CHRISTOPHER SILLIMAN

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint The role of endothelial activation in the pathogenesis of transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center and the Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80230, USA
    Transfusion 45:109S-116S. 2005
  2. ncbi request reprint Transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center, University of Colorado School of Medicine, 717 Yosemite Circle, Denver, CO 80230, USA
    Blood Rev 20:139-59. 2006
  3. ncbi request reprint Lysophosphatidylcholines prime the NADPH oxidase and stimulate multiple neutrophil functions through changes in cytosolic calcium
    Christopher C Silliman
    Bonfils Blood Center, Denver, Colorado 80230, USA
    J Leukoc Biol 73:511-24. 2003
  4. ncbi request reprint Plasma and lipids from stored platelets cause acute lung injury in an animal model
    Christopher C Silliman
    Bonfils Blood Center, 717 Yosemite Circle, Denver, CO 80123, USA
    Transfusion 43:633-40. 2003
  5. ncbi request reprint Acute Philadelphia chromosome-positive leukemia in an adolescent boy after liver transplantation
    Christopher C Silliman
    Bonfils Blood Center, 717 Yosemite Circle, Denver, CO 80220, U S A
    J Pediatr Hematol Oncol 25:565-8. 2003
  6. pmc Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model
    Christopher C Silliman
    Bonfils Blood Center and the Department of Pediatrics, University of Colorado at Denver School of Medicine 80230, USA
    Blood 109:1752-5. 2007
  7. ncbi request reprint Transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Blood 105:2266-73. 2005
  8. pmc Proteomic analysis of human mesenteric lymph
    Monika Dzieciatkowska
    Department of Biochemistry and Molecular Genetics, University of Colorado, Denver, CO, USA
    Shock 35:331-8. 2011
  9. ncbi request reprint Transfusion-related acute lung injury: definition and review
    Pearl Toy
    School of Medicine, University of California San Francisco, San Francisco, CA 94143 0100, USA
    Crit Care Med 33:721-6. 2005
  10. ncbi request reprint Systemic neutrophil priming by lipid mediators in post-shock mesenteric lymph exists across species
    Eric L Sarin
    Departments of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
    J Trauma 57:950-4. 2004

Research Grants

  1. ANIMAL MODEL OF TRANSFUSION RELATED ACUTE LUNG INJURY
    CHRISTOPHER SILLIMAN; Fiscal Year: 2002
  2. Lyso-PCs activate PMNs and endothelium via PKC
    CHRISTOPHER SILLIMAN; Fiscal Year: 2006

