Christopher C Silliman

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Transfusion of the injured patient: proceed with caution
    Christopher C Silliman
    Bonfils Blood Center, Denver Health Medical Center, Denver, Colorado 80230, USA
    Shock 21:291-9. 2004
  2. ncbi request reprint Lysophosphatidylcholines prime the NADPH oxidase and stimulate multiple neutrophil functions through changes in cytosolic calcium
    Christopher C Silliman
    Bonfils Blood Center, Denver, Colorado 80230, USA
    J Leukoc Biol 73:511-24. 2003
  3. pmc Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils
    Nathan J D McLaughlin
    Bonfils Blood Center, University of Colorado Denver School of Medicine, Children s Hospital, Denver, CO 80230, USA
    J Immunol 180:8192-203. 2008
  4. ncbi request reprint Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation
    Nathan J D McLaughlin
    Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    J Immunol 176:7039-50. 2006
  5. pmc Tumor necrosis factor-alpha causes release of cytosolic interleukin-18 from human neutrophils
    Christopher C Silliman
    Research Dept, Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Am J Physiol Cell Physiol 298:C714-24. 2010
  6. ncbi request reprint Formyl-Met-Leu-Phe induces calcium-dependent tyrosine phosphorylation of Rel-1 in neutrophils
    Marguerite R Kelher
    Department of Surgery, University of Colorado Health Science Center School of Medicine, Denver, CO 80230, USA
    Cell Calcium 34:445-55. 2003
  7. pmc Lysophosphatidylcholines activate G2A inducing G(αi)₋₁-/G(αq/)₁₁- Ca²(+) flux, G(βγ)-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs
    Samina Y Khan
    Bonfils Blood Center, Denver, CO 80230, USA
    Biochem J 432:35-45. 2010
  8. pmc Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophils
    Phillip C Eckels
    Department of Surgery, Denver Health Medical Center, Denver, Colorado, USA
    Am J Physiol Cell Physiol 297:C886-97. 2009
  9. pmc Hyperosmolarity attenuates TNF-α-mediated proinflammatory activation of human pulmonary microvascular endothelial cells
    Anirban Banerjee
    Department of Surgery, Denver Health Medical Center, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    Shock 39:366-72. 2013
  10. pmc Accumulation of pro-cancer cytokines in the plasma fraction of stored packed red cells
    Douglas D Benson
    Denver Health Medical Center, 777 Bannock St, Denver, CO 80204 0206, USA
    J Gastrointest Surg 16:460-8. 2012

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Transfusion of the injured patient: proceed with caution
    Christopher C Silliman
    Bonfils Blood Center, Denver Health Medical Center, Denver, Colorado 80230, USA
    Shock 21:291-9. 2004
    ..We further summarize studies with hemoglobin substitutes, whose use may obviate many of the untoward events of transfusion and promise to lead to better outcomes for injured patients...
  2. ncbi request reprint Lysophosphatidylcholines prime the NADPH oxidase and stimulate multiple neutrophil functions through changes in cytosolic calcium
    Christopher C Silliman
    Bonfils Blood Center, Denver, Colorado 80230, USA
    J Leukoc Biol 73:511-24. 2003
    ..In conclusion, lyso-PCs affect multiple PMN functions in a Ca(2)(+)-dependent manner that involves the activation of a pertussis toxin-sensitive G-protein...
  3. pmc Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils
    Nathan J D McLaughlin
    Bonfils Blood Center, University of Colorado Denver School of Medicine, Children s Hospital, Denver, CO 80230, USA
    J Immunol 180:8192-203. 2008
    ..In conclusion, PAF transduces signals through CME, and such GPCR signaling may allow for pharmacological manipulation of these cells to decrease PMN-mediated acute organ injury...
  4. ncbi request reprint Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation
    Nathan J D McLaughlin
    Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    J Immunol 176:7039-50. 2006
    ..We conclude that PAF signaling requires CME, beta-arrestin-1 recruitment of a p38 MAPK signalosome, and specific actin bundle formation at the PAFR for transduction before endosomal scission...
  5. pmc Tumor necrosis factor-alpha causes release of cytosolic interleukin-18 from human neutrophils
    Christopher C Silliman
    Research Dept, Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Am J Physiol Cell Physiol 298:C714-24. 2010
    ..Extracellular IL-18 participates in TNF-alpha priming of the PMN oxidase as demonstrated by inhibition with the IL-18 binding protein...
