Robert Silbergleit

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Lack of a neuroprotective effect from N-acetylcysteine after cardiac arrest and resuscitation in a canine model
    R Silbergleit
    Section of Emergency Medicine, University of Michigan, Ann Arbor 48109, USA
    Resuscitation 40:181-6. 1999
  2. ncbi request reprint Response to Food and Drug Administration draft guidance statement on research into the treatment of life-threatening emergency conditions using exception from informed consent: testimony of the neurological emergencies treatment trials
    Robert Silbergleit
    Neurological Emergencies Treatment Trials, Clinical Coordinating Center, Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Acad Emerg Med 14:e63-8. 2007
  3. ncbi request reprint Quality of emergency care on the night shift
    Robert Silbergleit
    Department of Emergency Medicine and Survival Flight, University of Michigan, Ann Arbor, MI 48109 0303, USA
    Acad Emerg Med 13:325-30. 2006
  4. ncbi request reprint Long-term air medical services system performance using APACHE-II and mortality benchmarking
    Robert Silbergleit
    University of Michigan Department of Emergency Medicine, UMMC TC, Ann Arbor 48109 0303, USA
    Prehosp Emerg Care 7:195-8. 2003
  5. pmc Lack of association between hyperglycaemia at arrival and clinical outcomes in acute stroke patients treated with tissue plasminogen activator
    William J Meurer
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Int J Stroke 5:163-6. 2010
  6. pmc Safety of intravenous thrombolytic use in four emergency departments without acute stroke teams
    Phillip A Scott
    Department of Emergency Medicine, University of Michigan, Ann Arbor, USA
    Acad Emerg Med 17:1062-71. 2010
  7. pmc A multilevel intervention to increase community hospital use of alteplase for acute stroke (INSTINCT): a cluster-randomised controlled trial
    Phillip A Scott
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Lancet Neurol 12:139-48. 2013
  8. pmc Intramuscular versus intravenous therapy for prehospital status epilepticus
    Robert Silbergleit
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI 48105, USA
    N Engl J Med 366:591-600. 2012
  9. pmc Lack of association between pretreatment neurology consultation and subsequent protocol deviation in tissue plasminogen activator-treated patients with stroke
    William J Meurer
    Department of Emergency Medicine, University of Michigan, Ann Arbor, Mich, USA
    Stroke 41:2098-101. 2010
  10. pmc Lessons from the RAMPART study--and which is the best route of administration of benzodiazepines in status epilepticus
    Robert Silbergleit
    Department of Emergency Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48105, U S A
    Epilepsia 54:74-7. 2013

Detail Information

Publications37

  1. ncbi request reprint Lack of a neuroprotective effect from N-acetylcysteine after cardiac arrest and resuscitation in a canine model
    R Silbergleit
    Section of Emergency Medicine, University of Michigan, Ann Arbor 48109, USA
    Resuscitation 40:181-6. 1999
    ..We hypothesized that treatment with NAC would improve neurological outcome after cardiac arrest and resuscitation...
  2. ncbi request reprint Response to Food and Drug Administration draft guidance statement on research into the treatment of life-threatening emergency conditions using exception from informed consent: testimony of the neurological emergencies treatment trials
    Robert Silbergleit
    Neurological Emergencies Treatment Trials, Clinical Coordinating Center, Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Acad Emerg Med 14:e63-8. 2007
  3. ncbi request reprint Quality of emergency care on the night shift
    Robert Silbergleit
    Department of Emergency Medicine and Survival Flight, University of Michigan, Ann Arbor, MI 48109 0303, USA
    Acad Emerg Med 13:325-30. 2006
    ..Despite a lack of data, medical errors have been attributed to these deficits, and pharmacologic solutions recently have been suggested...
  4. ncbi request reprint Long-term air medical services system performance using APACHE-II and mortality benchmarking
    Robert Silbergleit
    University of Michigan Department of Emergency Medicine, UMMC TC, Ann Arbor 48109 0303, USA
    Prehosp Emerg Care 7:195-8. 2003
    ..The authors examined severity scoring and mortality data from their air medical service to characterize its performance and to identify trends in acuity and mortality over a 15-year period...
  5. pmc Lack of association between hyperglycaemia at arrival and clinical outcomes in acute stroke patients treated with tissue plasminogen activator
    William J Meurer
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Int J Stroke 5:163-6. 2010
    ..Hyperglycaemia is associated with adverse outcomes in some studies of acute ischaemic stroke...
  6. pmc Safety of intravenous thrombolytic use in four emergency departments without acute stroke teams
    Phillip A Scott
    Department of Emergency Medicine, University of Michigan, Ann Arbor, USA
    Acad Emerg Med 17:1062-71. 2010
    ..The objective was to evaluate safety of intravenous (IV) tissue plasminogen activator (tPA) delivered without dedicated thrombolytic stroke teams...
