Alcino J Silva

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Encoding and storage of spatial information in the retrosplenial cortex
    Rafał Czajkowski
    Departments of Neurobiology, Integrative Center for Learning and Memory, Semel Institute, Brain Research Institute, Psychiatry, andPsychology, University of California, Los Angeles, CA 90095 Neurobiology Centre, Nencki Institute of Experimental Biology, Warsaw 02 093, Poland and
    Proc Natl Acad Sci U S A 111:8661-6. 2014
  2. pmc α-Calcium calmodulin kinase II modulates the temporal structure of hippocampal bursting patterns
    Jeiwon Cho
    Department of Neurobiology, Brain Research Institute, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e31649. 2012
  3. pmc Adult reversal of cognitive phenotypes in neurodevelopmental disorders
    Alcino J Silva
    Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology and the Brain Research Institute, University of California, 695 Charles Young Drive South, Los Angeles, CA 90095 1761 USA
    J Neurodev Disord 1:150-7. 2009
  4. ncbi request reprint Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning
    Yu Zhou
    Department of Neurobiology, Semel Institute, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
    J Neurosci 27:13843-53. 2007
  5. pmc Neurofibromin regulation of ERK signaling modulates GABA release and learning
    Yijun Cui
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 135:549-60. 2008
  6. ncbi request reprint Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction
    Inbal Israely
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Curr Biol 14:1657-63. 2004
  7. ncbi request reprint The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1
    Weidong Li
    Department of Neurobiology, University of California, Los Angeles, Los Angeles, California 90095, USA
    Curr Biol 15:1961-7. 2005
  8. ncbi request reprint Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory
    Adele P Chen
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, 90095 1761, USA
    J Neurosci Res 83:28-38. 2006
  9. pmc Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
    Jian Feng
    Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Nat Neurosci 13:423-30. 2010
  10. pmc Molecular and cellular approaches to memory allocation in neural circuits
    Alcino J Silva
    Department of Neurobiology, University of California, Los Angeles, 695 Charles Young Drive South, Los Angeles, CA 90095 1761, USA
    Science 326:391-5. 2009