  6. ncbi request reprint Formyl-Met-Leu-Phe induces calcium-dependent tyrosine phosphorylation of Rel-1 in neutrophils
    Marguerite R Kelher
    Department of Surgery, University of Colorado Health Science Center School of Medicine, Denver, CO 80230, USA
    Cell Calcium 34:445-55. 2003
    ..Thus, fMLP concentrations that prime or activate the oxidase cause a rapid Ca2+-dependent tyrosine phosphorylation of Rel-1 involving p38 MAPK activation...
  7. pmc Lysophosphatidylcholines activate G2A inducing G(αi)₋₁-/G(αq/)₁₁- Ca²(+) flux, G(βγ)-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs
    Samina Y Khan
    Bonfils Blood Center, Denver, CO 80230, USA
    Biochem J 432:35-45. 2010
    ..We conclude that lyso-PC activation of G2A caused release of G(αi)₋₁, G(αq/)₁₁ and G(βγ), resulting in cytosolic Ca²(+) flux, Hck activation, and recruitment of clathrin, β-arrestin-1 and GRK6...
  8. pmc Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophils
    Phillip C Eckels
    Department of Surgery, Denver Health Medical Center, Denver, Colorado, USA
    Am J Physiol Cell Physiol 297:C886-97. 2009
    ..Thus, amantadine and rimantadine have the potential to ameliorate PMN-mediated tissue damage in humans...
  9. pmc Hyperosmolarity attenuates TNF-α-mediated proinflammatory activation of human pulmonary microvascular endothelial cells
    Anirban Banerjee
    Department of Surgery, Denver Health Medical Center, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    Shock 39:366-72. 2013
    ..01). In conclusion, HTS reduces PMN-HMVEC adhesion and TNF-α-induced proinflammatory activation of primary HMVECs via attenuation of nuclear factor-κB signaling...
  10. pmc Accumulation of pro-cancer cytokines in the plasma fraction of stored packed red cells
    Douglas D Benson
    Denver Health Medical Center, 777 Bannock St, Denver, CO 80204 0206, USA
    J Gastrointest Surg 16:460-8. 2012
    ..We analyzed the plasma fraction of stored pRBCs for pro-cancer cytokines and evaluated the affect of both storage time and leukocyte reduction on these mediators...
  11. doi request reprint Arachidonic acid in postshock mesenteric lymph induces pulmonary synthesis of leukotriene B4
    Janeen R Jordan
    Department of Surgery, University of Colorado Denver, Denver, CO, USA
    J Appl Physiol (1985) 104:1161-6. 2008
    ..Collectively, these data indicate that splanchnic ischemia/reperfusion activates gut PLA(2)-mediated release of AA into the lymph where it is delivered to the lungs, provoking LTB(4) production and subsequent PMN-mediated lung injury...
  12. pmc Hemoglobin-based oxygen carrier mitigates transfusion-mediated pancreas cancer progression
    Karen K Lo
    Department of Surgery, Denver Health Medical Center, University of Colorado Denver, Denver, CO, USA
    Ann Surg Oncol 20:2073-7. 2013
    ..We hypothesize these untoward effects will be mitigated by use of a hemoglobin-based oxygen carrier (HBOC)...
  13. doi request reprint Activation state of stromal inflammatory cells in murine metastatic pancreatic adenocarcinoma
    Douglas D Benson
    Denver Health Medical Center, Denver, CO 80204 0206, USA
    Am J Physiol Regul Integr Comp Physiol 302:R1067-75. 2012
    ..TANs are localized at the invasive front of the metastasis, where they colocalize with MMP-9. Improved understanding of these interactions may lead to targeted therapies for pancreas adenocarcinoma...
  14. pmc Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury
    Christopher C Silliman
    Bonfils Blood Center, and the Department of Surgery, Denver Health Medical, Denver, Colorado 80230, USA
    Transfusion 51:2549-54. 2011
    ....
  15. pmc Leukotriene b4 and its metabolites prime the neutrophil oxidase and induce proinflammatory activation of human pulmonary microvascular endothelial cells
    John C Eun
    The Department of Surgery, Denver Health Medical Center, Colorado, USA
    Shock 35:240-4. 2011
    ..These data have expanded the repertoire of causative agents in acute lung injury and postinjury multiple organ failure...