  7. pmc A multilevel intervention to increase community hospital use of alteplase for acute stroke (INSTINCT): a cluster-randomised controlled trial
    Phillip A Scott
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Lancet Neurol 12:139-48. 2013
    ..Several types of barrier frequently prevent its use. We assessed whether a standardised, barrier-assessment, multicomponent intervention could increase alteplase use in community hospitals in Michigan, USA...
  8. pmc Intramuscular versus intravenous therapy for prehospital status epilepticus
    Robert Silbergleit
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI 48105, USA
    N Engl J Med 366:591-600. 2012
    ..Early termination of prolonged seizures with intravenous administration of benzodiazepines improves outcomes. For faster and more reliable administration, paramedics increasingly use an intramuscular route...
  9. pmc Lack of association between pretreatment neurology consultation and subsequent protocol deviation in tissue plasminogen activator-treated patients with stroke
    William J Meurer
    Department of Emergency Medicine, University of Michigan, Ann Arbor, Mich, USA
    Stroke 41:2098-101. 2010
    ..We evaluated the hypothesis that consultation with neurology would be associated with fewer protocol deviations in tissue plasminogen activator-treated patients with stroke...
  10. pmc Lessons from the RAMPART study--and which is the best route of administration of benzodiazepines in status epilepticus
    Robert Silbergleit
    Department of Emergency Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48105, U S A
    Epilepsia 54:74-7. 2013
    ..Lessons from the RAMPART study's findings and potential implications on clinical practice, on the potential role of other routes of administration, on the effect of timing of interventions, and on future clinical trials are discussed. ..
  11. ncbi request reprint Preconditioning with hyperbaric oxygen attenuates brain edema after experimental intracerebral hemorrhage
    Zhiyong Qin
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Neurosurg Focus 22:E13. 2007
    ..This study investigated if preconditioning with HBO2 protects against intracerebral hemorrhage (ICH)-induced brain edema formation and examined the role of p44/42 MAPK in such protection...
  12. pmc The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trial
    Arthur M Pancioli
    Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0769, USA
    Stroke 39:3268-76. 2008
    ....
  13. ncbi request reprint Misdiagnosis of stroke in tissue plasminogen activator-treated patients: characteristics and outcomes
    Phillip A Scott
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI 48109 0303, USA
    Ann Emerg Med 42:611-8. 2003
    ..We report an evaluation of emergency department misdiagnoses in patients treated with tissue plasminogen activator for acute ischemic stroke...
  14. doi request reprint Public health impact of full implementation of therapeutic hypothermia after cardiac arrest
    Jennifer J Majersik
    Department of Neurology, Stroke Program, University of Michigan Health System, Ann Arbor, MI, United States
    Resuscitation 77:189-94. 2008
    ..However, a minority of US physicians currently use the therapy. The aim of this study was to project the public health impact of implementing hypothermia in all eligible US out-of-hospital cardiac arrest (OHCA) survivors...
  15. doi request reprint Critical care transport of patients who have acute neurological emergencies
    Bradley Uren
    Department of Emergency Medicine and Survival Flight, University of Michigan, Ann Arbor, MI, USA
    Emerg Med Clin North Am 27:17-26, vii. 2009
    ..Finally, the cost of critical care transport of patients who have neurologic emergencies is considered...
  16. ncbi request reprint The 60-day temperature-dependent degradation of midazolam and Lorazepam in the prehospital environment
    Jason T McMullan
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH 45267 0769, USA
    Prehosp Emerg Care 17:1-7. 2013
    ..Lorazepam is preferred in the emergency department, but concerns about nonrefrigerated storage limits emergency medical services (EMS) use. Midazolam is increasingly popular, but its heat stability is undocumented...
  17. pmc Implementation of the exception from informed consent regulations in a large multicenter emergency clinical trials network: the RAMPART experience
    Robert Silbergleit
    Department of Emergency Medicine, University of Michigan, Ann Arbor, USA
    Acad Emerg Med 19:448-54. 2012
    ..The NETT model used in RAMPART demonstrates how EFIC may be effectively performed in established clinical trial networks...
  18. ncbi request reprint What treatments are "satisfactory?" divining regulatory intent and an ethical basis for exception to informed consent for emergency research
    Robert Silbergleit
    University of Michigan, USA
    Am J Bioeth 6:24-6; discussion W49-50. 2006
  19. pmc RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics
    Robert Silbergleit
    Department of Emergency Medicine, University of Michigan Health System, Ann Arbor, MI, U S A
    Epilepsia 52:45-7. 2011
    ..Secondary outcomes include timing of treatment and initial seizure cessation. At the time of writing this communication, enrollment of all subjects is near completion and the study data will soon be analyzed...
  20. ncbi request reprint Hyperbaric oxygen-induced attenuation of hemorrhagic transformation after experimental focal transient cerebral ischemia
    Zhiyong Qin
    Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Stroke 38:1362-7. 2007
    ....
  21. ncbi request reprint Determining intravenous rt-PA eligibility in the Emergency Department
    Amy C Mecozzi
    Stroke Program, University of Michigan Medical School, TC 1920 0316, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Neurocrit Care 7:103-8. 2007
    ..The purpose of this study was to assess the agreement of Emergency Department (ED) attendings, ED residents, and neurology residents compared with stroke neurologists in the assessment of intravenous rt-PA eligibility...
