C C Silliman

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Transfusion-related acute lung injury (TRALI): current concepts and misconceptions
    Christopher C Silliman
    Research Department, Bonfils Blood Center, Denver CO 80230, USA
    Blood Rev 23:245-55. 2009
  2. pmc Tumor necrosis factor-alpha causes release of cytosolic interleukin-18 from human neutrophils
    Christopher C Silliman
    Research Dept, Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Am J Physiol Cell Physiol 298:C714-24. 2010
  3. doi request reprint Transfusion-related acute lung injury: advances in understanding the role of proinflammatory mediators in its genesis
    F Bernadette West
    Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Expert Rev Hematol 6:265-76. 2013
  4. pmc Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI)
    John Paul Tung
    Research and Development, Australian Red Cross Blood Service, 44 Musk Avenue, Kelvin Grove, Brisbane, QLD 4059, Australia
    Crit Care 16:R19. 2012
  5. pmc Proteomic analyses of human plasma: Venus versus Mars
    Christopher C Silliman
    Bonfils Blood Center, Denver, Colorado 80230, USA
    Transfusion 52:417-24. 2012
  6. pmc Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury
    Christopher C Silliman
    Bonfils Blood Center, and the Department of Surgery, Denver Health Medical, Denver, Colorado 80230, USA
    Transfusion 51:2549-54. 2011
  7. pmc Mirasol Pathogen Reduction Technology treatment does not affect acute lung injury in a two-event in vivo model caused by stored blood components
    C C Silliman
    The Bonfils Blood Center, Denver, Colorado, USA
    Vox Sang 98:525-30. 2010
  8. ncbi request reprint Plasma from aged stored red blood cells delays neutrophil apoptosis and primes for cytotoxicity: abrogation by poststorage washing but not prestorage leukoreduction
    W L Biffl
    Department of Surgery, Denver Health Medical Center, Colorado, USA
    J Trauma 50:426-31; discussion 432. 2001
  9. pmc The pro-inflammatory effects of platelet contamination in plasma and mitigation strategies for avoidance
    R S Bercovitz
    Bonfils Blood Center, Denver, CO, USA
    Vox Sang 102:345-53. 2012
  10. ncbi request reprint Antibodies to the HLA-A2 antigen prime neutrophils and serve as the second event in an in vitro model of transfusion-related acute lung injury
    C C Silliman
    The Research Laboratory, Bonfils Blood Center, Denver, CO, USA Department of Pediatrics, School of Medicine, University of Colorado Denver, Aurora, CO, USA Department of Surgery, School of Medicine, University of Colorado Denver, Aurora, CO, USA
    Vox Sang 107:76-82. 2014

Collaborators

  • W L Biffl
  • Lynn K Boshkov
  • Ernest E Moore
  • P J Offner
  • CHARLES ANTHONY DINARELLO
  • Xianzhong Meng
  • Rachel S Bercovitz
  • D R Ambruso
  • Kirk C Hansen
  • C C Barnett
  • Yoke Lin Fung
  • Joel M Baumgartner
  • Neil Blumberg
  • Yong Song
  • Trevor L Nydam
  • Marguerite R Kelher
  • Anirban Banerjee
  • Forest R Sheppard
  • Nathan J D McLaughlin
  • Alexander B Benson
  • Fabia Gamboni-Robertson
  • Samina Y Khan
  • Marc Moss
  • Travis H Wyman
  • M W Kent
  • Eric L Sarin
  • F Bernadette West
  • John Paul Tung
  • Kelly M England
  • David J Elzi
  • Gregory L Austin
  • Jeffrey L Johnson
  • HUGO ROSEN
  • Peter K Moore
  • Phillip C Eckels
  • Janeen R Jordan
  • Samina Yasmin Khan
  • Nathan McLaughlin
  • orest R Sheppard
  • F B West
  • M R Kelher
  • Marguerite Kelher
  • Douglas Y Tamura
  • Kathryn I Colebourne
  • John F Fraser
  • Anna Y Zhou
  • Peter Wood
  • Adrian G Barnett
  • Kristen M Glenister
  • Maria Nataatmadja
  • Scott W Biggins
  • Igal Kam
  • Susan Mandell
  • James R Burton
  • Michael A Zimmerman
  • Marguerite Kehler
  • Sila Thomas
  • Douglas Benson
  • Kim K McFann
  • Mary Berg
  • Phillip Eckels
  • Gina Ramirez
  • Miguel Fragoso
  • Lynn M Gries
  • Sagar Damle
  • Jerry Niedzinski
  • Steven S Geier
  • Tomhiko Masuno
  • Xiayuan Liang
  • Janet L Lieber
  • Sagar S Damle
  • Sara B Kashuk