  16. ncbi request reprint Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute
    Jeffrey L Johnson
    Department of Surgery, Denver Health Medical Center, 777 Bannock Street, Denver, CO 80204, USA
    J Trauma 54:133-9; discussion 139-40. 2003
    ..Through the use of a polymerized human hemoglobin (PolyHeme), we have been able to measure the inflammatory response in patients resuscitated with minimal exposure to banked components in the early postinjury period...
  17. ncbi request reprint Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion
    Christopher C Silliman
    Bonfils Blood Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    Am J Physiol Cell Physiol 283:C1102-13. 2002
    ..sPLA(2)-IB and sPLA(2)-IIA caused PMN adhesion. We conclude that PMNs contain a membrane M-type sPLA(2)-R that activates p38 MAPK...
  18. pmc Red blood cell supernatant potentiates LPS-induced proinflammatory cytokine response from peripheral blood mononuclear cells
    Joel M Baumgartner
    Department of Surgery, University of Colorado, Denver, Aurora, CO 80045, USA
    J Interferon Cytokine Res 29:333-8. 2009
    ..This response is accentuated with storage duration and partially attenuated with leukoreduction. These findings may partially explain the immune activation seen clinically after blood transfusion...
  19. pmc Plasma from stored packed red blood cells and MHC class I antibodies causes acute lung injury in a 2-event in vivo rat model
    Marguerite R Kelher
    Bonfils Blood Center, Denver, CO 80230, USA
    Blood 113:2079-87. 2009
    ..We conclude that TRALI is the result of 2 events with the second events consisting of the plasma from stored blood and antibodies that prime PMNs...
  20. ncbi request reprint Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation
    Forest R Sheppard
    Department of Surgery, Denver Health Medical Center, Colorado, USA
    J Leukoc Biol 78:1025-42. 2005
    ..This review will discuss the individual components associated with the NADPH oxidase complex and the function of each of these units in each physiologic stage of the PMN: rested, primed, and activated...
  21. ncbi request reprint A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: requirements for adherence and chemokine release
    Travis H Wyman
    Bonfils Blood Center and Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80230, USA
    Am J Physiol Cell Physiol 283:C1592-603. 2002
    ..In conclusion, sequential exposure of PMNs to priming agents activates the microbicidal arsenal, and PMN-mediated HMVEC damage was the result of two insults: HMVEC activation and PMN oxidase assembly...
  22. ncbi request reprint Clinically relevant osmolar stress inhibits priming-induced PMN NADPH oxidase subunit translocation
    Forest R Sheppard
    Department of Surgery, Denver Health Medical Center, University of Colorado School of Medicine, Denver, Colorado, USA
    J Trauma 58:752-7; discussion 757. 2005
    ..Osmolar stress attenuates PAF priming of the oxidase. Consequently, we hypothesized that clinically relevant osmolar stress inhibits PAF priming-induced p67 translocation...
  23. pmc Hemodilution is not critical in the pathogenesis of the acute coagulopathy of trauma
    Max Valentin Wohlauer
    Department of Surgery, University of Colorado Denver, Denver, Colorado, USA
    J Surg Res 173:26-30. 2012
    ..We therefore hypothesized that hemodilution will impair coagulation following experimental trauma and hemorrhagic shock...
  24. ncbi request reprint Systemic neutrophil priming by lipid mediators in post-shock mesenteric lymph exists across species
    Eric L Sarin
    Departments of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
    J Trauma 57:950-4. 2004
    ....
  25. pmc The plasma fraction of stored erythrocytes augments pancreatic cancer metastasis in male versus female mice
    Peter K Moore
    School of Medicine, University of Colorado at Denver, Denver, Colorado, USA
    J Surg Res 164:23-7. 2010
    ..We therefore hypothesize that male mice with pancreatic cancer will have greater tumor progression than female mice in response to transfusion...
  26. pmc Cross-transfusion of postshock mesenteric lymph provokes acute lung injury
    Max Valentin Wohlauer
    Department of Surgery, University of Colorado Denver, Denver, Colorado, USA
    J Surg Res 170:314-8. 2011
    ..However, Koch's postulates remain to be satisfied via direct cross-transfusion into a naïve animal. We therefore hypothesized that real time cross-transfusion of postshock mesenteric lymph provokes acute lung injury...