Collaborators

Detail Information

Publications37

  1. ncbi request reprint The role of endothelial activation in the pathogenesis of transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center and the Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80230, USA
    Transfusion 45:109S-116S. 2005
  2. ncbi request reprint Transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center, University of Colorado School of Medicine, 717 Yosemite Circle, Denver, CO 80230, USA
    Blood Rev 20:139-59. 2006
    ..The definition of TRALI, patient predisposition, treatment, prevention and reporting guidelines are also examined...
  3. ncbi request reprint Lysophosphatidylcholines prime the NADPH oxidase and stimulate multiple neutrophil functions through changes in cytosolic calcium
    Christopher C Silliman
    Bonfils Blood Center, Denver, Colorado 80230, USA
    J Leukoc Biol 73:511-24. 2003
    ..In conclusion, lyso-PCs affect multiple PMN functions in a Ca(2)(+)-dependent manner that involves the activation of a pertussis toxin-sensitive G-protein...
  4. ncbi request reprint Plasma and lipids from stored platelets cause acute lung injury in an animal model
    Christopher C Silliman
    Bonfils Blood Center, 717 Yosemite Circle, Denver, CO 80123, USA
    Transfusion 43:633-40. 2003
    ..We hypothesize that lipids generated during storage of PLTs cause TRALI in a two-event animal model...
  5. ncbi request reprint Acute Philadelphia chromosome-positive leukemia in an adolescent boy after liver transplantation
    Christopher C Silliman
    Bonfils Blood Center, 717 Yosemite Circle, Denver, CO 80220, U S A
    J Pediatr Hematol Oncol 25:565-8. 2003
    ..The authors conclude that this patient may have presented in a lymphoid blast crisis of chronic myelogenous leukemia with an acute T-cell leukemia/lymphoma syndrome...
  6. pmc Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model
    Christopher C Silliman
    Bonfils Blood Center and the Department of Pediatrics, University of Colorado at Denver School of Medicine 80230, USA
    Blood 109:1752-5. 2007
    ..Thus, antibodies to HNA-3a primed PMNs and caused PMN-mediated HMVEC cytotoxicity in a two-event model identical to biologic response modifiers implicated in TRALI...
  7. ncbi request reprint Transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Blood 105:2266-73. 2005
    ..Prevention, treatment, and a proposed definition of TRALI, especially in the context of ALI, are also examined...
  8. pmc Proteomic analysis of human mesenteric lymph
    Monika Dzieciatkowska
    Department of Biochemistry and Molecular Genetics, University of Colorado, Denver, CO, USA
    Shock 35:331-8. 2011
    ..Further studies will be required to determine if the proteins identified participate in the pathogenesis of multiple organ failure and if they can be used as diagnostic markers...
  9. ncbi request reprint Transfusion-related acute lung injury: definition and review
    Pearl Toy
    School of Medicine, University of California San Francisco, San Francisco, CA 94143 0100, USA
    Crit Care Med 33:721-6. 2005
    ....
  10. ncbi request reprint Systemic neutrophil priming by lipid mediators in post-shock mesenteric lymph exists across species
    Eric L Sarin
    Departments of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
    J Trauma 57:950-4. 2004
    ....
  11. ncbi request reprint Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation
    Forest R Sheppard
    Department of Surgery, Denver Health Medical Center, Colorado, USA
    J Leukoc Biol 78:1025-42. 2005
    ..This review will discuss the individual components associated with the NADPH oxidase complex and the function of each of these units in each physiologic stage of the PMN: rested, primed, and activated...
  12. ncbi request reprint The two-event model of transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center and Departments of Pediatrics and Surgery, University of Colorado School of Medicine, Denver, CO, USA
    Crit Care Med 34:S124-31. 2006
    ..Laboratory studies, both in vitro and in vivo, are discussed as well as human studies of TRALI. Methods to avoid patient exposure to blood components that may cause TRALI are also discussed...
  13. ncbi request reprint Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation
    Nathan J D McLaughlin
    Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    J Immunol 176:7039-50. 2006
    ..We conclude that PAF signaling requires CME, beta-arrestin-1 recruitment of a p38 MAPK signalosome, and specific actin bundle formation at the PAFR for transduction before endosomal scission...
  14. pmc Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury
    Samina Yasmin Khan
    Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Blood 108:2455-62. 2006
    ..We concluded that sCD40L, which accumulates during blood component storage, has the capacity to activate adherent PMNs, causing endothelial damage and possibly TRALI in predisposed patients...
