Research Topics
Species | C C SillimanSummaryAffiliation: University of Colorado Denver Country: USA Publications
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Detail Information
Publications
Transfusion-related acute lung injury (TRALI): current concepts and misconceptionsChristopher C Silliman
Research Department, Bonfils Blood Center, Denver CO 80230, USA
Blood Rev 23:245-55. 2009..This review will detail the pathophysiology of TRALI including recent pre-clinical data, provide insight into newer areas of research, and critically assess current practices to decrease it prevalence and to make transfusion safer...- Tumor necrosis factor-alpha causes release of cytosolic interleukin-18 from human neutrophilsChristopher C Silliman
Research Dept, Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
Am J Physiol Cell Physiol 298:C714-24. 2010..Extracellular IL-18 participates in TNF-alpha priming of the PMN oxidase as demonstrated by inhibition with the IL-18 binding protein... - Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI)John Paul Tung
Research and Development, Australian Red Cross Blood Service, 44 Musk Avenue, Kelvin Grove, Brisbane, QLD 4059, Australia
Crit Care 16:R19. 2012..However, the existence of conflicting data endorses the need for research to either reject this association, or to confirm it and elucidate the underlying mechanisms... - Proteomic analyses of human plasma: Venus versus MarsChristopher C Silliman
Bonfils Blood Center, Denver, Colorado 80230, USA
Transfusion 52:417-24. 2012..Little is known about the human plasma proteome, and no comparisons have been made between male and female plasma; therefore, we hypothesize that there are significant differences between plasma from male and female donors... - Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injuryChristopher C Silliman
Bonfils Blood Center, and the Department of Surgery, Denver Health Medical, Denver, Colorado 80230, USA
Transfusion 51:2549-54. 2011.... - Mirasol Pathogen Reduction Technology treatment does not affect acute lung injury in a two-event in vivo model caused by stored blood componentsC C Silliman
The Bonfils Blood Center, Denver, Colorado, USA
Vox Sang 98:525-30. 2010..We hypothesize that PRT-treatment of blood components affects the priming activity generated during storage of packed RBCs (PRBCs) or platelet concentrates (PCs), which can elicit ALI in vivo... 
Plasma from aged stored red blood cells delays neutrophil apoptosis and primes for cytotoxicity: abrogation by poststorage washing but not prestorage leukoreductionW L Biffl
Department of Surgery, Denver Health Medical Center, Colorado, USA
J Trauma 50:426-31; discussion 432. 2001..We hypothesized that aged stored RBCs delay PMN apoptosis, but that prestorage leukodepletion or poststorage washing could abrogate the effect...
The pro-inflammatory effects of platelet contamination in plasma and mitigation strategies for avoidanceR S Bercovitz
Bonfils Blood Center, Denver, CO, USA
Vox Sang 102:345-53. 2012..We hypothesized that platelet contamination induces sCD40L generation that causes neutrophil [polymorphonuclear leucocyte (PMN)] priming and PMN-mediated cytotoxicity...- Transfusion-related acute lung injury in ICU patients admitted with gastrointestinal bleedingAlexander B Benson
Division of Pulmonary Sciences and Critical Care, University of Colorado Denver, Anschutz Medical Campus Research 2, Box C272, 9th Floor, 12770 East 19th Ave, Aurora, CO 80045, USA
Intensive Care Med 36:1710-7. 2010.... - Differential effects of plasma and red blood cell transfusions on acute lung injury and infection risk following liver transplantationAlexander B Benson
Division of Pulmonary Sciences and Critical Care, University of Colorado, Aurora, CO 80045, USA
Liver Transpl 17:149-58. 2011..Plasma-containing blood products were associated with the development of TRALI, whereas red blood cells were associated with the development of postoperative infections in a dose-dependent manner... - Lysophosphatidylcholines activate G2A inducing G(αi)₋₁-/G(αq/)₁₁- Ca²(+) flux, G(βγ)-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNsSamina Y Khan
Bonfils Blood Center, Denver, CO 80230, USA
Biochem J 432:35-45. 2010..We conclude that lyso-PC activation of G2A caused release of G(αi)₋₁, G(αq/)₁₁ and G(βγ), resulting in cytosolic Ca²(+) flux, Hck activation, and recruitment of clathrin, β-arrestin-1 and GRK6... - Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 MAP kinase activationTravis H Wyman
Bonfils Blood Center, Denver, CO 80230, USA
J Leukoc Biol 72:401-9. 2002..We conclude that IL-18, at physiologic concentrations, is an effective PMN priming agent that requires p38 MAP kinase activity... - ICAM-1-CD18 interaction mediates neutrophil cytotoxicity through protease releaseC C Barnett