  • Gary W Mierau
  • Nathan J McLaughlin
  • Joanna M Heal
  • Richard Phipps
  • Kelly F Gettings
  • Christine Hamiel
  • Margarite Kelher
  • John B Moore
  • Jessica L Moore
  • Aaron M Cheng
  • Tomohiko Masuno
  • Steven M Anderson
  • Gail W Thurman
  • Andrew J Paterson
  • Joao B Rezende-Neto
  • A Jason Bjornsen
  • David A Partrick
  • C Wayne Smith

Detail Information

Publications42

  1. pmc Transfusion-related acute lung injury (TRALI): current concepts and misconceptions
    Christopher C Silliman
    Research Department, Bonfils Blood Center, Denver CO 80230, USA
    Blood Rev 23:245-55. 2009
    ..This review will detail the pathophysiology of TRALI including recent pre-clinical data, provide insight into newer areas of research, and critically assess current practices to decrease it prevalence and to make transfusion safer...
  2. pmc Tumor necrosis factor-alpha causes release of cytosolic interleukin-18 from human neutrophils
    Christopher C Silliman
    Research Dept, Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Am J Physiol Cell Physiol 298:C714-24. 2010
    ..Extracellular IL-18 participates in TNF-alpha priming of the PMN oxidase as demonstrated by inhibition with the IL-18 binding protein...
  3. doi request reprint Transfusion-related acute lung injury: advances in understanding the role of proinflammatory mediators in its genesis
    F Bernadette West
    Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Expert Rev Hematol 6:265-76. 2013
    ..This review will detail the pathophysiology of TRALI, provide insight into newer areas of research and critically assess current practices to mitigate TRALI and improve transfusion safety...
  4. pmc Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI)
    John Paul Tung
    Research and Development, Australian Red Cross Blood Service, 44 Musk Avenue, Kelvin Grove, Brisbane, QLD 4059, Australia
    Crit Care 16:R19. 2012
    ..However, the existence of conflicting data endorses the need for research to either reject this association, or to confirm it and elucidate the underlying mechanisms...
  5. pmc Proteomic analyses of human plasma: Venus versus Mars
    Christopher C Silliman
    Bonfils Blood Center, Denver, Colorado 80230, USA
    Transfusion 52:417-24. 2012
    ..Little is known about the human plasma proteome, and no comparisons have been made between male and female plasma; therefore, we hypothesize that there are significant differences between plasma from male and female donors...
  6. pmc Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury
    Christopher C Silliman
    Bonfils Blood Center, and the Department of Surgery, Denver Health Medical, Denver, Colorado 80230, USA
    Transfusion 51:2549-54. 2011
    ....
  7. pmc Mirasol Pathogen Reduction Technology treatment does not affect acute lung injury in a two-event in vivo model caused by stored blood components
    C C Silliman
    The Bonfils Blood Center, Denver, Colorado, USA
    Vox Sang 98:525-30. 2010
    ..We hypothesize that PRT-treatment of blood components affects the priming activity generated during storage of packed RBCs (PRBCs) or platelet concentrates (PCs), which can elicit ALI in vivo...
  8. ncbi request reprint Plasma from aged stored red blood cells delays neutrophil apoptosis and primes for cytotoxicity: abrogation by poststorage washing but not prestorage leukoreduction
    W L Biffl
    Department of Surgery, Denver Health Medical Center, Colorado, USA
    J Trauma 50:426-31; discussion 432. 2001
    ..We hypothesized that aged stored RBCs delay PMN apoptosis, but that prestorage leukodepletion or poststorage washing could abrogate the effect...
  9. pmc The pro-inflammatory effects of platelet contamination in plasma and mitigation strategies for avoidance
    R S Bercovitz
    Bonfils Blood Center, Denver, CO, USA
    Vox Sang 102:345-53. 2012
    ..We hypothesized that platelet contamination induces sCD40L generation that causes neutrophil [polymorphonuclear leucocyte (PMN)] priming and PMN-mediated cytotoxicity...