Research Grants

  1. Molecular and Cellular Cognition Meeting
    Alcino Silva; Fiscal Year: 2006

Collaborators

Detail Information

Publications45

  1. pmc Encoding and storage of spatial information in the retrosplenial cortex
    Rafał Czajkowski
    Departments of Neurobiology, Integrative Center for Learning and Memory, Semel Institute, Brain Research Institute, Psychiatry, andPsychology, University of California, Los Angeles, CA 90095 Neurobiology Centre, Nencki Institute of Experimental Biology, Warsaw 02 093, Poland and
    Proc Natl Acad Sci U S A 111:8661-6. 2014
    ..Taken together, these results indicate that the retrosplenial cortex engages in the formation and storage of memory traces for spatial information. ..
  2. pmc α-Calcium calmodulin kinase II modulates the temporal structure of hippocampal bursting patterns
    Jeiwon Cho
    Department of Neurobiology, Brain Research Institute, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e31649. 2012
    ..These results suggest that some of the molecular processes involved in acquiring information may also shape the patterns used to encode this information...
  3. pmc Adult reversal of cognitive phenotypes in neurodevelopmental disorders
    Alcino J Silva
    Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology and the Brain Research Institute, University of California, 695 Charles Young Drive South, Los Angeles, CA 90095 1761 USA
    J Neurodev Disord 1:150-7. 2009
    ..The findings reviewed here provide hope to millions of individuals afflicted with a wide range of neurodevelopmental disorders, including autism, since they suggest that it may be possible to treat or even cure them in adults...
  4. ncbi request reprint Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning
    Yu Zhou
    Department of Neurobiology, Semel Institute, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
    J Neurosci 27:13843-53. 2007
    ..Together our results demonstrate the importance of interactions between CaMKII and NR2B for CaMKII activity, synaptic plasticity, and learning...
  5. pmc Neurofibromin regulation of ERK signaling modulates GABA release and learning
    Yijun Cui
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 135:549-60. 2008
    ..Importantly, our results also revealed lasting increases in GABA release triggered by learning, indicating that the mechanisms uncovered here are of general importance for learning...
  6. ncbi request reprint Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction
    Inbal Israely
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Curr Biol 14:1657-63. 2004
    ....
  7. ncbi request reprint The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1
    Weidong Li
    Department of Neurobiology, University of California, Los Angeles, Los Angeles, California 90095, USA
    Curr Biol 15:1961-7. 2005
    ..Therefore, these results demonstrate that lovastatin may prove useful in the treatment of Neurofibromatosis Type 1...
  8. ncbi request reprint Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory
    Adele P Chen
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, 90095 1761, USA
    J Neurosci Res 83:28-38. 2006
    ..Our findings demonstrate that B-raf plays a role in hippocampal ERK activation, synaptic plasticity, and L&M...
  9. pmc Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
    Jian Feng
    Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Nat Neurosci 13:423-30. 2010
    ..We conclude that Dnmt1 and Dnmt3a are required for synaptic plasticity, learning and memory through their overlapping roles in maintaining DNA methylation and modulating neuronal gene expression in adult CNS neurons...
  10. pmc Molecular and cellular approaches to memory allocation in neural circuits
    Alcino J Silva
    Department of Neurobiology, University of California, Los Angeles, 695 Charles Young Drive South, Los Angeles, CA 90095 1761, USA
    Science 326:391-5. 2009
    ..Results from these studies are likely to have a considerable impact on computer science, as well as on the understanding of memory and its disorders...
  11. ncbi request reprint Consolidation of CS and US representations in associative fear conditioning
    Paul W Frankland
    Departments of Neurobiology, Psychology and Psychiatry, University of California at Los Angeles, Los Angeles, California 90095 1761, USA
    Hippocampus 14:557-69. 2004
    ..Together, these data suggest that this approach is particularly suited for the characterization of molecular and cellular processes underlying the formation of stimulus representations...
  12. pmc CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala
    Yu Zhou
    Department of Neurobiology, University of California Los Angeles, Los Angeles, California, USA
    Nat Neurosci 12:1438-43. 2009
    ..Our findings demonstrate that CREB modulates the allocation of fear memory to specific cells in lateral amygdala and suggest that neuronal excitability is important in this process...
  13. pmc Neurofibromin regulates corticostriatal inhibitory networks during working memory performance
    Carrie Shilyansky
    Department of Neurobiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:13141-6. 2010
    ..Collectively, these integrative mouse and human studies reveal molecular and cellular mechanisms contributing to working memory deficits in NF1...
  14. ncbi request reprint Increased neuronal excitability, synaptic plasticity, and learning in aged Kvbeta1.1 knockout mice
    Geoffrey G Murphy
    Departments of Neurobiology, Psychology, and Psychiatry, Brain Research Institute, University of California, Los Angeles, 2554 Gonda Center, Box 951761, Los Angeles, CA 90095, USA
    Curr Biol 14:1907-15. 2004
    ....
  15. ncbi request reprint Investigation of age-related cognitive decline using mice as a model system: behavioral correlates
    Geoffrey G Murphy
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, CA 90095 1761, USA
    Am J Geriatr Psychiatry 14:1004-11. 2006
    ....
  16. pmc Synaptic tagging during memory allocation
    Thomas Rogerson
    Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, and Psychology, Integrative Center for Learning and Memory, Brain Research Institute, University of California, Los Angeles, California 90095 1761, USA
    Nat Rev Neurosci 15:157-69. 2014
    ..Importantly, the properties of these mechanisms suggest a set of rules that profoundly affect how memories are stored and recalled. ..
  17. ncbi request reprint The RAS effector RIN1 modulates the formation of aversive memories
    Ajay Dhaka
    Molecular Biology Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1737, USA
    J Neurosci 23:748-57. 2003
    ..These results indicate that RIN1 serves as an inhibitory modulator of neuronal plasticity in aversive memory formation...
  18. pmc Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway
    Steven A Kushner
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, California 90095 1761, USA
    J Neurosci 25:9721-34. 2005
    ..Together with previous invertebrate studies, these results demonstrate that presynaptic plasticity represents an important evolutionarily conserved mechanism for modulating learning and memory...
  19. ncbi request reprint The involvement of the anterior cingulate cortex in remote contextual fear memory
    Paul W Frankland
    Departments of Neurobiology, Psychiatry, Psychology and Brain Research Institute, UCLA, 695 Charles Young Drive South, Los Angeles, CA 90095 1761, USA
    Science 304:881-3. 2004
    ..Accordingly, reversible inactivation of this structure in normal mice disrupts remote memory without affecting recent memory...
  20. pmc Muscleblind1, but not Dmpk or Six5, contributes to a complex phenotype of muscular and motivational deficits in mouse models of myotonic dystrophy
    Anna Matynia
    Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology and the Brain Research Institute, Gonda Neuroscience and Genetics Center, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e9857. 2010
    ..All three models of cDM1 exhibit normal spatial learning and memory. These data identify MBNL1 as a potential regulator of emotional state with decreased MBNL1 levels underlying the motivational deficits observed in cDM1...
  21. ncbi request reprint Pharmacologically regulated induction of silent mutations (PRISM): combined pharmacological and genetic approaches for learning and memory
    Paul W Frankland
    Department of Neurobiology, University of California, Los Angeles, USA
    Neuroscientist 9:104-9. 2003
    ..This approach is easily set up and can be used to study the functional interactions between molecules in signaling pathways...
  22. pmc Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis
    Dan Ehninger
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, 695 Charles E Young Drive South, Los Angeles, California 90095, USA
    Nat Med 14:843-8. 2008
    ....
  23. pmc mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons
    MiOu Zhou
    Departments of Neurobiology, Psychology, and Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, UCLA, Los Angeles, CA 90095, USA
    Neuron 77:647-54. 2013
    ..Consequently, treatments directed at this cell population may have a significant impact on these phenotypes...
  24. pmc Associative fear learning enhances sparse network coding in primary sensory cortex
    Amos Gdalyahu
    Department of Neurobiology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neuron 75:121-32. 2012
    ..Our results define how the cortical representation of a sensory stimulus is shaped by associative fear learning. These changes are proposed to enhance efficient sensory processing after associative learning...
  25. pmc The molecular and cellular biology of enhanced cognition
    Yong Seok Lee
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, California 90095, USA
    Nat Rev Neurosci 10:126-40. 2009
    ..These findings represent the beginning of a fundamental new approach in the study of enhanced cognition...
  26. pmc A high through-put reverse genetic screen identifies two genes involved in remote memory in mice
    Anna Matynia
    Department of Neurobiology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 3:e2121. 2008
    ..This study identifies some of the first genes required for remote memory, and suggests that screens of targeted mutants may be an efficient strategy to identify molecular requirements for this process...
  27. ncbi request reprint Investigation of age-related cognitive decline using mice as a model system: neurophysiological correlates
    Geoffrey G Murphy
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095 1761, USA
    Am J Geriatr Psychiatry 14:1012-21. 2006
    ..Here, the authors explore the possibility that age-related changes in neuronal function may be the result of deregulation of cytosolic free calcium homeostasis...
  28. ncbi request reprint Molecular and cellular cognitive studies of the role of synaptic plasticity in memory
    Alcino J Silva
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, 695 Charles Young Drive South, Los Angeles, California 90095, USA
    J Neurobiol 54:224-37. 2003
    ..Here, I will review this literature, with a special focus on studies of hippocampal-dependent learning and memory...
  29. pmc Molecular and cellular mechanisms of memory allocation in neuronetworks
    Jaejoon Won
    Department of Neurobiology, and the Brain Research Institute, UCLA, Los Angeles, CA 90095, USA
    Neurobiol Learn Mem 89:285-92. 2008
    ..Beyond CREB, there may be a host of other processes that dynamically modulate memory allocation in neuronetworks by shaping cooperation and competition among neurons...
  30. pmc Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice
    Weidong Li
    Department of Neurobiology, Semel Institute, Brain Research Institute, and Department of Urology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:18280-5. 2007
    ..Our findings demonstrate that alterations in DISC1 function during brain development contribute to schizophrenia pathogenesis...
  31. ncbi request reprint Notch to remember
    Rui M Costa