  27. pmc Therapeutic options for transfusion related acute lung injury; the potential of the G2A receptor
    Michael A Ellison
    Belle Bonfils Memorial Blood Center, Denver, CO 80230, USA
    Curr Pharm Des 18:3255-9. 2012
    ..Additionally, characterization of the process by which lyso-PCs are generated in stored blood products could allow development of inhibitors and additive solutions to block their formation in the first place...
  28. pmc Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma
    Max V Wohlauer
    Department of Surgery, University of Colorado Denver, Denver, CO, USA
    J Am Coll Surg 214:739-46. 2012
    ..Although the current debate on acute traumatic coagulopathy has focused on the consumption or inhibition of coagulation factors, the question of early platelet dysfunction in this setting remains unclear...
  29. pmc Proteomic analyses of human plasma: Venus versus Mars
    Christopher C Silliman
    Bonfils Blood Center, Denver, Colorado 80230, USA
    Transfusion 52:417-24. 2012
    ..Little is known about the human plasma proteome, and no comparisons have been made between male and female plasma; therefore, we hypothesize that there are significant differences between plasma from male and female donors...
  30. doi request reprint A two-event in vitro model of acute chest syndrome: the role of secretory phospholipase A2 and neutrophils
    J Bradley Ball
    The Research Department, Bonfils Blood Center, 717 Yosemite Street, Denver, CO 80230, USA
    Pediatr Blood Cancer 58:399-405. 2012
    ..We hypothesize that sPLA(2) cleaves membrane lipids from sickled red blood cells (RBCs) causing PMN-mediated endothelial cell injury (ECI) as the second event in a two-event model...
  31. pmc Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury
    Samina Yasmin Khan
    Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Blood 108:2455-62. 2006
    ..We concluded that sCD40L, which accumulates during blood component storage, has the capacity to activate adherent PMNs, causing endothelial damage and possibly TRALI in predisposed patients...
  32. pmc Intravenous delivery of the plasma fraction of stored packed erythrocytes promotes pancreatic cancer growth in immunocompetent mice
    Carlton C Barnett
    Department of Surgery, University of Colorado at Denver, Denver Health Medical Center, Denver, Colorado 80204 0206, USA
    Cancer 116:3862-74. 2010
    ....
  33. ncbi request reprint Transfusion-induced leukocyte IL-8 gene expression is avoided by the use of human polymerized hemoglobin
    Forest R Sheppard
    Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
    J Trauma 57:720-4; discussion 724-5. 2004
    ..To further elucidate the mechanisms responsible for this difference in IL-8, we devised an ex-vivo transfusion model. We hypothesize that pRBC transfusion induces increased IL-8 gene expression that is avoided by the use of PolyHb...
  34. doi request reprint Postinjury hyperfibrinogenemia compromises efficacy of heparin-based venous thromboembolism prophylaxis
    Jeffrey N Harr
    Department of Surgery, University of Colorado Denver, Aurora Department of Surgery, Denver Health Medical Center, Denver Trauma Research Center and Department of Pediatrics, University of Colorado Denver, Aurora and Research Department, Bonfils Blood Center, Denver, Colorado
    Shock 41:33-9. 2014
    ..Therefore, we hypothesized that heparin is less effective for VTE prophylaxis following severe injury due to hyperfibrinogenemia...
  35. pmc Activated platelets in heparinized shed blood: the "second hit" of acute lung injury in trauma/hemorrhagic shock models
    Jeffrey N Harr
    Department of Surgery, University of Colorado Denver, Denver, Colorado, USA
    Shock 36:595-603. 2011
    ..0001). The return of heparinized SB functions as a "second hit" to enhance ALI, with activated platelets propagating microthrombi and pulmonary polymorphonuclear leukocyte recruitment...
  36. doi request reprint Viscoelastic clot strength predicts coagulation-related mortality within 15 minutes
    Michael Pezold
    Department of Surgery, University of Colorado at Denver, Denver, CO, USA
    Surgery 151:48-54. 2012
    ..We hypothesized that clot strength (G) measured by point-of-care rapid thrombelastography (r-TEG) on arrival in the emergency department can predict massive transfusion (MT) and coagulation-related mortality (MT-death)...