  10. ncbi request reprint Antibodies to the HLA-A2 antigen prime neutrophils and serve as the second event in an in vitro model of transfusion-related acute lung injury
    C C Silliman
    The Research Laboratory, Bonfils Blood Center, Denver, CO, USA Department of Pediatrics, School of Medicine, University of Colorado Denver, Aurora, CO, USA Department of Surgery, School of Medicine, University of Colorado Denver, Aurora, CO, USA
    Vox Sang 107:76-82. 2014
    ..We hypothesize that antibodies against HLA class I antigens bind to the antigens on the neutrophil (PMN) surface and induce priming and PMN cytotoxicity as the second event in a two-event in vitro model of PMN-mediated cytotoxicity...
  11. pmc Transfusion-related acute lung injury in ICU patients admitted with gastrointestinal bleeding
    Alexander B Benson
    Division of Pulmonary Sciences and Critical Care, University of Colorado Denver, Anschutz Medical Campus Research 2, Box C272, 9th Floor, 12770 East 19th Ave, Aurora, CO 80045, USA
    Intensive Care Med 36:1710-7. 2010
    ....
  12. pmc Differential effects of plasma and red blood cell transfusions on acute lung injury and infection risk following liver transplantation
    Alexander B Benson
    Division of Pulmonary Sciences and Critical Care, University of Colorado, Aurora, CO 80045, USA
    Liver Transpl 17:149-58. 2011
    ..Plasma-containing blood products were associated with the development of TRALI, whereas red blood cells were associated with the development of postoperative infections in a dose-dependent manner...
  13. ncbi request reprint Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 MAP kinase activation
    Travis H Wyman
    Bonfils Blood Center, Denver, CO 80230, USA
    J Leukoc Biol 72:401-9. 2002
    ..We conclude that IL-18, at physiologic concentrations, is an effective PMN priming agent that requires p38 MAP kinase activity...
  14. pmc Lysophosphatidylcholines activate G2A inducing G(αi)₋₁-/G(αq/)₁₁- Ca²(+) flux, G(βγ)-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs
    Samina Y Khan
    Bonfils Blood Center, Denver, CO 80230, USA
    Biochem J 432:35-45. 2010
    ..We conclude that lyso-PC activation of G2A caused release of G(αi)₋₁, G(αq/)₁₁ and G(βγ), resulting in cytosolic Ca²(+) flux, Hck activation, and recruitment of clathrin, β-arrestin-1 and GRK6...
  15. ncbi request reprint ICAM-1-CD18 interaction mediates neutrophil cytotoxicity through protease release
    C C Barnett
    Department of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
    Am J Physiol 274:C1634-44. 1998
    ..Collectively, these data suggest that ICAM-1 provokes PMN-mediated cytotoxicity via CD18-mediated protease release...
  16. ncbi request reprint The role of endothelial activation in the pathogenesis of transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center and the Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80230, USA
    Transfusion 45:109S-116S. 2005
  17. pmc Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils
    Nathan J D McLaughlin
    Bonfils Blood Center, University of Colorado Denver School of Medicine, Children s Hospital, Denver, CO 80230, USA
    J Immunol 180:8192-203. 2008
    ..In conclusion, PAF transduces signals through CME, and such GPCR signaling may allow for pharmacological manipulation of these cells to decrease PMN-mediated acute organ injury...
  18. ncbi request reprint Lysophosphatidylcholines prime the NADPH oxidase and stimulate multiple neutrophil functions through changes in cytosolic calcium
    Christopher C Silliman
    Bonfils Blood Center, Denver, Colorado 80230, USA
    J Leukoc Biol 73:511-24. 2003
    ..In conclusion, lyso-PCs affect multiple PMN functions in a Ca(2)(+)-dependent manner that involves the activation of a pertussis toxin-sensitive G-protein...
  19. ncbi request reprint The pro-inflammatory potential of microparticles in red blood cell units
    M W Kent
    Research Laboratory, Bonfils Blood Center, Denver, Colorado, USA Department of Pediatrics, University of Colorado, Denver, Colorado, USA
    Transfus Med 24:176-81. 2014
    ..Microparticles (MPs) are submicron size cell fragments that are released from cells...