  22. ncbi request reprint Empirical hospital and professional charges for patient care associated with out of hospital cardiac arrest before and after implementation of therapeutic hypothermia for comatose survivors
    Michael J Paulsen
    University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Resuscitation 83:1265-70. 2012
    ..The objectives of this study are to characterize the total hospital and professional charges for patients with out of hospital cardiac arrest both with and without therapeutic hypothermia treatment...
  23. pmc Resource utilization and outcome at a university versus a community teaching hospital in tPA treated stroke patients: a retrospective cohort study
    Angela F Caveney
    Department of Psychiatry, University of Michigan, Commonwealth Blvd, Ann Arbor, MI, USA
    BMC Health Serv Res 10:44. 2010
    ....
  24. doi request reprint Midazolam versus diazepam for the treatment of status epilepticus in children and young adults: a meta-analysis
    Jason McMullan
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA
    Acad Emerg Med 17:575-82. 2010
    ..Rapid treatment of status epilepticus (SE) is associated with better outcomes. Diazepam and midazolam are commonly used, but the optimal agent and administration route is unclear...
  25. ncbi request reprint Cost-effectiveness of helicopter transport of stroke patients for thrombolysis
    Robert Silbergleit
    Department of Emergency Medicine and Survival Flight, University of Michigan, Ann Arbor, MI 48109, USA
    Acad Emerg Med 10:966-72. 2003
    ..Helicopter transport for these patients has been described but without analysis of the effects of its additional cost. The authors examined the cost-effectiveness of helicopter transport for patients with acute stroke...
  26. doi request reprint NIH Roundtable on Emergency Trauma Research
    Charles B Cairns
    Department of Emergency Medicine, University of North Carolina, 170 Manning Dr, Chapel Hill, NC 27599, USA
    Ann Emerg Med 56:538-50. 2010
    ....
  27. ncbi request reprint Research conditions that qualify for emergency exception from informed consent
    Drew Watters
    Department of Emergency Medicine, University of Arizona, Tucson, AZ 85724, USA
    Acad Emerg Med 12:1040-4. 2005
    ..6) Further study should also address variability among institutional review boards, the goals of community involvement, and how best to engage and educate the public in research efforts using emergency exception from informed consent...
  28. doi request reprint Emergency treatment of status epilepticus: current thinking
    Dan Millikan
    Department of Emergency Medicine, University of Michigan Neuro Emergencies Research, Ann Arbor, MI 48106, USA
    Emerg Med Clin North Am 27:101-13, ix. 2009
    ....
  29. pmc An overview of the adaptive designs accelerating promising trials into treatments (ADAPT-IT) project
    William J Meurer
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Ann Emerg Med 60:451-7. 2012
    ....
  30. ncbi request reprint Rapid endovascular warming for profound hypothermia
    Megan Laniewicz
    Department of Emergency Medicine, University of Michigan Health System, Ann Arbor, MI, USA
    Ann Emerg Med 51:160-3. 2008
    ..Rapid warming from profound hypothermia can be accomplished with endovascular systems, and these may be an effective alternative to more invasive extracorporeal methods...
  31. ncbi request reprint Filming of patients in academic emergency departments
    Catherine A Marco
    Department of Emergency Medicine, St Vincent Mercy Medical Center, Toledo, OH 43608 2691, USA
    Acad Emerg Med 9:248-51. 2002
    ..Practices regarding filming of patients in academic emergency departments are reviewed, and suggested guidelines are provided regarding the appropriate and inappropriate filming of patients...
  32. doi request reprint Acute stroke imaging research roadmap
    Max Wintermark
    University of California, San Francisco, Department of Radiology, Neuroradiology Section, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143 0628, USA
    Stroke 39:1621-8. 2008
    ..The present article summarizes these recommendations and examines practical steps to achieve them...
  33. ncbi request reprint Thrombolysis for acute stroke: the incontrovertible, the controvertible, and the uncertain
    Robert Silbergleit
    Acad Emerg Med 12:348-51. 2005
  34. ncbi request reprint Hyperbaric oxygen reduces neuronal death and improves neurological outcome after canine cardiac arrest
    Robert E Rosenthal
    Program in Trauma, Department of Surgery, University of Maryland, Baltimore, USA
    Stroke 34:1311-6. 2003
    ....
  35. pmc Acute stroke imaging research roadmap
    Max Wintermark
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    AJNR Am J Neuroradiol 29:e23-30. 2008
    ..The present article summarizes these recommendations and examines practical steps to achieve them...
  36. ncbi request reprint Shift work and physician performance
    Robert Silbergleit
    Ann Emerg Med 39:349-51. 2002
  37. ncbi request reprint Economic benefit of increasing utilization of intravenous tissue plasminogen activator for acute ischemic stroke in the United States
    Phillip A Scott
    Stroke 37:943-4; author reply 944. 2006