remote contextual fear memories... - Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitabilityMasuo Ohno
Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611 3008, USA
Eur J Neurosci 23:2235-40. 2006..Our findings suggest that alphaCaMKII signaling may function to suppress learning-unrelated changes during training, thereby allowing hippocampal CA1 neurons to increase their excitability appropriately for encoding spatial memories...
Research Grants
- GENE TARGETING APPROACHES TO LEARNING AND MEMORY STUDIESAlcino Silva; Fiscal Year: 2004..The studies proposed here will not only further our understanding of the role of a-CaMKII in synaptic plasticity and in L&M, but they will also be critical for insights into cognitive deficits, such as those associated with aging. ..
- Forward Genetic Approaches to Mechanisms of Cortical PlasticityAlcino Silva; Fiscal Year: 2007....
- GENE TARGETING APPROACHES TO LEARNING AND MEMORY STUDIESAlcino Silva; Fiscal Year: 2007....
- Mechanisms for Neurological Dysfunction in NF1Alcino Silva; Fiscal Year: 2007..Importantly, they will also be crucial for developing targeted treatments for the debilitating learning disabilities associated with Neurofibromatosis Type I. ..
- AGE RELATED LEARNING AND MEMORY IMPROVEMENTSAlcino Silva; Fiscal Year: 2004..Additionally, these studies will further our understanding of the possible connections between sAHP, LTP and L&M. ..
- GENE TARGETING APPROACHES TO LEARNING AND MEMORY STUDIESAlcino Silva; Fiscal Year: 1999..To determine whether the alpha CaMKII+/- mutation disrupts memory formation. ..
- MECHANISMS FOR NEUROLOGICAL DYSFUNCTION IN NFIAlcino Silva; Fiscal Year: 2001....
- PHENOTYPING THE MOUSE NERVOUS SYSTEM AND BEHAVIORAlcino Silva; Fiscal Year: 2002..abstract_text> ..
- Mechanisms for Neurological Dysfunction in NF1 and Noonan SyndromeAlcino J Silva; Fiscal Year: 2010..Additionally, the drug studies proposed could be the preface for clinical trials of cognitive deficits associated with NS, and other mental health disorders, including learning disabilities, autism and schizophrenia. ..