Research Topics
| Robert SilbergleitSummaryAffiliation: University of Michigan Country: USA Publications
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Detail Information
Publications
Lack of a neuroprotective effect from N-acetylcysteine after cardiac arrest and resuscitation in a canine modelR Silbergleit
Section of Emergency Medicine, University of Michigan, Ann Arbor 48109, USA
Resuscitation 40:181-6. 1999..We hypothesized that treatment with NAC would improve neurological outcome after cardiac arrest and resuscitation...- Response to Food and Drug Administration draft guidance statement on research into the treatment of life-threatening emergency conditions using exception from informed consent: testimony of the neurological emergencies treatment trialsRobert Silbergleit
Neurological Emergencies Treatment Trials, Clinical Coordinating Center, Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
Acad Emerg Med 14:e63-8. 2007 - Quality of emergency care on the night shiftRobert Silbergleit
Department of Emergency Medicine and Survival Flight, University of Michigan, Ann Arbor, MI 48109 0303, USA
Acad Emerg Med 13:325-30. 2006..Despite a lack of data, medical errors have been attributed to these deficits, and pharmacologic solutions recently have been suggested... - Long-term air medical services system performance using APACHE-II and mortality benchmarkingRobert Silbergleit
University of Michigan Department of Emergency Medicine, UMMC TC, Ann Arbor 48109 0303, USA
Prehosp Emerg Care 7:195-8. 2003..The authors examined severity scoring and mortality data from their air medical service to characterize its performance and to identify trends in acuity and mortality over a 15-year period... 
Lack of association between hyperglycaemia at arrival and clinical outcomes in acute stroke patients treated with tissue plasminogen activatorWilliam J Meurer
Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
Int J Stroke 5:163-6. 2010..Hyperglycaemia is associated with adverse outcomes in some studies of acute ischaemic stroke...- Safety of intravenous thrombolytic use in four emergency departments without acute stroke teamsPhillip A Scott
Department of Emergency Medicine, University of Michigan, Ann Arbor, USA
Acad Emerg Med 17:1062-71. 2010..The objective was to evaluate safety of intravenous (IV) tissue plasminogen activator (tPA) delivered without dedicated thrombolytic stroke teams... - Intramuscular versus intravenous therapy for prehospital status epilepticusRobert Silbergleit
Department of Emergency Medicine, University of Michigan, Ann Arbor, MI 48105, USA
N Engl J Med 366:591-600. 2012..Early termination of prolonged seizures with intravenous administration of benzodiazepines improves outcomes. For faster and more reliable administration, paramedics increasingly use an intramuscular route... - Lack of association between pretreatment neurology consultation and subsequent protocol deviation in tissue plasminogen activator-treated patients with strokeWilliam J Meurer
Department of Emergency Medicine, University of Michigan, Ann Arbor, Mich, USA
Stroke 41:2098-101. 2010..We evaluated the hypothesis that consultation with neurology would be associated with fewer protocol deviations in tissue plasminogen activator-treated patients with stroke... - Preconditioning with hyperbaric oxygen attenuates brain edema after experimental intracerebral hemorrhageZhiyong Qin
Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
Neurosurg Focus 22:E13. 2007..This study investigated if preconditioning with HBO2 protects against intracerebral hemorrhage (ICH)-induced brain edema formation and examined the role of p44/42 MAPK in such protection... 
A multilevel intervention to increase community hospital use of alteplase for acute stroke (INSTINCT): a cluster-randomised controlled trialPhillip A Scott
Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA Stroke Program, University of Michigan, Ann Arbor, MI, USA Electronic address
Lancet Neurol 12:139-48. 2013..Several types of barrier frequently prevent its use. We assessed whether a standardised, barrier-assessment, multicomponent intervention could increase alteplase use in community hospitals in Michigan, USA...- Public health impact of full implementation of therapeutic hypothermia after cardiac arrestJennifer J Majersik
Department of Neurology, Stroke Program, University of Michigan Health System, Ann Arbor, MI, United States
Resuscitation 77:189-94. 2008..However, a minority of US physicians currently use the therapy. The aim of this study was to project the public health impact of implementing hypothermia in all eligible US out-of-hospital cardiac arrest (OHCA) survivors... - Critical care transport of patients who have acute neurological emergenciesBradley Uren
Department of Emergency Medicine and Survival Flight, University of Michigan, Ann Arbor, MI, USA
Emerg Med Clin North Am 27:17-26, vii. 2009..Finally, the cost of critical care transport of patients who have neurologic emergencies is considered... - The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trialArthur M Pancioli
Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0769, USA
Stroke 39:3268-76. 2008.... - Misdiagnosis of stroke in tissue plasminogen activator-treated patients: characteristics and outcomesPhillip A Scott
Department of Emergency Medicine, University of Michigan, Ann Arbor, MI 48109 0303, USA
Ann Emerg Med 42:611-8. 2003..We report an evaluation of emergency department misdiagnoses in patients treated with tissue plasminogen activator for acute ischemic stroke... - Implementation of the exception from informed consent regulations in a large multicenter emergency clinical trials network: the RAMPART experienceRobert Silbergleit
Department of Emergency Medicine, University of Michigan, Ann Arbor, USA
Acad Emerg Med 19:448-54. 2012..The NETT model used in RAMPART demonstrates how EFIC may be effectively performed in established clinical trial networks... - What treatments are "satisfactory?" divining regulatory intent and an ethical basis for exception to informed consent for emergency researchRobert Silbergleit