  15. ncbi request reprint High-volume transfusion from male-only versus female donor plasma and hypoxemia in the critically ill
    Christopher C Silliman
    Crit Care Med 35:1775. 2007
  16. doi request reprint Arachidonic acid in postshock mesenteric lymph induces pulmonary synthesis of leukotriene B4
    Janeen R Jordan
    Department of Surgery, University of Colorado Denver, Denver, CO, USA
    J Appl Physiol 104:1161-6. 2008
    ..Collectively, these data indicate that splanchnic ischemia/reperfusion activates gut PLA(2)-mediated release of AA into the lymph where it is delivered to the lungs, provoking LTB(4) production and subsequent PMN-mediated lung injury...
  17. pmc Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils
    Nathan J D McLaughlin
    Bonfils Blood Center, University of Colorado Denver School of Medicine, Children s Hospital, Denver, CO 80230, USA
    J Immunol 180:8192-203. 2008
    ..In conclusion, PAF transduces signals through CME, and such GPCR signaling may allow for pharmacological manipulation of these cells to decrease PMN-mediated acute organ injury...
  18. ncbi request reprint Transfusion-induced leukocyte IL-8 gene expression is avoided by the use of human polymerized hemoglobin
    Forest R Sheppard
    Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
    J Trauma 57:720-4; discussion 724-5. 2004
    ..To further elucidate the mechanisms responsible for this difference in IL-8, we devised an ex-vivo transfusion model. We hypothesize that pRBC transfusion induces increased IL-8 gene expression that is avoided by the use of PolyHb...
  19. ncbi request reprint Acute hypoxemia in humans enhances the neutrophil inflammatory response
    Douglas Y Tamura
    Department of Surgery, Denver Health Medical Center, Colorado, USA
    Shock 17:269-73. 2002
    ..These results indicate that relevant acute hypoxemic events observed in the clinical setting enhance several PMN cytotoxic functions and suggest that a transient hypoxemic insult may promote hyperinflammation...
  20. ncbi request reprint Hyperosmolarity abrogates neutrophil cytotoxicity provoked by post-shock mesenteric lymph
    Ricardo J Gonzalez
    Denver Health Medical Center, Department of Surgery, Colorado 80204, USA
    Shock 18:29-32. 2002
    ..These studies suggest inhibition of PMN signal transduction is a mechanism whereby HTS resuscitation abrogates acute lung injury...
  21. ncbi request reprint Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 MAP kinase activation
    Travis H Wyman
    Bonfils Blood Center, Denver, CO 80230, USA
    J Leukoc Biol 72:401-9. 2002
    ..We conclude that IL-18, at physiologic concentrations, is an effective PMN priming agent that requires p38 MAP kinase activity...
  22. ncbi request reprint Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion
    Christopher C Silliman
    Bonfils Blood Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    Am J Physiol Cell Physiol 283:C1102-13. 2002
    ..sPLA(2)-IB and sPLA(2)-IIA caused PMN adhesion. We conclude that PMNs contain a membrane M-type sPLA(2)-R that activates p38 MAPK...
  23. ncbi request reprint A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: requirements for adherence and chemokine release
    Travis H Wyman
    Bonfils Blood Center and Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80230, USA
    Am J Physiol Cell Physiol 283:C1592-603. 2002
    ..In conclusion, sequential exposure of PMNs to priming agents activates the microbicidal arsenal, and PMN-mediated HMVEC damage was the result of two insults: HMVEC activation and PMN oxidase assembly...
  24. ncbi request reprint Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors
    Christopher C Silliman
    Bonfils Blood Center and the Department of Pediatrics, University of Colorado School of Medicine, Denver, USA
    Blood 101:454-62. 2003
    ..TRALI, like the acute respiratory distress syndrome, may be a 2-event phenomenon with both recipient predisposition and factors in the stored units playing major roles...
  25. ncbi request reprint "Primed" human neutrophils on a standard peripheral blood smear
    orest R Sheppard
    University of Colorado Health Sciences Center, Denver, USA
    J Am Coll Surg 195:731. 2002
  26. ncbi request reprint The injured child is resistant to multiple organ failure: a different inflammatory response?
    Casey M Calkins
    Department of Surgery, University of Colorado Health Sciences Center, Denver 80262, USA
    J Trauma 53:1058-63. 2002
    ..The purpose of this study was to describe the incidence, course, and severity of pediatric postinjury MOF. We hypothesized that the incidence and severity of postinjury MOF in children would be less when compared with adults...
  27. ncbi request reprint Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute
    Jeffrey L Johnson