  20. ncbi request reprint Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C
    W L Biffl
    Department of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, CO, USA
    Surg Infect (Larchmt) 2:289-93; discussion 294-5. 2001
    ..We hypothesized that circulating platelet-activating factor (PAF) and PAF-like proinflammatory phospholipids mediate delayed postinjury PMN apoptosis and that PKC is integral to the signaling pathway...
  21. pmc Red blood cell supernatant potentiates LPS-induced proinflammatory cytokine response from peripheral blood mononuclear cells
    Joel M Baumgartner
    Department of Surgery, University of Colorado, Denver, Aurora, CO 80045, USA
    J Interferon Cytokine Res 29:333-8. 2009
    ..This response is accentuated with storage duration and partially attenuated with leukoreduction. These findings may partially explain the immune activation seen clinically after blood transfusion...
  22. ncbi request reprint A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: requirements for adherence and chemokine release
    Travis H Wyman
    Bonfils Blood Center and Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80230, USA
    Am J Physiol Cell Physiol 283:C1592-603. 2002
    ..In conclusion, sequential exposure of PMNs to priming agents activates the microbicidal arsenal, and PMN-mediated HMVEC damage was the result of two insults: HMVEC activation and PMN oxidase assembly...
  23. ncbi request reprint Acute hypoxemia in humans enhances the neutrophil inflammatory response
    Douglas Y Tamura
    Department of Surgery, Denver Health Medical Center, Colorado, USA
    Shock 17:269-73. 2002
    ..These results indicate that relevant acute hypoxemic events observed in the clinical setting enhance several PMN cytotoxic functions and suggest that a transient hypoxemic insult may promote hyperinflammation...
  24. ncbi request reprint Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors
    Christopher C Silliman
    Bonfils Blood Center and the Department of Pediatrics, University of Colorado School of Medicine, Denver, USA
    Blood 101:454-62. 2003
    ..TRALI, like the acute respiratory distress syndrome, may be a 2-event phenomenon with both recipient predisposition and factors in the stored units playing major roles...
  25. ncbi request reprint Formyl-Met-Leu-Phe induces calcium-dependent tyrosine phosphorylation of Rel-1 in neutrophils
    Marguerite R Kelher
    Department of Surgery, University of Colorado Health Science Center School of Medicine, Denver, CO 80230, USA
    Cell Calcium 34:445-55. 2003
    ..Thus, fMLP concentrations that prime or activate the oxidase cause a rapid Ca2+-dependent tyrosine phosphorylation of Rel-1 involving p38 MAPK activation...
  26. ncbi request reprint Systemic neutrophil priming by lipid mediators in post-shock mesenteric lymph exists across species
    Eric L Sarin
    Departments of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
    J Trauma 57:950-4. 2004
    ....
  27. ncbi request reprint Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation
    Forest R Sheppard
    Department of Surgery, Denver Health Medical Center, Colorado, USA
    J Leukoc Biol 78:1025-42. 2005
    ..This review will discuss the individual components associated with the NADPH oxidase complex and the function of each of these units in each physiologic stage of the PMN: rested, primed, and activated...
  28. ncbi request reprint The two-event model of transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center and Departments of Pediatrics and Surgery, University of Colorado School of Medicine, Denver, CO, USA
    Crit Care Med 34:S124-31. 2006
    ..Laboratory studies, both in vitro and in vivo, are discussed as well as human studies of TRALI. Methods to avoid patient exposure to blood components that may cause TRALI are also discussed...
  29. ncbi request reprint Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation
    Nathan J D McLaughlin
    Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    J Immunol 176:7039-50. 2006
    ..We conclude that PAF signaling requires CME, beta-arrestin-1 recruitment of a p38 MAPK signalosome, and specific actin bundle formation at the PAFR for transduction before endosomal scission...
  30. pmc Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury
    Samina Yasmin Khan
    Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Blood 108:2455-62. 2006
    ..We concluded that sCD40L, which accumulates during blood component storage, has the capacity to activate adherent PMNs, causing endothelial damage and possibly TRALI in predisposed patients...