    Departments of Neurobiology, Psychiatry, and Psychology, University of California Los Angeles, 695 Young Drive South, Room 2554, Box 951761, Los Angeles, CA 90095 1761, USA
    Trends Neurosci 28:429-35. 2005
    ..We also consider the possible involvement of Notch signaling in cognitive disorders...
  32. pmc DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation
    LEAH K HUTNICK
    Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, 695 Charles Young Drive South, Los Angeles, CA 90095, USA
    Hum Mol Genet 18:2875-88. 2009
    ..Our results suggest that DNA methylation, through its role in modulating neuronal gene expression, plays multiple roles in regulating cell survival and neuronal maturation in the CNS...
  33. ncbi request reprint Molecular and cellular cognition; the unraveling of memory retrieval
    Robert Brown
    Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 117:3-4. 2004
    ..In this issue of Cell, use molecular genetic approaches combined with pharmacology to demonstrate that beta-adrenergic receptor function regulates retrieval of certain forms of memory...
  34. ncbi request reprint Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice
    Stephan G Anagnostaras
    Department of Neurobiology, Brain Research Institute, 2554 Gonda Center, Box 951761, University of California, Los Angeles, California 90095 1761, USA
    Nat Neurosci 6:51-8. 2003
    ..Our results suggest that the M1 receptor is specifically involved in memory processes for which the cortex and hippocampus interact...
  35. ncbi request reprint Memory for context becomes less specific with time
    Brian J Wiltgen
    Departments of Neurobiology, Psychology, Psychiatry and the Brain Research Institute, UCLA, Los Angeles, California 90095, USA
    Learn Mem 14:313-7. 2007
    ..These results suggest that context memories are specific early after training when they require the hippocampus, and become more general as they are permanently stored in the cortex...
  36. pmc Reversing neurodevelopmental disorders in adults
    Dan Ehninger
    Department of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology and the Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095 1761, USA
    Neuron 60:950-60. 2008
    ..These findings mark a paradigmatic change in the way we understand and envision treating neurodevelopmental disorders...
  37. ncbi request reprint Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning
    Ype Elgersma
    Department of Neurobiology, Department of Psychiatry, Department of Psychology, Brain Research Institute, University of California, Los Angeles, CA 90095, USA
    Neuron 36:493-505. 2002
    ..Mimicking inhibitory phosphorylation dramatically decreased the association of CaMKII with the PSD and blocked both LTP and learning. These data demonstrate that inhibitory phosphorylation has a critical role in plasticity and learning...
  38. pmc NMDA mediated contextual conditioning changes miRNA expression
    Min Jeong Kye
    Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, United States of America
    PLoS ONE 6:e24682. 2011
    ..These findings point to a role for miRNAs in learning and memory that includes mTOR-dependent modulation of protein synthesis...
  39. ncbi request reprint Learning and memory deficits in Notch mutant mice
    Rui M Costa
    University of California, Los Angeles, Department of Neurobiology, and Brain Research Institute, 695 Young Drive South, Room 2554, Box 951761, Los Angeles, CA 90095 1761, USA
    Curr Biol 13:1348-54. 2003
    ....
  40. ncbi request reprint New circuits for old memories: the role of the neocortex in consolidation
    Brian J Wiltgen
    Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Neuron 44:101-8. 2004
    ..The studies reviewed here represent the first exciting steps toward the understanding of the molecular, cellular, and systems mechanisms of how the brain stores our oldest and perhaps most defining memories...
  41. ncbi request reprint Genetic approaches to molecular and cellular cognition: a focus on LTP and learning and memory
    Anna Matynia
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
    Annu Rev Genet 36:687-720. 2002
    ..Altogether, these findings not only demonstrate a role for plasticity in learning, they also lay down the foundations for the new field of molecular and cellular cognition...
  42. doi request reprint The science of research: the principles underlying the discovery of cognitive and other biological mechanisms
    Alcino J Silva
    Department of Neurobiology, UCLA, 695 Charles Young Drive South, Los Angeles, CA 90095 1761, United States
    J Physiol Paris 101:203-13. 2007
    ..I will discuss both strategies to test this hypothesis and its implications for studies of cognitive function...
  43. ncbi request reprint Mouse models of neurofibromatosis type I: bridging the GAP
    Rui M Costa
    Department of Neurobiology and Brain Research Institute, University of California, Los Angeles, Room 2554, 95 Young Drive South, 90095 1761, USA
    Trends Mol Med 9:19-23. 2003
    ..This knowledge will aid the development of treatments for the different pathological processes associated with NF1...
  44. ncbi request reprint A pharmacogenetic inducible approach to the study of NMDA/alphaCaMKII signaling in synaptic plasticity
    Masuo Ohno
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles 90095 1761, USA
    Curr Biol 12:654-6. 2002
    ..This ability to temporally induce recessive mutant phenotypes could be applicable to a broad range of problems and genetic systems...
  45. doi request reprint Molecular aspects, clinical aspects and possible treatment modalities for Costello syndrome: Proceedings from the 1st International Costello Syndrome Research Symposium 2007
    Katherine A Rauen
    Department of Pediatrics, Division of Medical Genetics, University of California, San Francisco, California, USA
    Am J Med Genet A 146:1205-17. 2008

Research Grants1

  1. Molecular and Cellular Cognition Meeting
    Alcino Silva; Fiscal Year: 2006
    ....