    Department of Surgery, Denver Health Medical Center, 777 Bannock Street, Denver, CO 80204, USA
    J Trauma 54:133-9; discussion 139-40. 2003
    ..Through the use of a polymerized human hemoglobin (PolyHeme), we have been able to measure the inflammatory response in patients resuscitated with minimal exposure to banked components in the early postinjury period...
  28. ncbi request reprint Formyl-Met-Leu-Phe induces calcium-dependent tyrosine phosphorylation of Rel-1 in neutrophils
    Marguerite R Kelher
    Department of Surgery, University of Colorado Health Science Center School of Medicine, Denver, CO 80230, USA
    Cell Calcium 34:445-55. 2003
    ..Thus, fMLP concentrations that prime or activate the oxidase cause a rapid Ca2+-dependent tyrosine phosphorylation of Rel-1 involving p38 MAPK activation...
  29. ncbi request reprint The abdominal compartment syndrome as a second insult during systemic neutrophil priming provokes multiple organ injury
    Joao B Rezende-Neto
    Department of Surgery, Faculty of Medicine of the Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil 30350 210
    Shock 20:303-8. 2003
    ..This clinically relevant two-event animal model of PMN organ injury may be useful in elucidating therapy strategies to prevent postinjury MOF...
  30. ncbi request reprint Clinically relevant hypertonicity prevents stored blood- and lipid-mediated delayed neutrophil apoptosis independent of p38 MAPK or caspase-3 activation
    Walter L Biffl
    Department of Surgery, Rhode Island Hospital Brown Medical School, Providence, RI, USA
    Surgery 134:86-91. 2003
    ..We hypothesized that clinically relevant HTS would provoke PMN apoptosis, as well as prevent stored blood- and lipid-mediated delayed PMN apoptosis through activation of p38 mitogen-activated protein kinase (MAPK) and caspase-3...
  31. ncbi request reprint Post-hemorrhagic shock mesenteric lymph activates human pulmonary microvascular endothelium for in vitro neutrophil-mediated injury: the role of intercellular adhesion molecule-1
    Ricardo J Gonzalez
    Department of Surgery, Denver Health Medical Center and University of Colorado, 80204, USA
    J Trauma 54:219-23. 2003
    ..We hypothesize that postshock lymph induces neutrophil (PMN)-mediated endothelial cell damage in an intercellular adhesion molecule-1 (ICAM-1)-dependent fashion, and devised a two-insult model to test this hypothesis...
  32. ncbi request reprint Clinically relevant osmolar stress inhibits priming-induced PMN NADPH oxidase subunit translocation
    Forest R Sheppard
    Department of Surgery, Denver Health Medical Center, University of Colorado School of Medicine, Denver, Colorado, USA
    J Trauma 58:752-7; discussion 757. 2005
    ..Osmolar stress attenuates PAF priming of the oxidase. Consequently, we hypothesized that clinically relevant osmolar stress inhibits PAF priming-induced p67 translocation...
  33. ncbi request reprint Hemolytic disease of the newborn caused by a high titer anti-group B IgG from a group A mother
    Michael Wang
    Pediatr Blood Cancer 45:861-2. 2005
  34. doi request reprint The transfusion of pre storage leukoreduced packed red blood cells to injured patients
    Christopher C Silliman
    Crit Care Med 36:1661-2. 2008
  35. ncbi request reprint Increased rate of infection associated with transfusion of old blood after severe injury
    Patrick J Offner
    Trauma Service, St Anthony Central Hospital, 4231 W 16th Ave, Denver, CO 80204, USA
    Arch Surg 137:711-6; discussion 716-7. 2002
    ..We hypothesized that transfusion of old blood increases infection risk in severely injured patients...
  36. doi request reprint Oncogenic and angiogenic growth factors accumulate during routine storage of apheresis platelet concentrates
    Julie Kanter
    Department of Pediatrics, Washington University, St Louis, Missouri, USA
    Clin Cancer Res 14:3942-7. 2008
    ....
  37. ncbi request reprint Transfusion of the injured patient: proceed with caution
    Christopher C Silliman
    Bonfils Blood Center, Denver Health Medical Center, Denver, Colorado 80230, USA
    Shock 21:291-9. 2004
    ..We further summarize studies with hemoglobin substitutes, whose use may obviate many of the untoward events of transfusion and promise to lead to better outcomes for injured patients...

Research Grants8

  1. ANIMAL MODEL OF TRANSFUSION RELATED ACUTE LUNG INJURY
    CHRISTOPHER SILLIMAN; Fiscal Year: 2002
    ..Completion of these specific aims will provide information to target areas for clinical intervention to make transfusions safer. ..
  2. Lyso-PCs activate PMNs and endothelium via PKC
    CHRISTOPHER SILLIMAN; Fiscal Year: 2006
    ..Completion of these specific aims will likely result in targets for in vitro, and possibly clinical, intervention to develop methods to inhibit or to attenuate the effects of these lipids and ultimately make transfusion safer. ..