  31. doi request reprint Transfusion-related acute lung injury (TRALI): a clinical review with emphasis on the critically ill
    Alexander B Benson
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, School of Medicine University of Colorado Denver, Aurora, CO 80230, USA
    Br J Haematol 147:431-43. 2009
    ..Avoidance including male-only transfusion practises, the use of leucoreduced components, fresher blood/blood components and solvent detergent plasma are also discussed...
  32. ncbi request reprint Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion
    Christopher C Silliman
    Bonfils Blood Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    Am J Physiol Cell Physiol 283:C1102-13. 2002
    ..sPLA(2)-IB and sPLA(2)-IIA caused PMN adhesion. We conclude that PMNs contain a membrane M-type sPLA(2)-R that activates p38 MAPK...
  33. ncbi request reprint "Primed" human neutrophils on a standard peripheral blood smear
    orest R Sheppard
    University of Colorado Health Sciences Center, Denver, USA
    J Am Coll Surg 195:731. 2002
  34. ncbi request reprint Plasma and lipids from stored platelets cause acute lung injury in an animal model
    Christopher C Silliman
    Bonfils Blood Center, 717 Yosemite Circle, Denver, CO 80123, USA
    Transfusion 43:633-40. 2003
    ..We hypothesize that lipids generated during storage of PLTs cause TRALI in a two-event animal model...
  35. pmc Plasma from stored packed red blood cells and MHC class I antibodies causes acute lung injury in a 2-event in vivo rat model
    Marguerite R Kelher
    Bonfils Blood Center, Denver, CO 80230, USA
    Blood 113:2079-87. 2009
    ..We conclude that TRALI is the result of 2 events with the second events consisting of the plasma from stored blood and antibodies that prime PMNs...
  36. ncbi request reprint Transfusion-induced leukocyte IL-8 gene expression is avoided by the use of human polymerized hemoglobin
    Forest R Sheppard
    Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
    J Trauma 57:720-4; discussion 724-5. 2004
    ..To further elucidate the mechanisms responsible for this difference in IL-8, we devised an ex-vivo transfusion model. We hypothesize that pRBC transfusion induces increased IL-8 gene expression that is avoided by the use of PolyHb...
  37. ncbi request reprint Transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Blood 105:2266-73. 2005
    ..Prevention, treatment, and a proposed definition of TRALI, especially in the context of ALI, are also examined...
  38. pmc The plasma fraction of stored erythrocytes augments pancreatic cancer metastasis in male versus female mice
    Peter K Moore
    School of Medicine, University of Colorado at Denver, Denver, Colorado, USA
    J Surg Res 164:23-7. 2010
    ..We therefore hypothesize that male mice with pancreatic cancer will have greater tumor progression than female mice in response to transfusion...
  39. pmc Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophils
    Phillip C Eckels
    Department of Surgery, Denver Health Medical Center, Denver, Colorado, USA
    Am J Physiol Cell Physiol 297:C886-97. 2009
    ..Thus, amantadine and rimantadine have the potential to ameliorate PMN-mediated tissue damage in humans...
  40. ncbi request reprint Clinically relevant osmolar stress inhibits priming-induced PMN NADPH oxidase subunit translocation
    Forest R Sheppard
    Department of Surgery, Denver Health Medical Center, University of Colorado School of Medicine, Denver, Colorado, USA
    J Trauma 58:752-7; discussion 757. 2005
    ..Osmolar stress attenuates PAF priming of the oxidase. Consequently, we hypothesized that clinically relevant osmolar stress inhibits PAF priming-induced p67 translocation...
  41. ncbi request reprint Transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center, University of Colorado School of Medicine, 717 Yosemite Circle, Denver, CO 80230, USA
    Blood Rev 20:139-59. 2006
    ..The definition of TRALI, patient predisposition, treatment, prevention and reporting guidelines are also examined...
  42. doi request reprint Arachidonic acid in postshock mesenteric lymph induces pulmonary synthesis of leukotriene B4
    Janeen R Jordan
    Department of Surgery, University of Colorado Denver, Denver, CO, USA
    J Appl Physiol (1985) 104:1161-6. 2008
    ..Collectively, these data indicate that splanchnic ischemia/reperfusion activates gut PLA(2)-mediated release of AA into the lymph where it is delivered to the lungs, provoking LTB(4) production and subsequent PMN-mediated lung injury...