  37. ncbi request reprint Increased rate of infection associated with transfusion of old blood after severe injury
    Patrick J Offner
    Trauma Service, St Anthony Central Hospital, 4231 W 16th Ave, Denver, CO 80204, USA
    Arch Surg 137:711-6; discussion 716-7. 2002
    ..We hypothesized that transfusion of old blood increases infection risk in severely injured patients...
  38. ncbi request reprint Plasma and lipids from stored platelets cause acute lung injury in an animal model
    Christopher C Silliman
    Bonfils Blood Center, 717 Yosemite Circle, Denver, CO 80123, USA
    Transfusion 43:633-40. 2003
    ..We hypothesize that lipids generated during storage of PLTs cause TRALI in a two-event animal model...
  39. ncbi request reprint The role of endothelial activation in the pathogenesis of transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center and the Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80230, USA
    Transfusion 45:109S-116S. 2005
  40. doi request reprint Transfusion-related acute lung injury: advances in understanding the role of proinflammatory mediators in its genesis
    F Bernadette West
    Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Expert Rev Hematol 6:265-76. 2013
    ..This review will detail the pathophysiology of TRALI, provide insight into newer areas of research and critically assess current practices to mitigate TRALI and improve transfusion safety...
  41. ncbi request reprint "Primed" human neutrophils on a standard peripheral blood smear
    orest R Sheppard
    University of Colorado Health Sciences Center, Denver, USA
    J Am Coll Surg 195:731. 2002
  42. ncbi request reprint The two-event model of transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center and Departments of Pediatrics and Surgery, University of Colorado School of Medicine, Denver, CO, USA
    Crit Care Med 34:S124-31. 2006
    ..Laboratory studies, both in vitro and in vivo, are discussed as well as human studies of TRALI. Methods to avoid patient exposure to blood components that may cause TRALI are also discussed...
  43. ncbi request reprint Transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Blood 105:2266-73. 2005
    ..Prevention, treatment, and a proposed definition of TRALI, especially in the context of ALI, are also examined...
  44. pmc Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following trauma
    Jeffrey N Harr
    Department of Surgery, University of Colorado Denver, Aurora, CO, USA
    Shock 39:45-9. 2013
    ..These data suggest that fibrinogen should be addressed early in trauma patients manifesting acute coagulopathy of trauma...
  45. pmc Gender-specific transfusion affects tumor-associated neutrophil: macrophage ratios in murine pancreatic adenocarcinoma
    Douglas D Benson
    Denver Health Medical Center, 777 Bannock Street, Denver, CO 80204 0206, USA
    J Gastrointest Surg 14:1560-5. 2010
    ..To test this hypothesis, we examined tumor-associated neutrophils and macrophage ratios in male and female mice with pancreatic cancer receiving blood transfusion from male or female donors...
  46. ncbi request reprint Hyperosmolarity abrogates neutrophil cytotoxicity provoked by post-shock mesenteric lymph
    Ricardo J Gonzalez
    Denver Health Medical Center, Department of Surgery, Colorado 80204, USA
    Shock 18:29-32. 2002
    ..These studies suggest inhibition of PMN signal transduction is a mechanism whereby HTS resuscitation abrogates acute lung injury...
  47. doi request reprint Stored red blood cell transfusion induces regulatory T cells
    Joel M Baumgartner
    Department of Surgery, University of Colorado Denver, Denver, CO, USA
    J Am Coll Surg 208:110-9. 2009
    ..We hypothesized that transfusion-related immunosuppression is, in part, mediated by induction of T(regs), and this induction is attenuated with prestorage leukoreduction and accentuated with prolonged storage...
  48. pmc Transfusion-related acute lung injury (TRALI): current concepts and misconceptions
    Christopher C Silliman
    Research Department, Bonfils Blood Center, Denver CO 80230, USA
    Blood Rev 23:245-55. 2009
    ..This review will detail the pathophysiology of TRALI including recent pre-clinical data, provide insight into newer areas of research, and critically assess current practices to decrease it prevalence and to make transfusion safer...
  49. ncbi request reprint Transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center, University of Colorado School of Medicine, 717 Yosemite Circle, Denver, CO 80230, USA
    Blood Rev 20:139-59. 2006
    ..The definition of TRALI, patient predisposition, treatment, prevention and reporting guidelines are also examined...
  50. ncbi request reprint Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors
    Christopher C Silliman
    Bonfils Blood Center and the Department of Pediatrics, University of Colorado School of Medicine, Denver, USA
    Blood 101:454-62. 2003
    ..TRALI, like the acute respiratory distress syndrome, may be a 2-event phenomenon with both recipient predisposition and factors in the stored units playing major roles...