University of Michigan, USA
Am J Bioeth 6:24-6; discussion W49-50. 2006 - Determining intravenous rt-PA eligibility in the Emergency DepartmentAmy C Mecozzi
Stroke Program, University of Michigan Medical School, TC 1920 0316, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
Neurocrit Care 7:103-8. 2007..The purpose of this study was to assess the agreement of Emergency Department (ED) attendings, ED residents, and neurology residents compared with stroke neurologists in the assessment of intravenous rt-PA eligibility... - RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedicsRobert Silbergleit
Department of Emergency Medicine, University of Michigan Health System, Ann Arbor, MI, U S A
Epilepsia 52:45-7. 2011..Secondary outcomes include timing of treatment and initial seizure cessation. At the time of writing this communication, enrollment of all subjects is near completion and the study data will soon be analyzed... - Hyperbaric oxygen-induced attenuation of hemorrhagic transformation after experimental focal transient cerebral ischemiaZhiyong Qin
Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109 2200, USA
Stroke 38:1362-7. 2007.... - Resource utilization and outcome at a university versus a community teaching hospital in tPA treated stroke patients: a retrospective cohort studyAngela F Caveney
Department of Psychiatry, University of Michigan, Commonwealth Blvd, Ann Arbor, MI, USA
BMC Health Serv Res 10:44. 2010.... - Midazolam versus diazepam for the treatment of status epilepticus in children and young adults: a meta-analysisJason McMullan
Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA
Acad Emerg Med 17:575-82. 2010..Rapid treatment of status epilepticus (SE) is associated with better outcomes. Diazepam and midazolam are commonly used, but the optimal agent and administration route is unclear... - NIH Roundtable on Emergency Trauma ResearchCharles B Cairns
Department of Emergency Medicine, University of North Carolina, 170 Manning Dr, Chapel Hill, NC 27599, USA
Ann Emerg Med 56:538-50. 2010.... - Research conditions that qualify for emergency exception from informed consentDrew Watters
Department of Emergency Medicine, University of Arizona, Tucson, AZ 85724, USA
Acad Emerg Med 12:1040-4. 2005..6) Further study should also address variability among institutional review boards, the goals of community involvement, and how best to engage and educate the public in research efforts using emergency exception from informed consent... - Cost-effectiveness of helicopter transport of stroke patients for thrombolysisRobert Silbergleit
Department of Emergency Medicine and Survival Flight, University of Michigan, Ann Arbor, MI 48109, USA
Acad Emerg Med 10:966-72. 2003..CONCLUSIONS: This model indicates helicopter transfer of patients with suspected acute ischemic stroke for potential thrombolysis is cost-effective for a wide range of system variables... - Empirical hospital and professional charges for patient care associated with out of hospital cardiac arrest before and after implementation of therapeutic hypothermia for comatose survivorsMichael J Paulsen
University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Resuscitation 83:1265-70. 2012..The objectives of this study are to characterize the total hospital and professional charges for patients with out of hospital cardiac arrest both with and without therapeutic hypothermia treatment... - Emergency treatment of status epilepticus: current thinkingDan Millikan
Department of Emergency Medicine, University of Michigan Neuro Emergencies Research, Ann Arbor, MI 48106, USA
Emerg Med Clin North Am 27:101-13, ix. 2009.... - An overview of the adaptive designs accelerating promising trials into treatments (ADAPT-IT) projectWilliam J Meurer
Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
Ann Emerg Med 60:451-7. 2012.... - Filming of patients in academic emergency departmentsCatherine A Marco
Department of Emergency Medicine, St Vincent Mercy Medical Center, Toledo, OH 43608 2691, USA
Acad Emerg Med 9:248-51. 2002..Practices regarding filming of patients in academic emergency departments are reviewed, and suggested guidelines are provided regarding the appropriate and inappropriate filming of patients... - Rapid endovascular warming for profound hypothermiaMegan Laniewicz
Department of Emergency Medicine, University of Michigan Health System, Ann Arbor, MI, USA
Ann Emerg Med 51:160-3. 2008..Rapid warming from profound hypothermia can be accomplished with endovascular systems, and these may be an effective alternative to more invasive extracorporeal methods... - Thrombolysis for acute stroke: the incontrovertible, the controvertible, and the uncertainRobert Silbergleit
Acad Emerg Med 12:348-51. 2005 - Acute stroke imaging research roadmapMax Wintermark
University of California, San Francisco, Department of Radiology, Neuroradiology Section, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143 0628, USA
Stroke 39:1621-8. 2008..The present article summarizes these recommendations and examines practical steps to achieve them... - Shift work and physician performanceRobert Silbergleit
Ann Emerg Med 39:349-51. 2002 - Acute stroke imaging research roadmapMax Wintermark
Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
AJNR Am J Neuroradiol 29:e23-30. 2008..The present article summarizes these recommendations and examines practical steps to achieve them... - Hyperbaric oxygen reduces neuronal death and improves neurological outcome after canine cardiac arrestRobert E Rosenthal
Program in Trauma, Department of Surgery, University of Maryland, Baltimore, USA
Stroke 34:1311-6. 2003.... - Economic benefit of increasing utilization of intravenous tissue plasminogen activator for acute ischemic stroke in the United StatesPhillip A Scott
Stroke 37:943-4; author reply 944. 2006