Department of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
Am J Physiol 274:C1634-44. 1998..Collectively, these data suggest that ICAM-1 provokes PMN-mediated cytotoxicity via CD18-mediated protease release... - Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophilsNathan J D McLaughlin
Bonfils Blood Center, University of Colorado Denver School of Medicine, Children s Hospital, Denver, CO 80230, USA
J Immunol 180:8192-203. 2008..In conclusion, PAF transduces signals through CME, and such GPCR signaling may allow for pharmacological manipulation of these cells to decrease PMN-mediated acute organ injury... - Lysophosphatidylcholines prime the NADPH oxidase and stimulate multiple neutrophil functions through changes in cytosolic calciumChristopher C Silliman
Bonfils Blood Center, Denver, Colorado 80230, USA
J Leukoc Biol 73:511-24. 2003..In conclusion, lyso-PCs affect multiple PMN functions in a Ca(2)(+)-dependent manner that involves the activation of a pertussis toxin-sensitive G-protein... - The role of endothelial activation in the pathogenesis of transfusion-related acute lung injuryChristopher C Silliman
Bonfils Blood Center and the Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80230, USA
Transfusion 45:109S-116S. 2005 - Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase CW L Biffl
Department of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, CO, USA
Surg Infect (Larchmt) 2:289-93; discussion 294-5. 2001..We hypothesized that circulating platelet-activating factor (PAF) and PAF-like proinflammatory phospholipids mediate delayed postinjury PMN apoptosis and that PKC is integral to the signaling pathway... - Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factorsChristopher C Silliman
Bonfils Blood Center and the Department of Pediatrics, University of Colorado School of Medicine, Denver, USA
Blood 101:454-62. 2003..TRALI, like the acute respiratory distress syndrome, may be a 2-event phenomenon with both recipient predisposition and factors in the stored units playing major roles... - A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: requirements for adherence and chemokine releaseTravis H Wyman
Bonfils Blood Center and Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80230, USA
Am J Physiol Cell Physiol 283:C1592-603. 2002..In conclusion, sequential exposure of PMNs to priming agents activates the microbicidal arsenal, and PMN-mediated HMVEC damage was the result of two insults: HMVEC activation and PMN oxidase assembly... - Acute hypoxemia in humans enhances the neutrophil inflammatory responseDouglas Y Tamura
Department of Surgery, Denver Health Medical Center, Colorado, USA
Shock 17:269-73. 2002..These results indicate that relevant acute hypoxemic events observed in the clinical setting enhance several PMN cytotoxic functions and suggest that a transient hypoxemic insult may promote hyperinflammation... - Formyl-Met-Leu-Phe induces calcium-dependent tyrosine phosphorylation of Rel-1 in neutrophilsMarguerite R Kelher
Department of Surgery, University of Colorado Health Science Center School of Medicine, Denver, CO 80230, USA
Cell Calcium 34:445-55. 2003..Thus, fMLP concentrations that prime or activate the oxidase cause a rapid Ca2+-dependent tyrosine phosphorylation of Rel-1 involving p38 MAPK activation... - Red blood cell supernatant potentiates LPS-induced proinflammatory cytokine response from peripheral blood mononuclear cellsJoel M Baumgartner
Department of Surgery, University of Colorado, Denver, Aurora, CO 80045, USA
J Interferon Cytokine Res 29:333-8. 2009..This response is accentuated with storage duration and partially attenuated with leukoreduction. These findings may partially explain the immune activation seen clinically after blood transfusion... - The two-event model of transfusion-related acute lung injuryChristopher C Silliman
Bonfils Blood Center and Departments of Pediatrics and Surgery, University of Colorado School of Medicine, Denver, CO, USA
Crit Care Med 34:S124-31. 2006..Laboratory studies, both in vitro and in vivo, are discussed as well as human studies of TRALI. Methods to avoid patient exposure to blood components that may cause TRALI are also discussed... - Systemic neutrophil priming by lipid mediators in post-shock mesenteric lymph exists across speciesEric L Sarin
Departments of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
J Trauma 57:950-4. 2004..Further, the causal agent(s) exist in the lipid fraction of the lymph and are active on both human and animal PMNs... - Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injurySamina Yasmin Khan
Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
Blood 108:2455-62. 2006..We concluded that sCD40L, which accumulates during blood component storage, has the capacity to activate adherent PMNs, causing endothelial damage and possibly TRALI in predisposed patients... - Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formationNathan J D McLaughlin
Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
J Immunol 176:7039-50. 2006..We conclude that PAF signaling requires CME, beta-arrestin-1 recruitment of a p38 MAPK signalosome, and specific actin bundle formation at the PAFR for transduction before endosomal scission... - Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activationForest R Sheppard
Department of Surgery, Denver Health Medical Center, Colorado, USA
J Leukoc Biol 78:1025-42. 2005..This review will discuss the individual components associated with the NADPH oxidase complex and the function of each of these units in each physiologic stage of the PMN: rested, primed, and activated... - Arachidonic acid in postshock mesenteric lymph induces pulmonary synthesis of leukotriene B4Janeen R Jordan
Department of Surgery, University of Colorado Denver, Denver, CO, USA
J Appl Physiol 104:1161-6. 2008..Collectively, these data indicate that splanchnic ischemia/reperfusion activates gut PLA(2)-mediated release of AA into the lymph where it is delivered to the lungs, provoking LTB(4) production and subsequent PMN-mediated lung injury... - Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesionChristopher C Silliman
Bonfils Blood Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
Am J Physiol Cell Physiol 283:C1102-13. 2002..sPLA(2)-IB and sPLA(2)-IIA caused PMN adhesion. We conclude that PMNs contain a membrane M-type sPLA(2)-R that activates p38 MAPK... - Clinically relevant osmolar stress inhibits priming-induced PMN NADPH oxidase subunit translocationForest R Sheppard
Department of Surgery, Denver Health Medical Center, University of Colorado School of Medicine, Denver, Colorado, USA
J Trauma 58:752-7; discussion 757. 2005..This finding provides new insight into the mechanisms responsible for osmolar control of PMN functional responses... - The plasma fraction of stored erythrocytes augments pancreatic cancer metastasis in male versus female micePeter K Moore
School of Medicine, University of Colorado at Denver, Denver, Colorado, USA
J Surg Res 164:23-7. 2010..We therefore hypothesize that male mice with pancreatic cancer will have greater tumor progression than female mice in response to transfusion... - "Primed" human neutrophils on a standard peripheral blood smearorest R Sheppard
University of Colorado Health Sciences Center, Denver, USA
J Am Coll Surg 195:731. 2002 - Transfusion-related acute lung injuryChristopher C Silliman
Bonfils Blood Center, University of Colorado School of Medicine, 717 Yosemite Circle, Denver, CO 80230, USA
Blood Rev 20:139-59. 2006..The definition of TRALI, patient predisposition, treatment, prevention and reporting guidelines are also examined... - Transfusion-induced leukocyte IL-8 gene expression is avoided by the use of human polymerized hemoglobinForest R Sheppard
Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
J Trauma 57:720-4; discussion 724-5. 2004..These experimental results corroborate our previous clinical studies and further encourage the study of PolyHb as a resuscitation strategy to decrease postinjury MOF... - Plasma and lipids from stored platelets cause acute lung injury in an animal modelChristopher C Silliman
Bonfils Blood Center, 717 Yosemite Circle, Denver, CO 80123, USA
Transfusion 43:633-40. 2003..We hypothesize that lipids generated during storage of PLTs cause TRALI in a two-event animal model... - Transfusion-related acute lung injury (TRALI): a clinical review with emphasis on the critically illAlexander B Benson
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, School of Medicine University of Colorado Denver, Aurora, CO 80230, USA
Br J Haematol 147:431-43. 2009..Avoidance including male-only transfusion practises, the use of leucoreduced components, fresher blood/blood components and solvent detergent plasma are also discussed... - Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophilsPhillip C Eckels
Department of Surgery, Denver Health Medical Center, Denver, Colorado, USA
Am J Physiol Cell Physiol 297:C886-97. 2009..Thus, amantadine and rimantadine have the potential to ameliorate PMN-mediated tissue damage in humans... - Plasma from stored packed red blood cells and MHC class I antibodies causes acute lung injury in a 2-event in vivo rat modelMarguerite R Kelher
Bonfils Blood Center, Denver, CO 80230, USA
Blood 113:2079-87. 2009..We conclude that TRALI is the result of 2 events with the second events consisting of the plasma from stored blood and antibodies that prime PMNs... - Transfusion-related acute lung injuryChristopher C Silliman
Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
Blood 105:2266-73. 2005..Prevention, treatment, and a proposed definition of TRALI, especially in the context of ALI, are also examined...