  51. pmc Biological response modifiers in photochemically pathogen-reduced versus untreated apheresis platelet concentrates
    Annette Vetlesen
    Department of Immunology and Transfusion Medicine, Oslo University Hospital, Ullevaal, Oslo, Norway
    Transfusion 53:147-55. 2013
    ..This study compared the content and impact of some biological response modifiers in PCs treated with pathogen reduction (PR) technology and nontreated PCs...
  52. pmc Sexual dimorphism in hematocrit response following red blood cell transfusion of critically ill surgical patients
    Fredric M Pieracci
    Department of Surgery, Denver Health Medical Center, University of Colorado Health Science Center, 777 Bannock Street MC0206, Denver, CO 80206, USA
    ISRN Hematol 2012:298345. 2012
    ..This association does not appear related to either demographic or anthropomorphic factors, raising the possibility of gender-related differences in recipient immune response to transfusion...
  53. ncbi request reprint Acute hypoxemia in humans enhances the neutrophil inflammatory response
    Douglas Y Tamura
    Department of Surgery, Denver Health Medical Center, Colorado, USA
    Shock 17:269-73. 2002
    ..These results indicate that relevant acute hypoxemic events observed in the clinical setting enhance several PMN cytotoxic functions and suggest that a transient hypoxemic insult may promote hyperinflammation...
  54. ncbi request reprint Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 MAP kinase activation
    Travis H Wyman
    Bonfils Blood Center, Denver, CO 80230, USA
    J Leukoc Biol 72:401-9. 2002
    ..We conclude that IL-18, at physiologic concentrations, is an effective PMN priming agent that requires p38 MAP kinase activity...
  55. doi request reprint Differentiation of enzymatic from platelet hypercoagulability using the novel thrombelastography parameter delta (delta)
    Eduardo Gonzalez
    Department of Surgery, Denver Health Medical Center and University of Colorado School of Medicine, Denver, Colorado, USA
    J Surg Res 163:96-101. 2010
    ..Delta)..
  56. ncbi request reprint The abdominal compartment syndrome as a second insult during systemic neutrophil priming provokes multiple organ injury
    Joao B Rezende-Neto
    Department of Surgery, Faculty of Medicine of the Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil 30350 210
    Shock 20:303-8. 2003
    ..This clinically relevant two-event animal model of PMN organ injury may be useful in elucidating therapy strategies to prevent postinjury MOF...
  57. ncbi request reprint Clinically relevant hypertonicity prevents stored blood- and lipid-mediated delayed neutrophil apoptosis independent of p38 MAPK or caspase-3 activation
    Walter L Biffl
    Department of Surgery, Rhode Island Hospital Brown Medical School, Providence, RI, USA
    Surgery 134:86-91. 2003
    ..We hypothesized that clinically relevant HTS would provoke PMN apoptosis, as well as prevent stored blood- and lipid-mediated delayed PMN apoptosis through activation of p38 mitogen-activated protein kinase (MAPK) and caspase-3...
  58. ncbi request reprint Post-hemorrhagic shock mesenteric lymph activates human pulmonary microvascular endothelium for in vitro neutrophil-mediated injury: the role of intercellular adhesion molecule-1
    Ricardo J Gonzalez
    Department of Surgery, Denver Health Medical Center and University of Colorado, 80204, USA
    J Trauma 54:219-23. 2003
    ..We hypothesize that postshock lymph induces neutrophil (PMN)-mediated endothelial cell damage in an intercellular adhesion molecule-1 (ICAM-1)-dependent fashion, and devised a two-insult model to test this hypothesis...
  59. ncbi request reprint The injured child is resistant to multiple organ failure: a different inflammatory response?
    Casey M Calkins
    Department of Surgery, University of Colorado Health Sciences Center, Denver 80262, USA
    J Trauma 53:1058-63. 2002
    ..The purpose of this study was to describe the incidence, course, and severity of pediatric postinjury MOF. We hypothesized that the incidence and severity of postinjury MOF in children would be less when compared with adults...
  60. doi request reprint The transfusion of pre storage leukoreduced packed red blood cells to injured patients
    Christopher C Silliman
    Crit Care Med 36:1661-2. 2008